{"id":"https://openalex.org/W2128728937","doi":"https://doi.org/10.2337/diabetes.52.3.829","title":"Characterization of Retinal Leukostasis and Hemodynamics in Insulin Resistance and Diabetes","display_name":"Characterization of Retinal Leukostasis and Hemodynamics in Insulin Resistance and Diabetes","publication_year":2003,"publication_date":"2003-03-01","ids":{"openalex":"https://openalex.org/W2128728937","doi":"https://doi.org/10.2337/diabetes.52.3.829","mag":"2128728937","pmid":"https://pubmed.ncbi.nlm.nih.gov/12606527"},"language":"en","primary_location":{"id":"doi:10.2337/diabetes.52.3.829","doi":"https://doi.org/10.2337/diabetes.52.3.829","is_oa":true,"landing_page_url":"https://doi.org/10.2337/diabetes.52.3.829","pdf_url":"https://diabetesjournals.org/diabetes/article-pdf/52/3/829/374229/db0303000829.pdf","source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://diabetesjournals.org/diabetes/article-pdf/52/3/829/374229/db0303000829.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111929697","display_name":"T. Abiko","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1293231726","display_name":"Joslin Diabetes Center","ror":"https://ror.org/0280a3n32","country_code":"US","type":"facility","lineage":["https://openalex.org/I1293231726"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Toru Abiko","raw_affiliation_strings":["Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I1293231726","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013501220","display_name":"Atsuko Abiko","orcid":"https://orcid.org/0000-0001-5083-2620","observed_orcids":["https://orcid.org/0000-0001-5083-2620"]},"institutions":[{"id":"https://openalex.org/I1293231726","display_name":"Joslin Diabetes Center","ror":"https://ror.org/0280a3n32","country_code":"US","type":"facility","lineage":["https://openalex.org/I1293231726"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Atsuko Abiko","raw_affiliation_strings":["Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I1293231726","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073527313","display_name":"Allen C. Clermont","orcid":"https://orcid.org/0009-0000-5939-5754","observed_orcids":["https://orcid.org/0009-0000-5939-5754"]},"institutions":[{"id":"https://openalex.org/I1293231726","display_name":"Joslin Diabetes Center","ror":"https://ror.org/0280a3n32","country_code":"US","type":"facility","lineage":["https://openalex.org/I1293231726"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Allen C. Clermont","raw_affiliation_strings":["Beetham Eye Institute, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beetham Eye Institute, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I1293231726","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005972641","display_name":"Brett Shoelson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1293231726","display_name":"Joslin Diabetes Center","ror":"https://ror.org/0280a3n32","country_code":"US","type":"facility","lineage":["https://openalex.org/I1293231726"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brett Shoelson","raw_affiliation_strings":["Beetham Eye Institute, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beetham Eye Institute, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I1293231726","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003824609","display_name":"Naoichi Horio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1293231726","display_name":"Joslin Diabetes Center","ror":"https://ror.org/0280a3n32","country_code":"US","type":"facility","lineage":["https://openalex.org/I1293231726"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Naoichi Horio","raw_affiliation_strings":["Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I1293231726","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052288893","display_name":"Junichi Takahashi","orcid":"https://orcid.org/0000-0002-0143-3145","observed_orcids":["https://orcid.org/0000-0002-0143-3145"]},"institutions":[{"id":"https://openalex.org/I1293231726","display_name":"Joslin Diabetes Center","ror":"https://ror.org/0280a3n32","country_code":"US","type":"facility","lineage":["https://openalex.org/I1293231726"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Junichi Takahashi","raw_affiliation_strings":["Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I1293231726","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085600986","display_name":"Anthony P. Adamis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1287163989","display_name":"Massachusetts Eye and Ear Infirmary","ror":"https://ror.org/04g3dn724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1287163989"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony P. Adamis","raw_affiliation_strings":["Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I1287163989","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009528569","display_name":"George Liang King","orcid":"https://orcid.org/0000-0002-0335-5881","observed_orcids":["https://orcid.org/0000-0002-0335-5881"]},"institutions":[{"id":"https://openalex.org/I1293231726","display_name":"Joslin Diabetes Center","ror":"https://ror.org/0280a3n32","country_code":"US","type":"facility","lineage":["https://openalex.org/I1293231726"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George L. King","raw_affiliation_strings":["Department of Medicine, Harvard Medical School, Boston, Massachusetts","Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I1293231726","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059202016","display_name":"Sven\u2013Erik Bursell","orcid":"https://orcid.org/0009-0007-4348-6425","observed_orcids":["https://orcid.org/0009-0007-4348-6425","https://orcid.org/0000-0003-4902-5455"]},"institutions":[{"id":"https://openalex.org/I1293231726","display_name":"Joslin Diabetes Center","ror":"https://ror.org/0280a3n32","country_code":"US","type":"facility","lineage":["https://openalex.org/I1293231726"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sven-Erik Bursell","raw_affiliation_strings":["Beetham Eye Institute, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts","Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beetham Eye Institute, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I1293231726","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":14.3077,"has_fulltext":true,"cited_by_count":154,"citation_normalized_percentile":{"value":0.99274381,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"52","issue":"3","first_page":"829","last_page":"837"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12533","display_name":"Aldose Reductase and Taurine","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leukostasis","display_name":"leukostasis","score":0.8830000162124634},{"id":"https://openalex.org/keywords/retinal-hemodynamics","display_name":"retinal hemodynamics","score":0.7260000109672546},{"id":"https://openalex.org/keywords/retinal-blood-flow","display_name":"retinal blood flow","score":0.8610000014305115},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.8479999899864197},{"id":"https://openalex.org/keywords/diabetic-retinopathy","display_name":"diabetic retinopathy","score":0.9079999923706055},{"id":"https://openalex.org/keywords/monocyte-adhesion","display_name":"monocyte adhesion","score":0.8489999771118164},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.7390000224113464},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9620000123977661},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.843999981880188},{"id":"https://openalex.org/keywords/alpha-lipoic-acid","display_name":"alpha-lipoic acid","score":0.9919999837875366},{"id":"https://openalex.org/keywords/d-alpha-tocopherol","display_name":"D-alpha-tocopherol","score":0.9340000152587891},{"id":"https://openalex.org/keywords/prkcb","display_name":"protein kinase C beta","score":0.8270000219345093},{"id":"https://openalex.org/keywords/ruboxistaurin","display_name":"ruboxistaurin","score":0.9850000143051147},{"id":"https://openalex.org/keywords/antioxidant-therapy","display_name":"antioxidant therapy","score":0.47600001096725464}],"concepts":[{"id":"https://openalex.org/C2777432695","wikidata":"https://www.wikidata.org/wiki/Q3237103","display_name":"Leukostasis","level":3,"score":0.9866728186607361},{"id":"https://openalex.org/C2779829184","wikidata":"https://www.wikidata.org/wiki/Q631361","display_name":"Diabetic retinopathy","level":3,"score":0.7080138921737671},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6507948040962219},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.6154451966285706},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5867645144462585},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5406003594398499},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.536243200302124},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.4770438075065613},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.455679714679718},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.4173640012741089},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.41717085242271423},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1860010325908661},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.11673352122306824},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08464476466178894},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.05536431074142456}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001783","descriptor_name":"Blood Flow Velocity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D003930","descriptor_name":"Diabetic Retinopathy","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008063","descriptor_name":"Thioctic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008301","descriptor_name":"Maleimides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008833","descriptor_name":"Microcirculation","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008863","descriptor_name":"Microspheres","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011924","descriptor_name":"Rats, Zucker","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012171","descriptor_name":"Retinal Vessels","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012171","descriptor_name":"Retinal Vessels","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D016877","descriptor_name":"Oxidants","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018921","descriptor_name":"Leukostasis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D020318","descriptor_name":"Rats, Long-Evans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024502","descriptor_name":"alpha-Tocopherol","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064546","descriptor_name":"Protein Kinase C beta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.2337/diabetes.52.3.829","doi":"https://doi.org/10.2337/diabetes.52.3.829","is_oa":true,"landing_page_url":"https://doi.org/10.2337/diabetes.52.3.829","pdf_url":"https://diabetesjournals.org/diabetes/article-pdf/52/3/829/374229/db0303000829.pdf","source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},{"id":"pmid:12606527","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12606527","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.866.1091","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.866.1091","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://diabetes.diabetesjournals.org/content/52/3/829.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.2337/diabetes.52.3.829","doi":"https://doi.org/10.2337/diabetes.52.3.829","is_oa":true,"landing_page_url":"https://doi.org/10.2337/diabetes.52.3.829","pdf_url":"https://diabetesjournals.org/diabetes/article-pdf/52/3/829/374229/db0303000829.pdf","source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9789000153541565,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5665467367","display_name":null,"funder_award_id":"EY/RO 15110","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2128728937.pdf","grobid_xml":"https://content.openalex.org/works/W2128728937.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W45900541","https://openalex.org/W1263018205","https://openalex.org/W1549192554","https://openalex.org/W1810991871","https://openalex.org/W1966419887","https://openalex.org/W1972492725","https://openalex.org/W1979356762","https://openalex.org/W2000327216","https://openalex.org/W2000625731","https://openalex.org/W2003996544","https://openalex.org/W2011500110","https://openalex.org/W2013620038","https://openalex.org/W2015971850","https://openalex.org/W2016366656","https://openalex.org/W2018555496","https://openalex.org/W2027478328","https://openalex.org/W2028483247","https://openalex.org/W2044437167","https://openalex.org/W2058030813","https://openalex.org/W2061444964","https://openalex.org/W2064382412","https://openalex.org/W2084148825","https://openalex.org/W2096326428","https://openalex.org/W2102665979","https://openalex.org/W2105532009","https://openalex.org/W2109168147","https://openalex.org/W2109507411","https://openalex.org/W2114258800","https://openalex.org/W2114332755","https://openalex.org/W2120780093","https://openalex.org/W2122109377","https://openalex.org/W2166389986","https://openalex.org/W2169235788","https://openalex.org/W2262880677","https://openalex.org/W2337454357","https://openalex.org/W2407890933","https://openalex.org/W2471178894","https://openalex.org/W2769264260"],"related_works":["https://openalex.org/W1899758820","https://openalex.org/W2050664131","https://openalex.org/W2736565903","https://openalex.org/W2011500110","https://openalex.org/W2741477711","https://openalex.org/W1490372003","https://openalex.org/W2072210889","https://openalex.org/W2127126726","https://openalex.org/W2102665979","https://openalex.org/W2271847305"],"abstract_inverted_index":{"Increases":[0],"in":[1,11,22,35,39,46,103,107,111,123],"leukostasis/monocyte":[2],"adhesion":[3],"to":[4,160,168,180],"the":[5,23,75,80,101],"capillary":[6,60],"endothelium":[7],"(leukostasis)":[8],"and":[9,19,52,94,105,134,153,164,188],"decreases":[10,45,106],"retinal":[12,47,59,67,86,108,161],"blood":[13,48,68,87,109,162],"flow":[14,49,110,163],"may":[15],"be":[16],"causally":[17],"associated":[18,147],"are":[20,37],"implicated":[21],"pathogenesis":[24],"of":[25,82,118],"diabetic":[26,71,112,124],"retinopathy.":[27,171],"In":[28,70,89],"this":[29],"study,":[30],"we":[31],"demonstrate":[32],"that":[33,144],"increases":[34,102],"leukostasis":[36,83,104,145],"observed":[38],"insulin-resistant":[40],"states":[41],"without":[42],"diabetes,":[43],"whereas":[44],"require":[50],"diabetes":[51,182],"hyperglycemia.":[53],"Microimpaction":[54],"studies":[55],"using":[56],"beads":[57],"mimicking":[58],"obstruction":[61],"by":[62,128],"leukocytes":[63],"did":[64],"not":[65,85,158,166],"affect":[66],"flow.":[69,88],"rats,":[72,125],"treatment":[73,91,129,173],"with":[74,92,130,148,174],"antioxidant":[76],"alpha-lipoic":[77,132],"acid":[78,133],"normalized":[79,127],"amount":[81],"but":[84,126,156],"contrast,":[90],"D-alpha-tocopherol":[93,135],"protein":[95],"kinase-C":[96],"beta-isoform":[97,139,186],"inhibition":[98,177],"(LY333531)":[99],"prevented":[100],"rats.":[113],"Serum":[114],"hydroxyperoxide,":[115],"a":[116],"marker":[117],"oxidative":[119,154,189],"stress,":[120],"was":[121],"increased":[122],"antioxidants":[131],"and,":[136],"surprisingly,":[137],"PKC":[138,175,185],"inhibition.":[140],"These":[141],"findings":[142],"suggest":[143],"is":[146,157,165,178],"endothelial":[149],"dysfunction,":[150],"insulin":[151],"resistance,":[152],"stress":[155],"related":[159],"sufficient":[167],"cause":[169],"diabetic-like":[170],"Moreover,":[172],"beta":[176],"effective":[179],"normalize":[181],"or":[183],"hyperglycemia-induced":[184],"activation":[187],"stress.":[190]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
