{"id":"https://openalex.org/W2129090112","doi":"https://doi.org/10.2147/ijn.s75090","title":"PLGA-PLL-PEG-Tf-based targeted nanoparticles drug delivery system enhance antitumor efficacy via intrinsic apoptosis pathway","display_name":"PLGA-PLL-PEG-Tf-based targeted nanoparticles drug delivery system enhance antitumor efficacy via intrinsic apoptosis pathway","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2129090112","doi":"https://doi.org/10.2147/ijn.s75090","mag":"2129090112","pmid":"https://pubmed.ncbi.nlm.nih.gov/25609961","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4298335"},"language":"en","primary_location":{"id":"doi:10.2147/ijn.s75090","doi":"https://doi.org/10.2147/ijn.s75090","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ijn.s75090","pdf_url":"https://www.dovepress.com/getfile.php?fileID=23202","source":{"id":"https://openalex.org/S101287785","display_name":"International Journal of Nanomedicine","issn_l":"1176-9114","issn":["1176-9114","1178-2013"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Nanomedicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.dovepress.com/getfile.php?fileID=23202","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Bao-An Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105806","display_name":"Zhongda Hospital Southeast University","ror":"https://ror.org/01k3hq685","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105806"]},{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Bao-An Chen","raw_affiliation_strings":["Department of Hematology and Oncology, Key Medical Disciplines of Jiangsu Province, Zhongda Hospital, Medical School of Southeast University, Nanjing, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Oncology, Key Medical Disciplines of Jiangsu Province, Zhongda Hospital, Medical School of Southeast University, Nanjing, People's Republic of China","institution_ids":["https://openalex.org/I4210105806","https://openalex.org/I76569877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100563298","display_name":"Wen Bao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105806","display_name":"Zhongda Hospital Southeast University","ror":"https://ror.org/01k3hq685","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105806"]},{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wen Bao","raw_affiliation_strings":["Department of Hematology and Oncology, Key Medical Disciplines of Jiangsu Province, Zhongda Hospital, Medical School of Southeast University, Nanjing, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Oncology, Key Medical Disciplines of Jiangsu Province, Zhongda Hospital, Medical School of Southeast University, Nanjing, People's Republic of China","institution_ids":["https://openalex.org/I4210105806","https://openalex.org/I76569877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100448090","display_name":"Ran Liu","orcid":"https://orcid.org/0000-0001-8150-6799","observed_orcids":["https://orcid.org/0000-0001-8150-6799","https://orcid.org/0000-0001-9402-3761","https://orcid.org/0000-0003-3929-1864"]},"institutions":[{"id":"https://openalex.org/I134687103","display_name":"Nanjing Tech University","ror":"https://ror.org/03sd35x91","country_code":"CN","type":"education","lineage":["https://openalex.org/I134687103"]},{"id":"https://openalex.org/I4210105806","display_name":"Zhongda Hospital Southeast University","ror":"https://ror.org/01k3hq685","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105806"]},{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ran Liu","raw_affiliation_strings":["Department of Hematology and Oncology, Key Medical Disciplines of Jiangsu Province, Zhongda Hospital, Medical School of Southeast University, Nanjing, People's Republic of China","Department of Hematology and Oncology, Key Medical Disciplines of Jiangsu Province, Zhongda Hospital, Medical School of Southeast University, Nanjing, People's Republic of China ; College of Pharmacy, Nanjing University of Technology, Nanjing, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Oncology, Key Medical Disciplines of Jiangsu Province, Zhongda Hospital, Medical School of Southeast University, Nanjing, People's Republic of China","institution_ids":["https://openalex.org/I4210105806","https://openalex.org/I76569877"]},{"raw_affiliation_string":"Department of Hematology and Oncology, Key Medical Disciplines of Jiangsu Province, Zhongda Hospital, Medical School of Southeast University, Nanjing, People's Republic of China ; College of Pharmacy, Nanjing University of Technology, Nanjing, People's Republic of China","institution_ids":["https://openalex.org/I134687103","https://openalex.org/I4210105806","https://openalex.org/I76569877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115695117","display_name":"Yonglu Wang","orcid":"https://orcid.org/0000-0001-5775-4848","observed_orcids":["https://orcid.org/0000-0001-5775-4848"]},"institutions":[{"id":"https://openalex.org/I134687103","display_name":"Nanjing Tech University","ror":"https://ror.org/03sd35x91","country_code":"CN","type":"education","lineage":["https://openalex.org/I134687103"]},{"id":"https://openalex.org/I4210105806","display_name":"Zhongda Hospital Southeast University","ror":"https://ror.org/01k3hq685","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105806"]},{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yonglu Wang","raw_affiliation_strings":["Department of Hematology and Oncology, Key Medical Disciplines of Jiangsu Province, Zhongda Hospital, Medical School of Southeast University, Nanjing, People's Republic of China ; College of Pharmacy, Nanjing University of Technology, Nanjing, People's Republic of China","Department of Hematology and Oncology, Key Medical Disciplines of Jiangsu Province, Zhongda Hospital, Medical School of Southeast University, Nanjing, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Oncology, Key Medical Disciplines of Jiangsu Province, Zhongda Hospital, Medical School of Southeast University, Nanjing, People's Republic of China ; College of Pharmacy, Nanjing University of Technology, Nanjing, People's Republic of China","institution_ids":["https://openalex.org/I134687103","https://openalex.org/I4210105806","https://openalex.org/I76569877"]},{"raw_affiliation_string":"Department of Hematology and Oncology, Key Medical Disciplines of Jiangsu Province, Zhongda Hospital, Medical School of Southeast University, Nanjing, People's Republic of China","institution_ids":["https://openalex.org/I4210105806","https://openalex.org/I76569877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100455718","display_name":"Fei Wang","orcid":"https://orcid.org/0000-0001-6428-5111","observed_orcids":["https://orcid.org/0000-0001-6428-5111","https://orcid.org/0000-0001-7949-6114"]},"institutions":[{"id":"https://openalex.org/I4210105806","display_name":"Zhongda Hospital Southeast University","ror":"https://ror.org/01k3hq685","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105806"]},{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fei Wang","raw_affiliation_strings":["Department of Hematology and Oncology, Key Medical Disciplines of Jiangsu Province, Zhongda Hospital, Medical School of Southeast University, Nanjing, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Oncology, Key Medical Disciplines of Jiangsu Province, Zhongda Hospital, Medical School of Southeast University, Nanjing, People's Republic of China","institution_ids":["https://openalex.org/I4210105806","https://openalex.org/I76569877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107770755","display_name":"Guohua Xia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105806","display_name":"Zhongda Hospital Southeast University","ror":"https://ror.org/01k3hq685","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105806"]},{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guohua Xia","raw_affiliation_strings":["Department of Hematology and Oncology, Key Medical Disciplines of Jiangsu Province, Zhongda Hospital, Medical School of Southeast University, Nanjing, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Oncology, Key Medical Disciplines of Jiangsu Province, Zhongda Hospital, Medical School of Southeast University, Nanjing, People's Republic of China","institution_ids":["https://openalex.org/I4210105806","https://openalex.org/I76569877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111916900","display_name":"Haijun Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I134687103","display_name":"Nanjing Tech University","ror":"https://ror.org/03sd35x91","country_code":"CN","type":"education","lineage":["https://openalex.org/I134687103"]},{"id":"https://openalex.org/I4210105806","display_name":"Zhongda Hospital Southeast University","ror":"https://ror.org/01k3hq685","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105806"]},{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haijun Zhang","raw_affiliation_strings":["Department of Hematology and Oncology, Key Medical Disciplines of Jiangsu Province, Zhongda Hospital, Medical School of Southeast University, Nanjing, People's Republic of China","College of Pharmacy, Nanjing University of Technology, Nanjing, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Oncology, Key Medical Disciplines of Jiangsu Province, Zhongda Hospital, Medical School of Southeast University, Nanjing, People's Republic of China","institution_ids":["https://openalex.org/I4210105806","https://openalex.org/I76569877"]},{"raw_affiliation_string":"College of Pharmacy, Nanjing University of Technology, Nanjing, People's Republic of China","institution_ids":["https://openalex.org/I134687103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100421863","display_name":"Xueming Li","orcid":"https://orcid.org/0000-0001-6081-5592","observed_orcids":["https://orcid.org/0000-0001-6081-5592"]},"institutions":[{"id":"https://openalex.org/I134687103","display_name":"Nanjing Tech University","ror":"https://ror.org/03sd35x91","country_code":"CN","type":"education","lineage":["https://openalex.org/I134687103"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xueming Li","raw_affiliation_strings":["College of Pharmacy, Nanjing University of Technology, Nanjing, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Nanjing University of Technology, Nanjing, People's Republic of China","institution_ids":["https://openalex.org/I134687103"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014550093","display_name":"Haixiang Yin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I134687103","display_name":"Nanjing Tech University","ror":"https://ror.org/03sd35x91","country_code":"CN","type":"education","lineage":["https://openalex.org/I134687103"]},{"id":"https://openalex.org/I4210105806","display_name":"Zhongda Hospital Southeast University","ror":"https://ror.org/01k3hq685","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105806"]},{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haixiang Yin","raw_affiliation_strings":["College of Pharmacy, Nanjing University of Technology, Nanjing, People's Republic of China","Department of Hematology and Oncology, Key Medical Disciplines of Jiangsu Province, Zhongda Hospital, Medical School of Southeast University, Nanjing, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Nanjing University of Technology, Nanjing, People's Republic of China","institution_ids":["https://openalex.org/I134687103"]},{"raw_affiliation_string":"Department of Hematology and Oncology, Key Medical Disciplines of Jiangsu Province, Zhongda Hospital, Medical School of Southeast University, Nanjing, People's Republic of China","institution_ids":["https://openalex.org/I4210105806","https://openalex.org/I76569877"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210105806","https://openalex.org/I76569877"],"apc_list":{"value":2836,"currency":"USD","value_usd":2836},"apc_paid":{"value":2836,"currency":"USD","value_usd":2836},"fwci":2.0981,"has_fulltext":true,"cited_by_count":49,"citation_normalized_percentile":{"value":0.86024488,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"10","issue":null,"first_page":"557","last_page":"557"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/daunorubicin","display_name":"daunorubicin","score":0.9570000171661377},{"id":"https://openalex.org/keywords/targeted-drug-delivery","display_name":"targeted drug delivery","score":0.906000018119812},{"id":"https://openalex.org/keywords/transferrin-receptor","display_name":"transferrin receptor","score":0.7070000171661377},{"id":"https://openalex.org/keywords/mitochondrial-apoptosis","display_name":"mitochondrial apoptosis","score":0.7590000033378601},{"id":"https://openalex.org/keywords/leukemia","display_name":"leukemia","score":0.7419999837875366},{"id":"https://openalex.org/keywords/k562-cells","display_name":"K562 cells","score":0.9909999966621399},{"id":"https://openalex.org/keywords/bcl-2-bax","display_name":"Bcl-2/Bax","score":0.7829999923706055},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.7680000066757202},{"id":"https://openalex.org/keywords/caspase-9","display_name":"caspase-9","score":0.996999979019165},{"id":"https://openalex.org/keywords/cleaved-parp","display_name":"cleaved PARP","score":0.8029999732971191},{"id":"https://openalex.org/keywords/chemotherapy-toxicity","display_name":"chemotherapy toxicity","score":0.39899998903274536},{"id":"https://openalex.org/keywords/tumor-xenografts","display_name":"tumor xenografts","score":0.6859999895095825},{"id":"https://openalex.org/keywords/sustained-release","display_name":"sustained drug release","score":0.6309999823570251}],"concepts":[{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5966172218322754},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.553766667842865},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5316591262817383},{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.5292752981185913},{"id":"https://openalex.org/C2780165375","wikidata":"https://www.wikidata.org/wiki/Q2102907","display_name":"PLGA","level":3,"score":0.5184235572814941},{"id":"https://openalex.org/C2777292972","wikidata":"https://www.wikidata.org/wiki/Q423762","display_name":"Paclitaxel","level":3,"score":0.45848318934440613},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.45394542813301086},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4471816122531891},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.44141221046447754},{"id":"https://openalex.org/C54400483","wikidata":"https://www.wikidata.org/wiki/Q1793202","display_name":"PEG ratio","level":2,"score":0.4213002324104309},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33020728826522827},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3273777961730957},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.32069581747055054},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.294763445854187},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.19929036498069763},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.19190025329589844},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.14614182710647583},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13852983713150024},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11977273225784302},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09938052296638489},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C10138342","wikidata":"https://www.wikidata.org/wiki/Q43015","display_name":"Finance","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D003630","descriptor_name":"Daunorubicin","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D003630","descriptor_name":"Daunorubicin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003630","descriptor_name":"Daunorubicin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011091","descriptor_name":"Polyesters","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011107","descriptor_name":"Polylysine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D011107","descriptor_name":"Polylysine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014168","descriptor_name":"Transferrin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.2147/ijn.s75090","doi":"https://doi.org/10.2147/ijn.s75090","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ijn.s75090","pdf_url":"https://www.dovepress.com/getfile.php?fileID=23202","source":{"id":"https://openalex.org/S101287785","display_name":"International Journal of Nanomedicine","issn_l":"1176-9114","issn":["1176-9114","1178-2013"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Nanomedicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4298335","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4298335","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Nanomedicine","raw_type":"Text"},{"id":"pmid:25609961","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25609961","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of nanomedicine","raw_type":"Journal Article"},{"id":"pmh:oai:dovepress.com/19925","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/plga-pll-peg-tf-based-targeted-nanoparticles-drug-delivery-system-enha-peer-reviewed-article-IJN","pdf_url":null,"source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.2147/ijn.s75090","doi":"https://doi.org/10.2147/ijn.s75090","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ijn.s75090","pdf_url":"https://www.dovepress.com/getfile.php?fileID=23202","source":{"id":"https://openalex.org/S101287785","display_name":"International Journal of Nanomedicine","issn_l":"1176-9114","issn":["1176-9114","1178-2013"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Nanomedicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1109865658","display_name":"\u5316\u7597\u836f\u548c\u4e2d\u836f\u4e0e\u8f6c\u94c1\u86cb\u767d\u7eb3\u7c73\u8f7d\u4f53\u7684\u8bbe\u8ba1\u53ca\u9006\u8f6c\u767d\u8840\u75c5\u8010\u836f\u7684\u673a\u5236\u7814\u7a76","funder_award_id":"81170492","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4108091861","display_name":null,"funder_award_id":"81370673","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321605","display_name":"Government of Jiangsu Province","ror":"https://ror.org/004svx814"},{"id":"https://openalex.org/F4320335773","display_name":"National High-tech Research and Development Program","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2129090112.pdf","grobid_xml":"https://content.openalex.org/works/W2129090112.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W1830813972","https://openalex.org/W1966033901","https://openalex.org/W1966962897","https://openalex.org/W1972909206","https://openalex.org/W1975088956","https://openalex.org/W1975269134","https://openalex.org/W1976041621","https://openalex.org/W1979685750","https://openalex.org/W1981412372","https://openalex.org/W1988318590","https://openalex.org/W1994781349","https://openalex.org/W2003474213","https://openalex.org/W2006682224","https://openalex.org/W2011090397","https://openalex.org/W2014509855","https://openalex.org/W2023494010","https://openalex.org/W2029749273","https://openalex.org/W2033520317","https://openalex.org/W2039793277","https://openalex.org/W2041521061","https://openalex.org/W2055574464","https://openalex.org/W2062663577","https://openalex.org/W2068382906","https://openalex.org/W2085419794","https://openalex.org/W2089591522","https://openalex.org/W2092974291","https://openalex.org/W2093118292","https://openalex.org/W2094672113","https://openalex.org/W2105630041","https://openalex.org/W2106877996","https://openalex.org/W2109375301","https://openalex.org/W2159944012","https://openalex.org/W2166415797","https://openalex.org/W2315387567","https://openalex.org/W2316673155","https://openalex.org/W2766250687","https://openalex.org/W2979363792","https://openalex.org/W4297952755","https://openalex.org/W6745730503"],"related_works":["https://openalex.org/W2935079231","https://openalex.org/W3176922329","https://openalex.org/W1776205939","https://openalex.org/W4372354863","https://openalex.org/W2892283741","https://openalex.org/W2027560573","https://openalex.org/W3044657432","https://openalex.org/W4395446818","https://openalex.org/W1769001866","https://openalex.org/W2910921847"],"abstract_inverted_index":{"Chemotherapy":[0],"offers":[1],"a":[2,60,88,195,289],"systemic":[3],"cancer":[4,20],"treatment;":[5],"however,":[6],"it":[7,278],"is":[8],"limited":[9],"in":[10,46,126,142,147,188,191,198,201,204,225,232,266],"clinical":[11,291],"administration":[12],"due":[13],"to":[14,55,82,242],"its":[15,65],"serious":[16],"side":[17],"effects.":[18],"In":[19,49,246],"medicine,":[21],"the":[22,37,42,50,57,98,105,117,122,132,148,160,202,226,243,248,256,262,267,283],"use":[23],"of":[24,44,59,108,119,124,135,162,186,208,215,264,269],"nanoparticles":[25],"(NPs)":[26],"drug":[27,35,285],"delivery":[28,286],"system":[29],"(DDS)":[30],"can":[31,279],"sustainedly":[32],"release":[33],"anticancer":[34,199],"at":[36],"specific":[38],"site":[39],"and":[40,64,95,104,131,159,170,193,213,219,271],"reduce":[41],"incidence":[43],"toxicity":[45,134],"normal":[47],"tissues.":[48],"present":[51],"study,":[52],"we":[53],"aimed":[54],"evaluate":[56],"benefit":[58],"novel":[61,257],"chemotherapeutic":[62],"DDS":[63,259],"underlying":[66],"mechanisms.":[67],"Daunorubicin":[68],"(DNR)":[69],"was":[70,110,129,140,151,172,211],"loaded":[71],"into":[72],"poly":[73],"(lactic-co-glycolic":[74],"acid)":[75],"(PLGA)-poly-L-lysine":[76],"(PLL)-polyethylene":[77],"glycol":[78],"(PEG)-transferrin":[79],"(Tf)":[80],"NPs":[81,182,228,258],"construct":[83],"DNR-PLGA-PLL-PEG-Tf-NPs":[84],"(DNR-loaded":[85],"NPs)":[86],"as":[87],"DDS.":[89],"After":[90],"incubating":[91],"with":[92],"PLGA-PLL-PEG-Tf-NPs,":[93],"DNR,":[94],"DNR-loaded":[96,181,227],"NPs,":[97],"leukemia":[99,270],"K562":[100,127,189],"cells":[101,190],"were":[102,222],"collected":[103],"intracellular":[106,184],"concentration":[107,185],"DNR":[109,187,265],"detected":[111],"by":[112,153,174],"flow":[113],"cytometry,":[114],"respectively.":[115],"Furthermore,":[116],"effect":[118],"drugs":[120,137],"on":[121,138],"growth":[123],"tumors":[125],"xenografts":[128,150,203],"observed":[130],"relevant":[133],"therapeutic":[136],"organs":[139],"investigated":[141],"vivo.":[143,205],"Meanwhile,":[144],"cell":[145],"apoptosis":[146,273],"excised":[149],"measured":[152],"transferase-mediated":[154],"dUTP":[155],"nick-end":[156],"labeling":[157],"assay,":[158],"expression":[161,207],"apoptosis-related":[163],"proteins,":[164],"including":[165],"Bcl-2,":[166],"Bax,":[167,216],"Caspase-9,":[168,217],"Caspase-3,":[169,218],"cleaved-PARP,":[171],"determined":[173],"Western":[175],"blotting":[176],"analysis.":[177],"Results":[178],"showed":[179,238,254],"that":[180,214,231,255,282],"increased":[183],"vitro":[192],"induced":[194],"remarkable":[196],"improvement":[197],"activity":[200],"The":[206],"Bcl-2":[209],"protein":[210],"downregulated":[212],"cleaved-PARP":[220],"proteins":[221],"obviously":[223],"upregulated":[224],"group":[229],"than":[230],"other":[233],"ones.":[234],"Interestingly,":[235],"pathological":[236],"assessment":[237],"no":[239],"apparent":[240],"damage":[241],"main":[244],"organs.":[245],"summary,":[247],"results":[249],"obtained":[250],"from":[251],"this":[252],"study":[253],"could":[260],"improve":[261],"efficacy":[263],"treatment":[268],"induce":[272],"via":[274],"intrinsic":[275],"pathway.":[276],"Thus,":[277],"be":[280,288],"inferred":[281],"new":[284],"may":[287],"useful":[290],"tool.":[292]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
