{"id":"https://openalex.org/W2129017850","doi":"https://doi.org/10.1099/mic.0.000049","title":"The pleiotropic transcriptional response of Mycobacterium tuberculosis to vitamin C is robust and overlaps with the bacterial response to multiple intracellular stresses","display_name":"The pleiotropic transcriptional response of Mycobacterium tuberculosis to vitamin C is robust and overlaps with the bacterial response to multiple intracellular stresses","publication_year":2015,"publication_date":"2015-02-03","ids":{"openalex":"https://openalex.org/W2129017850","doi":"https://doi.org/10.1099/mic.0.000049","mag":"2129017850","pmid":"https://pubmed.ncbi.nlm.nih.gov/25645949"},"language":"en","primary_location":{"id":"doi:10.1099/mic.0.000049","doi":"https://doi.org/10.1099/mic.0.000049","is_oa":false,"landing_page_url":"https://doi.org/10.1099/mic.0.000049","pdf_url":null,"source":{"id":"https://openalex.org/S196799759","display_name":"Microbiology","issn_l":"1350-0872","issn":["1350-0872","1465-2080"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320497","host_organization_name":"Microbiology Society","host_organization_lineage":["https://openalex.org/P4310320497"],"host_organization_lineage_names":["Microbiology Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062615549","display_name":"Kriti Sikri","orcid":"https://orcid.org/0000-0003-0814-9486","observed_orcids":["https://orcid.org/0000-0003-0814-9486"]},"institutions":[{"id":"https://openalex.org/I63739035","display_name":"All India Institute of Medical Sciences","ror":"https://ror.org/02dwcqs71","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210148677","https://openalex.org/I63739035"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Kriti Sikri","raw_affiliation_strings":["Department of Biotechnology, All India Institute of Medical Sciences, New Delhi, India-110029","1Department of Biotechnology, All India Institute of Medical Sciences, New Delhi, India-110029"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, All India Institute of Medical Sciences, New Delhi, India-110029","institution_ids":["https://openalex.org/I63739035"]},{"raw_affiliation_string":"1Department of Biotechnology, All India Institute of Medical Sciences, New Delhi, India-110029","institution_ids":["https://openalex.org/I63739035"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055051141","display_name":"Priyanka Kumari","orcid":"https://orcid.org/0000-0002-7210-172X","observed_orcids":["https://orcid.org/0000-0002-7210-172X"]},"institutions":[{"id":"https://openalex.org/I63739035","display_name":"All India Institute of Medical Sciences","ror":"https://ror.org/02dwcqs71","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210148677","https://openalex.org/I63739035"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Priyanka Kumari","raw_affiliation_strings":["Department of Biotechnology, All India Institute of Medical Sciences, New Delhi, India-110029","1Department of Biotechnology, All India Institute of Medical Sciences, New Delhi, India-110029"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, All India Institute of Medical Sciences, New Delhi, India-110029","institution_ids":["https://openalex.org/I63739035"]},{"raw_affiliation_string":"1Department of Biotechnology, All India Institute of Medical Sciences, New Delhi, India-110029","institution_ids":["https://openalex.org/I63739035"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059245133","display_name":"Jaya Sivaswami Tyagi","orcid":"https://orcid.org/0000-0002-6052-1137","observed_orcids":["https://orcid.org/0000-0002-6052-1137"]},"institutions":[{"id":"https://openalex.org/I2801880299","display_name":"Translational Health Science and Technology Institute","ror":"https://ror.org/01qjqvr92","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I2801880299","https://openalex.org/I4210134808"]},{"id":"https://openalex.org/I63739035","display_name":"All India Institute of Medical Sciences","ror":"https://ror.org/02dwcqs71","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210148677","https://openalex.org/I63739035"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Jaya Sivaswami Tyagi","raw_affiliation_strings":["Department of Biotechnology, All India Institute of Medical Sciences, New Delhi, India-110029 Centre for Biodesign and Diagnostics, Translational Health Science and Technology Institute, Gurgaon-122016, Haryana, India jstyagi@aiims.ac.in jstyagi@gmail.com","1Department of Biotechnology, All India Institute of Medical Sciences, New Delhi, India-110029","2Centre for Biodesign and Diagnostics, Translational Health Science and Technology Institute, Gurgaon-122016, Haryana, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, All India Institute of Medical Sciences, New Delhi, India-110029 Centre for Biodesign and Diagnostics, Translational Health Science and Technology Institute, Gurgaon-122016, Haryana, India jstyagi@aiims.ac.in jstyagi@gmail.com","institution_ids":["https://openalex.org/I2801880299","https://openalex.org/I63739035"]},{"raw_affiliation_string":"1Department of Biotechnology, All India Institute of Medical Sciences, New Delhi, India-110029","institution_ids":["https://openalex.org/I63739035"]},{"raw_affiliation_string":"2Centre for Biodesign and Diagnostics, Translational Health Science and Technology Institute, Gurgaon-122016, Haryana, India","institution_ids":["https://openalex.org/I2801880299"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012546554","display_name":"Malobi Nandi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63739035","display_name":"All India Institute of Medical Sciences","ror":"https://ror.org/02dwcqs71","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210148677","https://openalex.org/I63739035"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Malobi Nandi","raw_affiliation_strings":["Department of Biotechnology, All India Institute of Medical Sciences, New Delhi, India-110029","1Department of Biotechnology, All India Institute of Medical Sciences, New Delhi, India-110029"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, All India Institute of Medical Sciences, New Delhi, India-110029","institution_ids":["https://openalex.org/I63739035"]},{"raw_affiliation_string":"1Department of Biotechnology, All India Institute of Medical Sciences, New Delhi, India-110029","institution_ids":["https://openalex.org/I63739035"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074478504","display_name":"Neetu Kumra Taneja","orcid":"https://orcid.org/0000-0002-2390-7647","observed_orcids":["https://orcid.org/0000-0002-2390-7647"]},"institutions":[{"id":"https://openalex.org/I63739035","display_name":"All India Institute of Medical Sciences","ror":"https://ror.org/02dwcqs71","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210148677","https://openalex.org/I63739035"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Neetu Kumra Taneja","raw_affiliation_strings":["Department of Biotechnology, All India Institute of Medical Sciences, New Delhi, India-110029","1Department of Biotechnology, All India Institute of Medical Sciences, New Delhi, India-110029"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, All India Institute of Medical Sciences, New Delhi, India-110029","institution_ids":["https://openalex.org/I63739035"]},{"raw_affiliation_string":"1Department of Biotechnology, All India Institute of Medical Sciences, New Delhi, India-110029","institution_ids":["https://openalex.org/I63739035"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032459287","display_name":"Sakshi Dhingra Batra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63739035","display_name":"All India Institute of Medical Sciences","ror":"https://ror.org/02dwcqs71","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210148677","https://openalex.org/I63739035"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sakshi Dhingra Batra","raw_affiliation_strings":["Department of Biotechnology, All India Institute of Medical Sciences, New Delhi, India-110029","1Department of Biotechnology, All India Institute of Medical Sciences, New Delhi, India-110029"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, All India Institute of Medical Sciences, New Delhi, India-110029","institution_ids":["https://openalex.org/I63739035"]},{"raw_affiliation_string":"1Department of Biotechnology, All India Institute of Medical Sciences, New Delhi, India-110029","institution_ids":["https://openalex.org/I63739035"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.7138,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.89907693,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"161","issue":"4","first_page":"739","last_page":"753"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11316","display_name":"Mycobacterium research and diagnosis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":1.0},{"id":"https://openalex.org/keywords/vitamin-c","display_name":"vitamin C","score":0.8700000047683716},{"id":"https://openalex.org/keywords/bacterial-dormancy","display_name":"bacterial dormancy","score":0.8740000128746033},{"id":"https://openalex.org/keywords/latent-tuberculosis-infection","display_name":"latent tuberculosis infection","score":0.8569999933242798},{"id":"https://openalex.org/keywords/transcriptional-response","display_name":"transcriptional response","score":0.8659999966621399},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.7170000076293945},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.8849999904632568},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.9779999852180481},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9649999737739563},{"id":"https://openalex.org/keywords/nitrosative-stress","display_name":"nitrosative stress","score":0.9139999747276306},{"id":"https://openalex.org/keywords/nutrient-starvation","display_name":"nutrient deprivation","score":0.9610000252723694},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.7139999866485596},{"id":"https://openalex.org/keywords/virulence-genes","display_name":"virulence genes","score":0.6520000100135803},{"id":"https://openalex.org/keywords/detoxification-genes","display_name":"detoxification genes","score":0.7749999761581421}],"concepts":[{"id":"https://openalex.org/C62361671","wikidata":"https://www.wikidata.org/wiki/Q1754612","display_name":"Regulon","level":4,"score":0.7551763653755188},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7307988405227661},{"id":"https://openalex.org/C3527866","wikidata":"https://www.wikidata.org/wiki/Q162267","display_name":"Dormancy","level":3,"score":0.7042244672775269},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.6329176425933838},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.5669408440589905},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5151513814926147},{"id":"https://openalex.org/C26628138","wikidata":"https://www.wikidata.org/wiki/Q22272147","display_name":"Stringent response","level":4,"score":0.5126275420188904},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3961222469806671},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3849290907382965},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.34636878967285156},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3194478750228882},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.2680625915527344},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C100701293","wikidata":"https://www.wikidata.org/wiki/Q193838","display_name":"Germination","level":2,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D001205","descriptor_name":"Ascorbic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006360","descriptor_name":"Heat-Shock Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008658","descriptor_name":"Inactivation, Metabolic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009171","descriptor_name":"Mycolic Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013312","descriptor_name":"Stress, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018832","descriptor_name":"Molecular Chaperones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1099/mic.0.000049","doi":"https://doi.org/10.1099/mic.0.000049","is_oa":false,"landing_page_url":"https://doi.org/10.1099/mic.0.000049","pdf_url":null,"source":{"id":"https://openalex.org/S196799759","display_name":"Microbiology","issn_l":"1350-0872","issn":["1350-0872","1465-2080"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320497","host_organization_name":"Microbiology Society","host_organization_lineage":["https://openalex.org/P4310320497"],"host_organization_lineage_names":["Microbiology Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbiology","raw_type":"journal-article"},{"id":"pmid:25645949","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25645949","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbiology (Reading, England)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":81,"referenced_works":["https://openalex.org/W24796312","https://openalex.org/W1547585735","https://openalex.org/W1548443534","https://openalex.org/W1549522998","https://openalex.org/W1583403909","https://openalex.org/W1748790621","https://openalex.org/W1864461701","https://openalex.org/W1910931001","https://openalex.org/W1967212902","https://openalex.org/W1969919262","https://openalex.org/W1971208758","https://openalex.org/W1974234256","https://openalex.org/W1976278094","https://openalex.org/W1976768342","https://openalex.org/W1979955102","https://openalex.org/W1984523365","https://openalex.org/W1984579412","https://openalex.org/W2001336978","https://openalex.org/W2004361822","https://openalex.org/W2006309936","https://openalex.org/W2007097682","https://openalex.org/W2008994306","https://openalex.org/W2009263783","https://openalex.org/W2014451521","https://openalex.org/W2014578355","https://openalex.org/W2020201637","https://openalex.org/W2035293624","https://openalex.org/W2036032145","https://openalex.org/W2042971327","https://openalex.org/W2045074814","https://openalex.org/W2048556830","https://openalex.org/W2050091105","https://openalex.org/W2053700342","https://openalex.org/W2058299829","https://openalex.org/W2059857557","https://openalex.org/W2060509240","https://openalex.org/W2061418578","https://openalex.org/W2067828311","https://openalex.org/W2069179741","https://openalex.org/W2076420407","https://openalex.org/W2076535674","https://openalex.org/W2077088025","https://openalex.org/W2078663039","https://openalex.org/W2080354196","https://openalex.org/W2087375033","https://openalex.org/W2090197974","https://openalex.org/W2092230382","https://openalex.org/W2094222845","https://openalex.org/W2099183065","https://openalex.org/W2100103275","https://openalex.org/W2101830136","https://openalex.org/W2104624709","https://openalex.org/W2107443178","https://openalex.org/W2114513616","https://openalex.org/W2118636097","https://openalex.org/W2119069290","https://openalex.org/W2120696671","https://openalex.org/W2120842435","https://openalex.org/W2123084649","https://openalex.org/W2123624778","https://openalex.org/W2124258222","https://openalex.org/W2125094371","https://openalex.org/W2125112523","https://openalex.org/W2127609477","https://openalex.org/W2132216270","https://openalex.org/W2132473872","https://openalex.org/W2133942178","https://openalex.org/W2140867711","https://openalex.org/W2142605259","https://openalex.org/W2145072890","https://openalex.org/W2146918483","https://openalex.org/W2148519348","https://openalex.org/W2149448078","https://openalex.org/W2156224052","https://openalex.org/W2159050264","https://openalex.org/W2159465637","https://openalex.org/W2163931695","https://openalex.org/W2165005042","https://openalex.org/W2170405498","https://openalex.org/W2272837046","https://openalex.org/W2398205323"],"related_works":["https://openalex.org/W2100103275","https://openalex.org/W7100801256","https://openalex.org/W2782470314","https://openalex.org/W2990998266","https://openalex.org/W7126194093","https://openalex.org/W6939676747","https://openalex.org/W2078663039","https://openalex.org/W2035149220","https://openalex.org/W1984523365","https://openalex.org/W2498799823"],"abstract_inverted_index":{"Mycobacterium":[0],"tuberculosis":[1,28],"(Mtb)":[2],"owes":[3],"its":[4,13],"success":[5],"as":[6,187],"a":[7,18,25,106,163,172],"pathogen":[8],"in":[9,17,24,40,90,100,117,126,155],"large":[10],"measure":[11],"to":[12,15,43,70,80,139,153,178,183,231,236,240,246],"ability":[14],"exist":[16],"persistent":[19],"state":[20],"of":[21,33,88,97,109,114,150,211,228],"'dormancy'":[22],"resulting":[23],"lifelong":[26],"latent":[27,45],"(TB)":[29],"infection.":[30,47],"An":[31],"understanding":[32],"bacterial":[34,56,68,176],"adaptation":[35],"during":[36],"dormancy":[37,98,223],"will":[38],"help":[39],"devising":[41],"approaches":[42],"counter":[44,241],"TB":[46],"In":[48],"vitro":[49],"models":[50,157],"have":[51,60],"provided":[52],"valuable":[53],"insights":[54],"into":[55],"adaptation;":[57],"however,":[58],"they":[59,63],"limitations":[61],"because":[62],"do":[64],"not":[65],"disclose":[66,237],"the":[67,71,75,85,91,115,200,209,221,229,242],"response":[69,87,152,177,230],"intracellular":[72],"environment":[73,165,203],"wherein":[74],"bacteria":[76],"are":[77],"simultaneously":[78],"exposed":[79],"multiple":[81],"stresses.":[82],"We":[83],"describe":[84],"pleiotropic":[86],"Mtb":[89,118,168,215,247],"vitamin":[92],"C":[93,104,161,180,213,233],"(vit":[94],"C)":[95],"model":[96],"developed":[99],"our":[101],"laboratory.":[102],"Vit":[103],"mediates":[105],"rapid":[107],"regulation":[108],"genes":[110,122,136],"representing":[111],"~14":[112],"%":[113],"genome":[116],"cultures.":[119],"The":[120,134,175],"upregulated":[121],"were":[123],"better":[124],"represented":[125],"lipid,":[127],"intermediary":[128],"metabolism":[129],"and":[130,144,189,193],"regulatory":[131],"protein":[132],"categories.":[133],"downregulated":[135],"mainly":[137],"related":[138],"virulence,":[140],"detoxification,":[141],"information":[142],"pathways":[143],"cell":[145],"wall":[146],"processes.":[147],"A":[148,225],"comparison":[149],"this":[151],"that":[154,159,170,208],"other":[156],"indicates":[158],"vit":[160,179,212,232],"generates":[162],"multiple-stress":[164],"for":[166],"axenic":[167],"cultures":[169],"resembles":[171,181],"macrophage-like":[173],"environment.":[174],"responses":[182,206],"gaseous":[184],"stresses":[185],"such":[186],"hypoxia":[188],"nitric":[190],"oxide,":[191],"oxidative":[192],"nitrosative":[194],"stresses,":[195],"nutrient":[196],"starvation":[197],"and,":[198],"notably,":[199],"activated":[201],"macrophage":[202],"itself.":[204],"These":[205],"demonstrate":[207],"influence":[210],"on":[214],"gene":[216],"expression":[217],"extends":[218],"well":[219],"beyond":[220],"DevR":[222],"regulon.":[224],"detailed":[226],"characterization":[227],"is":[234],"expected":[235],"useful":[238],"strategies":[239],"adaptive":[243],"mechanisms":[244],"essential":[245],"dormancy.":[248]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
