{"id":"https://openalex.org/W2129011201","doi":"https://doi.org/10.1186/1741-7015-12-110","title":"Urinary metabolic profiles in early pregnancy are associated with preterm birth and fetal growth restriction in the Rhea mother\u2013child cohort study","display_name":"Urinary metabolic profiles in early pregnancy are associated with preterm birth and fetal growth restriction in the Rhea mother\u2013child cohort study","publication_year":2014,"publication_date":"2014-07-11","ids":{"openalex":"https://openalex.org/W2129011201","doi":"https://doi.org/10.1186/1741-7015-12-110","mag":"2129011201","pmid":"https://pubmed.ncbi.nlm.nih.gov/25012562","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4094172"},"language":"en","primary_location":{"id":"doi:10.1186/1741-7015-12-110","doi":"https://doi.org/10.1186/1741-7015-12-110","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1741-7015-12-110","pdf_url":"https://bmcmedicine.biomedcentral.com/counter/pdf/10.1186/1741-7015-12-110","source":{"id":"https://openalex.org/S135560524","display_name":"BMC Medicine","issn_l":"1741-7015","issn":["1741-7015"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcmedicine.biomedcentral.com/counter/pdf/10.1186/1741-7015-12-110","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086312272","display_name":"L\u00e9a Ma\u00eetre","orcid":"https://orcid.org/0000-0003-3682-7117","observed_orcids":["https://orcid.org/0000-0003-3682-7117"]},"institutions":[{"id":"https://openalex.org/I4392738229","display_name":"MRC Centre for Environment and Health","ror":"https://ror.org/01vw4c203","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210087105","https://openalex.org/I4392738229","https://openalex.org/I47508984","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"L\u00e9a Maitre","raw_affiliation_strings":["Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, SW7 2AZ, UK","Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, London, W2 1PG, UK","MRC-PHE Centre for Environment and Health, Imperial College London, London, W2 1PG, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, SW7 2AZ, UK","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, London, W2 1PG, UK","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"MRC-PHE Centre for Environment and Health, Imperial College London, London, W2 1PG, UK","institution_ids":["https://openalex.org/I4392738229","https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035228282","display_name":"Eleni Fthenou","orcid":"https://orcid.org/0000-0002-1178-6841","observed_orcids":["https://orcid.org/0000-0002-1178-6841"]},"institutions":[{"id":"https://openalex.org/I142617266","display_name":"University of Crete","ror":"https://ror.org/00dr28g20","country_code":"GR","type":"education","lineage":["https://openalex.org/I142617266"]},{"id":"https://openalex.org/I4210092159","display_name":"Center for Research in Environmental Epidemiology","ror":"https://ror.org/00ftv8552","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210092159"]}],"countries":["ES","GR"],"is_corresponding":false,"raw_author_name":"Eleni Fthenou","raw_affiliation_strings":["Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain","Department of Social Medicine, Faculty of Medicine, University of Crete, PO Box 2208, 71003, Heraklion, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain","institution_ids":["https://openalex.org/I4210092159"]},{"raw_affiliation_string":"Department of Social Medicine, Faculty of Medicine, University of Crete, PO Box 2208, 71003, Heraklion, Greece","institution_ids":["https://openalex.org/I142617266"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047831421","display_name":"Toby James Athersuch","orcid":"https://orcid.org/0000-0002-5732-9574","observed_orcids":["https://orcid.org/0000-0002-5732-9574"]},"institutions":[{"id":"https://openalex.org/I4392738229","display_name":"MRC Centre for Environment and Health","ror":"https://ror.org/01vw4c203","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210087105","https://openalex.org/I4392738229","https://openalex.org/I47508984","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Toby Athersuch","raw_affiliation_strings":["Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, SW7 2AZ, UK","MRC-PHE Centre for Environment and Health, Imperial College London, London, W2 1PG, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, SW7 2AZ, UK","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"MRC-PHE Centre for Environment and Health, Imperial College London, London, W2 1PG, UK","institution_ids":["https://openalex.org/I4392738229","https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069972235","display_name":"Muireann Coen","orcid":"https://orcid.org/0000-0003-3542-8325","observed_orcids":["https://orcid.org/0000-0003-3542-8325"]},"institutions":[{"id":"https://openalex.org/I4392738229","display_name":"MRC Centre for Environment and Health","ror":"https://ror.org/01vw4c203","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210087105","https://openalex.org/I4392738229","https://openalex.org/I47508984","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Muireann Coen","raw_affiliation_strings":["Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, SW7 2AZ, UK","MRC-PHE Centre for Environment and Health, Imperial College London, London, W2 1PG, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, SW7 2AZ, UK","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"MRC-PHE Centre for Environment and Health, Imperial College London, London, W2 1PG, UK","institution_ids":["https://openalex.org/I4392738229","https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064320185","display_name":"Mireille B. Toledano","orcid":"https://orcid.org/0000-0001-5695-6210","observed_orcids":["https://orcid.org/0000-0001-5695-6210"]},"institutions":[{"id":"https://openalex.org/I4392738229","display_name":"MRC Centre for Environment and Health","ror":"https://ror.org/01vw4c203","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210087105","https://openalex.org/I4392738229","https://openalex.org/I47508984","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mireille B Toledano","raw_affiliation_strings":["Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, London, W2 1PG, UK","MRC-PHE Centre for Environment and Health, Imperial College London, London, W2 1PG, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, London, W2 1PG, UK","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"MRC-PHE Centre for Environment and Health, Imperial College London, London, W2 1PG, UK","institution_ids":["https://openalex.org/I4392738229","https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037616278","display_name":"Elaine C. Holmes","orcid":"https://orcid.org/0000-0002-0556-8389","observed_orcids":["https://orcid.org/0000-0002-0556-8389"]},"institutions":[{"id":"https://openalex.org/I4392738229","display_name":"MRC Centre for Environment and Health","ror":"https://ror.org/01vw4c203","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210087105","https://openalex.org/I4392738229","https://openalex.org/I47508984","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Elaine Holmes","raw_affiliation_strings":["Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, SW7 2AZ, UK","MRC-PHE Centre for Environment and Health, Imperial College London, London, W2 1PG, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, SW7 2AZ, UK","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"MRC-PHE Centre for Environment and Health, Imperial College London, London, W2 1PG, UK","institution_ids":["https://openalex.org/I4392738229","https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025023257","display_name":"Manolis Kogevinas","orcid":"https://orcid.org/0000-0002-9605-0461","observed_orcids":["https://orcid.org/0000-0002-9605-0461"]},"institutions":[{"id":"https://openalex.org/I4210092159","display_name":"Center for Research in Environmental Epidemiology","ror":"https://ror.org/00ftv8552","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210092159"]},{"id":"https://openalex.org/I4210094245","display_name":"National School of Public Health","ror":"https://ror.org/00mjaaf25","country_code":"GR","type":"education","lineage":["https://openalex.org/I4210094245"]},{"id":"https://openalex.org/I4210136145","display_name":"Municipal Institute for Medical Research","ror":"https://ror.org/039evc422","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210136145"]},{"id":"https://openalex.org/I4210154894","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Epidemiolog\u00eda y Salud P\u00fablica","ror":"https://ror.org/050q0kv47","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210115082","https://openalex.org/I4210154894","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210156109","display_name":"Hospital del Mar Research Institute","ror":"https://ror.org/042nkmz09","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210156109","https://openalex.org/I4387153040"]}],"countries":["ES","GR"],"is_corresponding":false,"raw_author_name":"Manolis Kogevinas","raw_affiliation_strings":["CIBER Epidemiologia y Salud P\u00fablica (CIBERESP), Barcelona, Spain","Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain","IMIM, Hospital del Mar Research Institute, Barcelona, Spain","National School of Public Health, Alexandras Avenue 196, 115 21, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CIBER Epidemiologia y Salud P\u00fablica (CIBERESP), Barcelona, Spain","institution_ids":["https://openalex.org/I4210154894"]},{"raw_affiliation_string":"Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain","institution_ids":["https://openalex.org/I4210092159"]},{"raw_affiliation_string":"IMIM, Hospital del Mar Research Institute, Barcelona, Spain","institution_ids":["https://openalex.org/I4210136145","https://openalex.org/I4210156109"]},{"raw_affiliation_string":"National School of Public Health, Alexandras Avenue 196, 115 21, Athens, Greece","institution_ids":["https://openalex.org/I4210094245"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112486340","display_name":"Leda Chatzi","orcid":"https://orcid.org/0000-0002-3319-2438","observed_orcids":["https://orcid.org/0000-0002-3319-2438"]},"institutions":[{"id":"https://openalex.org/I142617266","display_name":"University of Crete","ror":"https://ror.org/00dr28g20","country_code":"GR","type":"education","lineage":["https://openalex.org/I142617266"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB","GR"],"is_corresponding":true,"raw_author_name":"Leda Chatzi","raw_affiliation_strings":["Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London SW7 2AZ, UK. lchatzi@med.uoc.gr","Department of Social Medicine, Faculty of Medicine, University of Crete, PO Box 2208, 71003, Heraklion, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London SW7 2AZ, UK. lchatzi@med.uoc.gr","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Department of Social Medicine, Faculty of Medicine, University of Crete, PO Box 2208, 71003, Heraklion, Greece","institution_ids":["https://openalex.org/I142617266"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042788986","display_name":"Hector C. Keun","orcid":"https://orcid.org/0000-0001-7358-8851","observed_orcids":["https://orcid.org/0000-0001-7358-8851"]},"institutions":[{"id":"https://openalex.org/I4392738229","display_name":"MRC Centre for Environment and Health","ror":"https://ror.org/01vw4c203","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210087105","https://openalex.org/I4392738229","https://openalex.org/I47508984","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Hector C Keun","raw_affiliation_strings":["Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, SW7 2AZ, UK","MRC-PHE Centre for Environment and Health, Imperial College London, London, W2 1PG, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, SW7 2AZ, UK","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"MRC-PHE Centre for Environment and Health, Imperial College London, London, W2 1PG, UK","institution_ids":["https://openalex.org/I4392738229","https://openalex.org/I47508984"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5042788986","https://openalex.org/A5112486340"],"corresponding_institution_ids":["https://openalex.org/I142617266","https://openalex.org/I4392738229","https://openalex.org/I47508984"],"apc_list":{"value":4190,"currency":"USD","value_usd":4190},"apc_paid":{"value":4190,"currency":"USD","value_usd":4190},"fwci":2.864,"has_fulltext":true,"cited_by_count":94,"citation_normalized_percentile":{"value":0.92423605,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"12","issue":"1","first_page":"110","last_page":"110"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.6586999893188477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.6586999893188477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":0.17640000581741333,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11629","display_name":"Birth, Development, and Health","score":0.1500999927520752,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/urine-metabolomics","display_name":"urine metabolomics","score":0.8009999990463257},{"id":"https://openalex.org/keywords/preterm-birth","display_name":"preterm birth","score":0.9100000262260437},{"id":"https://openalex.org/keywords/intrauterine-growth-restriction","display_name":"fetal growth restriction","score":0.9940000176429749},{"id":"https://openalex.org/keywords/small-for-gestational-age","display_name":"small for gestational age","score":0.9139999747276306},{"id":"https://openalex.org/keywords/early-pregnancy","display_name":"early pregnancy","score":0.7300000190734863},{"id":"https://openalex.org/keywords/induced-preterm-birth","display_name":"induced preterm birth","score":0.7490000128746033},{"id":"https://openalex.org/keywords/maternal-obesity","display_name":"maternal obesity","score":0.6710000038146973},{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.3479999899864197},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.7300000190734863},{"id":"https://openalex.org/keywords/exposome","display_name":"exposome","score":0.597000002861023},{"id":"https://openalex.org/keywords/metabolic-syndrome","display_name":"metabolic syndrome","score":0.6309999823570251}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9552466869354248},{"id":"https://openalex.org/C2993726049","wikidata":"https://www.wikidata.org/wiki/Q2297155","display_name":"Fetal growth","level":4,"score":0.642708420753479},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.6260008811950684},{"id":"https://openalex.org/C2778780700","wikidata":"https://www.wikidata.org/wiki/Q1671598","display_name":"Intrauterine growth restriction","level":4,"score":0.6050378680229187},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.5836529731750488},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5701135396957397},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.5402593016624451},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.5219151973724365},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.5121981501579285},{"id":"https://openalex.org/C2992196862","wikidata":"https://www.wikidata.org/wiki/Q1671598","display_name":"Growth restriction","level":4,"score":0.4389033317565918},{"id":"https://openalex.org/C2776344615","wikidata":"https://www.wikidata.org/wiki/Q625506","display_name":"Premature birth","level":4,"score":0.4271255433559418},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.34056830406188965},{"id":"https://openalex.org/C2778376644","wikidata":"https://www.wikidata.org/wiki/Q2253111","display_name":"Gestational age","level":3,"score":0.2557629942893982},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.16768652200698853},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13269683718681335},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0705098807811737},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005317","descriptor_name":"Fetal Growth Retardation","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":true},{"descriptor_ui":"D006115","descriptor_name":"Greece","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011261","descriptor_name":"Pregnancy Trimester, First","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":true},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012306","descriptor_name":"Risk","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D015992","descriptor_name":"Body Mass Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016017","descriptor_name":"Odds Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024821","descriptor_name":"Metabolic Syndrome","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D047928","descriptor_name":"Premature Birth","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":true},{"descriptor_ui":"D050177","descriptor_name":"Overweight","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/1741-7015-12-110","doi":"https://doi.org/10.1186/1741-7015-12-110","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1741-7015-12-110","pdf_url":"https://bmcmedicine.biomedcentral.com/counter/pdf/10.1186/1741-7015-12-110","source":{"id":"https://openalex.org/S135560524","display_name":"BMC Medicine","issn_l":"1741-7015","issn":["1741-7015"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medicine","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3064804","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4094172","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:25012562","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25012562","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4094172","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4094172/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Med","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1741-7015-12-110","doi":"https://doi.org/10.1186/1741-7015-12-110","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1741-7015-12-110","pdf_url":"https://bmcmedicine.biomedcentral.com/counter/pdf/10.1186/1741-7015-12-110","source":{"id":"https://openalex.org/S135560524","display_name":"BMC Medicine","issn_l":"1741-7015","issn":["1741-7015"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1537515585","display_name":"Genomics biomarkers of environmental health","funder_award_id":"226756","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G6630942479","display_name":"The Human Early-Life Exposome \u2013 novel tools for integrating early-life environmental exposures and child health across Europe","funder_award_id":"308333","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320311246","display_name":"European Chemical Industry Council","ror":"https://ror.org/00j6a4d92"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320330037","display_name":"MRC-PHE Centre for Environment and Health","ror":"https://ror.org/01vw4c203"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2129011201.pdf","grobid_xml":"https://content.openalex.org/works/W2129011201.grobid-xml"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W118404054","https://openalex.org/W1580347875","https://openalex.org/W1638078919","https://openalex.org/W1922663624","https://openalex.org/W1949591994","https://openalex.org/W1965985248","https://openalex.org/W1975755498","https://openalex.org/W1986797986","https://openalex.org/W1988629244","https://openalex.org/W1993166271","https://openalex.org/W2006565594","https://openalex.org/W2006617902","https://openalex.org/W2013036395","https://openalex.org/W2013946566","https://openalex.org/W2014584719","https://openalex.org/W2014594852","https://openalex.org/W2017142654","https://openalex.org/W2017771330","https://openalex.org/W2018988206","https://openalex.org/W2027192605","https://openalex.org/W2031406605","https://openalex.org/W2036436696","https://openalex.org/W2047075436","https://openalex.org/W2051366884","https://openalex.org/W2053369230","https://openalex.org/W2053385401","https://openalex.org/W2056553293","https://openalex.org/W2060552707","https://openalex.org/W2061858646","https://openalex.org/W2062267845","https://openalex.org/W2068354067","https://openalex.org/W2078909413","https://openalex.org/W2083637865","https://openalex.org/W2090799239","https://openalex.org/W2093339513","https://openalex.org/W2096773810","https://openalex.org/W2099245420","https://openalex.org/W2101153618","https://openalex.org/W2103761010","https://openalex.org/W2108888044","https://openalex.org/W2110272025","https://openalex.org/W2112433162","https://openalex.org/W2112927272","https://openalex.org/W2114949397","https://openalex.org/W2115944543","https://openalex.org/W2117162017","https://openalex.org/W2121671360","https://openalex.org/W2125905177","https://openalex.org/W2127471221","https://openalex.org/W2131041948","https://openalex.org/W2138649409","https://openalex.org/W2148044501","https://openalex.org/W2154694631","https://openalex.org/W2161952535","https://openalex.org/W2169632325","https://openalex.org/W2324335241","https://openalex.org/W2334131709","https://openalex.org/W2339084277","https://openalex.org/W2582743722"],"related_works":["https://openalex.org/W2794911074","https://openalex.org/W4404674216","https://openalex.org/W2560905023","https://openalex.org/W2906673054","https://openalex.org/W3013476370","https://openalex.org/W2991612473","https://openalex.org/W2617785220","https://openalex.org/W2585817209","https://openalex.org/W2967942011","https://openalex.org/W2547317801"],"abstract_inverted_index":{"BACKGROUND:":[0],"Preterm":[1],"birth":[2,43,65,361],"(PB)":[3],"and":[4,16,49,67,93,139,194,209,239,255,298,305,312,332,363,399],"fetal":[5],"growth":[6],"restriction":[7],"(FGR)":[8],"convey":[9],"the":[10,22,35,62,79,97,154,168,171,348,351,368,376,382],"highest":[11],"risk":[12,358],"of":[13,24,78,170,350,359,384,387,397],"perinatal":[14],"mortality":[15],"morbidity,":[17],"as":[18,20,76,199,389],"well":[19],"increasing":[21],"chance":[23],"developing":[25],"chronic":[26],"disease":[27,111],"in":[28,33,69,74,126,162,192,277,310,375],"later":[29],"life.":[30],"Identifying":[31],"early":[32,73],"pregnancy":[34,75],"unfavourable":[36],"maternal":[37,70,163,250,252],"conditions":[38],"that":[39,302],"can":[40,87],"predict":[41],"poor":[42],"outcomes":[44,66],"could":[45],"help":[46],"their":[47,105],"prevention":[48],"management.":[50],"Here":[51],"we":[52,129,189],"used":[53,190],"an":[54,102],"exploratory":[55],"metabolic":[56,115,137,385],"profiling":[57,386],"approach":[58],"(metabolomics)":[59],"to":[60,121,131,140,187,221,229,237,246,287,330,341,372,392],"investigate":[61],"association":[63],"between":[64,207],"metabolites":[68,158,260,345],"urine":[71,164,388],"collected":[72,166],"part":[77],"prospective":[80],"mother-child":[81],"cohort":[82],"Rhea":[83,155,377],"study.":[84],"Metabolomic":[85],"techniques":[86],"simultaneously":[88],"capture":[89],"information":[90,366],"about":[91,367],"genotype":[92],"its":[94],"interaction":[95],"with":[96,124,264,268,294,321,356],"accumulated":[98],"exposures":[99],"experienced":[100],"by":[101],"individual":[103],"from":[104],"diet,":[106],"environment,":[107],"physical":[108],"activity":[109],"or":[110],"(the":[112],"exposome).":[113],"As":[114],"syndrome":[116],"has":[117],"previously":[118],"been":[119],"shown":[120],"be":[122],"associated":[123,309,320,355],"PB":[125,271,317,398],"this":[127],"cohort,":[128],"sought":[130],"gain":[132],"further":[133],"insight":[134],"into":[135],"PB-linked":[136],"phenotypes":[138],"define":[141],"new":[142],"predictive":[143],"biomarkers.":[144],"METHODS:":[145],"Our":[146],"study":[147,151,200,380],"was":[148,291],"a":[149,274,278,390],"case-control":[150],"nested":[152],"within":[153],"cohort.":[156,378],"Major":[157],"(n":[159,174],"=":[160,175,217,225,233,242,283,326,337],"34)":[161],"samples":[165],"at":[167,347],"end":[169,349],"first":[172,352],"trimester":[173,353],"438)":[176],"were":[177,261,307,319],"measured":[178,346],"using":[179],"proton":[180],"nuclear":[181],"magnetic":[182],"resonance":[183,281,290],"spectroscopy.":[184],"In":[185],"addition":[186],"PB,":[188],"FGR":[191,208,400],"weight":[193],"small":[195],"for":[196,249],"gestational":[197],"age":[198],"endpoints.":[201],"RESULTS:":[202],"We":[203],"observed":[204],"significant":[205,275],"associations":[206],"decreased":[210],"urinary":[211,323],"acetate":[212],"(interquartile":[213],"odds":[214],"ratio":[215],"(IOR)":[216],"0.18":[218],"CI":[219,227,235,244,285,328,339],"0.04":[220,245],"0.60),":[222],"formate":[223,334],"(IOR":[224,232,241,282,325,336],"0.24":[226],"0.07":[228],"0.71),":[230],"tyrosine":[231],"0.27":[234],"0.08":[236],"0.81)":[238],"trimethylamine":[240],"0.14":[243],"0.40)":[247],"adjusting":[248],"education,":[251],"age,":[253],"parity,":[254],"smoking":[256],"during":[257],"pregnancy.":[258],"These":[259],"inversely":[262],"correlated":[263,293],"blood":[265],"insulin.":[266],"Women":[267],"clinically":[269],"induced":[270],"(IPB)":[272],"had":[273],"increase":[276],"glycoprotein":[279,304],"N-acetyl":[280,303],"5.84":[284],"1.44":[286],"39.50).":[288],"This":[289,379],"positively":[292],"body":[295],"mass":[296],"index,":[297],"stratified":[299],"analysis":[300],"confirmed":[301],"IPB":[306],"significantly":[308],"overweight":[311],"obese":[313],"women":[314],"only.":[315],"Spontaneous":[316],"cases":[318],"elevated":[322],"lysine":[324],"2.79":[327],"1.20":[329],"6.98)":[331],"lower":[333],"levels":[335],"0.42":[338],"0.19":[340],"0.94).":[342],"CONCLUSIONS:":[343],"Urinary":[344],"are":[354],"increased":[357],"negative":[360],"outcomes,":[362],"provide":[364],"novel":[365,394],"possible":[369],"mechanisms":[370],"leading":[371],"adverse":[373],"pregnancies":[374],"emphasizes":[381],"potential":[383],"means":[391],"identify":[393],"non-invasive":[395],"biomarkers":[396],"risk.":[401]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":15},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":7}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}