{"id":"https://openalex.org/W2129043193","doi":"https://doi.org/10.1186/1475-2867-12-31","title":"Neuropeptide-inducible upregulation of proteasome activity precedes nuclear factor kappa B activation in androgen-independent prostate cancer cells","display_name":"Neuropeptide-inducible upregulation of proteasome activity precedes nuclear factor kappa B activation in androgen-independent prostate cancer cells","publication_year":2012,"publication_date":"2012-06-20","ids":{"openalex":"https://openalex.org/W2129043193","doi":"https://doi.org/10.1186/1475-2867-12-31","mag":"2129043193","pmid":"https://pubmed.ncbi.nlm.nih.gov/22715899","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3441896"},"language":"en","primary_location":{"id":"doi:10.1186/1475-2867-12-31","doi":"https://doi.org/10.1186/1475-2867-12-31","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1475-2867-12-31","pdf_url":"https://cancerci.biomedcentral.com/counter/pdf/10.1186/1475-2867-12-31","source":{"id":"https://openalex.org/S130214813","display_name":"Cancer Cell International","issn_l":"1475-2867","issn":["1475-2867"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Cell International","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://cancerci.biomedcentral.com/counter/pdf/10.1186/1475-2867-12-31","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074461929","display_name":"Anna Patrikidou","orcid":"https://orcid.org/0000-0001-5066-601X","observed_orcids":["https://orcid.org/0000-0001-5066-601X"]},"institutions":[{"id":"https://openalex.org/I2801843802","display_name":"Institut Gustave Roussy","ror":"https://ror.org/0321g0743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801843802"]},{"id":"https://openalex.org/I4210107217","display_name":"University Hospital of Larissa","ror":"https://ror.org/01s5dt366","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210107217"]}],"countries":["FR","GR"],"is_corresponding":false,"raw_author_name":"Anna Patrikidou","raw_affiliation_strings":["Department of Medical Oncology, University Hospital of Larissa, Larissa, Greece. cpapandreou@med.uth.gr","Department of Medicine, Institut Gustave-Roussy, Villejuif, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, University Hospital of Larissa, Larissa, Greece. cpapandreou@med.uth.gr","institution_ids":["https://openalex.org/I4210107217"]},{"raw_affiliation_string":"Department of Medicine, Institut Gustave-Roussy, Villejuif, France","institution_ids":["https://openalex.org/I2801843802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061020970","display_name":"Panagiotis J. Vlachostergios","orcid":"https://orcid.org/0000-0002-1704-1517","observed_orcids":["https://orcid.org/0000-0002-1704-1517"]},"institutions":[{"id":"https://openalex.org/I4210107217","display_name":"University Hospital of Larissa","ror":"https://ror.org/01s5dt366","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210107217"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Panagiotis J Vlachostergios","raw_affiliation_strings":["Department of Medical Oncology, University Hospital of Larissa, Larissa, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, University Hospital of Larissa, Larissa, Greece","institution_ids":["https://openalex.org/I4210107217"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038353919","display_name":"Ioannis A. Voutsadakis","orcid":"https://orcid.org/0000-0002-9301-5951","observed_orcids":["https://orcid.org/0000-0002-9301-5951"]},"institutions":[{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Ioannis A Voutsadakis","raw_affiliation_strings":["Centre Pluridisciplinaire d\u2019Oncologie, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre Pluridisciplinaire d\u2019Oncologie, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland","institution_ids":["https://openalex.org/I2802229882"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029518615","display_name":"Eleana Hatzidaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210107217","display_name":"University Hospital of Larissa","ror":"https://ror.org/01s5dt366","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210107217"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Eleana Hatzidaki","raw_affiliation_strings":["Department of Medical Oncology, University Hospital of Larissa, Larissa, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, University Hospital of Larissa, Larissa, Greece","institution_ids":["https://openalex.org/I4210107217"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111610851","display_name":"Rosalia\u2010Maria Valeri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087568","display_name":"Theageneio General Hospital","ror":"https://ror.org/004hfxk38","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210087568"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Rosalia-Maria Valeri","raw_affiliation_strings":["Department of Cytopathology, \u201cTheagenio\u201d Cancer Hospital, Thessaloniki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cytopathology, \u201cTheagenio\u201d Cancer Hospital, Thessaloniki, Greece","institution_ids":["https://openalex.org/I4210087568"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110615630","display_name":"Chariklia Destouni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087568","display_name":"Theageneio General Hospital","ror":"https://ror.org/004hfxk38","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210087568"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Chariklia Destouni","raw_affiliation_strings":["Department of Cytopathology, \u201cTheagenio\u201d Cancer Hospital, Thessaloniki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cytopathology, \u201cTheagenio\u201d Cancer Hospital, Thessaloniki, Greece","institution_ids":["https://openalex.org/I4210087568"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017913027","display_name":"Effie Apostolou","orcid":"https://orcid.org/0000-0002-8111-0863","observed_orcids":["https://orcid.org/0000-0002-8111-0863"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I206127235","display_name":"Academy of Athens","ror":"https://ror.org/00qsdn986","country_code":"GR","type":"education","lineage":["https://openalex.org/I206127235"]},{"id":"https://openalex.org/I4210093138","display_name":"Biomedical Research Foundation of the Academy of Athens","ror":"https://ror.org/00gban551","country_code":"GR","type":"nonprofit","lineage":["https://openalex.org/I4210093138"]}],"countries":["GR","US"],"is_corresponding":false,"raw_author_name":"Effie Apostolou","raw_affiliation_strings":["Howard Hughes Medical Institute and Department of Stem Cell and Regenerative Biology, Harvard University and Harvard Medical School, Cambridge, MA, USA","Institute of Molecular Biology, Genetics and Biotechnology, Biomedical Research Foundation, Academy of Athens, Athens, Greece","Academy of Athens","Harvard University and Harvard Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute and Department of Stem Cell and Regenerative Biology, Harvard University and Harvard Medical School, Cambridge, MA, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Institute of Molecular Biology, Genetics and Biotechnology, Biomedical Research Foundation, Academy of Athens, Athens, Greece","institution_ids":["https://openalex.org/I206127235","https://openalex.org/I4210093138"]},{"raw_affiliation_string":"Academy of Athens","institution_ids":["https://openalex.org/I206127235"]},{"raw_affiliation_string":"Harvard University and Harvard Medical School","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032663338","display_name":"Christos N. Papandreou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210107217","display_name":"University Hospital of Larissa","ror":"https://ror.org/01s5dt366","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210107217"]}],"countries":["GR"],"is_corresponding":true,"raw_author_name":"Christos N Papandreou","raw_affiliation_strings":["Department of Medical Oncology, University Hospital of Larissa, Larissa, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, University Hospital of Larissa, Larissa, Greece","institution_ids":["https://openalex.org/I4210107217"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5032663338"],"corresponding_institution_ids":["https://openalex.org/I4210107217"],"apc_list":{"value":3190,"currency":"USD","value_usd":3190},"apc_paid":{"value":3190,"currency":"USD","value_usd":3190},"fwci":0.516,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.74175996,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"12","issue":"1","first_page":"31","last_page":"31"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuropeptides","display_name":"neuropeptides","score":0.9580000042915344},{"id":"https://openalex.org/keywords/nf-kappab-activation","display_name":"NF-\u03baB activation","score":0.6179999709129333},{"id":"https://openalex.org/keywords/proteasome-activity","display_name":"proteasome activity","score":0.8799999952316284},{"id":"https://openalex.org/keywords/castration-resistant-prostate-cancer","display_name":"castration-resistant prostate cancer","score":0.9760000109672546},{"id":"https://openalex.org/keywords/castration-resistance","display_name":"castration resistance","score":0.7929999828338623},{"id":"https://openalex.org/keywords/ikappabalpha","display_name":"I\u03baB\u03b1","score":0.597000002861023},{"id":"https://openalex.org/keywords/ikappab-kinase","display_name":"I\u03baB kinase","score":0.7429999709129333},{"id":"https://openalex.org/keywords/neutral-endopeptidase","display_name":"neutral endopeptidase","score":0.8629999756813049},{"id":"https://openalex.org/keywords/endothelin-1","display_name":"endothelin-1","score":0.949999988079071},{"id":"https://openalex.org/keywords/neuroendocrine-differentiation","display_name":"neuroendocrine differentiation","score":0.9089999794960022},{"id":"https://openalex.org/keywords/prostate-cancer-progression","display_name":"prostate cancer progression","score":0.6859999895095825}],"concepts":[{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.6861275434494019},{"id":"https://openalex.org/C27740335","wikidata":"https://www.wikidata.org/wiki/Q14878333","display_name":"Proteasome","level":2,"score":0.64344722032547},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.579404354095459},{"id":"https://openalex.org/C183978625","wikidata":"https://www.wikidata.org/wiki/Q903596","display_name":"Electrophoretic mobility shift assay","level":4,"score":0.534184455871582},{"id":"https://openalex.org/C100175707","wikidata":"https://www.wikidata.org/wiki/Q6103519","display_name":"I\u03baB kinase","level":4,"score":0.48643994331359863},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4837906062602997},{"id":"https://openalex.org/C61367390","wikidata":"https://www.wikidata.org/wiki/Q416601","display_name":"Androgen receptor","level":4,"score":0.4706166088581085},{"id":"https://openalex.org/C2777899217","wikidata":"https://www.wikidata.org/wiki/Q4759439","display_name":"Androgen deprivation therapy","level":4,"score":0.4515319764614105},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42708611488342285},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4256551265716553},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40691882371902466},{"id":"https://openalex.org/C2777730290","wikidata":"https://www.wikidata.org/wiki/Q411114","display_name":"NF-\u03baB","level":3,"score":0.3994199335575104},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3944079875946045},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.384514182806015},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.3761407434940338},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3318457007408142},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2463969588279724},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.21016159653663635},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17471036314964294},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07430559396743774}],"mesh":[],"locations_count":8,"locations":[{"id":"doi:10.1186/1475-2867-12-31","doi":"https://doi.org/10.1186/1475-2867-12-31","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1475-2867-12-31","pdf_url":"https://cancerci.biomedcentral.com/counter/pdf/10.1186/1475-2867-12-31","source":{"id":"https://openalex.org/S130214813","display_name":"Cancer Cell International","issn_l":"1475-2867","issn":["1475-2867"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Cell International","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2445135","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3441896","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3441896","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3441896","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Cell Int","raw_type":"Text"},{"id":"pmid:22715899","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22715899","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer cell international","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unil.ch:iris/96791","doi":null,"is_oa":true,"landing_page_url":"https://iris.unil.ch/handle/iris/96791","pdf_url":"https://iris.unil.ch/bitstreams/99680f40-e44b-4601-8b96-9c1601b4337b/download","source":{"id":"https://openalex.org/S7407055444","display_name":"IRIS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:oai:dash.harvard.edu:1/10536958","doi":null,"is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:10536958","pdf_url":null,"source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:9fe30544f1cd405183ee27516845a73e","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/9fe30544f1cd405183ee27516845a73e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancer Cell International, Vol 12, Iss 1, p 31 (2012)","raw_type":"article"},{"id":"pmh:oai:serval.unil.ch:BIB_3387D467F9F8","doi":null,"is_oa":true,"landing_page_url":"https://serval.unil.ch/notice/serval:BIB_3387D467F9F8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401797","display_name":"SERVAL (Universit\u00e9 de Lausanne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210093590","host_organization_name":"Swiss School of Archaeology in Greece","host_organization_lineage":["https://openalex.org/I4210093590"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancer Cell International, vol. 12, no. 1, pp. 31","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1186/1475-2867-12-31","doi":"https://doi.org/10.1186/1475-2867-12-31","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1475-2867-12-31","pdf_url":"https://cancerci.biomedcentral.com/counter/pdf/10.1186/1475-2867-12-31","source":{"id":"https://openalex.org/S130214813","display_name":"Cancer Cell International","issn_l":"1475-2867","issn":["1475-2867"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Cell International","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332513","display_name":"Weill Cornell Medical College","ror":"https://ror.org/02r109517"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2129043193.pdf","grobid_xml":"https://content.openalex.org/works/W2129043193.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W93318950","https://openalex.org/W1494294895","https://openalex.org/W1526636100","https://openalex.org/W1526801044","https://openalex.org/W1799214675","https://openalex.org/W1807380980","https://openalex.org/W1977953804","https://openalex.org/W1980613758","https://openalex.org/W1981315914","https://openalex.org/W1983792141","https://openalex.org/W1984995889","https://openalex.org/W1985316232","https://openalex.org/W1985662208","https://openalex.org/W1986118099","https://openalex.org/W1988887575","https://openalex.org/W1989861100","https://openalex.org/W1999144667","https://openalex.org/W1999520767","https://openalex.org/W2000181720","https://openalex.org/W2008409590","https://openalex.org/W2013362071","https://openalex.org/W2017902645","https://openalex.org/W2019822560","https://openalex.org/W2023403785","https://openalex.org/W2025925482","https://openalex.org/W2029741892","https://openalex.org/W2034575708","https://openalex.org/W2038771887","https://openalex.org/W2042148434","https://openalex.org/W2042808371","https://openalex.org/W2045715263","https://openalex.org/W2054425455","https://openalex.org/W2056402897","https://openalex.org/W2065771840","https://openalex.org/W2075172606","https://openalex.org/W2075427744","https://openalex.org/W2077041282","https://openalex.org/W2084249136","https://openalex.org/W2086232140","https://openalex.org/W2087260579","https://openalex.org/W2095499213","https://openalex.org/W2114149589","https://openalex.org/W2120210240","https://openalex.org/W2122452293","https://openalex.org/W2124902862","https://openalex.org/W2133010896","https://openalex.org/W2136784153","https://openalex.org/W2137798097","https://openalex.org/W2138825607","https://openalex.org/W2152363723","https://openalex.org/W2163404860","https://openalex.org/W2186130713","https://openalex.org/W2306612938","https://openalex.org/W4211027273"],"related_works":["https://openalex.org/W2152363723","https://openalex.org/W2034575708","https://openalex.org/W1982222581","https://openalex.org/W7100686511","https://openalex.org/W2133010896","https://openalex.org/W2096654508","https://openalex.org/W1122237190","https://openalex.org/W2091591620","https://openalex.org/W7100312949","https://openalex.org/W2126127142"],"abstract_inverted_index":{"BACKGROUND:":[0],"Upregulation":[1],"of":[2,33,69,80,102,151],"nuclear":[3,100,175],"factor":[4],"kappa":[5],"B":[6],"(NF\u03baB)":[7],"activity":[8,93,135],"and":[9,42,49,56,91,120,139,143,167,201],"neuroendocrine":[10],"differentiation":[11],"are":[12],"two":[13],"mechanisms":[14],"known":[15],"to":[16,24],"be":[17],"involved":[18],"in":[19,53,60,104,108,124,210],"prostate":[20],"cancer":[21,215],"(PC)":[22],"progression":[23],"castration":[25],"resistance.":[26],"We":[27,63],"have":[28,64],"observed":[29],"that":[30],"major":[31],"components":[32],"these":[34,75],"pathways,":[35,204],"including":[36],"NF\u03baB,":[37,163],"proteasome,":[38],"neutral":[39],"endopeptidase":[40],"(NEP)":[41],"endothelin":[43],"1":[44],"(ET-1),":[45],"exhibit":[46],"an":[47],"inverse":[48],"mirror":[50],"image":[51],"pattern":[52],"androgen-dependent":[54],"(AD)":[55],"-independent":[57],"(AI)":[58],"states":[59],"vitro.":[61],"METHODS:":[62],"now":[65],"investigated":[66],"for":[67,193],"evidence":[68,192],"a":[70,105,194,206],"direct":[71,195],"mechanistic":[72,196],"connection":[73,197],"between":[74,198],"pathways":[76],"with":[77,180,205],"the":[78,199,211],"use":[79],"immunocytochemistry":[81],"(ICC),":[82],"western":[83],"blot":[84],"analysis,":[85],"electrophoretic":[86],"mobility":[87],"shift":[88],"assay":[89],"(EMSA)":[90],"proteasome":[92,134,168],"assessment.":[94],"RESULTS:":[95],"Neuropeptide":[96],"(NP)":[97],"stimulation":[98],"induced":[99,154],"translocation":[101,176],"NF\u03baB":[103],"dose-dependent":[106],"manner":[107],"AI":[109,214],"cells,":[110],"also":[111],"evident":[112],"as":[113,160,162],"reduced":[114],"total":[115],"inhibitor":[116],"\u03baB":[117],"(I\u03baB)":[118],"levels":[119],"increased":[121,131],"DNA":[122,183],"binding":[123,184],"EMSA.":[125,187],"These":[126],"effects":[127],"were":[128,144],"preceded":[129],"by":[130,155],"20":[132],"S":[133],"at":[136,140,145],"lower":[137],"doses":[138],"earlier":[141],"times":[142],"least":[146],"partially":[147],"reversed":[148],"under":[149],"conditions":[150],"NP":[152,157,178],"deprivation":[153],"specific":[156],"receptor":[158],"inhibitors,":[159],"well":[161],"I\u03baB":[164],"kinase":[165],"(IKK)":[166],"inhibitors.":[169],"AD":[170],"cells":[171],"showed":[172],"no":[173],"appreciable":[174],"upon":[177],"stimulation,":[179],"less":[181],"intense":[182],"signal":[185],"on":[186],"CONCLUSIONS:":[188],"Our":[189],"results":[190],"support":[191],"NPs":[200],"NF\u03baB/proteasome":[202],"signaling":[203],"distinct":[207],"NP-induced":[208],"profile":[209],"more":[212],"aggressive":[213],"state.":[216]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}
