{"id":"https://openalex.org/W2128756608","doi":"https://doi.org/10.1016/j.jcrc.2009.06.024","title":"Porcine endotoxemia: Multiplexed cytokine analysis and mathematical modeling","display_name":"Porcine endotoxemia: Multiplexed cytokine analysis and mathematical modeling","publication_year":2009,"publication_date":"2009-08-06","ids":{"openalex":"https://openalex.org/W2128756608","doi":"https://doi.org/10.1016/j.jcrc.2009.06.024","mag":"2128756608"},"language":"en","primary_location":{"id":"doi:10.1016/j.jcrc.2009.06.024","doi":"https://doi.org/10.1016/j.jcrc.2009.06.024","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jcrc.2009.06.024","pdf_url":null,"source":{"id":"https://openalex.org/S126993733","display_name":"Journal of Critical Care","issn_l":"0883-9441","issn":["0883-9441","1557-8615"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Critical Care","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073022985","display_name":"Yoram Vodovotz B","orcid":"https://orcid.org/0000-0002-4389-8768","observed_orcids":["https://orcid.org/0000-0002-4389-8768"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yoram Vodovotz","raw_affiliation_strings":["Department of Surgery, University of Pittsburgh, Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Steve Chang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steve Chang","raw_affiliation_strings":["Immunetrics, Inc., Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunetrics, Inc., Pittsburgh, PA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009837588","display_name":"Derek A. Barclay","orcid":"https://orcid.org/0000-0003-4740-745X","observed_orcids":["https://orcid.org/0000-0003-4740-745X"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Derek Barclay","raw_affiliation_strings":["Department of Surgery, University of Pittsburgh, Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025257016","display_name":"Brian D. Kubiak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20388574","display_name":"SUNY Upstate Medical University","ror":"https://ror.org/040kfrw16","country_code":"US","type":"education","lineage":["https://openalex.org/I20388574"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian Kubiak","raw_affiliation_strings":["Department of Surgery, Upstate Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Upstate Medical University","institution_ids":["https://openalex.org/I20388574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010774473","display_name":"Christopher J. Vieau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20388574","display_name":"SUNY Upstate Medical University","ror":"https://ror.org/040kfrw16","country_code":"US","type":"education","lineage":["https://openalex.org/I20388574"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chris Vieau","raw_affiliation_strings":["Department of Surgery, Upstate Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Upstate Medical University","institution_ids":["https://openalex.org/I20388574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065550494","display_name":"Louis A. Gatto","orcid":"https://orcid.org/0000-0001-7658-264X","observed_orcids":["https://orcid.org/0000-0001-7658-264X"]},"institutions":[{"id":"https://openalex.org/I20388574","display_name":"SUNY Upstate Medical University","ror":"https://ror.org/040kfrw16","country_code":"US","type":"education","lineage":["https://openalex.org/I20388574"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Louis Gatto","raw_affiliation_strings":["Department of Surgery, Upstate Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Upstate Medical University","institution_ids":["https://openalex.org/I20388574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111929739","display_name":"Kris Maier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20388574","display_name":"SUNY Upstate Medical University","ror":"https://ror.org/040kfrw16","country_code":"US","type":"education","lineage":["https://openalex.org/I20388574"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kris Maier","raw_affiliation_strings":["Department of Surgery, Upstate Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Upstate Medical University","institution_ids":["https://openalex.org/I20388574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030851778","display_name":"Cordelia Ziraldo","orcid":"https://orcid.org/0000-0001-8095-4506","observed_orcids":["https://orcid.org/0000-0001-8095-4506"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cordelia Ziraldo","raw_affiliation_strings":["Department of Surgery, University of Pittsburgh, Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076170464","display_name":"Qi Mi","orcid":"https://orcid.org/0000-0002-0197-8671","observed_orcids":["https://orcid.org/0000-0002-0197-8671"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qi Mi","raw_affiliation_strings":["Department of Mathematics, University of Pittsburgh","Department of Sports Medicine and Rehabilitation, University of Pittsburgh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics, University of Pittsburgh","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Sports Medicine and Rehabilitation, University of Pittsburgh","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001656066","display_name":"Rub\u00e9n Zamora","orcid":"https://orcid.org/0000-0003-3882-9087","observed_orcids":["https://orcid.org/0000-0003-3882-9087"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ruben Zamora","raw_affiliation_strings":["Department of Surgery, University of Pittsburgh, Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011575122","display_name":"Gary F. Nieman","orcid":"https://orcid.org/0000-0002-4541-4472","observed_orcids":["https://orcid.org/0000-0002-4541-4472"]},"institutions":[{"id":"https://openalex.org/I20388574","display_name":"SUNY Upstate Medical University","ror":"https://ror.org/040kfrw16","country_code":"US","type":"education","lineage":["https://openalex.org/I20388574"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary Nieman","raw_affiliation_strings":["Department of Surgery, Upstate Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Upstate Medical University","institution_ids":["https://openalex.org/I20388574"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3610,"currency":"USD","value_usd":3610},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.22092763,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"24","issue":"3","first_page":"e23","last_page":"e23"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.8568999767303467,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.8568999767303467,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12322","display_name":"Animal health and immunology","score":0.04830000177025795,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":0.015300000086426735,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9610000252723694},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.8140000104904175},{"id":"https://openalex.org/keywords/immune-activation","display_name":"immune activation","score":0.6610000133514404},{"id":"https://openalex.org/keywords/tail-biting","display_name":"tail biting","score":0.5889999866485596},{"id":"https://openalex.org/keywords/social-behavior","display_name":"social behavior","score":0.7440000176429749},{"id":"https://openalex.org/keywords/cortisol","display_name":"cortisol","score":0.5860000252723694},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.843999981880188},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.8569999933242798},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.9229999780654907},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.8870000243186951},{"id":"https://openalex.org/keywords/norepinephrine","display_name":"norepinephrine","score":0.9739999771118164},{"id":"https://openalex.org/keywords/hypothalamus","display_name":"hypothalamus","score":0.8489999771118164},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.7860000133514404},{"id":"https://openalex.org/keywords/frontal-cortex","display_name":"frontal cortex","score":0.9700000286102295},{"id":"https://openalex.org/keywords/food-consumption","display_name":"dietary intake","score":0.7749999761581421},{"id":"https://openalex.org/keywords/mathematical-modeling","display_name":"mathematical modeling","score":0.546999990940094},{"id":"https://openalex.org/keywords/gilts","display_name":"gilts","score":0.6679999828338623}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6323837041854858},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.630500078201294},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6283476948738098},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6213392019271851},{"id":"https://openalex.org/C138906646","wikidata":"https://www.wikidata.org/wiki/Q7507668","display_name":"Sickness behavior","level":3,"score":0.6145539283752441},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.5642862915992737},{"id":"https://openalex.org/C2776039942","wikidata":"https://www.wikidata.org/wiki/Q4918888","display_name":"Biting","level":2,"score":0.5526986122131348},{"id":"https://openalex.org/C2777260799","wikidata":"https://www.wikidata.org/wiki/Q15637420","display_name":"Lethargy","level":2,"score":0.5447210073471069},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.44525837898254395},{"id":"https://openalex.org/C2777003273","wikidata":"https://www.wikidata.org/wiki/Q164386","display_name":"Hypothalamus","level":2,"score":0.43403300642967224},{"id":"https://openalex.org/C2780820931","wikidata":"https://www.wikidata.org/wiki/Q29299","display_name":"Irritability","level":3,"score":0.43187737464904785},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4296684265136719},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.307020902633667},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15524384379386902},{"id":"https://openalex.org/C2778562196","wikidata":"https://www.wikidata.org/wiki/Q177708","display_name":"Menopause","level":2,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jcrc.2009.06.024","doi":"https://doi.org/10.1016/j.jcrc.2009.06.024","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jcrc.2009.06.024","pdf_url":null,"source":{"id":"https://openalex.org/S126993733","display_name":"Journal of Critical Care","issn_l":"0883-9441","issn":["0883-9441","1557-8615"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Critical Care","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.7300000190734863,"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3164810262","https://openalex.org/W2047378293","https://openalex.org/W3119264702","https://openalex.org/W2516359773","https://openalex.org/W2041028278","https://openalex.org/W622993943","https://openalex.org/W4387503844","https://openalex.org/W2009540351","https://openalex.org/W2036053527","https://openalex.org/W4301370096"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}