{"id":"https://openalex.org/W2128596172","doi":"https://doi.org/10.1210/jc.2003-031283","title":"Acromegalic Axial Arthropathy: A Clinical Case-Control Study","display_name":"Acromegalic Axial Arthropathy: A Clinical Case-Control Study","publication_year":2004,"publication_date":"2004-02-01","ids":{"openalex":"https://openalex.org/W2128596172","doi":"https://doi.org/10.1210/jc.2003-031283","mag":"2128596172","pmid":"https://pubmed.ncbi.nlm.nih.gov/14764768"},"language":"en","primary_location":{"id":"doi:10.1210/jc.2003-031283","doi":"https://doi.org/10.1210/jc.2003-031283","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jc.2003-031283","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology &amp; Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101665248","display_name":"Raffaele Scarpa","orcid":"https://orcid.org/0000-0002-5808-6607","observed_orcids":["https://orcid.org/0000-0002-5808-6607"]},"institutions":[{"id":"https://openalex.org/I4210117450","display_name":"Federico II University Hospital","ror":"https://ror.org/02jr6tp70","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210117450","https://openalex.org/I71267560"]},{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Raffaele Scarpa","raw_affiliation_strings":["Department of Clinical Medicine, Section of Rheumatology, Federico II University of Naples, 80131 Naples, Italy","Departments of Clinical and Experimental Medicine, Sections of Rheumatology (R.S., D.D.B., F.M., P.O.), 80131 Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine, Section of Rheumatology, Federico II University of Naples, 80131 Naples, Italy","institution_ids":["https://openalex.org/I4210117450","https://openalex.org/I71267560"]},{"raw_affiliation_string":"Departments of Clinical and Experimental Medicine, Sections of Rheumatology (R.S., D.D.B., F.M., P.O.), 80131 Naples, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103419438","display_name":"Davide De Brasi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Davide De Brasi","raw_affiliation_strings":["Departments of Clinical and Experimental Medicine, Sections of Rheumatology (R.S., D.D.B., F.M., P.O.), 80131 Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Clinical and Experimental Medicine, Sections of Rheumatology (R.S., D.D.B., F.M., P.O.), 80131 Naples, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063936702","display_name":"Rosario Pivonello","orcid":"https://orcid.org/0000-0002-9632-1348","observed_orcids":["https://orcid.org/0000-0002-9632-1348"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rosario Pivonello","raw_affiliation_strings":["Molecular and Clinical Endocrinology and Oncology (R.P., P.M., G.L., A.C.), 80131 Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Clinical Endocrinology and Oncology (R.P., P.M., G.L., A.C.), 80131 Naples, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043401504","display_name":"Paolo Marzullo","orcid":"https://orcid.org/0000-0003-3215-5747","observed_orcids":["https://orcid.org/0000-0003-3215-5747"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paolo Marzullo","raw_affiliation_strings":["Molecular and Clinical Endocrinology and Oncology (R.P., P.M., G.L., A.C.), 80131 Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Clinical Endocrinology and Oncology (R.P., P.M., G.L., A.C.), 80131 Naples, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080352321","display_name":"Francesco Manguso","orcid":"https://orcid.org/0000-0002-9617-7892","observed_orcids":["https://orcid.org/0000-0002-9617-7892"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Francesco Manguso","raw_affiliation_strings":["Departments of Clinical and Experimental Medicine, Sections of Rheumatology (R.S., D.D.B., F.M., P.O.), 80131 Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Clinical and Experimental Medicine, Sections of Rheumatology (R.S., D.D.B., F.M., P.O.), 80131 Naples, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067090773","display_name":"A Sodano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Antonio Sodano","raw_affiliation_strings":["Biomorphological and Functional Sciences (A.S.), \u201cFederico II\u201d University of Naples, 80131 Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomorphological and Functional Sciences (A.S.), \u201cFederico II\u201d University of Naples, 80131 Naples, Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111627155","display_name":"Pasquale Oriente","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pasquale Oriente","raw_affiliation_strings":["Departments of Clinical and Experimental Medicine, Sections of Rheumatology (R.S., D.D.B., F.M., P.O.), 80131 Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Clinical and Experimental Medicine, Sections of Rheumatology (R.S., D.D.B., F.M., P.O.), 80131 Naples, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109160083","display_name":"Gaetano Lombardi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gaetano Lombardi","raw_affiliation_strings":["Molecular and Clinical Endocrinology and Oncology (R.P., P.M., G.L., A.C.), 80131 Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Clinical Endocrinology and Oncology (R.P., P.M., G.L., A.C.), 80131 Naples, Italy","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003544129","display_name":"Annamaria Colao","orcid":"https://orcid.org/0000-0001-6986-266X","observed_orcids":["https://orcid.org/0000-0001-6986-266X","https://orcid.org/0000-0003-4049-2559"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Annamaria Colao","raw_affiliation_strings":["Molecular and Clinical Endocrinology and Oncology (R.P., P.M., G.L., A.C.), 80131 Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Clinical Endocrinology and Oncology (R.P., P.M., G.L., A.C.), 80131 Naples, Italy","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":2.0973,"has_fulltext":false,"cited_by_count":84,"citation_normalized_percentile":{"value":0.87879516,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"89","issue":"2","first_page":"598","last_page":"603"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14057","display_name":"Hypertrophic osteoarthropathy and related conditions","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acromegaly","display_name":"acromegaly","score":0.996999979019165},{"id":"https://openalex.org/keywords/spinal-involvement","display_name":"spinal involvement","score":0.6150000095367432},{"id":"https://openalex.org/keywords/diffuse-idiopathic-skeletal-hyperostosis","display_name":"diffuse idiopathic skeletal hyperostosis","score":0.9390000104904175},{"id":"https://openalex.org/keywords/spinal-mobility","display_name":"spinal mobility","score":0.6150000095367432},{"id":"https://openalex.org/keywords/thoracic-cage","display_name":"thoracic cage","score":0.6110000014305115},{"id":"https://openalex.org/keywords/l2-vertebra","display_name":"L2 vertebra","score":0.5329999923706055},{"id":"https://openalex.org/keywords/intervertebral-disc-space","display_name":"intervertebral disc space","score":0.8009999990463257},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.8199999928474426},{"id":"https://openalex.org/keywords/growth-hormone-excess","display_name":"growth hormone excess","score":0.8230000138282776},{"id":"https://openalex.org/keywords/disease-duration","display_name":"disease duration","score":0.6380000114440918},{"id":"https://openalex.org/keywords/glucose-tolerance","display_name":"glucose tolerance","score":0.652999997138977},{"id":"https://openalex.org/keywords/radiographic-findings","display_name":"radiographic findings","score":0.4269999861717224},{"id":"https://openalex.org/keywords/articular-symptoms","display_name":"articular symptoms","score":0.5789999961853027},{"id":"https://openalex.org/keywords/lumbar-spine-mobility","display_name":"lumbar spine mobility","score":0.5830000042915344},{"id":"https://openalex.org/keywords/vertebral-height","display_name":"vertebral body height","score":0.6759999990463257}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9519584774971008},{"id":"https://openalex.org/C2779146052","wikidata":"https://www.wikidata.org/wiki/Q708176","display_name":"Arthropathy","level":4,"score":0.8480744361877441},{"id":"https://openalex.org/C2777433750","wikidata":"https://www.wikidata.org/wiki/Q189580","display_name":"Acromegaly","level":4,"score":0.8053579926490784},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.629412055015564},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.4771168529987335},{"id":"https://openalex.org/C2910502555","wikidata":"https://www.wikidata.org/wiki/Q742762","display_name":"Diffuse Idiopathic Skeletal Hyperostosis","level":3,"score":0.46698707342147827},{"id":"https://openalex.org/C97834683","wikidata":"https://www.wikidata.org/wiki/Q942508","display_name":"Thorax (insect anatomy)","level":2,"score":0.46165502071380615},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.45565178990364075},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.4370138645172119},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.38291677832603455},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.37815070152282715},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3066740334033966},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.26190388202667236},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.21435460448265076},{"id":"https://openalex.org/C2984496839","wikidata":"https://www.wikidata.org/wiki/Q29956617","display_name":"Growth hormone","level":3,"score":0.14164310693740845},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.08889120817184448},{"id":"https://openalex.org/C2778842504","wikidata":"https://www.wikidata.org/wiki/Q1121544","display_name":"Ossification","level":2,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000172","descriptor_name":"Acromegaly","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004057","descriptor_name":"Hyperostosis, Diffuse Idiopathic Skeletal","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D004057","descriptor_name":"Hyperostosis, Diffuse Idiopathic Skeletal","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D004057","descriptor_name":"Hyperostosis, Diffuse Idiopathic Skeletal","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011859","descriptor_name":"Radiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013122","descriptor_name":"Spinal Diseases","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D013122","descriptor_name":"Spinal Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D013122","descriptor_name":"Spinal Diseases","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D013131","descriptor_name":"Spine","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1210/jc.2003-031283","doi":"https://doi.org/10.1210/jc.2003-031283","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jc.2003-031283","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology &amp; Metabolism","raw_type":"journal-article"},{"id":"pmid:14764768","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14764768","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical endocrinology and metabolism","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W50658442","https://openalex.org/W195640360","https://openalex.org/W1965259708","https://openalex.org/W1970349847","https://openalex.org/W1990485831","https://openalex.org/W2001123601","https://openalex.org/W2047379634","https://openalex.org/W2064092633","https://openalex.org/W2066545456","https://openalex.org/W2068262180","https://openalex.org/W2068706667","https://openalex.org/W2068809035","https://openalex.org/W2091940299","https://openalex.org/W2109653214","https://openalex.org/W2131374385","https://openalex.org/W2137413588","https://openalex.org/W2140572454","https://openalex.org/W2163580538","https://openalex.org/W2386198853","https://openalex.org/W2397006219","https://openalex.org/W2400948709","https://openalex.org/W2412051933","https://openalex.org/W2435432774","https://openalex.org/W2467667708","https://openalex.org/W2468460604","https://openalex.org/W2500556552","https://openalex.org/W3167021965","https://openalex.org/W4229984599"],"related_works":["https://openalex.org/W2066719306","https://openalex.org/W7120801470","https://openalex.org/W3043212727","https://openalex.org/W2099993737","https://openalex.org/W4301463126","https://openalex.org/W2128615761","https://openalex.org/W1992821070","https://openalex.org/W4318323786","https://openalex.org/W2165728577","https://openalex.org/W7081998359"],"abstract_inverted_index":{"Arthropathy":[0],"is":[1,310],"the":[2,11,92,183,224,287,314],"major":[3],"cause":[4],"of":[5,54,94,150,182,194,209,223,292,295,302,308,316],"morbidity":[6],"in":[7,39,107,127,145,155,176,200,217,324],"acromegaly.":[8],"To":[9],"feature":[10],"spinal":[12,123,151],"involvement,":[13],"54":[14,28],"patients":[15,109,129,147,157,178,219,325],"with":[16,100,236,253,263,290,326],"active":[17],"acromegaly":[18,309],"(27":[19],"men,":[20],"27":[21],"women;":[22],"age":[23],"range,":[24],"21-69":[25],"yr)":[26],"and":[27,31,52,61,68,72,76,81,96,111,131,159,169,180,192,203,221,250,268,282,298],"sex-,":[29],"age-,":[30],"body":[32,238],"mass":[33],"index-matched":[34],"healthy":[35],"controls":[36,113,133,161,184,225],"were":[37,153,174,198,215,321],"enrolled":[38],"this":[40],"observational":[41],"analytical":[42],"prospective":[43],"case-control":[44],"study.":[45],"A":[46],"questionnaire":[47],"to":[48,90,312],"describe":[49],"onset,":[50],"duration,":[51],"severity":[53,260,315],"articular":[55],"symptoms;":[56],"rheumatological":[57],"examination,":[58],"including":[59],"vertebral":[60,237],"chest":[62],"mobility,":[63],"Schober":[64],"test,":[65],"thorax":[66,254],"expansion,":[67],"axial":[69,288],"radiological":[70],"study;":[71],"IGF-I,":[73],"GH,":[74],"insulin,":[75],"glucose":[77,85,273,276],"level":[78],"measurement":[79],"(baseline":[80],"after":[82,275],"an":[83],"oral":[84],"tolerance":[86],"test)":[87],"was":[88,105,125,143,234,261],"used":[89],"investigate":[91],"prevalence":[93],"arthropathy":[95,104],"correlate":[97],"these":[98],"findings":[99],"hormonal":[101],"parameters.":[102],"Axial":[103],"found":[106,199,216],"28":[108],"(52%)":[110],"12":[112],"(22%;":[114],"chi(2)":[115,135,163],"=":[116,119,136,164,186,227,241,248,257,266,271],"8.9;":[117],"P":[118,138,166,188,229],"0.003).":[120],"In":[121,278],"detail,":[122],"mobility":[124,252],"reduced":[126],"30":[128],"(56%)":[130],"10":[132],"(18%;":[134],"14.3;":[137],"<":[139,167,189,230],"0.0001),":[140,168],"thoracic":[141],"cage":[142],"involved":[144],"six":[146],"(11%),":[148],"alterations":[149,294],"profile":[152],"observed":[154,175],"37":[156],"(68%)":[158],"15":[160],"(28%;":[162],"16.3;":[165],"increased":[170],"L2":[171],"vertebra":[172],"diameters":[173],"34":[177],"(63%)":[179],"none":[181,222],"(chi(2)":[185,226],"46.7;":[187],"0.0001).":[190],"Narrowing":[191],"widening":[193],"L2-L3":[195],"disk":[196],"space":[197,245],"20":[201],"(37%)":[202],"seven":[204],"(13%)":[205],"patients,":[206],"respectively.":[207],"Features":[208],"diffuse":[210],"idiopathic":[211],"skeletal":[212],"hyperostosis":[213],"(DISH)":[214],"11":[218],"(20%)":[220],"10.1;":[228],"0.001).":[231],"Disease":[232],"duration":[233],"correlated":[235,262],"height":[239,246],"(P":[240,247,256,265,270],"0.001)":[242],"or":[243],"intervertebral":[244],"0.02),":[249],"lumbar":[251],"expansion":[255],"0.004);":[258],"DISH":[259,303],"basal":[264],"0.04)":[267],"peak":[269],"0.01)":[272],"levels":[274],"load.":[277],"conclusion,":[279],"chronic":[280],"GH":[281],"IGF-I":[283],"excess":[284],"typically":[285],"affects":[286],"skeleton":[289],"development":[291],"severe":[293],"spine":[296,317],"morphology":[297],"function":[299],"until":[300],"features":[301],"occur.":[304],"An":[305],"early":[306],"diagnosis":[307],"mandatory":[311],"reduce":[313],"abnormalities":[318],"as":[319],"they":[320],"significantly":[322],"higher":[323],"longer":[327],"disease":[328],"duration.":[329]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}