{"id":"https://openalex.org/W2128779884","doi":"https://doi.org/10.1007/978-1-4614-8357-1_6","title":"Alternative Future Therapies for Lysosomal Storage Diseases: Embryonic Stem Cell- and Induced Pluripotent Stem Cell Therapy","display_name":"Alternative Future Therapies for Lysosomal Storage Diseases: Embryonic Stem Cell- and Induced Pluripotent Stem Cell Therapy","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2128779884","doi":"https://doi.org/10.1007/978-1-4614-8357-1_6","mag":"2128779884"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-4614-8357-1_6","doi":"https://doi.org/10.1007/978-1-4614-8357-1_6","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4614-8357-1_6","pdf_url":null,"source":{"id":"https://openalex.org/S4210216322","display_name":"Stem cell biology and regenerative medicine","issn_l":"2196-8985","issn":["2196-8985","2196-8993"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cell Biology and Regenerative Medicine","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W2505138304","display_name":"Stem Cell Therapy in Lysosomal Storage Diseases"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002646117","display_name":"Arie Koen Braat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]},{"id":"https://openalex.org/I4210162850","display_name":"Wilhelmina Children's Hospital","ror":"https://ror.org/05fqypv61","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916","https://openalex.org/I4210162850"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Arie Koen Braat","raw_affiliation_strings":["Center for Molecular and Cellular Intervention, Wilhelmina Children\u2019s Hospital, Utrecht, The Netherlands","Department of Cell Biology, University Medical Center Utrecht, Utrecht, The Netherlands","Center for Molecular and Cellular Intervention, Wilhelmina Children\u2019s Hospital","University Medical Center Utrecht"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular and Cellular Intervention, Wilhelmina Children\u2019s Hospital, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I4210162850"]},{"raw_affiliation_string":"Department of Cell Biology, University Medical Center Utrecht, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I3018483916"]},{"raw_affiliation_string":"Center for Molecular and Cellular Intervention, Wilhelmina Children\u2019s Hospital","institution_ids":["https://openalex.org/I4210162850"]},{"raw_affiliation_string":"University Medical Center Utrecht","institution_ids":["https://openalex.org/I3018483916"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067990066","display_name":"Paul James Coffer","orcid":"https://orcid.org/0000-0001-8775-1939","observed_orcids":["https://orcid.org/0000-0001-8775-1939","https://orcid.org/0000-0002-8332-6828"]},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]},{"id":"https://openalex.org/I4210162850","display_name":"Wilhelmina Children's Hospital","ror":"https://ror.org/05fqypv61","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916","https://openalex.org/I4210162850"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Paul J. Coffer","raw_affiliation_strings":["Center for Molecular and Cellular Intervention, Wilhelmina Children\u2019s Hospital, Utrecht, The Netherlands","Department of Cell Biology, University Medical Center Utrecht, Utrecht, The Netherlands","Center for Molecular and Cellular Intervention, Wilhelmina Children\u2019s Hospital","University Medical Center Utrecht"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular and Cellular Intervention, Wilhelmina Children\u2019s Hospital, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I4210162850"]},{"raw_affiliation_string":"Department of Cell Biology, University Medical Center Utrecht, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I3018483916"]},{"raw_affiliation_string":"Center for Molecular and Cellular Intervention, Wilhelmina Children\u2019s Hospital","institution_ids":["https://openalex.org/I4210162850"]},{"raw_affiliation_string":"University Medical Center Utrecht","institution_ids":["https://openalex.org/I3018483916"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072347898","display_name":"Niels Geijsen","orcid":"https://orcid.org/0000-0003-3592-4353","observed_orcids":["https://orcid.org/0000-0003-3592-4353"]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]},{"id":"https://openalex.org/I4210115206","display_name":"Hubrecht Institute for Developmental Biology and Stem Cell Research","ror":"https://ror.org/023qc4a07","country_code":"NL","type":"facility","lineage":["https://openalex.org/I1322597698","https://openalex.org/I4210115206"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Niels Geijsen","raw_affiliation_strings":["Hubrecht Institute for Developmental Biology and Stem Cell Research, Utrecht, The Netherlands","Utrecht University Veterinary School, Utrecht, The Netherlands","Utrecht University Veterinary School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hubrecht Institute for Developmental Biology and Stem Cell Research, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I4210115206"]},{"raw_affiliation_string":"Utrecht University Veterinary School, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I193662353"]},{"raw_affiliation_string":"Utrecht University Veterinary School","institution_ids":["https://openalex.org/I193662353"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5002646117"],"corresponding_institution_ids":["https://openalex.org/I3018483916","https://openalex.org/I4210162850"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.16624719,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"139","last_page":"158"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10945","display_name":"Lysosomal Storage Disorders Research","score":0.01549999974668026,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lysosomal-storage-disorders","display_name":"lysosomal storage disease","score":1.0},{"id":"https://openalex.org/keywords/stem-cell-therapy","display_name":"stem cell therapy","score":0.6150000095367432},{"id":"https://openalex.org/keywords/regenerative-medicine","display_name":"regenerative medicine","score":0.7670000195503235},{"id":"https://openalex.org/keywords/pluripotency","display_name":"pluripotency","score":0.746999979019165},{"id":"https://openalex.org/keywords/cellular-reprogramming","display_name":"cellular reprogramming","score":0.781000018119812}],"concepts":[{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.9103678464889526},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.7727906703948975},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.7247239947319031},{"id":"https://openalex.org/C10854531","wikidata":"https://www.wikidata.org/wiki/Q1061415","display_name":"Regenerative medicine","level":3,"score":0.5927729606628418},{"id":"https://openalex.org/C2779389132","wikidata":"https://www.wikidata.org/wiki/Q1533033","display_name":"Stem-cell therapy","level":3,"score":0.5413321256637573},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5002481937408447},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49541962146759033},{"id":"https://openalex.org/C27390768","wikidata":"https://www.wikidata.org/wiki/Q862600","display_name":"Cell potency","level":5,"score":0.4665073752403259},{"id":"https://openalex.org/C10882517","wikidata":"https://www.wikidata.org/wiki/Q15268054","display_name":"Cell therapy","level":3,"score":0.43348583579063416},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.42770296335220337},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4230450391769409},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15016359090805054},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.078663170337677},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-1-4614-8357-1_6","doi":"https://doi.org/10.1007/978-1-4614-8357-1_6","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4614-8357-1_6","pdf_url":null,"source":{"id":"https://openalex.org/S4210216322","display_name":"Stem cell biology and regenerative medicine","issn_l":"2196-8985","issn":["2196-8985","2196-8993"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cell Biology and Regenerative Medicine","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8999999761581421}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":90,"referenced_works":["https://openalex.org/W36849100","https://openalex.org/W1487014009","https://openalex.org/W1532262643","https://openalex.org/W1603508604","https://openalex.org/W1733233436","https://openalex.org/W1819540738","https://openalex.org/W1963806491","https://openalex.org/W1966697925","https://openalex.org/W1970894097","https://openalex.org/W1971496676","https://openalex.org/W1973175103","https://openalex.org/W1976327288","https://openalex.org/W1977442228","https://openalex.org/W1978173381","https://openalex.org/W1978261848","https://openalex.org/W1979055428","https://openalex.org/W1981088384","https://openalex.org/W1981621010","https://openalex.org/W1981809048","https://openalex.org/W1991037959","https://openalex.org/W1992525863","https://openalex.org/W1992949513","https://openalex.org/W2006829233","https://openalex.org/W2009092429","https://openalex.org/W2010031978","https://openalex.org/W2013205740","https://openalex.org/W2014073178","https://openalex.org/W2014416902","https://openalex.org/W2016838090","https://openalex.org/W2023168515","https://openalex.org/W2023456870","https://openalex.org/W2025175358","https://openalex.org/W2029695904","https://openalex.org/W2029840709","https://openalex.org/W2037926353","https://openalex.org/W2045081995","https://openalex.org/W2045899482","https://openalex.org/W2049949169","https://openalex.org/W2050689355","https://openalex.org/W2052002403","https://openalex.org/W2052004719","https://openalex.org/W2053911973","https://openalex.org/W2054521968","https://openalex.org/W2058021805","https://openalex.org/W2058553784","https://openalex.org/W2059075043","https://openalex.org/W2061184843","https://openalex.org/W2064621113","https://openalex.org/W2066480270","https://openalex.org/W2067937496","https://openalex.org/W2072239613","https://openalex.org/W2073377349","https://openalex.org/W2075039427","https://openalex.org/W2080008193","https://openalex.org/W2086943348","https://openalex.org/W2087137170","https://openalex.org/W2087774011","https://openalex.org/W2088101102","https://openalex.org/W2094689158","https://openalex.org/W2095424411","https://openalex.org/W2098597036","https://openalex.org/W2100761325","https://openalex.org/W2102560467","https://openalex.org/W2103612759","https://openalex.org/W2104708641","https://openalex.org/W2104978512","https://openalex.org/W2106485710","https://openalex.org/W2107385641","https://openalex.org/W2108931314","https://openalex.org/W2109057676","https://openalex.org/W2110301828","https://openalex.org/W2115357728","https://openalex.org/W2122214027","https://openalex.org/W2125987139","https://openalex.org/W2126580353","https://openalex.org/W2126851387","https://openalex.org/W2136541538","https://openalex.org/W2142046859","https://openalex.org/W2145492799","https://openalex.org/W2145641219","https://openalex.org/W2150163104","https://openalex.org/W2151220680","https://openalex.org/W2151517892","https://openalex.org/W2152483372","https://openalex.org/W2153199196","https://openalex.org/W2153411657","https://openalex.org/W2157645703","https://openalex.org/W2158979552","https://openalex.org/W2167121336","https://openalex.org/W2167202160"],"related_works":["https://openalex.org/W3081118517","https://openalex.org/W2096641433","https://openalex.org/W4412198645","https://openalex.org/W3163316651","https://openalex.org/W2505138304","https://openalex.org/W4221080148","https://openalex.org/W2624407428","https://openalex.org/W3088773668","https://openalex.org/W2902789988","https://openalex.org/W144352173"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2016-06-24T00:00:00"}