{"id":"https://openalex.org/W2129097224","doi":"https://doi.org/10.1001/jama.279.5.365","title":"Low Dosage and Long Treatment Duration of \u03b2-Lactam","display_name":"Low Dosage and Long Treatment Duration of \u03b2-Lactam","publication_year":1998,"publication_date":"1998-02-04","ids":{"openalex":"https://openalex.org/W2129097224","doi":"https://doi.org/10.1001/jama.279.5.365","mag":"2129097224","pmid":"https://pubmed.ncbi.nlm.nih.gov/9459469"},"language":"en","primary_location":{"id":"doi:10.1001/jama.279.5.365","doi":"https://doi.org/10.1001/jama.279.5.365","is_oa":false,"landing_page_url":"https://doi.org/10.1001/jama.279.5.365","pdf_url":null,"source":{"id":"https://openalex.org/S172573765","display_name":"JAMA","issn_l":"0002-9955","issn":["0002-9955","0098-7484","1538-3598","2376-8118"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068874661","display_name":"Didier Guillemot","orcid":"https://orcid.org/0000-0002-8497-1765","observed_orcids":["https://orcid.org/0000-0002-8497-1765"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Didier Guillemot","raw_affiliation_strings":["Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Unit\u00e9 21 and Facult\u00e9 de M\u00e9decine Paris Sud, Villejuif, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Unit\u00e9 21 and Facult\u00e9 de M\u00e9decine Paris Sud, Villejuif, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109218361","display_name":"Claude Carbon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Claude Carbon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061767086","display_name":"Beverley Balkau","orcid":"https://orcid.org/0000-0003-2021-413X","observed_orcids":["https://orcid.org/0000-0003-2021-413X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Beverley Balkau","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112792580","display_name":"Pierre Geslin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pierre Geslin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Herv\u00e9 Lecoeur","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Herv\u00e9 Lecoeur","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040653181","display_name":"Fran\u00e7oise Vauzelle-Kervroedan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fran\u00e7oise Vauzelle-Kervro\u00ebdan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044263444","display_name":"G Bouvenot","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gilles Bouvenot","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109224704","display_name":"\u00c9. Eschw\u00e8ge","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eveline Eschw\u00e9ge","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":26.6797,"has_fulltext":false,"cited_by_count":550,"citation_normalized_percentile":{"value":0.99852381,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"279","issue":"5","first_page":"365","last_page":"365"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10654","display_name":"Pneumonia and Respiratory Infections","score":0.5976999998092651,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10654","display_name":"Pneumonia and Respiratory Infections","score":0.5976999998092651,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10897","display_name":"Antibiotic Use and Resistance","score":0.38449999690055847,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.011099999770522118,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/penicillin-resistant-streptococcus-pneumoniae","display_name":"penicillin-resistant Streptococcus pneumoniae","score":0.9240000247955322},{"id":"https://openalex.org/keywords/pharyngeal-carriage","display_name":"pharyngeal carriage","score":0.7789999842643738},{"id":"https://openalex.org/keywords/beta-lactam-antibiotics","display_name":"beta-lactam antibiotics","score":0.8370000123977661},{"id":"https://openalex.org/keywords/antibiotic-dosing","display_name":"antibiotic dosing","score":0.6880000233650208},{"id":"https://openalex.org/keywords/antibiotic-duration","display_name":"antibiotic duration","score":0.8510000109672546},{"id":"https://openalex.org/keywords/antibiotic-resistance","display_name":"antibiotic resistance","score":0.675000011920929},{"id":"https://openalex.org/keywords/children","display_name":"children","score":0.546999990940094},{"id":"https://openalex.org/keywords/selective-pressure","display_name":"selection pressure","score":0.6679999828338623},{"id":"https://openalex.org/keywords/pneumococcal-serotyping","display_name":"pneumococcal serotyping","score":0.753000020980835}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9207082986831665},{"id":"https://openalex.org/C32762888","wikidata":"https://www.wikidata.org/wiki/Q235356","display_name":"Carriage","level":2,"score":0.7809501886367798},{"id":"https://openalex.org/C174802600","wikidata":"https://www.wikidata.org/wiki/Q12190","display_name":"Penicillin","level":3,"score":0.6590840220451355},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.6064963936805725},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.5520107746124268},{"id":"https://openalex.org/C2781253189","wikidata":"https://www.wikidata.org/wiki/Q221179","display_name":"Streptococcus pneumoniae","level":3,"score":0.54230797290802},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5174618363380432},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.5070505142211914},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.4003763198852539},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.15581893920898438},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D002353","descriptor_name":"Carrier State","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D002353","descriptor_name":"Carrier State","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003625","descriptor_name":"Data Collection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005602","descriptor_name":"France","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010403","descriptor_name":"Penicillin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010614","descriptor_name":"Pharynx","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D011008","descriptor_name":"Pneumococcal Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011008","descriptor_name":"Pneumococcal Infections","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012574","descriptor_name":"Schools","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012703","descriptor_name":"Serotyping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013296","descriptor_name":"Streptococcus pneumoniae","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D013296","descriptor_name":"Streptococcus pneumoniae","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013296","descriptor_name":"Streptococcus pneumoniae","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047090","descriptor_name":"beta-Lactams","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1001/jama.279.5.365","doi":"https://doi.org/10.1001/jama.279.5.365","is_oa":false,"landing_page_url":"https://doi.org/10.1001/jama.279.5.365","pdf_url":null,"source":{"id":"https://openalex.org/S172573765","display_name":"JAMA","issn_l":"0002-9955","issn":["0002-9955","0098-7484","1538-3598","2376-8118"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA","raw_type":"journal-article"},{"id":"pmid:9459469","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9459469","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W64096637","https://openalex.org/W1556863319","https://openalex.org/W1833207062","https://openalex.org/W1927315993","https://openalex.org/W1973948212","https://openalex.org/W1980595924","https://openalex.org/W1987747972","https://openalex.org/W2001166659","https://openalex.org/W2005405440","https://openalex.org/W2009939166","https://openalex.org/W2023774267","https://openalex.org/W2025603203","https://openalex.org/W2028849916","https://openalex.org/W2029800232","https://openalex.org/W2033424626","https://openalex.org/W2035064373","https://openalex.org/W2035233582","https://openalex.org/W2037676805","https://openalex.org/W2039467079","https://openalex.org/W2044621058","https://openalex.org/W2049706595","https://openalex.org/W2055750915","https://openalex.org/W2060956926","https://openalex.org/W2068321209","https://openalex.org/W2073905935","https://openalex.org/W2077667189","https://openalex.org/W2079242999","https://openalex.org/W2085125965","https://openalex.org/W2088425425","https://openalex.org/W2105360924","https://openalex.org/W2107466522","https://openalex.org/W2161806706","https://openalex.org/W2163485143","https://openalex.org/W2335063593"],"related_works":["https://openalex.org/W7097212883","https://openalex.org/W2159497520","https://openalex.org/W4254890629","https://openalex.org/W2021282685","https://openalex.org/W2002510559","https://openalex.org/W2046517300","https://openalex.org/W2058324368","https://openalex.org/W2052782825","https://openalex.org/W2163320378","https://openalex.org/W2074938457"],"abstract_inverted_index":{"CONTEXT:":[0],"The":[1,63],"spread":[2],"of":[3,49,55,68,73,86,116,134,153,167,185,199,221,236],"drug-resistant":[4],"Streptococcus":[5],"pneumoniae":[6,43],"in":[7,15,29,65,232],"the":[8,27,38,66,95,114,229],"community":[9],"is":[10,24,32],"a":[11,191,213,218],"public":[12],"health":[13],"problem":[14],"developed":[16],"and":[17,47,91,106,113,217],"developing":[18],"nations,":[19],"but":[20],"whether":[21],"antibiotic":[22,89],"use":[23,115,127],"responsible":[25],"for":[26],"increase":[28],"drug":[30],"resistance":[31],"not":[33,119,176],"known.":[34],"OBJECTIVE:":[35],"To":[36],"analyze":[37],"relationship":[39],"between":[40],"penicillin-resistant":[41],"S":[42,87],"(PRSp)":[44],"pharyngeal":[45,234],"carriage":[46,85,136,201,235],"characteristics":[48],"beta-lactam":[50,126,156,192,226],"use.":[51],"DESIGN:":[52],"Observational":[53],"study":[54],"children":[56,173],"attending":[57],"20":[58],"randomly":[59],"sampled":[60],"schools.":[61],"SETTING:":[62],"Loiret,":[64],"center":[67],"France.":[69],"PARTICIPANTS:":[70],"A":[71,183],"total":[72],"941":[74],"children,":[75],"3":[76],"to":[77,228],"6":[78],"years":[79],"old.":[80],"MAIN":[81],"OUTCOME":[82],"MEASURE(S):":[83],"Pharyngeal":[84],"pneumoniae,":[88],"use,":[90],"medical":[92],"events":[93],"during":[94],"preceding":[96],"30":[97],"days.":[98],"Pneumococcal":[99],"penicillin":[100],"G":[101],"sodium":[102],"minimal":[103],"inhibitory":[104],"concentrations":[105],"serotyping":[107],"were":[108,118],"performed.":[109],"RESULTS:":[110],"Medical":[111],"illnesses":[112],"antibiotics":[117],"associated":[120,129,194],"with":[121,130,172,190,195,223],"PRSp":[122,135,168,200],"carriage.":[123],"However,":[124],"oral":[125,155,225],"was":[128,193],"an":[131,154,164,196,224],"increased":[132,165,197],"risk":[133,166,198],"(odds":[137],"ratio":[138],"[OR],":[139],"3.0;":[140],"95%":[141,179,204],"confidence":[142],"interval":[143],"[CI],":[144],"1.1-8.3;":[145],"P=.03).":[146],"Children":[147],"treated":[148],"by":[149],"low":[150,214],"daily":[151,215],"doses":[152],"(defined":[157],"as":[158,170],"lower":[159],"than":[160],"clinical":[161],"recommendations)":[162],"had":[163],"carriage,":[169],"compared":[171],"who":[174],"did":[175],"(OR,":[177,202],"5.9;":[178],"CI,":[180,205],"2.1-16.7;":[181],"P=.002).":[182],"treatment":[184,222],"long":[186,219],"duration":[187,220],"(>5":[188],"days)":[189],"3.5;":[203],"1.3-9.8;":[206],"P=.02).":[207],"CONCLUSIONS:":[208],"Our":[209],"results":[210],"suggest":[211],"that":[212],"dose":[216],"contribute":[227],"selective":[230],"pressure":[231],"promoting":[233],"PRSp.":[237]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":18},{"year":2018,"cited_by_count":16},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":15},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}