{"id":"https://openalex.org/W2128561069","doi":"https://doi.org/10.4103/0973-8258.49376","title":"Effect of cross-linking on physicochemical properties of chitosan mucoadhesive microspheres: A factorial approach","display_name":"Effect of cross-linking on physicochemical properties of chitosan mucoadhesive microspheres: A factorial approach","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2128561069","doi":"https://doi.org/10.4103/0973-8258.49376","mag":"2128561069"},"language":"en","primary_location":{"id":"doi:10.4103/0973-8258.49376","doi":"https://doi.org/10.4103/0973-8258.49376","is_oa":false,"landing_page_url":"https://doi.org/10.4103/0973-8258.49376","pdf_url":null,"source":{"id":"https://openalex.org/S52073246","display_name":"International Journal of Green Pharmacy","issn_l":"0973-8258","issn":["0973-8258","1998-4103"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Green Pharmacy","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2128561069"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081924009","display_name":"Rajendra Kotadiya","orcid":"https://orcid.org/0000-0002-5484-874X","observed_orcids":["https://orcid.org/0000-0002-5484-874X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Kotadiya","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"V Patel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V Patel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112895994","display_name":"Harsha Patel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Patel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5024731589","display_name":"H Koradiya","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Koradiya","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4446,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.56018605,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"3","issue":"1","first_page":"58","last_page":"58"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12048","display_name":"Microencapsulation and Drying Processes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chitosan","display_name":"chitosan","score":0.8339999914169312},{"id":"https://openalex.org/keywords/clarithromycin","display_name":"clarithromycin","score":0.9210000038146973},{"id":"https://openalex.org/keywords/mucoadhesive-microspheres","display_name":"mucoadhesive microspheres","score":0.9900000095367432},{"id":"https://openalex.org/keywords/glutaraldehyde-crosslinking","display_name":"glutaraldehyde crosslinking","score":0.9570000171661377},{"id":"https://openalex.org/keywords/gastric-ulcer","display_name":"gastric ulcer","score":0.3499999940395355},{"id":"https://openalex.org/keywords/sustained-release","display_name":"sustained drug release","score":0.7689999938011169},{"id":"https://openalex.org/keywords/encapsulation-efficiency","display_name":"encapsulation efficiency","score":0.8809999823570251},{"id":"https://openalex.org/keywords/mucoadhesion","display_name":"mucoadhesion","score":0.9509999752044678},{"id":"https://openalex.org/keywords/factorial-design-optimization","display_name":"factorial design optimization","score":0.7350000143051147}],"concepts":[{"id":"https://openalex.org/C2779732960","wikidata":"https://www.wikidata.org/wiki/Q408510","display_name":"Chitosan","level":2,"score":0.8316417932510376},{"id":"https://openalex.org/C189942447","wikidata":"https://www.wikidata.org/wiki/Q61186","display_name":"Microsphere","level":2,"score":0.813948392868042},{"id":"https://openalex.org/C169222746","wikidata":"https://www.wikidata.org/wiki/Q4116558","display_name":"Factorial experiment","level":2,"score":0.7665241360664368},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4794941544532776},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.256850004196167},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.24275252223014832},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.07424807548522949},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.07332006096839905},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.03848838806152344}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4103/0973-8258.49376","doi":"https://doi.org/10.4103/0973-8258.49376","is_oa":false,"landing_page_url":"https://doi.org/10.4103/0973-8258.49376","pdf_url":null,"source":{"id":"https://openalex.org/S52073246","display_name":"International Journal of Green Pharmacy","issn_l":"0973-8258","issn":["0973-8258","1998-4103"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Green Pharmacy","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1986189423","https://openalex.org/W2009338923","https://openalex.org/W2038353794","https://openalex.org/W3004555802","https://openalex.org/W2474124373","https://openalex.org/W3012176439","https://openalex.org/W2511619449","https://openalex.org/W1993528259","https://openalex.org/W2886230272","https://openalex.org/W7098318664"],"abstract_inverted_index":{"The":[0,72,117,140,159],"objective":[1],"of":[2,12,23,84,92,136,149,213],"the":[3,53,82,85,125,167,203,211],"present":[4],"study":[5],"was":[6,66,157,164,181,187],"to":[7,14,25,98,220,231],"develop":[8],"chitosan-based":[9],"mucoadhesive":[10,30,122,224,244],"microspheres":[11,31,74,118,163,218,245],"Clarithromycin,":[13,230],"provide":[15],"a":[16,48,59,70,120,133,144],"prolonged":[17],"contact":[18],"time":[19,91,209],"for":[20,64,175,228],"drug":[21,105,137,146,160,184,225],"delivery":[22,226],"antibiotics,":[24],"treat":[26,232],"stomach":[27,233],"ulcers.":[28,234],"Chitosan":[29],"with":[32,96,189],"small":[33],"particle":[34],"size":[35],"and":[36,90,107,114,130,151,195,206],"good":[37,121],"sphericity":[38],"were":[39,75,111],"prepared":[40,73],"by":[41,77,166,172],"an":[42,190,196],"emulsification":[43],"technique":[44],"using":[45,81],"glutaraldehyde":[46,193,204],"as":[47,58,69],"cross":[49,61,86,93,199,207,239],"linking":[50,87,94,200,208],"agent.":[51],"Glutaraldehyde,":[52],"aldehyde":[54],"most":[55],"frequently":[56],"employed":[57],"chemical":[60],"linker":[62],"agent":[63,88],"proteins,":[65],"also":[67,131],"used":[68],"control.":[71],"optimized":[76],"32":[78],"factorial":[79,241],"design,":[80,242],"concentration":[83,194,205],"(X1)":[89],"(X2)":[95],"respect":[97],"their":[99],"morphological":[100],"aspects,":[101],"percentage":[102,108,135,152,212],"entrapment,":[103],"in-vitro":[104],"release":[106,161,174],"mucoadhesion.":[109],"Microspheres":[110],"discrete,":[112],"spherical":[113],"free":[115],"flowing.":[116],"exhibited":[119,143],"property":[123],"in":[124,126,192,198],"vitro":[127],"wash-off":[128],"test":[129],"showed":[132],"high":[134,145],"entrapment":[138,147,185],"efficiency.":[139],"best":[141],"batch":[142],"efficiency":[148,186],"45%":[150],"mucoadhesion":[153,214],"after":[154],"5":[155],"hours":[156],"15%.":[158],"from":[162],"characterized":[165],"initial":[168],"burst":[169],"effect":[170],"followed":[171],"sustained":[173],"more":[176],"than":[177],"12":[178],"hours.":[179],"It":[180],"concluded":[182],"that":[183],"increased":[188],"increase":[191,197],"time.":[201],"As":[202],"increased,":[210],"decreased.":[215],"Thus":[216],"chitosan":[217],"appeared":[219],"be,":[221],"technically,":[222],"promising":[223],"systems":[227],"delivering":[229],"Key":[235],"words:":[236],"Chitosan,":[237],"clarithromycin,":[238],"linking,":[240],"glutaraldehyde,":[243]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}
