{"id":"https://openalex.org/W2129127301","doi":"https://doi.org/10.1677/joe.0.0450515","title":"PREMATURE DELIVERY OF FOETAL LAMBS INFUSED WITH GLUCOCORTICOIDS","display_name":"PREMATURE DELIVERY OF FOETAL LAMBS INFUSED WITH GLUCOCORTICOIDS","publication_year":1969,"publication_date":"1969-12-01","ids":{"openalex":"https://openalex.org/W2129127301","doi":"https://doi.org/10.1677/joe.0.0450515","mag":"2129127301","pmid":"https://pubmed.ncbi.nlm.nih.gov/5366112"},"language":"en","primary_location":{"id":"doi:10.1677/joe.0.0450515","doi":"https://doi.org/10.1677/joe.0.0450515","is_oa":false,"landing_page_url":"https://doi.org/10.1677/joe.0.0450515","pdf_url":null,"source":{"id":"https://openalex.org/S34842069","display_name":"Journal of Endocrinology","issn_l":"0022-0795","issn":["0022-0795","1479-6805"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113520893","display_name":"G. C. Liggins","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"G. C. LIGGINS","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5113520893"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":20.0151,"has_fulltext":false,"cited_by_count":820,"citation_normalized_percentile":{"value":0.99758818,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"45","issue":"4","first_page":"515","last_page":"523"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10584","display_name":"Reproductive Physiology in Livestock","score":0.45410001277923584,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10584","display_name":"Reproductive Physiology in Livestock","score":0.45410001277923584,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11290","display_name":"Preterm Birth and Chorioamnionitis","score":0.2345999926328659,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.12080000340938568,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":0.9190000295639038},{"id":"https://openalex.org/keywords/preterm-birth","display_name":"preterm birth","score":0.796999990940094},{"id":"https://openalex.org/keywords/glucocorticoids","display_name":"glucocorticoids","score":0.8539999723434448},{"id":"https://openalex.org/keywords/fetal-sheep","display_name":"fetal sheep","score":0.7139999866485596},{"id":"https://openalex.org/keywords/deoxycorticosterone","display_name":"deoxycorticosterone","score":0.7839999794960022},{"id":"https://openalex.org/keywords/corticosterone","display_name":"corticosterone","score":0.9950000047683716},{"id":"https://openalex.org/keywords/progesterone","display_name":"progesterone","score":0.8679999709129333},{"id":"https://openalex.org/keywords/uterine-contractility","display_name":"uterine contractility","score":0.9520000219345093},{"id":"https://openalex.org/keywords/pulmonary-surfactant","display_name":"pulmonary surfactant","score":0.9279999732971191},{"id":"https://openalex.org/keywords/mineralocorticoid-activity","display_name":"mineralocorticoid activity","score":0.7269999980926514}],"concepts":[{"id":"https://openalex.org/C2780401358","wikidata":"https://www.wikidata.org/wiki/Q422252","display_name":"Dexamethasone","level":2,"score":0.9119900465011597},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8483462929725647},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8413726687431335},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.7293368577957153},{"id":"https://openalex.org/C2780841215","wikidata":"https://www.wikidata.org/wiki/Q422549","display_name":"Glucocorticoid","level":2,"score":0.642487645149231},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.5899311304092407},{"id":"https://openalex.org/C2780352252","wikidata":"https://www.wikidata.org/wiki/Q422543","display_name":"Corticosterone","level":3,"score":0.583695650100708},{"id":"https://openalex.org/C2776069600","wikidata":"https://www.wikidata.org/wiki/Q422519","display_name":"Mineralocorticoid","level":3,"score":0.47650495171546936},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.4694119393825531},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4486064910888672},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31539714336395264},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.2485578954219818},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003345","descriptor_name":"Corticosterone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003900","descriptor_name":"Desoxycorticosterone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003907","descriptor_name":"Dexamethasone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005333","descriptor_name":"Fetus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D005865","descriptor_name":"Gestational Age","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D007752","descriptor_name":"Obstetric Labor, Premature","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D007752","descriptor_name":"Obstetric Labor, Premature","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011374","descriptor_name":"Progesterone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011374","descriptor_name":"Progesterone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012756","descriptor_name":"Sheep","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014427","descriptor_name":"Twins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014599","descriptor_name":"Uterus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1677/joe.0.0450515","doi":"https://doi.org/10.1677/joe.0.0450515","is_oa":false,"landing_page_url":"https://doi.org/10.1677/joe.0.0450515","pdf_url":null,"source":{"id":"https://openalex.org/S34842069","display_name":"Journal of Endocrinology","issn_l":"0022-0795","issn":["0022-0795","1479-6805"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Endocrinology","raw_type":"journal-article"},{"id":"pmid:5366112","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/5366112","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of endocrinology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.820.9232","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.820.9232","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://joe.endocrinology-journals.org/content/45/4/515.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":5,"referenced_works":["https://openalex.org/W1571266414","https://openalex.org/W1963694295","https://openalex.org/W1993009863","https://openalex.org/W2005791879","https://openalex.org/W2419559204"],"related_works":["https://openalex.org/W2045613848","https://openalex.org/W4409137696","https://openalex.org/W2049762612","https://openalex.org/W2094535779","https://openalex.org/W2059471627","https://openalex.org/W2163639471","https://openalex.org/W2023580840","https://openalex.org/W1998554981","https://openalex.org/W2033386934","https://openalex.org/W2105116728"],"abstract_inverted_index":{"Abstract":[0],"SUMMARY":[1],"Dexamethasone":[2],"caused":[3],"premature":[4,65],"delivery":[5],"when":[6,22],"infused":[7],"into":[8,35],"foetal":[9],"lambs":[10,150],"at":[11,27,153],"rates":[12],"of":[13,30,38,45,61,85,102,105,113,124,137,144,156,170,173],"0\u00b706\u20134\u00b70":[14],"mg./24":[15,32],"hr.":[16,33,89],"but":[17],"it":[18],"had":[19],"no":[20],"effect":[21],"administered":[23],"to":[24,63,68,90,94],"pregnant":[25],"ewes":[26],"the":[28,36,59,91,95,108,114,122,130,145,168],"rate":[29],"4\u00b70":[31],"Infusions":[34],"foetus":[37,131],"deoxycorticosterone":[39,48],"or":[40,93,120],"corticosterone":[41],"were":[42],"ineffective;":[43],"mixtures":[44],"dexamethasone":[46,56,79],"and":[47],"did":[49],"not":[50,81],"cause":[51,64],"parturition":[52,66,125],"more":[53],"rapidly":[54],"than":[55,73],"alone.":[57],"Thus,":[58],"ability":[60],"corticosteroids":[62,128],"appears":[67],"depend":[69],"on":[70,107,139],"glucocorticoid":[71],"rather":[72],"mineralocorticoid":[74],"activity.":[75,175],"Parturition":[76],"induced":[77],"by":[78,83,127],"was":[80,147],"delayed":[82],"administration":[84],"100":[86],"mg.":[87],"progesterone/24":[88],"ewe":[92],"foetus.":[96],"This":[97],"suggests":[98],"either":[99],"that":[100,121,164],"withdrawal":[101],"inhibitory":[103],"effects":[104],"progesterone":[106,115,138],"myometrium":[109],"can":[110,132],"occur":[111],"independently":[112],"concentration":[116],"in":[117,129,149],"peripheral":[118],"plasma,":[119],"mechanism":[123],"provoked":[126],"override":[133],"any":[134],"regulatory":[135],"influence":[136],"myometrial":[140],"contractility.":[141],"Partial":[142],"aeration":[143],"lungs":[146],"observed":[148],"born":[151],"vaginally":[152],"117\u2013123":[154],"days":[155],"gestation":[157],"after":[158],"receiving":[159],"dexamethasone.":[160],"It":[161],"is":[162],"suggested":[163],"this":[165],"may":[166],"be":[167],"result":[169],"accelerated":[171],"appearance":[172],"surfactant":[174]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":20},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":19},{"year":2021,"cited_by_count":17},{"year":2020,"cited_by_count":18},{"year":2019,"cited_by_count":21},{"year":2018,"cited_by_count":24},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":25},{"year":2015,"cited_by_count":19},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":26},{"year":2012,"cited_by_count":20}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}