{"id":"https://openalex.org/W2129043348","doi":"https://doi.org/10.1042/bj20111542","title":"The antioxidative effect of de novo generated vitamin B6 in Plasmodium falciparum validated by protein interference","display_name":"The antioxidative effect of de novo generated vitamin B6 in Plasmodium falciparum validated by protein interference","publication_year":2012,"publication_date":"2012-01-17","ids":{"openalex":"https://openalex.org/W2129043348","doi":"https://doi.org/10.1042/bj20111542","mag":"2129043348","pmid":"https://pubmed.ncbi.nlm.nih.gov/22242896"},"language":"en","primary_location":{"id":"doi:10.1042/bj20111542","doi":"https://doi.org/10.1042/bj20111542","is_oa":false,"landing_page_url":"https://doi.org/10.1042/bj20111542","pdf_url":null,"source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109240130","display_name":"Julia Kn\u00f6ckel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I94402716","display_name":"Bernhard Nocht Institute for Tropical Medicine","ror":"https://ror.org/01evwfd48","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I94402716"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Julia Kn\u00f6ckel","raw_affiliation_strings":["Department of Biochemistry, Bernhard Nocht Institute for Tropical Medicine, Bernhard-Nocht-Strasse 74, D-20359 Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Bernhard Nocht Institute for Tropical Medicine, Bernhard-Nocht-Strasse 74, D-20359 Hamburg, Germany","institution_ids":["https://openalex.org/I94402716"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ingrid\u00a0B. M\u00fcller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I94402716","display_name":"Bernhard Nocht Institute for Tropical Medicine","ror":"https://ror.org/01evwfd48","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I94402716"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ingrid\u00a0B. M\u00fcller","raw_affiliation_strings":["Department of Biochemistry, Bernhard Nocht Institute for Tropical Medicine, Bernhard-Nocht-Strasse 74, D-20359 Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Bernhard Nocht Institute for Tropical Medicine, Bernhard-Nocht-Strasse 74, D-20359 Hamburg, Germany","institution_ids":["https://openalex.org/I94402716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087568434","display_name":"Sabine Butzloff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I94402716","display_name":"Bernhard Nocht Institute for Tropical Medicine","ror":"https://ror.org/01evwfd48","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I94402716"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Sabine Butzloff","raw_affiliation_strings":["Department of Biochemistry, Bernhard Nocht Institute for Tropical Medicine, Bernhard-Nocht-Strasse 74, D-20359 Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Bernhard Nocht Institute for Tropical Medicine, Bernhard-Nocht-Strasse 74, D-20359 Hamburg, Germany","institution_ids":["https://openalex.org/I94402716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042878293","display_name":"B\u00e4rbel Bergmann","orcid":"https://orcid.org/0000-0002-1869-3533","observed_orcids":["https://orcid.org/0000-0002-1869-3533"]},"institutions":[{"id":"https://openalex.org/I94402716","display_name":"Bernhard Nocht Institute for Tropical Medicine","ror":"https://ror.org/01evwfd48","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I94402716"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"B\u00e4rbel Bergmann","raw_affiliation_strings":["Department of Biochemistry, Bernhard Nocht Institute for Tropical Medicine, Bernhard-Nocht-Strasse 74, D-20359 Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Bernhard Nocht Institute for Tropical Medicine, Bernhard-Nocht-Strasse 74, D-20359 Hamburg, Germany","institution_ids":["https://openalex.org/I94402716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113611092","display_name":"Rolf D. Walter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I94402716","display_name":"Bernhard Nocht Institute for Tropical Medicine","ror":"https://ror.org/01evwfd48","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I94402716"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Rolf\u00a0D. Walter","raw_affiliation_strings":["Department of Biochemistry, Bernhard Nocht Institute for Tropical Medicine, Bernhard-Nocht-Strasse 74, D-20359 Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Bernhard Nocht Institute for Tropical Medicine, Bernhard-Nocht-Strasse 74, D-20359 Hamburg, Germany","institution_ids":["https://openalex.org/I94402716"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021210565","display_name":"Carsten Wrenger","orcid":"https://orcid.org/0000-0001-5987-1749","observed_orcids":["https://orcid.org/0000-0001-5987-1749"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I94402716","display_name":"Bernhard Nocht Institute for Tropical Medicine","ror":"https://ror.org/01evwfd48","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I94402716"]}],"countries":["BR","DE"],"is_corresponding":true,"raw_author_name":"Carsten Wrenger","raw_affiliation_strings":["Department of Biochemistry, Bernhard Nocht Institute for Tropical Medicine, Bernhard-Nocht-Strasse 74, D-20359 Hamburg, Germany","Department of Parasitology, Institute of Biomedical Science, University of S\u00e3o Paulo, Av. Prof. Lineu Prestes 1374, 05508-000 S\u00e3o Paulo-SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Bernhard Nocht Institute for Tropical Medicine, Bernhard-Nocht-Strasse 74, D-20359 Hamburg, Germany","institution_ids":["https://openalex.org/I94402716"]},{"raw_affiliation_string":"Department of Parasitology, Institute of Biomedical Science, University of S\u00e3o Paulo, Av. Prof. Lineu Prestes 1374, 05508-000 S\u00e3o Paulo-SP, Brazil","institution_ids":["https://openalex.org/I17974374"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5021210565","https://openalex.org/A5087568434"],"corresponding_institution_ids":["https://openalex.org/I17974374","https://openalex.org/I94402716"],"apc_list":null,"apc_paid":null,"fwci":3.4314,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.92226705,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"443","issue":"2","first_page":"397","last_page":"405"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasmodium-falciparum","display_name":"Plasmodium falciparum","score":0.9869999885559082},{"id":"https://openalex.org/keywords/vitamin-b6-biosynthesis","display_name":"vitamin B6 biosynthesis","score":0.9549999833106995},{"id":"https://openalex.org/keywords/pyridoxal-5-phosphate","display_name":"pyridoxal phosphate","score":0.9919999837875366},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8920000195503235},{"id":"https://openalex.org/keywords/hemoglobin-digestion","display_name":"hemoglobin digestion","score":0.8090000152587891},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.8700000047683716},{"id":"https://openalex.org/keywords/antioxidant-defense","display_name":"antioxidant defense","score":0.7009999752044678},{"id":"https://openalex.org/keywords/antimalarial-drug-targets","display_name":"antimalarial drug targets","score":0.8180000185966492},{"id":"https://openalex.org/keywords/plasmodium","display_name":"Plasmodium","score":0.48899999260902405}],"concepts":[{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.71074378490448},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6194071769714355},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5949310064315796},{"id":"https://openalex.org/C197957613","wikidata":"https://www.wikidata.org/wiki/Q407280","display_name":"Cofactor","level":3,"score":0.5243423581123352},{"id":"https://openalex.org/C2780859938","wikidata":"https://www.wikidata.org/wiki/Q3065731","display_name":"Pyridoxal","level":3,"score":0.47860950231552124},{"id":"https://openalex.org/C2781095387","wikidata":"https://www.wikidata.org/wiki/Q192471","display_name":"Menadione","level":3,"score":0.4580068290233612},{"id":"https://openalex.org/C88742014","wikidata":"https://www.wikidata.org/wiki/Q1063702","display_name":"De novo synthesis","level":3,"score":0.4508499801158905},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4481356739997864},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.2029637098312378},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.11450284719467163}],"mesh":[{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010569","descriptor_name":"Perylene","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D010569","descriptor_name":"Perylene","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015800","descriptor_name":"Protozoan Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015800","descriptor_name":"Protozoan Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019884","descriptor_name":"Nitrogenous Group Transferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019884","descriptor_name":"Nitrogenous Group Transferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D025101","descriptor_name":"Vitamin B 6","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1042/bj20111542","doi":"https://doi.org/10.1042/bj20111542","is_oa":false,"landing_page_url":"https://doi.org/10.1042/bj20111542","pdf_url":null,"source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},{"id":"pmid:22242896","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22242896","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Biochemical journal","raw_type":"Journal Article"},{"id":"pmh:oai:www.producao.usp.br:BDPI/42553","doi":null,"is_oa":false,"landing_page_url":"http://www.producao.usp.br/handle/BDPI/42553","pdf_url":null,"source":{"id":"https://openalex.org/S4306401373","display_name":"Scientific Electronic Library Online (S\u00e3o Paulo Research Foundation, Latin American and Caribbean Center on Health Sciences Information, Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2982035970","host_organization_name":"Costa Rican Department of Social Security","host_organization_lineage":["https://openalex.org/I2982035970"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W1568523187","https://openalex.org/W1586999772","https://openalex.org/W1963775811","https://openalex.org/W1967527121","https://openalex.org/W1969503178","https://openalex.org/W1970115015","https://openalex.org/W1978653284","https://openalex.org/W1978847058","https://openalex.org/W1984275070","https://openalex.org/W1988492560","https://openalex.org/W1989242002","https://openalex.org/W1993194332","https://openalex.org/W1994066024","https://openalex.org/W1995596815","https://openalex.org/W1996878825","https://openalex.org/W1998199040","https://openalex.org/W2000933179","https://openalex.org/W2001262070","https://openalex.org/W2004487155","https://openalex.org/W2009106952","https://openalex.org/W2016174382","https://openalex.org/W2017306058","https://openalex.org/W2022738557","https://openalex.org/W2028583646","https://openalex.org/W2034612846","https://openalex.org/W2037525379","https://openalex.org/W2041605619","https://openalex.org/W2053828364","https://openalex.org/W2058074298","https://openalex.org/W2061393819","https://openalex.org/W2062507279","https://openalex.org/W2064773460","https://openalex.org/W2073080160","https://openalex.org/W2078308068","https://openalex.org/W2080253489","https://openalex.org/W2081252762","https://openalex.org/W2090392562","https://openalex.org/W2112047656","https://openalex.org/W2128951021","https://openalex.org/W2136383137","https://openalex.org/W2139027244","https://openalex.org/W2147150988","https://openalex.org/W2149677408","https://openalex.org/W2160455928","https://openalex.org/W2163027365","https://openalex.org/W2167481674","https://openalex.org/W2169731243","https://openalex.org/W2174723130","https://openalex.org/W2418869581","https://openalex.org/W2492750234","https://openalex.org/W3021924366"],"related_works":["https://openalex.org/W1621938701","https://openalex.org/W2053828364","https://openalex.org/W2972903277","https://openalex.org/W6946529561","https://openalex.org/W1970783176","https://openalex.org/W1996878825","https://openalex.org/W1979876583","https://openalex.org/W7112047049","https://openalex.org/W3159614333","https://openalex.org/W3184511665"],"abstract_inverted_index":{"The":[0,54],"malaria":[1],"parasite":[2,37,63],"Plasmodium":[3],"falciparum":[4,152],"is":[5,33],"able":[6],"to":[7,38,118,127,155],"synthesize":[8],"de":[9,29,197],"novo":[10,30,198],"PLP":[11,32,77,110,181],"(pyridoxal":[12],"5'-phosphate),":[13],"the":[14,21,28,36,59,62,80,88,100,122,137,141,161,169,177,194,203],"active":[15],"form":[16],"of":[17,56,61,76,84,99,147,164,171,180,185,193,206,212],"vitamin":[18,89,165,195],"B6.":[19],"In":[20,133],"present":[22],"study,":[23],"we":[24],"have":[25],"shown":[26],"that":[27],"synthesized":[31],"used":[34],"by":[35,66,70,74,135],"detoxify":[39],"1O2":[40,57,172],"(singlet":[41],"molecular":[42],"oxygen),":[43],"a":[44,128,183,210],"highly":[45],"destructive":[46],"reactive":[47],"oxygen":[48],"species":[49],"arising":[50],"from":[51,112],"haemoglobin":[52],"digestion.":[53],"formation":[55],"and":[58,73,93,125,149],"response":[60],"were":[64],"monitored":[65],"live-cell":[67],"fluorescence":[68],"microscopy,":[69],"transcription":[71],"analysis":[72],"determination":[75],"levels":[78],"in":[79,103,107,115,121,168,173],"parasite.":[81],"Pull-down":[82],"experiments":[83],"transgenic":[85],"parasites":[86,117],"overexpressing":[87],"B6-biosynthetic":[90],"enzymes":[91],"PfPdx1":[92,148],"PfPdx2":[94],"clearly":[95,160],"demonstrated":[96],"an":[97,108],"interaction":[98],"two":[101],"proteins":[102],"vivo":[104],"which":[105],"results":[106,158],"elevated":[109],"level":[111,143],"12.5":[113],"\u03bcM":[114,120],"wild-type":[116],"36.6":[119],"PfPdx1/PfPdx2-overexpressing":[123],"cells":[124],"thus":[126],"higher":[129],"tolerance":[130],"towards":[131],"1O2.":[132,156],"contrast,":[134],"applying":[136],"dominant-negative":[138],"effect":[139],"on":[140],"cellular":[142],"using":[144],"inactive":[145],"mutants":[146],"PfPdx2,":[150],"P.":[151,174],"becomes":[153],"susceptible":[154],"Our":[157],"demonstrate":[159],"crucial":[162],"role":[163,179],"B6":[166,196],"biosynthesis":[167],"detoxification":[170],"falciparum.":[175],"Besides":[176],"known":[178],"as":[182,200,209],"cofactor":[184],"many":[186],"essential":[187],"enzymes,":[188],"this":[189,207],"second":[190],"important":[191],"task":[192],"synthesis":[199],"antioxidant":[201],"emphasizes":[202],"high":[204],"potential":[205],"pathway":[208],"target":[211],"new":[213],"anti-malarial":[214],"drugs.":[215]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
