{"id":"https://openalex.org/W4313344519","doi":"https://doi.org/10.4049/jimmunol.162.6.3308","title":"IL-2-Mediated Cell Cycle Progression and Inhibition of Apoptosis Does Not Require NF-\u03baB or Activating Protein-1 Activation in Primary Human T Cells","display_name":"IL-2-Mediated Cell Cycle Progression and Inhibition of Apoptosis Does Not Require NF-\u03baB or Activating Protein-1 Activation in Primary Human T Cells","publication_year":1999,"publication_date":"1999-03-01","ids":{"openalex":"https://openalex.org/W4313344519","doi":"https://doi.org/10.4049/jimmunol.162.6.3308","mag":"2129064993","pmid":"https://pubmed.ncbi.nlm.nih.gov/10092783"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.162.6.3308","doi":"https://doi.org/10.4049/jimmunol.162.6.3308","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.162.6.3308","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035561028","display_name":"Milena Iacobelli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I26538001","display_name":"San Diego State University","ror":"https://ror.org/0264fdx42","country_code":"US","type":"education","lineage":["https://openalex.org/I26538001"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Milena Iacobelli","raw_affiliation_strings":["Department of Biology and Molecular Biology Institute, San Diego State University, San Diego, CA 92182"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology and Molecular Biology Institute, San Diego State University, San Diego, CA 92182","institution_ids":["https://openalex.org/I26538001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026525836","display_name":"Forest L. Rohwer","orcid":"https://orcid.org/0000-0003-1548-5429","observed_orcids":["https://orcid.org/0000-0003-1548-5429"]},"institutions":[{"id":"https://openalex.org/I26538001","display_name":"San Diego State University","ror":"https://ror.org/0264fdx42","country_code":"US","type":"education","lineage":["https://openalex.org/I26538001"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Forest Rohwer","raw_affiliation_strings":["Department of Biology and Molecular Biology Institute, San Diego State University, San Diego, CA 92182"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology and Molecular Biology Institute, San Diego State University, San Diego, CA 92182","institution_ids":["https://openalex.org/I26538001"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Paul Shanahan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I26538001","display_name":"San Diego State University","ror":"https://ror.org/0264fdx42","country_code":"US","type":"education","lineage":["https://openalex.org/I26538001"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Shanahan","raw_affiliation_strings":["Department of Biology and Molecular Biology Institute, San Diego State University, San Diego, CA 92182"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology and Molecular Biology Institute, San Diego State University, San Diego, CA 92182","institution_ids":["https://openalex.org/I26538001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088699892","display_name":"Jose A. Quiroz","orcid":"https://orcid.org/0000-0001-8525-930X","observed_orcids":["https://orcid.org/0000-0001-8525-930X"]},"institutions":[{"id":"https://openalex.org/I26538001","display_name":"San Diego State University","ror":"https://ror.org/0264fdx42","country_code":"US","type":"education","lineage":["https://openalex.org/I26538001"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jose A Quiroz","raw_affiliation_strings":["Department of Biology and Molecular Biology Institute, San Diego State University, San Diego, CA 92182"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology and Molecular Biology Institute, San Diego State University, San Diego, CA 92182","institution_ids":["https://openalex.org/I26538001"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055383437","display_name":"Kathleen L. McGuire","orcid":"https://orcid.org/0000-0002-5357-3721","observed_orcids":["https://orcid.org/0000-0002-5357-3721"]},"institutions":[{"id":"https://openalex.org/I26538001","display_name":"San Diego State University","ror":"https://ror.org/0264fdx42","country_code":"US","type":"education","lineage":["https://openalex.org/I26538001"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathleen L McGuire","raw_affiliation_strings":["Department of Biology and Molecular Biology Institute, San Diego State University, San Diego, CA 92182"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology and Molecular Biology Institute, San Diego State University, San Diego, CA 92182","institution_ids":["https://openalex.org/I26538001"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I26538001"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":0.4921,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.62362882,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"162","issue":"6","first_page":"3308","last_page":"3315"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.9390000104904175,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.9390000104904175,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.02280000038444996,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.022099999710917473,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.9229999780654907},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.7929999828338623},{"id":"https://openalex.org/keywords/cell-cycle-progression","display_name":"cell cycle progression","score":0.9520000219345093},{"id":"https://openalex.org/keywords/apoptosis-inhibition","display_name":"apoptosis inhibition","score":0.902999997138977},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.9599999785423279},{"id":"https://openalex.org/keywords/ap-1","display_name":"AP-1","score":0.7549999952316284},{"id":"https://openalex.org/keywords/stat3","display_name":"STAT3","score":0.8230000138282776},{"id":"https://openalex.org/keywords/stat5","display_name":"STAT5","score":1.0},{"id":"https://openalex.org/keywords/ikappabalpha-degradation","display_name":"I\u03baB\u03b1 degradation","score":0.8970000147819519},{"id":"https://openalex.org/keywords/jnk","display_name":"JNK","score":0.9390000104904175},{"id":"https://openalex.org/keywords/t-cell-survival","display_name":"T cell survival","score":0.6710000038146973},{"id":"https://openalex.org/keywords/transcription-factors","display_name":"transcription factors","score":0.46000000834465027}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6227737069129944},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5853460431098938},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.5060307383537292},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.5010850429534912},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4740321934223175},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.432358980178833},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.4270175099372864},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4179622232913971},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33254849910736084},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3245428800582886},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3004075288772583},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1997423768043518},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09929215908050537},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008894","descriptor_name":"Milk Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013950","descriptor_name":"Thymus Gland","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013950","descriptor_name":"Thymus Gland","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013950","descriptor_name":"Thymus Gland","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018808","descriptor_name":"Transcription Factor AP-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018808","descriptor_name":"Transcription Factor AP-1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050799","descriptor_name":"STAT5 Transcription Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.4049/jimmunol.162.6.3308","doi":"https://doi.org/10.4049/jimmunol.162.6.3308","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.162.6.3308","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:10092783","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10092783","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"},{"id":"mag:2129064993","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10092783","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2503176721","display_name":"IL2 AND HTLV-I MEDIATED TRANSFORMATION OF T-CELLS","funder_award_id":"5r29ca053382-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G933884037","display_name":"SAN DIEGO STATE UNIVERSITY, MBRS PROGRAM","funder_award_id":"5s06gm045765-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":61,"referenced_works":["https://openalex.org/W187263029","https://openalex.org/W193383342","https://openalex.org/W1492606093","https://openalex.org/W1497061219","https://openalex.org/W1500101213","https://openalex.org/W1527677525","https://openalex.org/W1573050868","https://openalex.org/W1615126021","https://openalex.org/W1731547224","https://openalex.org/W1830422521","https://openalex.org/W1888783223","https://openalex.org/W1965150386","https://openalex.org/W1968015127","https://openalex.org/W1969158591","https://openalex.org/W1970548320","https://openalex.org/W1976385326","https://openalex.org/W1977707442","https://openalex.org/W1979676829","https://openalex.org/W1982785554","https://openalex.org/W1992147495","https://openalex.org/W1992393431","https://openalex.org/W1993844866","https://openalex.org/W1995297089","https://openalex.org/W1998574404","https://openalex.org/W2021820438","https://openalex.org/W2026422981","https://openalex.org/W2030592815","https://openalex.org/W2033222990","https://openalex.org/W2034403893","https://openalex.org/W2035147500","https://openalex.org/W2036224418","https://openalex.org/W2039940527","https://openalex.org/W2045427520","https://openalex.org/W2046867705","https://openalex.org/W2049819186","https://openalex.org/W2053102794","https://openalex.org/W2053648381","https://openalex.org/W2053798662","https://openalex.org/W2053813963","https://openalex.org/W2062263881","https://openalex.org/W2065257477","https://openalex.org/W2067185645","https://openalex.org/W2084223366","https://openalex.org/W2087852931","https://openalex.org/W2092109378","https://openalex.org/W2096155166","https://openalex.org/W2108664888","https://openalex.org/W2108707241","https://openalex.org/W2111910803","https://openalex.org/W2122559781","https://openalex.org/W2137407985","https://openalex.org/W2139551512","https://openalex.org/W2151892297","https://openalex.org/W2155280531","https://openalex.org/W2160644552","https://openalex.org/W2166781237","https://openalex.org/W2169649037","https://openalex.org/W2237135375","https://openalex.org/W2406069463","https://openalex.org/W2414695173","https://openalex.org/W7214202606"],"related_works":["https://openalex.org/W2129064993","https://openalex.org/W2006183334","https://openalex.org/W1498398420","https://openalex.org/W1615126021","https://openalex.org/W2069441639","https://openalex.org/W2088819693","https://openalex.org/W1895524259","https://openalex.org/W2112108730","https://openalex.org/W1577234690","https://openalex.org/W4313379041"],"abstract_inverted_index":{"The":[0,100],"IL-2":[1,18,106,127,137],"growth":[2,7,90,159],"hormone":[3],"is":[4,19,187],"the":[5,89,130,155,158,163],"major":[6],"factor":[8,91,160],"of":[9,43,66,165],"activated":[10,197],"T":[11,32,85,122,200],"lymphocytes":[12],"during":[13],"a":[14,147],"developing":[15],"immune":[16],"response.":[17],"required":[20,188],"not":[21,108],"only":[22],"for":[23,94,189],"cell":[24,36,40,73,76,131,193],"cycle":[25,77,132,194],"progression":[26,78,195],"but":[27],"also":[28],"to":[29,53,81,88,126,146],"protect":[30],"Ag-activated":[31],"cells":[33,86,123],"from":[34],"programmed":[35],"death.":[37],"In":[38],"several":[39],"types,":[41],"activation":[42,118,164,186],"NF-kappa":[44,95,116,182],"B":[45,96,112,117,183],"and/or":[46],"activating":[47],"protein-1":[48],"(AP-1)":[49],"has":[50,173],"been":[51,174],"demonstrated":[52],"be":[54],"extremely":[55],"important":[56],"in":[57,72,79,119,169,196],"blocking":[58],"apoptosis.":[59,135],"To":[60],"determine":[61],"whether":[62],"either":[63],"or":[64,75,115,192],"both":[65],"these":[67,170],"transcription":[68],"factors":[69],"are":[70],"involved":[71],"survival":[74,191],"response":[80,152],"IL-2,":[82],"primary":[83,120,198],"human":[84,121,199],"responsive":[87],"were":[92],"analyzed":[93],"and":[97,133,167],"AP-1":[98,143,185],"activation.":[99],"current":[101],"study":[102],"clearly":[103],"demonstrates":[104],"that":[105,124,180],"does":[107,161],"induce":[109,162],"I":[110],"kappa":[111],"alpha":[113],"degradation":[114],"respond":[125],"by":[128],"entering":[129],"avoiding":[134],"Similarly,":[136],"neither":[138,181],"activates":[139],"JNK":[140],"nor":[141,184],"increases":[142],"binding":[144],"activity":[145],"consensus":[148],"o-tetradecanoylphorbol":[149],"13-acetate":[150],"(TPA)":[151],"element.":[153],"On":[154],"other":[156],"hand,":[157],"STAT3":[166],"STAT5":[168],"cells,":[171],"as":[172],"previously":[175],"demonstrated.":[176],"These":[177],"data":[178],"show":[179],"IL-2-mediated":[190],"cells.":[201]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-01-06T00:00:00"}
