{"id":"https://openalex.org/W2128770167","doi":"https://doi.org/10.1128/ec.5.4.712-722.2006","title":"Endoplasmic Reticulum-Associated Degradation Is Required for Cold Adaptation and Regulation of Sterol Biosynthesis in the Yeast Saccharomyces cerevisiae","display_name":"Endoplasmic Reticulum-Associated Degradation Is Required for Cold Adaptation and Regulation of Sterol Biosynthesis in the Yeast Saccharomyces cerevisiae","publication_year":2006,"publication_date":"2006-04-01","ids":{"openalex":"https://openalex.org/W2128770167","doi":"https://doi.org/10.1128/ec.5.4.712-722.2006","mag":"2128770167","pmid":"https://pubmed.ncbi.nlm.nih.gov/16607018","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1459677"},"language":"en","primary_location":{"id":"doi:10.1128/ec.5.4.712-722.2006","doi":"https://doi.org/10.1128/ec.5.4.712-722.2006","is_oa":true,"landing_page_url":"https://doi.org/10.1128/ec.5.4.712-722.2006","pdf_url":null,"source":{"id":"https://openalex.org/S177547185","display_name":"Eukaryotic Cell","issn_l":"1535-9778","issn":["1535-9778","1535-9786"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Eukaryotic Cell","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.1128/ec.5.4.712-722.2006","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052943060","display_name":"Jennifer A. Loertscher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58610484","display_name":"Seattle University","ror":"https://ror.org/02jqc0m91","country_code":"US","type":"education","lineage":["https://openalex.org/I58610484"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Loertscher","raw_affiliation_strings":["Department of Chemistry, Seattle University, Seattle, Washington 98122"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Seattle University, Seattle, Washington 98122","institution_ids":["https://openalex.org/I58610484"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088421323","display_name":"Lynnelle L. Larson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I236478094","display_name":"Promundo","ror":"https://ror.org/03mwbkd48","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I236478094"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lynnelle L. Larson","raw_affiliation_strings":["Redmond High School, Redmond, Washington 98052"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Redmond High School, Redmond, Washington 98052","institution_ids":["https://openalex.org/I236478094"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000930062","display_name":"Clinton K. Matson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Clinton K. Matson","raw_affiliation_strings":["Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota 55455"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota 55455","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089628118","display_name":"Mark L Parrish","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark L. Parrish","raw_affiliation_strings":["Department of Zoology, University of Washington, Seattle, Washington 98195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Zoology, University of Washington, Seattle, Washington 98195","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069439830","display_name":"Alicia M. Felthauser","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alicia Felthauser","raw_affiliation_strings":["Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota 55455"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota 55455","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044957766","display_name":"Aaron M. Sturm","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron Sturm","raw_affiliation_strings":["Department of Biology, Indiana University Purdue University Indianapolis, Indianapolis, Indiana 46202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Indiana University Purdue University Indianapolis, Indianapolis, Indiana 46202","institution_ids":["https://openalex.org/I55769427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108787855","display_name":"Christine Tachibana","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christine Tachibana","raw_affiliation_strings":["Department of Biochemistry, University of Washington, Seattle, Washington 98195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Washington, Seattle, Washington 98195","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027241044","display_name":"Martin Bard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martin Bard","raw_affiliation_strings":["Department of Biology, Indiana University Purdue University Indianapolis, Indianapolis, Indiana 46202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Indiana University Purdue University Indianapolis, Indianapolis, Indiana 46202","institution_ids":["https://openalex.org/I55769427"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102932995","display_name":"Robin Wright","orcid":"https://orcid.org/0000-0002-3499-0204","observed_orcids":["https://orcid.org/0000-0002-3499-0204"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robin Wright","raw_affiliation_strings":["Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota 55455"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota 55455","institution_ids":["https://openalex.org/I130238516"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5102932995"],"corresponding_institution_ids":["https://openalex.org/I130238516"],"apc_list":null,"apc_paid":null,"fwci":0.5777,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.62783514,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"5","issue":"4","first_page":"712","last_page":"722"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.7432000041007996,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.7432000041007996,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.06319999694824219,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.05130000039935112,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/er-associated-degradation","display_name":"ER-associated degradation","score":0.9649999737739563},{"id":"https://openalex.org/keywords/cold-adaptation","display_name":"cold adaptation","score":0.8069999814033508},{"id":"https://openalex.org/keywords/sterol-biosynthesis","display_name":"sterol biosynthesis","score":0.972000002861023},{"id":"https://openalex.org/keywords/3-hydroxy-3-methylglutaryl-coenzyme-a-reductase","display_name":"HMGR","score":0.9459999799728394},{"id":"https://openalex.org/keywords/ubc7","display_name":"Ubc7","score":0.8349999785423279},{"id":"https://openalex.org/keywords/doa10","display_name":"Doa10","score":0.9980000257492065},{"id":"https://openalex.org/keywords/membrane-fluidity","display_name":"membrane fluidity","score":0.5529999732971191},{"id":"https://openalex.org/keywords/proteasome","display_name":"proteasome","score":0.6399999856948853},{"id":"https://openalex.org/keywords/misfolded-protein-degradation","display_name":"misfolded protein degradation","score":0.7210000157356262},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.9259999990463257}],"concepts":[{"id":"https://openalex.org/C158619295","wikidata":"https://www.wikidata.org/wiki/Q21101062","display_name":"Endoplasmic-reticulum-associated protein degradation","level":4,"score":0.9458528757095337},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.8082162737846375},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7097225785255432},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.6280136108398438},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.578669548034668},{"id":"https://openalex.org/C2778718757","wikidata":"https://www.wikidata.org/wiki/Q143623","display_name":"Sterol","level":3,"score":0.5665022134780884},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5011649131774902},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.46649858355522156},{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.4358684718608856},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.4306909441947937},{"id":"https://openalex.org/C2992195973","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Protein degradation","level":2,"score":0.42487940192222595},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11891144514083862},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.07786685228347778}],"mesh":[{"descriptor_ui":"D000064","descriptor_name":"Acclimatization","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D003080","descriptor_name":"Cold Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010749","descriptor_name":"Phosphoprotein Phosphatases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010749","descriptor_name":"Phosphoprotein Phosphatases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013261","descriptor_name":"Sterols","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D013261","descriptor_name":"Sterols","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D044763","descriptor_name":"Ubiquitin-Conjugating Enzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044763","descriptor_name":"Ubiquitin-Conjugating Enzymes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D044764","descriptor_name":"Ubiquitin-Activating Enzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D046988","descriptor_name":"Proteasome Endopeptidase Complex","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/ec.5.4.712-722.2006","doi":"https://doi.org/10.1128/ec.5.4.712-722.2006","is_oa":true,"landing_page_url":"https://doi.org/10.1128/ec.5.4.712-722.2006","pdf_url":null,"source":{"id":"https://openalex.org/S177547185","display_name":"Eukaryotic Cell","issn_l":"1535-9778","issn":["1535-9778","1535-9786"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Eukaryotic Cell","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1459677","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1459677","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Eukaryot Cell","raw_type":"Text"},{"id":"pmid:16607018","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16607018","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Eukaryotic cell","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.424.1305","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.424.1305","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://ec.highwire.org/content/5/4/712.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1128/ec.5.4.712-722.2006","doi":"https://doi.org/10.1128/ec.5.4.712-722.2006","is_oa":true,"landing_page_url":"https://doi.org/10.1128/ec.5.4.712-722.2006","pdf_url":null,"source":{"id":"https://openalex.org/S177547185","display_name":"Eukaryotic Cell","issn_l":"1535-9778","issn":["1535-9778","1535-9786"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Eukaryotic Cell","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G218403217","display_name":"The Yeast Ergosterol Pathway","funder_award_id":"R01GM062104","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3146432584","display_name":"Exploring the Roles of Ubiquitin in ER Biogenesis","funder_award_id":"F32GM067368","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8200504923","display_name":null,"funder_award_id":"GM67368-01","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W65545262","https://openalex.org/W1483746134","https://openalex.org/W1548889676","https://openalex.org/W1598193192","https://openalex.org/W1668688100","https://openalex.org/W1855382658","https://openalex.org/W1914512945","https://openalex.org/W1986342078","https://openalex.org/W1990606700","https://openalex.org/W1990647376","https://openalex.org/W1996109826","https://openalex.org/W2002439304","https://openalex.org/W2007422965","https://openalex.org/W2019165625","https://openalex.org/W2025226894","https://openalex.org/W2031300832","https://openalex.org/W2031307848","https://openalex.org/W2033179504","https://openalex.org/W2034804054","https://openalex.org/W2051573163","https://openalex.org/W2052779687","https://openalex.org/W2052858784","https://openalex.org/W2054664724","https://openalex.org/W2061199758","https://openalex.org/W2068208419","https://openalex.org/W2075553383","https://openalex.org/W2083516848","https://openalex.org/W2086195258","https://openalex.org/W2089949661","https://openalex.org/W2090839709","https://openalex.org/W2094489008","https://openalex.org/W2096634218","https://openalex.org/W2098671352","https://openalex.org/W2100057937","https://openalex.org/W2104984080","https://openalex.org/W2105663973","https://openalex.org/W2105821361","https://openalex.org/W2114360920","https://openalex.org/W2118655754","https://openalex.org/W2119870315","https://openalex.org/W2129089207","https://openalex.org/W2137662702","https://openalex.org/W2139499348","https://openalex.org/W2139577310","https://openalex.org/W2142221263","https://openalex.org/W2144029424","https://openalex.org/W2145922063","https://openalex.org/W2148125211","https://openalex.org/W2150717990","https://openalex.org/W2153458899","https://openalex.org/W2157935239","https://openalex.org/W2161145629","https://openalex.org/W2419116927","https://openalex.org/W7046198777"],"related_works":["https://openalex.org/W7098549444","https://openalex.org/W2756979598","https://openalex.org/W44232771","https://openalex.org/W2304044751","https://openalex.org/W4308790692","https://openalex.org/W2017496199","https://openalex.org/W2129498461","https://openalex.org/W7100457242","https://openalex.org/W2170162733","https://openalex.org/W2145922063"],"abstract_inverted_index":{"Endoplasmic":[0],"reticulum-associated":[1],"degradation":[2,151],"(ERAD)":[3],"mediates":[4],"the":[5,13,39,59,69,99,114,119,159,164,170,199],"turnover":[6],"of":[7,20,52,58,96,116,122,143,152,179,187,201,207],"short-lived":[8],"and":[9,45],"misfolded":[10],"proteins":[11,41,227],"in":[12,33,140,231],"ER":[14],"membrane":[15,197],"or":[16,88,218],"lumen.":[17],"In":[18],"spite":[19],"its":[21],"important":[22],"role,":[23],"only":[24],"subtle":[25],"growth":[26,51,71,142],"phenotypes":[27],"have":[28,36,228],"been":[29],"associated":[30],"with":[31,145],"defects":[32],"ERAD.":[34],"We":[35],"discovered":[37],"that":[38,54,101,134,149,186,224],"ERAD":[40,124,153,166,202,226],"Ubc7":[42],"(Qri8),":[43],"Cue1,":[44],"Doa10":[46],"(Ssm4)":[47],"are":[48,193],"required":[49],"for":[50,158],"yeast":[53,144,171],"express":[55],"high":[56,108],"levels":[57,192,206],"sterol":[60,176,191,238],"biosynthetic":[61],"enzyme,":[62],"3-hydroxy-3-methylglutaryl":[63],"coenzyme":[64],"A":[65],"reductase":[66],"(HMGR).":[67],"Interestingly,":[68],"observed":[70,160],"defect":[72],"was":[73,126,182,209],"exacerbated":[74],"at":[75,107,211],"low":[76,212],"temperatures,":[77],"producing":[78],"an":[79],"HMGR-dependent":[80],"cold":[81,120,221,232],"sensitivity.":[82],"Yeast":[83],"strains":[84],"lacking":[85,215],"UBC7,":[86,216],"CUE1,":[87,217],"DOA10":[89,219],"also":[90,138],"assembled":[91],"aberrant":[92],"karmellae":[93],"(ordered":[94],"arrays":[95],"membranes":[97],"surrounding":[98],"nucleus":[100],"assemble":[102],"when":[103],"HMGR":[104,130,172,208],"is":[105],"expressed":[106],"levels).":[109],"However,":[110,163],"rather":[111],"than":[112],"reflecting":[113],"accumulation":[115],"abnormal":[117],"karmellae,":[118],"sensitivity":[121],"these":[123,225],"mutants":[125,203],"due":[127],"to":[128,185,195],"increased":[129],"catalytic":[131],"activity.":[132],"Mutations":[133],"compromise":[135],"proteasomal":[136],"function":[137],"resulted":[139],"cold-sensitive":[141,161],"elevated":[146],"HMGR,":[147],"suggesting":[148,223],"improper":[150],"targets":[154,167],"might":[155],"be":[156],"responsible":[157],"phenotype.":[162],"essential":[165],"were":[168,220],"not":[169],"enzymes":[173],"themselves.":[174],"The":[175],"metabolite":[177],"profile":[178],"ubc7Delta":[180],"cells":[181],"altered":[183],"relative":[184],"wild-type":[188],"cells.":[189],"Since":[190],"known":[194],"regulate":[196],"fluidity,":[198],"viability":[200],"expressing":[204],"normal":[205],"examined":[210],"temperatures.":[213],"Cells":[214],"sensitive,":[222],"a":[229],"role":[230],"adaptation,":[233],"perhaps":[234],"through":[235],"effects":[236],"on":[237],"biosynthesis.":[239]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":4}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
