{"id":"https://openalex.org/W2129055641","doi":null,"title":"Protection of the amide side-chain of asparagine with the 1-tetralinyl group in the solid-phase peptide synthesis of lysine-vasopressin","display_name":"Protection of the amide side-chain of asparagine with the 1-tetralinyl group in the solid-phase peptide synthesis of lysine-vasopressin","publication_year":2002,"publication_date":"2002-01-01","ids":{"openalex":"https://openalex.org/W2129055641","mag":"2129055641"},"language":"en","primary_location":{"id":"mag:2129055641","doi":null,"is_oa":true,"landing_page_url":"http://erepository.uonbi.ac.ke/handle/11295/40528","pdf_url":null,"source":{"id":"https://openalex.org/S2764769916","display_name":"South African Journal of Chemistry","issn_l":"0379-4350","issn":["0379-4350","1996-840X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jpps-2","norway-1","poland-20","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310315338","host_organization_name":"Sabinet","host_organization_lineage":["https://openalex.org/P4310315338"],"host_organization_lineage_names":["Sabinet"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"South African Journal of Chemistry","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://erepository.uonbi.ac.ke/handle/11295/40528","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112078071","display_name":"Amir Okeyo Yusuf","orcid":"https://orcid.org/0009-0001-1931-315X","observed_orcids":["https://orcid.org/0009-0001-1931-315X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amir Yusuf","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076191920","display_name":"Bhalendu Bhatt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bhalendu Bhatt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5046735562","display_name":"Peter M. Gitu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter M. Gitu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.13463902,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"55","issue":"1","first_page":"87","last_page":"96"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13649","display_name":"Advanced Synthetic Organic Chemistry","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13326","display_name":"Biochemical and Structural Characterization","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lysine-vasopressin","display_name":"lysine vasopressin","score":0.9900000095367432},{"id":"https://openalex.org/keywords/solid-phase-peptide-synthesis","display_name":"solid-phase peptide synthesis","score":0.9629999995231628},{"id":"https://openalex.org/keywords/benzyl-protecting-group","display_name":"benzyl protecting group","score":0.7739999890327454},{"id":"https://openalex.org/keywords/peptide-cleavage","display_name":"peptide cleavage","score":0.5910000205039978},{"id":"https://openalex.org/keywords/one-pot-synthesis","display_name":"one-pot synthesis","score":0.6119999885559082},{"id":"https://openalex.org/keywords/nonapeptide","display_name":"nonapeptide","score":0.765999972820282}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9139530658721924},{"id":"https://openalex.org/C2775895851","wikidata":"https://www.wikidata.org/wiki/Q185906","display_name":"Asparagine","level":3,"score":0.7499165534973145},{"id":"https://openalex.org/C2780112151","wikidata":"https://www.wikidata.org/wiki/Q412033","display_name":"Trifluoroacetic acid","level":2,"score":0.7335450649261475},{"id":"https://openalex.org/C204921945","wikidata":"https://www.wikidata.org/wiki/Q899689","display_name":"Side chain","level":3,"score":0.6768606305122375},{"id":"https://openalex.org/C19014433","wikidata":"https://www.wikidata.org/wiki/Q5130995","display_name":"Cleave","level":3,"score":0.66376793384552},{"id":"https://openalex.org/C2778439535","wikidata":"https://www.wikidata.org/wiki/Q188777","display_name":"Amide","level":2,"score":0.6307564377784729},{"id":"https://openalex.org/C2908938740","wikidata":"https://www.wikidata.org/wiki/Q9087778","display_name":"Thioanisole","level":3,"score":0.6289243698120117},{"id":"https://openalex.org/C2779746882","wikidata":"https://www.wikidata.org/wiki/Q898525","display_name":"Protecting group","level":3,"score":0.5474768280982971},{"id":"https://openalex.org/C2779809887","wikidata":"https://www.wikidata.org/wiki/Q14864278","display_name":"Peptide synthesis","level":3,"score":0.5417265892028809},{"id":"https://openalex.org/C2776469878","wikidata":"https://www.wikidata.org/wiki/Q2026994","display_name":"Solid-phase synthesis","level":3,"score":0.5401282906532288},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.5315924286842346},{"id":"https://openalex.org/C2776016237","wikidata":"https://www.wikidata.org/wiki/Q178430","display_name":"Lysine","level":3,"score":0.5087042450904846},{"id":"https://openalex.org/C134121241","wikidata":"https://www.wikidata.org/wiki/Q899301","display_name":"Yield (engineering)","level":2,"score":0.48104289174079895},{"id":"https://openalex.org/C2779349466","wikidata":"https://www.wikidata.org/wiki/Q181619","display_name":"Glutamine","level":3,"score":0.47411826252937317},{"id":"https://openalex.org/C60984968","wikidata":"https://www.wikidata.org/wiki/Q389172","display_name":"Cyclic peptide","level":3,"score":0.469682514667511},{"id":"https://openalex.org/C2777468819","wikidata":"https://www.wikidata.org/wiki/Q173670","display_name":"Arginine","level":3,"score":0.45549875497817993},{"id":"https://openalex.org/C2779303437","wikidata":"https://www.wikidata.org/wiki/Q422899","display_name":"Carbamate","level":2,"score":0.4397616982460022},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.4356684386730194},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.42581063508987427},{"id":"https://openalex.org/C2779201268","wikidata":"https://www.wikidata.org/wiki/Q186474","display_name":"Cysteine","level":3,"score":0.4185866713523865},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1923244297504425},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.13099518418312073},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.0},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0},{"id":"https://openalex.org/C2780263894","wikidata":"https://www.wikidata.org/wiki/Q335268","display_name":"Alkyl","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2129055641","doi":null,"is_oa":true,"landing_page_url":"http://erepository.uonbi.ac.ke/handle/11295/40528","pdf_url":null,"source":{"id":"https://openalex.org/S2764769916","display_name":"South African Journal of Chemistry","issn_l":"0379-4350","issn":["0379-4350","1996-840X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jpps-2","norway-1","poland-20","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310315338","host_organization_name":"Sabinet","host_organization_lineage":["https://openalex.org/P4310315338"],"host_organization_lineage_names":["Sabinet"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"South African Journal of Chemistry","raw_type":null}],"best_oa_location":{"id":"mag:2129055641","doi":null,"is_oa":true,"landing_page_url":"http://erepository.uonbi.ac.ke/handle/11295/40528","pdf_url":null,"source":{"id":"https://openalex.org/S2764769916","display_name":"South African Journal of Chemistry","issn_l":"0379-4350","issn":["0379-4350","1996-840X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jpps-2","norway-1","poland-20","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310315338","host_organization_name":"Sabinet","host_organization_lineage":["https://openalex.org/P4310315338"],"host_organization_lineage_names":["Sabinet"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"South African Journal of Chemistry","raw_type":null},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":3,"referenced_works":["https://openalex.org/W1991211808","https://openalex.org/W3101180015","https://openalex.org/W3215286494"],"related_works":["https://openalex.org/W1602584021","https://openalex.org/W7100045259","https://openalex.org/W7019839336","https://openalex.org/W7024810813","https://openalex.org/W1686333760","https://openalex.org/W2126145476","https://openalex.org/W2021649678","https://openalex.org/W7024687746","https://openalex.org/W2264994133","https://openalex.org/W1528422305"],"abstract_inverted_index":{"Lysine-vasopressin,":[0],"a":[1,6,76],"nonapeptide,":[2],"was":[3,18,55,85],"synthesised":[4],"on":[5],"benzhydryl-resin":[7],"using":[8],"solid-phase":[9],"peptide":[10],"synthesis":[11],"via":[12],"the":[13,21,24,39,42,59,79],"Boc-strategy.":[14],"The":[15,65],"benzyl":[16],"group":[17],"used":[19,37,56],"in":[20,38,75],"protection":[22,40],"of":[23,26,41,44,92],"side-chains":[25,43],"tyrosine":[27],"and":[28,33,47],"cysteine,":[29],"while":[30],"1-tetralinyl,":[31],"benzhydryl":[32],"benzyloxycarbonyl":[34],"groups":[35],"were":[36],"asparagine,":[45],"glutamine":[46],"lysine,":[48],"respectively.":[49],"Thioanisole-1,2-ethanedithiol-trifluoroacetic":[50],"acid-trifluoromethanesulphonic":[51],"acid":[52],"(2:1:20:2":[53],"v/v)":[54],"to":[57],"cleave":[58],"peptide-resin":[60],"under":[61],"different":[62],"temperature":[63],"conditions.":[64],"cleavage":[66],"at":[67],"40":[68],"oC":[69],"for":[70],"two":[71],"hours":[72],"gave":[73],"lysine-vasopressin":[74],"one-pot":[77],"reaction;":[78],"yield":[80],"after":[81],"reversed-phase":[82],"HPLC":[83],"purification":[84],"62%.":[86],"\nSouth":[89],"African":[90],"Journal":[91],"Chemistry":[93],"Vol.55":[94],"2002:":[95],"87-96":[96]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}