{"id":"https://openalex.org/W2129127779","doi":"https://doi.org/10.1074/jbc.m100181200","title":"Integrin \u03b1v\u03b23/Vitronectin Interaction Affects Expression of the Urokinase System in Human Ovarian Cancer Cells","display_name":"Integrin \u03b1v\u03b23/Vitronectin Interaction Affects Expression of the Urokinase System in Human Ovarian Cancer Cells","publication_year":2001,"publication_date":"2001-07-01","ids":{"openalex":"https://openalex.org/W2129127779","doi":"https://doi.org/10.1074/jbc.m100181200","mag":"2129127779","pmid":"https://pubmed.ncbi.nlm.nih.gov/11331280"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m100181200","doi":"https://doi.org/10.1074/jbc.m100181200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m100181200","pdf_url":"http://www.jbc.org/article/S0021925819301942/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925819301942/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058466106","display_name":"Sandra Hapke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I2802619606","display_name":"TUM Klinikum","ror":"https://ror.org/04jc43x05","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Sandra Hapke","raw_affiliation_strings":["Frauenklinik der Technischen Universit\u00e4t M\u00fcnchen, Klinikum rechts der Isar, Ismaninger Strasse 22, D-81675 M\u00fcnchen, Germany","University of California, San Francisco, San Francisco, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Frauenklinik der Technischen Universit\u00e4t M\u00fcnchen, Klinikum rechts der Isar, Ismaninger Strasse 22, D-81675 M\u00fcnchen, Germany","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"raw_affiliation_string":"University of California, San Francisco, San Francisco, United States","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081381092","display_name":"Horst Kessler","orcid":"https://orcid.org/0000-0002-7292-9789","observed_orcids":["https://orcid.org/0000-0002-7292-9789"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Horst Kessler","raw_affiliation_strings":["Institut fu\u0308r Organische Chemie und Biochemie, Technische Universita\u0308t Mu\u0308nchen, Lichtenbergstrasse 4, D-85747 Garching, Germany, and the","University of California, San Francisco, San Francisco, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut fu\u0308r Organische Chemie und Biochemie, Technische Universita\u0308t Mu\u0308nchen, Lichtenbergstrasse 4, D-85747 Garching, Germany, and the","institution_ids":["https://openalex.org/I62916508"]},{"raw_affiliation_string":"University of California, San Francisco, San Francisco, United States","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030761488","display_name":"Nuria Arroyo de Prada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I2802619606","display_name":"TUM Klinikum","ror":"https://ror.org/04jc43x05","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Nuria Arroyo de Prada","raw_affiliation_strings":["Frauenklinik der Technischen Universita\u0308t Mu\u0308nchen, Klinikum rechts der Isar, Ismaninger Strasse 22, D-81675 Mu\u0308nchen, Germany, the","University of California, San Francisco, San Francisco, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Frauenklinik der Technischen Universita\u0308t Mu\u0308nchen, Klinikum rechts der Isar, Ismaninger Strasse 22, D-81675 Mu\u0308nchen, Germany, the","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"raw_affiliation_string":"University of California, San Francisco, San Francisco, United States","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020575310","display_name":"Anke Benge","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I2802619606","display_name":"TUM Klinikum","ror":"https://ror.org/04jc43x05","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Anke Benge","raw_affiliation_strings":["Frauenklinik der Technischen Universita\u0308t Mu\u0308nchen, Klinikum rechts der Isar, Ismaninger Strasse 22, D-81675 Mu\u0308nchen, Germany, the","University of California, San Francisco, San Francisco, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Frauenklinik der Technischen Universita\u0308t Mu\u0308nchen, Klinikum rechts der Isar, Ismaninger Strasse 22, D-81675 Mu\u0308nchen, Germany, the","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"raw_affiliation_string":"University of California, San Francisco, San Francisco, United States","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023638355","display_name":"Manfred Schmitt","orcid":"https://orcid.org/0000-0002-9978-8357","observed_orcids":["https://orcid.org/0000-0002-9978-8357"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I2802619606","display_name":"TUM Klinikum","ror":"https://ror.org/04jc43x05","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Manfred Schmitt","raw_affiliation_strings":["Frauenklinik der Technischen Universita\u0308t Mu\u0308nchen, Klinikum rechts der Isar, Ismaninger Strasse 22, D-81675 Mu\u0308nchen, Germany, the","University of California, San Francisco, San Francisco, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Frauenklinik der Technischen Universita\u0308t Mu\u0308nchen, Klinikum rechts der Isar, Ismaninger Strasse 22, D-81675 Mu\u0308nchen, Germany, the","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"raw_affiliation_string":"University of California, San Francisco, San Francisco, United States","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027620152","display_name":"Ernst R. Lengyel","orcid":"https://orcid.org/0000-0001-8624-1507","observed_orcids":["https://orcid.org/0000-0001-8624-1507"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210110664","display_name":"University of California San Francisco Medical Center","ror":"https://ror.org/01t8svj65","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210110664"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ernst Lengyel","raw_affiliation_strings":["Department of Obstetrics, Gynecology & Reproductive Sciences, University of California San Francisco Cancer Center, Cancer Research Institute, San Francisco, CA 94143-0875","University of California, San Francisco, San Francisco, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics, Gynecology & Reproductive Sciences, University of California San Francisco Cancer Center, Cancer Research Institute, San Francisco, CA 94143-0875","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210110664"]},{"raw_affiliation_string":"University of California, San Francisco, San Francisco, United States","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022140307","display_name":"Ute Reuning","orcid":"https://orcid.org/0000-0001-9262-3712","observed_orcids":["https://orcid.org/0000-0001-9262-3712"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I2802619606","display_name":"TUM Klinikum","ror":"https://ror.org/04jc43x05","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE","US"],"is_corresponding":true,"raw_author_name":"Ute Reuning","raw_affiliation_strings":["Frauenklinik der Technischen Universita\u0308t Mu\u0308nchen, Klinikum rechts der Isar, Ismaninger Strasse 22, D-81675 Mu\u0308nchen, Germany, the","University of California, San Francisco, San Francisco, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Frauenklinik der Technischen Universita\u0308t Mu\u0308nchen, Klinikum rechts der Isar, Ismaninger Strasse 22, D-81675 Mu\u0308nchen, Germany, the","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"raw_affiliation_string":"University of California, San Francisco, San Francisco, United States","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5022140307"],"corresponding_institution_ids":["https://openalex.org/I180670191","https://openalex.org/I2802619606","https://openalex.org/I62916508"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":2.4956,"has_fulltext":true,"cited_by_count":69,"citation_normalized_percentile":{"value":0.89828204,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"276","issue":"28","first_page":"26340","last_page":"26348"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.8169000148773193,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.8169000148773193,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.17970000207424164,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/integrin-alphavbeta3","display_name":"integrin \u03b1v\u03b23","score":0.8889999985694885},{"id":"https://openalex.org/keywords/vitronectin","display_name":"vitronectin","score":1.0},{"id":"https://openalex.org/keywords/urokinase-type-plasminogen-activator","display_name":"urokinase","score":0.9100000262260437},{"id":"https://openalex.org/keywords/upar","display_name":"uPAR","score":0.9350000023841858},{"id":"https://openalex.org/keywords/plasminogen-activator-inhibitor-1","display_name":"plasminogen activator inhibitor-1","score":0.9580000042915344},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.7120000123977661},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.8450000286102295},{"id":"https://openalex.org/keywords/rel-transcription-factors","display_name":"Rel transcription factors","score":0.6579999923706055},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.8500000238418579},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.8450000286102295},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.6800000071525574},{"id":"https://openalex.org/keywords/fibronectin","display_name":"fibronectin","score":0.902999997138977},{"id":"https://openalex.org/keywords/type-iv-collagen","display_name":"type IV collagen","score":0.968999981880188}],"concepts":[{"id":"https://openalex.org/C164144092","wikidata":"https://www.wikidata.org/wiki/Q6587033","display_name":"Vitronectin","level":4,"score":0.9677848815917969},{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.6439327597618103},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.6186094284057617},{"id":"https://openalex.org/C2776892390","wikidata":"https://www.wikidata.org/wiki/Q7119591","display_name":"Urokinase","level":2,"score":0.5681696534156799},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5651337504386902},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.45699992775917053},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.44908612966537476},{"id":"https://openalex.org/C56219504","wikidata":"https://www.wikidata.org/wiki/Q7900869","display_name":"Urokinase receptor","level":3,"score":0.4414736032485962},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.41273263096809387},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3930455446243286},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3636341094970703},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30207473039627075},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2695334255695343},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.17249897122383118},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13836559653282166}],"mesh":[{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014568","descriptor_name":"Urokinase-Type Plasminogen Activator","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D014568","descriptor_name":"Urokinase-Type Plasminogen Activator","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D014568","descriptor_name":"Urokinase-Type Plasminogen Activator","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D019030","descriptor_name":"Receptors, Vitronectin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019030","descriptor_name":"Receptors, Vitronectin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019030","descriptor_name":"Receptors, Vitronectin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019096","descriptor_name":"Vitronectin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019096","descriptor_name":"Vitronectin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019096","descriptor_name":"Vitronectin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.m100181200","doi":"https://doi.org/10.1074/jbc.m100181200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m100181200","pdf_url":"http://www.jbc.org/article/S0021925819301942/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:11331280","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11331280","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m100181200","doi":"https://doi.org/10.1074/jbc.m100181200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m100181200","pdf_url":"http://www.jbc.org/article/S0021925819301942/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6800000071525574}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2129127779.pdf","grobid_xml":"https://content.openalex.org/works/W2129127779.grobid-xml"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W143133239","https://openalex.org/W264579827","https://openalex.org/W1544975530","https://openalex.org/W1548286725","https://openalex.org/W1555563546","https://openalex.org/W1560207700","https://openalex.org/W1571549380","https://openalex.org/W1591097516","https://openalex.org/W1607041879","https://openalex.org/W1670322156","https://openalex.org/W1926488772","https://openalex.org/W1973270637","https://openalex.org/W1982849453","https://openalex.org/W1983212899","https://openalex.org/W1989434876","https://openalex.org/W1995412965","https://openalex.org/W1996722746","https://openalex.org/W2002082738","https://openalex.org/W2003593894","https://openalex.org/W2006678973","https://openalex.org/W2007026034","https://openalex.org/W2010275471","https://openalex.org/W2012710893","https://openalex.org/W2013813330","https://openalex.org/W2019728202","https://openalex.org/W2020567039","https://openalex.org/W2023242965","https://openalex.org/W2023285074","https://openalex.org/W2027077889","https://openalex.org/W2035830356","https://openalex.org/W2041111722","https://openalex.org/W2042155824","https://openalex.org/W2042274047","https://openalex.org/W2043513099","https://openalex.org/W2043648660","https://openalex.org/W2044949296","https://openalex.org/W2047013487","https://openalex.org/W2048653605","https://openalex.org/W2049631846","https://openalex.org/W2055884349","https://openalex.org/W2063147847","https://openalex.org/W2064484362","https://openalex.org/W2064517965","https://openalex.org/W2068561314","https://openalex.org/W2073993982","https://openalex.org/W2074012988","https://openalex.org/W2075172358","https://openalex.org/W2081475030","https://openalex.org/W2092492313","https://openalex.org/W2099213932","https://openalex.org/W2102577298","https://openalex.org/W2106761248","https://openalex.org/W2113185415","https://openalex.org/W2123764828","https://openalex.org/W2126749305","https://openalex.org/W2130580559","https://openalex.org/W2139625377","https://openalex.org/W2164921896","https://openalex.org/W2167280914","https://openalex.org/W2169942415","https://openalex.org/W2256510372","https://openalex.org/W2411677906","https://openalex.org/W2414052497","https://openalex.org/W2419154990","https://openalex.org/W2444477924","https://openalex.org/W2888511473","https://openalex.org/W4213141530"],"related_works":["https://openalex.org/W3080232038","https://openalex.org/W3097943679","https://openalex.org/W2029441481","https://openalex.org/W1969517840","https://openalex.org/W1520764241","https://openalex.org/W2131243830","https://openalex.org/W3161586667","https://openalex.org/W2095900203","https://openalex.org/W2088779716","https://openalex.org/W2039445887"],"abstract_inverted_index":{"The":[0,40,152,168],"urokinase":[1],"type":[2,101],"plasminogen":[3,13],"activator":[4,14],"(uPA),":[5],"together":[6],"with":[7,30],"its":[8],"receptor":[9],"uPAR":[10,47,111],"and":[11,25,38,48,73,84,110,142,196],"the":[12,31,52,67,145,171,187,208],"inhibitor":[15],"type-1":[16],"(PAI-1)":[17],"plays":[18],"a":[19,127,181,205],"pivotal":[20],"role":[21],"during":[22],"tumor":[23],"invasion":[24],"metastasis.":[26],"Integrins,":[27],"via":[28],"interaction":[29],"extracellular":[32],"matrix":[33],"(ECM),":[34],"control":[35],"cell":[36,164],"adhesion":[37,165],"motility.":[39],"two":[41],"systems":[42],"are":[43,75],"functionally":[44],"linked":[45],"because":[46],"PAI-1":[49,74,85,114,173],"bind":[50],"to":[51,117,166,177],"ECM":[53],"component":[54],"vitronectin":[55],"(VN).":[56],"Because":[57],"integrin":[58],"signaling":[59],"alters":[60],"gene":[61],"expression":[62,68],"patterns,":[63],"we":[64],"investigated":[65],"whether":[66],"levels":[69],"of":[70,81,108,121,130,147,154,170,183,192,210],"uPA,":[71,82,193],"uPAR,":[72,83,194],"affected":[76],"by":[77,115,126],"ECM/integrin":[78],"interactions.":[79],"Expression":[80],"was":[86,124,135,158,175],"significantly":[87,160],"enhanced":[88],"when":[89],"human":[90,199],"ovarian":[91,200],"cancer":[92,201],"cells":[93,202],"(OV-MZ-6)":[94],"were":[95],"cultivated":[96],"on":[97,144],"fibronectin":[98],"or":[99],"collagen":[100],"IV.":[102],"In":[103],"contrast,":[104],"VN":[105],"induced":[106,179],"down-regulation":[107],"uPA":[109,122,131],"while":[112],"increasing":[113],"up":[116,176],"4-fold.":[118],"VN-dependent":[119],"decrease":[120],"protein":[123],"paralleled":[125],"significant":[128],"reduction":[129],"promoter":[132,174],"activity":[133,153,169],"that":[134],"even":[136],"more":[137],"pronounced":[138],"upon":[139,162],"alpha(v)beta(3)":[140],"overexpression":[141],"depended":[143],"presence":[146],"intact":[148],"Rel":[149,155],"protein-binding":[150],"sites.":[151],"transcription":[156],"factors":[157],"also":[159],"reduced":[161],"alpha(v)beta(3)-mediated":[163],"VN.":[167],"Rel-unresponsive":[172],"5-fold":[178],"as":[180],"function":[182],"alpha(v)beta(3)/VN":[184],"interaction.":[185],"Thus,":[186],"balance":[188],"between":[189],"available":[190],"concentrations":[191],"PAI-1,":[195],"integrins":[197],"in":[198],"might":[203],"provide":[204],"switch":[206],"within":[207],"regulation":[209],"their":[211],"invasive":[212],"phenotype.":[213]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2016-06-24T00:00:00"}
