{"id":"https://openalex.org/W2128792807","doi":"https://doi.org/10.1073/pnas.1108487108","title":"Human embryonic stem cell-derived neurons adopt and regulate the activity of an established neural network","display_name":"Human embryonic stem cell-derived neurons adopt and regulate the activity of an established neural network","publication_year":2011,"publication_date":"2011-11-21","ids":{"openalex":"https://openalex.org/W2128792807","doi":"https://doi.org/10.1073/pnas.1108487108","mag":"2128792807","pmid":"https://pubmed.ncbi.nlm.nih.gov/22106298","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3250161"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.1108487108","doi":"https://doi.org/10.1073/pnas.1108487108","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1108487108","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3250161","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046543647","display_name":"Jason Porter Weick","orcid":"https://orcid.org/0000-0003-3135-9860","observed_orcids":["https://orcid.org/0000-0003-3135-9860"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jason P. Weick","raw_affiliation_strings":["Waisman Center,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Waisman Center,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100350985","display_name":"Yan Liu","orcid":"https://orcid.org/0000-0001-5616-9428","observed_orcids":["https://orcid.org/0000-0001-5616-9428"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yan Liu","raw_affiliation_strings":["Waisman Center,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Waisman Center,","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030394012","display_name":"Su\u2010Chun Zhang","orcid":"https://orcid.org/0000-0003-0563-5147","observed_orcids":["https://orcid.org/0000-0003-0563-5147","https://orcid.org/0009-0008-4367-0270","https://orcid.org/0000-0003-2670-6426"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Su-Chun Zhang","raw_affiliation_strings":["Departments of cNeuroscience and","Neurology, and","Neuroscience Training Program,","School of Medicine and Public Health, University of Wisconsin\u2013Madison, 647 Waisman Center, Madison, WI 53705","Waisman Center,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of cNeuroscience and","institution_ids":[]},{"raw_affiliation_string":"Neurology, and","institution_ids":[]},{"raw_affiliation_string":"Neuroscience Training Program,","institution_ids":[]},{"raw_affiliation_string":"School of Medicine and Public Health, University of Wisconsin\u2013Madison, 647 Waisman Center, Madison, WI 53705","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Waisman Center,","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.3168,"has_fulltext":false,"cited_by_count":82,"citation_normalized_percentile":{"value":0.93882929,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"108","issue":"50","first_page":"20189","last_page":"20194"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.2639000117778778,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.2639000117778778,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.23350000381469727,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.20810000598430634,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-embryonic-stem-cell-derived-neurons","display_name":"human embryonic stem cell-derived neurons","score":0.9359999895095825},{"id":"https://openalex.org/keywords/neural-network-integration","display_name":"neural network integration","score":0.8989999890327454},{"id":"https://openalex.org/keywords/synaptic-integration","display_name":"synaptic integration","score":0.9750000238418579},{"id":"https://openalex.org/keywords/postsynaptic-currents","display_name":"postsynaptic currents","score":0.9589999914169312},{"id":"https://openalex.org/keywords/chr2","display_name":"channelrhodopsin-2","score":0.8799999952316284},{"id":"https://openalex.org/keywords/optical-stimulation","display_name":"optical stimulation","score":0.5899999737739563},{"id":"https://openalex.org/keywords/network-bursting","display_name":"network bursting","score":0.7170000076293945},{"id":"https://openalex.org/keywords/pyramidal-neurons","display_name":"pyramidal neurons","score":0.8489999771118164},{"id":"https://openalex.org/keywords/neural-network-modulation","display_name":"neural network modulation","score":0.48399999737739563}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7794902324676514},{"id":"https://openalex.org/C112592302","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Excitatory postsynaptic potential","level":3,"score":0.7735402584075928},{"id":"https://openalex.org/C197341189","wikidata":"https://www.wikidata.org/wiki/Q863533","display_name":"Postsynaptic potential","level":3,"score":0.7397526502609253},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.692502498626709},{"id":"https://openalex.org/C118403218","wikidata":"https://www.wikidata.org/wiki/Q43283","display_name":"Biological neural network","level":2,"score":0.5696471333503723},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5497631430625916},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.5394670963287354},{"id":"https://openalex.org/C195221683","wikidata":"https://www.wikidata.org/wiki/Q5000649","display_name":"Bursting","level":2,"score":0.5011701583862305},{"id":"https://openalex.org/C2910581834","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Postsynaptic Current","level":4,"score":0.44874781370162964},{"id":"https://openalex.org/C103072069","wikidata":"https://www.wikidata.org/wiki/Q5058372","display_name":"Cellular neuroscience","level":2,"score":0.4416504502296448},{"id":"https://openalex.org/C136834591","wikidata":"https://www.wikidata.org/wiki/Q2944097","display_name":"Neural stem cell","level":3,"score":0.41973087191581726},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3900526165962219},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.21390816569328308},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.10199591517448425},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009415","descriptor_name":"Nerve Net","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016513","descriptor_name":"Mice, SCID","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1073/pnas.1108487108","doi":"https://doi.org/10.1073/pnas.1108487108","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1108487108","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2378272","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3250161","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:22106298","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22106298","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3250161","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3250161/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"mag:2289094269","doi":null,"is_oa":false,"landing_page_url":"https://www.waisman.wisc.edu/~palumbo/ALSPublications/PNAS-2011%20Weick.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2378272","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3250161","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.4043000042438507,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3066666395","display_name":"Functional integration and plasticity of human ESC-derived neurons","funder_award_id":"R03NS074281","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G4194903476","display_name":"Stem Cell Therapy and Growth Factor Therapy for ALS","funder_award_id":"P01NS057778","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G5198294765","display_name":"Neural Specification of Embryonic Stem Cells","funder_award_id":"R01NS045926","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G6622198684","display_name":"Waisman Intellectual and Developmental Disabilities Research Center","funder_award_id":"P30HD003352","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G7781371239","display_name":null,"funder_award_id":"RNS074281A","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"}],"funders":[{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W596980360","https://openalex.org/W613555460","https://openalex.org/W1578187492","https://openalex.org/W1665323890","https://openalex.org/W1770278075","https://openalex.org/W1925492557","https://openalex.org/W1980505651","https://openalex.org/W2001344057","https://openalex.org/W2002112050","https://openalex.org/W2003357682","https://openalex.org/W2013393348","https://openalex.org/W2016961314","https://openalex.org/W2021823732","https://openalex.org/W2026734788","https://openalex.org/W2033625079","https://openalex.org/W2034064942","https://openalex.org/W2038755739","https://openalex.org/W2040479298","https://openalex.org/W2045899482","https://openalex.org/W2049717499","https://openalex.org/W2054521968","https://openalex.org/W2063466545","https://openalex.org/W2083939751","https://openalex.org/W2086943348","https://openalex.org/W2095025631","https://openalex.org/W2099548919","https://openalex.org/W2103612759","https://openalex.org/W2104793567","https://openalex.org/W2105302788","https://openalex.org/W2111004700","https://openalex.org/W2111191613","https://openalex.org/W2120811265","https://openalex.org/W2125095601","https://openalex.org/W2125908939","https://openalex.org/W2138977668","https://openalex.org/W2142046859","https://openalex.org/W2144284928","https://openalex.org/W2147015050","https://openalex.org/W2148633182","https://openalex.org/W2155734183","https://openalex.org/W2163438163","https://openalex.org/W2167095271","https://openalex.org/W2168025879","https://openalex.org/W4243162360"],"related_works":["https://openalex.org/W2289094269","https://openalex.org/W2050788543","https://openalex.org/W2081772480","https://openalex.org/W18519643","https://openalex.org/W2036412754","https://openalex.org/W2967243286","https://openalex.org/W3212479715","https://openalex.org/W4405488948","https://openalex.org/W2991628492","https://openalex.org/W2168025879"],"abstract_inverted_index":{"Whether":[0],"hESC-derived":[1,20,48,70,91],"neurons":[2,21,49,71,85,92],"can":[3,93],"fully":[4],"integrate":[5],"with":[6],"and":[7,29,32,55,59,96,119],"functionally":[8],"regulate":[9],"an":[10],"existing":[11],"neural":[12,98,112],"network":[13,61,99,113],"remains":[14],"unknown.":[15],"Here,":[16],"we":[17],"demonstrate":[18],"that":[19],"receive":[22],"unitary":[23],"postsynaptic":[24,57,80],"currents":[25,58,81],"both":[26,53,116],"in":[27,30,63,82,86,95,117,120],"vitro":[28,118],"vivo":[31],"adopt":[33],"the":[34,74],"rhythmic":[35],"firing":[36],"behavior":[37],"of":[38,47,69,76,109],"mouse":[39,64],"cortical":[40],"networks":[41],"via":[42],"synaptic":[43,103],"integration.":[44],"Optical":[45],"stimulation":[46,68],"expressing":[50],"Channelrhodopsin-2":[51],"elicited":[52],"inhibitory":[54],"excitatory":[56],"triggered":[60,79],"bursting":[62],"neurons.":[65],"Furthermore,":[66],"light":[67],"transplanted":[72],"to":[73,111],"hippocampus":[75],"adult":[77],"mice":[78],"host":[83],"pyramidal":[84],"acute":[87],"slice":[88],"preparations.":[89],"Thus,":[90],"participate":[94],"modulate":[97],"activity":[100],"through":[101],"functional":[102],"integration,":[104],"suggesting":[105],"they":[106],"are":[107],"capable":[108],"contributing":[110],"information":[114],"processing":[115],"vivo.":[121]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
