{"id":"https://openalex.org/W2128668534","doi":null,"title":"An ELISA system to detect anti-factor VIII antibodies without interference by lupus anticoagulants. Preliminary data in hemophilia A patients.","display_name":"An ELISA system to detect anti-factor VIII antibodies without interference by lupus anticoagulants. Preliminary data in hemophilia A patients.","publication_year":2000,"publication_date":"2000-10-01","ids":{"openalex":"https://openalex.org/W2128668534","mag":"2128668534","pmid":"https://pubmed.ncbi.nlm.nih.gov/11025595"},"language":"en","primary_location":{"id":"pmid:11025595","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11025595","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haematologica","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084202100","display_name":"Alicia Noem\u00ed Blanco","orcid":"https://orcid.org/0000-0002-6933-1057","observed_orcids":["https://orcid.org/0000-0002-6933-1057"]},"institutions":[{"id":"https://openalex.org/I14429277","display_name":"Academia Nacional de Medicina","ror":"https://ror.org/05k2xsz75","country_code":"AR","type":"nonprofit","lineage":["https://openalex.org/I14429277"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"A N Blanco","raw_affiliation_strings":["Instituto de Investigaciones Hematol\u00f3gicas \"Mariano R. Castex\", Academia Nacional de Medicina, Pacheco de Melo 3081, 1425 Buenos Aires, Argentina. blanco@connmed.com.ar","Instituto de Investigaciones Hematol\u00f3gicas Mariano R Castex, Academia Nacional de Medicina, Pacheco de Melo 3081, 1425 Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Investigaciones Hematol\u00f3gicas \"Mariano R. Castex\", Academia Nacional de Medicina, Pacheco de Melo 3081, 1425 Buenos Aires, Argentina. blanco@connmed.com.ar","institution_ids":["https://openalex.org/I14429277"]},{"raw_affiliation_string":"Instituto de Investigaciones Hematol\u00f3gicas Mariano R Castex, Academia Nacional de Medicina, Pacheco de Melo 3081, 1425 Buenos Aires, Argentina","institution_ids":["https://openalex.org/I14429277"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069647849","display_name":"A Peirano","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A A Peirano","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041924135","display_name":"Silvia Grosso","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S H Grosso","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007079342","display_name":"Laura Gennari","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L C Gennari","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045758346","display_name":"Ra\u00fal P\u00e9rez Bianco","orcid":"https://orcid.org/0009-0006-2124-0689","observed_orcids":["https://orcid.org/0009-0006-2124-0689"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R P Bianco","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5108083374","display_name":"Maria Angela Lazzari","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M A Lazzari","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.18266736,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"85","issue":"10","first_page":"1045","last_page":"50"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anti-factor-viii-antibodies","display_name":"anti-factor VIII antibodies","score":0.9589999914169312},{"id":"https://openalex.org/keywords/lupus-anticoagulant","display_name":"lupus anticoagulant","score":0.949999988079071},{"id":"https://openalex.org/keywords/hemophilia-a","display_name":"hemophilia A","score":0.9369999766349792},{"id":"https://openalex.org/keywords/elisa-development","display_name":"ELISA development","score":0.5529999732971191},{"id":"https://openalex.org/keywords/assay-interference","display_name":"assay interference","score":0.8420000076293945},{"id":"https://openalex.org/keywords/neutralizing-antibodies","display_name":"neutralizing antibodies","score":0.8920000195503235},{"id":"https://openalex.org/keywords/non-neutralizing-antibodies","display_name":"non-neutralizing antibodies","score":0.7870000004768372}],"concepts":[{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.7577497363090515},{"id":"https://openalex.org/C2780022809","wikidata":"https://www.wikidata.org/wiki/Q5786759","display_name":"Lupus anticoagulant","level":3,"score":0.7334601879119873},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.7218366265296936},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.5432934761047363},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5073084235191345},{"id":"https://openalex.org/C2776912625","wikidata":"https://www.wikidata.org/wiki/Q1485","display_name":"Systemic lupus erythematosus","level":3,"score":0.46067675948143005},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.44394245743751526},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4375007748603821},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.42020317912101746},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35165584087371826},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3333323895931244},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21816971898078918},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10023114085197449},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07535475492477417},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003429","descriptor_name":"Cross Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005169","descriptor_name":"Factor VIII","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006467","descriptor_name":"Hemophilia A","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006467","descriptor_name":"Hemophilia A","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016682","descriptor_name":"Lupus Coagulation Inhibitor","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:11025595","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11025595","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haematologica","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:7077019ecf5e497ba353309d657d35af","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/7077019ecf5e497ba353309d657d35af","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Haematologica, Vol 85, Iss 10 (2000)","raw_type":"article"},{"id":"mag:2128668534","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11025595","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W24561140","https://openalex.org/W42078093","https://openalex.org/W93524816","https://openalex.org/W126476414","https://openalex.org/W169490990","https://openalex.org/W1977004360","https://openalex.org/W1991508429","https://openalex.org/W1998162825","https://openalex.org/W2038267649","https://openalex.org/W2045499358","https://openalex.org/W2091869095","https://openalex.org/W2111047217","https://openalex.org/W2149564822","https://openalex.org/W2278553352","https://openalex.org/W2333330110","https://openalex.org/W2410329637","https://openalex.org/W2412835183","https://openalex.org/W2416151354","https://openalex.org/W2616282010","https://openalex.org/W4292576288","https://openalex.org/W4296981399"],"related_works":["https://openalex.org/W1583216264","https://openalex.org/W2151857581","https://openalex.org/W24561140","https://openalex.org/W2897538183","https://openalex.org/W2018955424","https://openalex.org/W2884269864","https://openalex.org/W1994107592","https://openalex.org/W3111280481","https://openalex.org/W2783427898","https://openalex.org/W1991305546"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1,48,147],"OBJECTIVES:":[2],"Difficulties":[3],"in":[4],"identifying":[5],"the":[6,22,34,65,159,163],"coexistence":[7],"of":[8,24,36],"neutralizing":[9,167,174],"anti-factor":[10],"VIII":[11,63],"antibodies":[12],"(anti-fVIII)":[13],"and":[14,94,107,116,131,140,168],"lupus":[15],"anticoagulant":[16],"(LA)":[17],"are":[18],"mainly":[19],"due":[20],"to":[21,32],"interference":[23],"LA":[25,96,106,114,139,154],"on":[26,89],"anti-fVIII":[27,37,69,93,109,130,160,170],"assays.":[28],"Our":[29],"aim":[30],"was":[31,70,87],"reveal":[33],"presence":[35],"using":[38,80],"a":[39,73,173],"system":[40],"that":[41,58,153],"is":[42],"not":[43,156],"affected":[44],"by":[45,79],"LA.":[46],"DESIGN":[47],"METHODS:":[49],"We":[50],"developed":[51],"an":[52],"enzyme-linked":[53],"immunosorbent":[54],"assay":[55,164],"(ELISA)":[56],"method":[57],"uses":[59],"phospholipid-free":[60],"recombinant":[61],"factor":[62],"as":[64,72,122],"antigen.":[66],"A":[67],"monoclonal":[68,83],"tested":[71,121],"positive":[74],"control,":[75],"excluding":[76],"non-specific":[77],"binding":[78],"two":[81],"unrelated":[82],"antibodies.":[84],"The":[85],"ELISA":[86],"performed":[88],"hemophilic":[90,103,133],"plasmas":[91,104,119,128,134],"with":[92,105,129,158],"negative":[95,123],"(n=12)":[97,115],"or":[98],"without":[99,135],"inhibitors":[100,136],"(n=12).":[101],"Two":[102],"presumably":[108],"were":[110,120,137,144],"also":[111],"assayed.":[112],"Positive":[113],"normal":[117,141],"(n=10)":[118],"controls.":[124],"RESULTS:":[125],"All":[126],"(12/12)":[127],"5/12":[132],"positive;":[138],"plasma":[142],"controls":[143],"negative.":[145],"INTERPRETATION":[146],"CONCLUSIONS:":[148],"Results":[149],"presented":[150],"here":[151],"show":[152],"does":[155],"interfere":[157],"ELISA:":[161],"However,":[162],"detects":[165],"both":[166],"non-neutralizing":[169],"antibodies,":[171],"therefore":[172],"effect":[175],"must":[176],"be":[177],"confirmed":[178],"through":[179],"functional":[180],"tests.":[181]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
