{"id":"https://openalex.org/W2129114362","doi":"https://doi.org/10.1128/jvi.00675-11","title":"Adenovirus Type 5 Rupture of Lysosomes Leads to Cathepsin B-Dependent Mitochondrial Stress and Production of Reactive Oxygen Species","display_name":"Adenovirus Type 5 Rupture of Lysosomes Leads to Cathepsin B-Dependent Mitochondrial Stress and Production of Reactive Oxygen Species","publication_year":2011,"publication_date":"2011-08-11","ids":{"openalex":"https://openalex.org/W2129114362","doi":"https://doi.org/10.1128/jvi.00675-11","mag":"2129114362","pmid":"https://pubmed.ncbi.nlm.nih.gov/21835790","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3187480"},"language":"en","primary_location":{"id":"doi:10.1128/jvi.00675-11","doi":"https://doi.org/10.1128/jvi.00675-11","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.00675-11","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3187480","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057417173","display_name":"Kathleen A. McGuire","orcid":"https://orcid.org/0000-0002-7984-2053","observed_orcids":["https://orcid.org/0000-0002-7984-2053"]},"institutions":[{"id":"https://openalex.org/I1925986","display_name":"Loyola University Chicago","ror":"https://ror.org/04b6x2g63","country_code":"US","type":"education","lineage":["https://openalex.org/I1925986"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathleen A. McGuire","raw_affiliation_strings":["Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, 2160 S. First Avenue, Maywood, Illinois 60153","Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, 2160 S. First Avenue, Maywood, IL 60153, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, 2160 S. First Avenue, Maywood, Illinois 60153","institution_ids":["https://openalex.org/I1925986"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, 2160 S. First Avenue, Maywood, IL 60153, USA","institution_ids":["https://openalex.org/I1925986"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076260831","display_name":"Arlene U. Barlan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1925986","display_name":"Loyola University Chicago","ror":"https://ror.org/04b6x2g63","country_code":"US","type":"education","lineage":["https://openalex.org/I1925986"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arlene U. Barlan","raw_affiliation_strings":["Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, 2160 S. First Avenue, Maywood, Illinois 60153"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, 2160 S. First Avenue, Maywood, Illinois 60153","institution_ids":["https://openalex.org/I1925986"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078183414","display_name":"Tina Griffin","orcid":"https://orcid.org/0000-0002-0560-2364","observed_orcids":["https://orcid.org/0000-0002-0560-2364"]},"institutions":[{"id":"https://openalex.org/I1925986","display_name":"Loyola University Chicago","ror":"https://ror.org/04b6x2g63","country_code":"US","type":"education","lineage":["https://openalex.org/I1925986"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tina M. Griffin","raw_affiliation_strings":["Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, 2160 S. First Avenue, Maywood, Illinois 60153"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, 2160 S. First Avenue, Maywood, Illinois 60153","institution_ids":["https://openalex.org/I1925986"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043937432","display_name":"Christopher M. Wiethoff","orcid":"https://orcid.org/0000-0001-9102-7492","observed_orcids":["https://orcid.org/0000-0001-9102-7492"]},"institutions":[{"id":"https://openalex.org/I1925986","display_name":"Loyola University Chicago","ror":"https://ror.org/04b6x2g63","country_code":"US","type":"education","lineage":["https://openalex.org/I1925986"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Christopher M. Wiethoff","raw_affiliation_strings":["Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, 2160 S. First Avenue, Maywood, Illinois 60153"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, 2160 S. First Avenue, Maywood, Illinois 60153","institution_ids":["https://openalex.org/I1925986"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5043937432"],"corresponding_institution_ids":["https://openalex.org/I1925986"],"apc_list":null,"apc_paid":null,"fwci":3.6751,"has_fulltext":false,"cited_by_count":69,"citation_normalized_percentile":{"value":0.93535223,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"85","issue":"20","first_page":"10806","last_page":"10813"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.4426000118255615,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.4426000118255615,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.21130000054836273,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.04989999905228615,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adenovirus-type-5","display_name":"adenovirus type 5","score":0.9990000128746033},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8700000047683716},{"id":"https://openalex.org/keywords/mitochondrial-membrane-potential","display_name":"mitochondrial membrane potential","score":0.7829999923706055},{"id":"https://openalex.org/keywords/mitochondrial-stress","display_name":"mitochondrial stress","score":0.6800000071525574},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.8050000071525574},{"id":"https://openalex.org/keywords/nadph-oxidase","display_name":"NADPH oxidase","score":0.8059999942779541},{"id":"https://openalex.org/keywords/nox2","display_name":"NOX2","score":0.7839999794960022},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.8560000061988831},{"id":"https://openalex.org/keywords/cytokine-production","display_name":"cytokine production","score":0.8349999785423279}],"concepts":[{"id":"https://openalex.org/C2778175917","wikidata":"https://www.wikidata.org/wiki/Q17125553","display_name":"Mitochondrial ROS","level":3,"score":0.7852708101272583},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7156208157539368},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.7060964107513428},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6881160736083984},{"id":"https://openalex.org/C2779719074","wikidata":"https://www.wikidata.org/wiki/Q2038057","display_name":"NADPH oxidase","level":3,"score":0.6565864682197571},{"id":"https://openalex.org/C102747710","wikidata":"https://www.wikidata.org/wiki/Q824237","display_name":"Endosome","level":3,"score":0.5990611910820007},{"id":"https://openalex.org/C28021979","wikidata":"https://www.wikidata.org/wiki/Q14911946","display_name":"Cathepsin B","level":3,"score":0.5255992412567139},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.5131540894508362},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.4310660660266876},{"id":"https://openalex.org/C167844969","wikidata":"https://www.wikidata.org/wiki/Q426245","display_name":"Cathepsin","level":3,"score":0.42902541160583496},{"id":"https://openalex.org/C75385678","wikidata":"https://www.wikidata.org/wiki/Q4896390","display_name":"Inner mitochondrial membrane","level":3,"score":0.41025757789611816},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16196224093437195},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000256","descriptor_name":"Adenoviridae","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002401","descriptor_name":"Cathepsin B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008247","descriptor_name":"Lysosomes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D008247","descriptor_name":"Lysosomes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051336","descriptor_name":"Mitochondrial Membranes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D053078","descriptor_name":"Membrane Potential, Mitochondrial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1128/jvi.00675-11","doi":"https://doi.org/10.1128/jvi.00675-11","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.00675-11","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3187480","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3187480","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},{"id":"pmid:21835790","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21835790","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of virology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3187480","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3187480","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2671266743","display_name":null,"funder_award_id":"AI007508","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4040295950","display_name":"Experimental Immunology Training Grant","funder_award_id":"T32AI007508","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6493049096","display_name":"Inflammasome activation by a respiratory virus","funder_award_id":"R21AI082430","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7694714605","display_name":null,"funder_award_id":"AI082430","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W154761593","https://openalex.org/W1542737599","https://openalex.org/W1544232861","https://openalex.org/W1585390661","https://openalex.org/W1740655975","https://openalex.org/W1825621539","https://openalex.org/W1910519909","https://openalex.org/W1961219990","https://openalex.org/W1968512491","https://openalex.org/W1970154782","https://openalex.org/W1970436087","https://openalex.org/W1970684883","https://openalex.org/W1975261219","https://openalex.org/W1983761290","https://openalex.org/W1985538633","https://openalex.org/W1993205112","https://openalex.org/W1996758156","https://openalex.org/W2006193439","https://openalex.org/W2012001358","https://openalex.org/W2015785153","https://openalex.org/W2028701745","https://openalex.org/W2039843171","https://openalex.org/W2040837189","https://openalex.org/W2042212295","https://openalex.org/W2049001563","https://openalex.org/W2056810047","https://openalex.org/W2059296004","https://openalex.org/W2065864183","https://openalex.org/W2066571367","https://openalex.org/W2076010157","https://openalex.org/W2079045730","https://openalex.org/W2092415828","https://openalex.org/W2096328031","https://openalex.org/W2106008384","https://openalex.org/W2107277218","https://openalex.org/W2109055236","https://openalex.org/W2111496511","https://openalex.org/W2116071714","https://openalex.org/W2116175479","https://openalex.org/W2121865606","https://openalex.org/W2132630105","https://openalex.org/W2134155371","https://openalex.org/W2136764118","https://openalex.org/W2146355738","https://openalex.org/W2147823227","https://openalex.org/W2152998216","https://openalex.org/W2153861014","https://openalex.org/W2162574319","https://openalex.org/W2163053975","https://openalex.org/W2165073006","https://openalex.org/W2165655956"],"related_works":["https://openalex.org/W7100562490","https://openalex.org/W4241220395","https://openalex.org/W2088003826","https://openalex.org/W2724881933","https://openalex.org/W2944043627","https://openalex.org/W2016404508","https://openalex.org/W2032656149","https://openalex.org/W2070992746","https://openalex.org/W2118921720","https://openalex.org/W7171845178"],"abstract_inverted_index":{"In":[0,146],"response":[1,192,204],"to":[2,17,193,205,216,226],"viral":[3],"infection,":[4],"reactive":[5],"oxygen":[6],"species":[7],"(ROS)":[8],"mediate":[9],"innate":[10],"immune":[11,19],"signaling":[12],"or":[13],"generate":[14],"danger":[15],"signals":[16],"activate":[18],"cells.":[20,145],"The":[21],"mechanisms":[22],"of":[23,39,45,63,81,91,103,115,136,143,155,173,189,223,234],"virally":[24,211],"induced":[25,212],"ROS":[26,34,69,82,104,190,201,235],"are":[27,35],"poorly":[28],"defined,":[29],"however.":[30],"We":[31,55],"demonstrate":[32],"that":[33,48,57,200],"produced":[36,202],"within":[37],"minutes":[38],"adenovirus":[40],"type":[41],"5":[42],"(Ad5)":[43],"infection":[44,161,207],"macrophages":[46,84],"and":[47,168,230],"oxidative":[49],"stress":[50],"supports":[51],"Ad5-induced":[52,176],"cytokine":[53,76],"secretion.":[54,77],"show":[56],"short":[58],"hairpin":[59],"RNA":[60],"(shRNA)":[61],"knockdown":[62,90],"TLR9":[64],"has":[65],"no":[66],"effect":[67],"on":[68,209],"production":[70],"despite":[71],"observed":[72,107],"decreases":[73],"in":[74,83,108,121,191,203],"Ad-induced":[75,100],"A":[78],"major":[79],"source":[80,188],"is":[85,105,119],"NADPH":[86,93],"oxidase.":[87],"However,":[88],"shRNA":[89],"the":[92,134,141,180,187,210,221,232,237],"oxidase":[94],"subunit":[95],"NOX2":[96],"does":[97],"not":[98,106,131],"attenuate":[99],"ROS.":[101],"Induction":[102],"cells":[109],"infected":[110,144],"with":[111,148],"a":[112,153],"temperature-sensitive":[113],"mutant":[114],"Ad2,":[116],"ts1,":[117,132],"which":[118,162],"defective":[120],"endosomal":[122,165,213],"membrane":[123,157,166,184,214,228],"penetration":[124,167],"during":[125],"cell":[126],"entry.":[127],"Further,":[128],"Ad5,":[129],"but":[130],"induces":[133],"release":[135,217,222,233],"lysosomal":[137,218],"cathepsin":[138,169],"B":[139,170],"into":[140],"cytoplasm":[142],"agreement":[147],"this":[149],"finding,":[150],"we":[151],"observe":[152],"loss":[154],"mitochondrial":[156,183,227],"potential":[158],"upon":[159],"Ad":[160,164],"requires":[163],"activity.":[171],"Overexpression":[172],"Bcl-2":[174],"attenuates":[175],"ROS,":[177],"further":[178],"supporting":[179],"role":[181],"for":[182],"destabilization":[185],"as":[186],"Ad5":[194,206],"infection.":[195],"Together,":[196],"these":[197],"data":[198],"suggest":[199],"depends":[208],"rupture":[215],"cathepsins.":[219],"Furthermore,":[220],"cathepsins":[224],"leads":[225],"disruption":[229],"thus":[231],"from":[236],"mitochondria.":[238]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":15},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}