{"id":"https://openalex.org/W2129077500","doi":"https://doi.org/10.1084/jem.20021788","title":"Activation of Dendritic Cells through the Interleukin 1 Receptor 1 Is Critical for the Induction of Autoimmune Myocarditis","display_name":"Activation of Dendritic Cells through the Interleukin 1 Receptor 1 Is Critical for the Induction of Autoimmune Myocarditis","publication_year":2003,"publication_date":"2003-01-27","ids":{"openalex":"https://openalex.org/W2129077500","doi":"https://doi.org/10.1084/jem.20021788","mag":"2129077500","pmid":"https://pubmed.ncbi.nlm.nih.gov/12566416","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2193833"},"language":"en","primary_location":{"id":"doi:10.1084/jem.20021788","doi":"https://doi.org/10.1084/jem.20021788","is_oa":true,"landing_page_url":"https://doi.org/10.1084/jem.20021788","pdf_url":"https://rupress.org/jem/article-pdf/197/3/323/1144594/jem1973323.pdf","source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Experimental Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://rupress.org/jem/article-pdf/197/3/323/1144594/jem1973323.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015449875","display_name":"Urs Eriksson","orcid":"https://orcid.org/0000-0003-1217-9696","observed_orcids":["https://orcid.org/0000-0003-1217-9696"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CA","CH"],"is_corresponding":false,"raw_author_name":"Urs Eriksson","raw_affiliation_strings":["1Medicine A, University Hospital, CH-4031 Basel, Switzerland","2University Health Network, Departments of Medical Biophysics and Immunology, University of Toronto, Toronto, Ontario M5S 1A8, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Medicine A, University Hospital, CH-4031 Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]},{"raw_affiliation_string":"2University Health Network, Departments of Medical Biophysics and Immunology, University of Toronto, Toronto, Ontario M5S 1A8, Canada","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021410407","display_name":"Michael Odo Kurrer","orcid":"https://orcid.org/0000-0001-5842-973X","observed_orcids":["https://orcid.org/0000-0001-5842-973X"]},"institutions":[{"id":"https://openalex.org/I4210100468","display_name":"University Hospital Zurich","ror":"https://ror.org/01462r250","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210100468"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Michael O. Kurrer","raw_affiliation_strings":["3Department of Pathology, University Hospital, CH-8091 Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Department of Pathology, University Hospital, CH-8091 Zurich, Switzerland","institution_ids":["https://openalex.org/I4210100468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015792928","display_name":"Ivo Sonderegger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Ivo Sonderegger","raw_affiliation_strings":["5Molecular Biomedicine, Swiss Federal Institute of Technology, CH-8952 Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Molecular Biomedicine, Swiss Federal Institute of Technology, CH-8952 Zurich, Switzerland","institution_ids":["https://openalex.org/I35440088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023122501","display_name":"Giandomenica Iezzi","orcid":"https://orcid.org/0000-0001-5841-495X","observed_orcids":["https://orcid.org/0000-0001-5841-495X"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Giandomenica Iezzi","raw_affiliation_strings":["5Molecular Biomedicine, Swiss Federal Institute of Technology, CH-8952 Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Molecular Biomedicine, Swiss Federal Institute of Technology, CH-8952 Zurich, Switzerland","institution_ids":["https://openalex.org/I35440088"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Anna Tafuri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Anna Tafuri","raw_affiliation_strings":["2University Health Network, Departments of Medical Biophysics and Immunology, University of Toronto, Toronto, Ontario M5S 1A8, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2University Health Network, Departments of Medical Biophysics and Immunology, University of Toronto, Toronto, Ontario M5S 1A8, Canada","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101659752","display_name":"Lukas Hunziker","orcid":"https://orcid.org/0000-0003-0081-8518","observed_orcids":["https://orcid.org/0000-0003-0081-8518"]},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Lukas Hunziker","raw_affiliation_strings":["1Medicine A, University Hospital, CH-4031 Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Medicine A, University Hospital, CH-4031 Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040834993","display_name":"Shinobu Suzuki","orcid":"https://orcid.org/0000-0003-0631-7060","observed_orcids":["https://orcid.org/0000-0003-0631-7060"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Shinobu Suzuki","raw_affiliation_strings":["2University Health Network, Departments of Medical Biophysics and Immunology, University of Toronto, Toronto, Ontario M5S 1A8, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2University Health Network, Departments of Medical Biophysics and Immunology, University of Toronto, Toronto, Ontario M5S 1A8, Canada","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022390052","display_name":"Kurt Bachmaier","orcid":"https://orcid.org/0000-0002-0299-2707","observed_orcids":["https://orcid.org/0000-0002-0299-2707"]},"institutions":[{"id":"https://openalex.org/I125523173","display_name":"Institute of Molecular Biotechnology","ror":"https://ror.org/01zqrxf85","country_code":"AT","type":"facility","lineage":["https://openalex.org/I125523173","https://openalex.org/I138211613"]},{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I138211613","display_name":"Austrian Academy of Sciences","ror":"https://ror.org/03anc3s24","country_code":"AT","type":"government","lineage":["https://openalex.org/I138211613"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["AT","CA"],"is_corresponding":false,"raw_author_name":"Kurt Bachmaier","raw_affiliation_strings":["2University Health Network, Departments of Medical Biophysics and Immunology, University of Toronto, Toronto, Ontario M5S 1A8, Canada","4IMBA, Institute for Molecular Biotechnology of the Austrian Academy of Sciences, A-1030 Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2University Health Network, Departments of Medical Biophysics and Immunology, University of Toronto, Toronto, Ontario M5S 1A8, Canada","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I185261750"]},{"raw_affiliation_string":"4IMBA, Institute for Molecular Biotechnology of the Austrian Academy of Sciences, A-1030 Vienna, Austria","institution_ids":["https://openalex.org/I125523173","https://openalex.org/I138211613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062437739","display_name":"Roland M Bingisser","orcid":"https://orcid.org/0000-0001-8223-9792","observed_orcids":["https://orcid.org/0000-0001-8223-9792","https://orcid.org/0000-0003-1424-3460"]},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Roland M. Bingisser","raw_affiliation_strings":["1Medicine A, University Hospital, CH-4031 Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Medicine A, University Hospital, CH-4031 Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059310975","display_name":"Josef Martin Penninger","orcid":"https://orcid.org/0000-0002-8194-3777","observed_orcids":["https://orcid.org/0000-0002-8194-3777"]},"institutions":[{"id":"https://openalex.org/I125523173","display_name":"Institute of Molecular Biotechnology","ror":"https://ror.org/01zqrxf85","country_code":"AT","type":"facility","lineage":["https://openalex.org/I125523173","https://openalex.org/I138211613"]},{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I138211613","display_name":"Austrian Academy of Sciences","ror":"https://ror.org/03anc3s24","country_code":"AT","type":"government","lineage":["https://openalex.org/I138211613"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["AT","CA"],"is_corresponding":false,"raw_author_name":"Josef M. Penninger","raw_affiliation_strings":["2University Health Network, Departments of Medical Biophysics and Immunology, University of Toronto, Toronto, Ontario M5S 1A8, Canada","4IMBA, Institute for Molecular Biotechnology of the Austrian Academy of Sciences, A-1030 Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2University Health Network, Departments of Medical Biophysics and Immunology, University of Toronto, Toronto, Ontario M5S 1A8, Canada","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I185261750"]},{"raw_affiliation_string":"4IMBA, Institute for Molecular Biotechnology of the Austrian Academy of Sciences, A-1030 Vienna, Austria","institution_ids":["https://openalex.org/I125523173","https://openalex.org/I138211613"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087304114","display_name":"Manfred K\u00f6pf","orcid":"https://orcid.org/0000-0002-0628-7140","observed_orcids":["https://orcid.org/0000-0002-0628-7140"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Manfred Kopf","raw_affiliation_strings":["5Molecular Biomedicine, Swiss Federal Institute of Technology, CH-8952 Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Molecular Biomedicine, Swiss Federal Institute of Technology, CH-8952 Zurich, Switzerland","institution_ids":["https://openalex.org/I35440088"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":9.8297,"has_fulltext":true,"cited_by_count":161,"citation_normalized_percentile":{"value":0.98785881,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"197","issue":"3","first_page":"323","last_page":"331"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11112","display_name":"Viral Infections and Immunology Research","score":0.4713999927043915,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11112","display_name":"Viral Infections and Immunology Research","score":0.4713999927043915,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.3582000136375427,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.08179999887943268,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/il-1r1","display_name":"IL1R1","score":0.9290000200271606},{"id":"https://openalex.org/keywords/dendritic-cell-activation","display_name":"dendritic cell activation","score":0.9350000023841858},{"id":"https://openalex.org/keywords/autoimmune-myocarditis","display_name":"autoimmune myocarditis","score":0.9869999885559082},{"id":"https://openalex.org/keywords/dilated-cardiomyopathy","display_name":"dilated cardiomyopathy","score":0.9620000123977661},{"id":"https://openalex.org/keywords/cd4-t-cell-activation","display_name":"CD4+ T cell activation","score":0.9359999895095825},{"id":"https://openalex.org/keywords/autoreactive-t-cells","display_name":"autoreactive T cells","score":0.871999979019165},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.4359999895095825}],"concepts":[{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5812638401985168},{"id":"https://openalex.org/C2780130043","wikidata":"https://www.wikidata.org/wiki/Q192360","display_name":"Autoimmunity","level":3,"score":0.44113075733184814},{"id":"https://openalex.org/C2780875844","wikidata":"https://www.wikidata.org/wiki/Q186235","display_name":"Myocarditis","level":2,"score":0.43576762080192566},{"id":"https://openalex.org/C67662055","wikidata":"https://www.wikidata.org/wiki/Q1047791","display_name":"Antigen-presenting cell","level":4,"score":0.41895782947540283},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.4135608673095703},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.41011545062065125},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4100706875324249},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3983168601989746},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.34363487362861633},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28804370760917664},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.24126309156417847},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10375607013702393}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001327","descriptor_name":"Autoimmune Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D001327","descriptor_name":"Autoimmune Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001327","descriptor_name":"Autoimmune Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002311","descriptor_name":"Cardiomyopathy, Dilated","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D002311","descriptor_name":"Cardiomyopathy, Dilated","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009205","descriptor_name":"Myocarditis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D009205","descriptor_name":"Myocarditis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009205","descriptor_name":"Myocarditis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015551","descriptor_name":"Autoimmunity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016513","descriptor_name":"Mice, SCID","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017472","descriptor_name":"Receptors, Interleukin-1","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D017472","descriptor_name":"Receptors, Interleukin-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017472","descriptor_name":"Receptors, Interleukin-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019264","descriptor_name":"Adoptive Transfer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024723","descriptor_name":"Ventricular Myosins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024723","descriptor_name":"Ventricular Myosins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053573","descriptor_name":"Receptors, Interleukin-1 Type I","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1084/jem.20021788","doi":"https://doi.org/10.1084/jem.20021788","is_oa":true,"landing_page_url":"https://doi.org/10.1084/jem.20021788","pdf_url":"https://rupress.org/jem/article-pdf/197/3/323/1144594/jem1973323.pdf","source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Experimental Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2193833","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2193833","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Exp Med","raw_type":"Text"},{"id":"pmid:12566416","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12566416","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of experimental medicine","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.282.7395","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.282.7395","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/24/e0/J_Exp_Med_2003_Feb_3_197(3)_323-331.tar.gz","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1084/jem.20021788","doi":"https://doi.org/10.1084/jem.20021788","is_oa":true,"landing_page_url":"https://doi.org/10.1084/jem.20021788","pdf_url":"https://rupress.org/jem/article-pdf/197/3/323/1144594/jem1973323.pdf","source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Experimental Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9789000153541565,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310389","display_name":"Novartis Foundation","ror":"https://ror.org/02f9zrr09"},{"id":"https://openalex.org/F4320322584","display_name":"Schweizerische Herzstiftung","ror":"https://ror.org/01k789405"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2129077500.pdf","grobid_xml":"https://content.openalex.org/works/W2129077500.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W425633012","https://openalex.org/W1515994079","https://openalex.org/W1519700871","https://openalex.org/W1520272833","https://openalex.org/W1539596409","https://openalex.org/W1720513081","https://openalex.org/W1905620693","https://openalex.org/W1926671788","https://openalex.org/W1942463334","https://openalex.org/W1954812914","https://openalex.org/W2022616509","https://openalex.org/W2030562643","https://openalex.org/W2050033307","https://openalex.org/W2059277480","https://openalex.org/W2078814319","https://openalex.org/W2079092923","https://openalex.org/W2080166276","https://openalex.org/W2082420129","https://openalex.org/W2087050793","https://openalex.org/W2092235636","https://openalex.org/W2100378067","https://openalex.org/W2101103404","https://openalex.org/W2101911216","https://openalex.org/W2111668089","https://openalex.org/W2116397875","https://openalex.org/W2135498543","https://openalex.org/W2148029579","https://openalex.org/W2148361763","https://openalex.org/W2152672837","https://openalex.org/W2157666264","https://openalex.org/W2160155632","https://openalex.org/W2160909954","https://openalex.org/W2165653830","https://openalex.org/W2166695274","https://openalex.org/W2169785058","https://openalex.org/W2171398137","https://openalex.org/W4244510412","https://openalex.org/W4313335775","https://openalex.org/W4313335958","https://openalex.org/W4313347845"],"related_works":["https://openalex.org/W7095777744","https://openalex.org/W2040977790","https://openalex.org/W1993281653","https://openalex.org/W2901299602","https://openalex.org/W1980378085","https://openalex.org/W1964025326","https://openalex.org/W2162625088","https://openalex.org/W2079789795","https://openalex.org/W2040617259","https://openalex.org/W2079319994"],"abstract_inverted_index":{"Dilated":[0],"cardiomyopathy,":[1],"resulting":[2],"from":[3,29,41],"myocarditis,":[4],"is":[5,139,148],"the":[6,67,105],"most":[7],"common":[8],"cause":[9],"of":[10,31,69,90,113,144,155],"heart":[11],"failure":[12],"in":[13,85,101,149],"young":[14],"patients.":[15],"We":[16],"here":[17],"show":[18],"that":[19,66],"interleukin":[20],"(IL)-1":[21],"receptor":[22,107],"type":[23,108],"1-deficient":[24],"(IL-1R1(-/-))":[25],"mice":[26,44,124],"are":[27],"protected":[28],"development":[30],"autoimmune":[32],"myocarditis":[33],"after":[34,52],"immunization":[35],"with":[36],"alpha-myosin-peptide(614-629).":[37],"CD4(+)":[38,132,157],"T":[39,71,133,158],"cells":[40,72,82,103,121,134,159],"immunized":[42],"IL-1R1(-/-)":[43,86,119,123,131],"proliferated":[45],"poorly":[46],"and":[47,97,160],"failed":[48],"to":[49],"transfer":[50],"disease":[51,127],"injection":[53,112],"into":[54,122],"naive":[55],"severe":[56],"combined":[57],"immunodeficiency":[58],"(SCID)":[59],"mice.":[60,87],"In":[61,110],"vitro":[62],"stimulation":[63],"experiments":[64],"suggested":[65],"function":[68],"IL-1R1(-/-)CD4(+)":[70],"was":[73,83,99],"not":[74,118],"intrinsically":[75],"defect,":[76],"but":[77,117],"their":[78],"activation":[79,143],"by":[80,129],"dendritic":[81,102,120,145],"impaired":[84],"Accordingly,":[88],"production":[89],"tumor":[91],"necrosis":[92],"factor":[93],"(TNF)-alpha,":[94],"IL-1,":[95],"IL-6,":[96],"IL-12p70":[98],"reduced":[100],"lacking":[104],"IL-1":[106],"1.":[109],"fact,":[111],"immature,":[114],"antigen-loaded":[115],"IL-1R1(+/+)":[116],"fully":[125],"restored":[126],"susceptibility":[128],"rendering":[130],"pathogenic.":[135],"Thus,":[136],"IL-1R1":[137],"triggering":[138],"required":[140],"for":[141,153],"efficient":[142],"cells,":[146],"which":[147],"turn":[150],"a":[151],"prerequisite":[152],"induction":[154],"autoreactive":[156],"autoimmunity.":[161]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}