{"id":"https://openalex.org/W2128536686","doi":"https://doi.org/10.1083/jcb.107.4.1449","title":"Tau proteins: the molecular structure and mode of binding on microtubules.","display_name":"Tau proteins: the molecular structure and mode of binding on microtubules.","publication_year":1988,"publication_date":"1988-10-01","ids":{"openalex":"https://openalex.org/W2128536686","doi":"https://doi.org/10.1083/jcb.107.4.1449","mag":"2128536686","pmid":"https://pubmed.ncbi.nlm.nih.gov/3139677","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2115262"},"language":"en","primary_location":{"id":"doi:10.1083/jcb.107.4.1449","doi":"https://doi.org/10.1083/jcb.107.4.1449","is_oa":false,"landing_page_url":"https://doi.org/10.1083/jcb.107.4.1449","pdf_url":null,"source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of cell biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2115262","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065735206","display_name":"Nobutaka Hirokawa","orcid":"https://orcid.org/0000-0002-0081-5264","observed_orcids":["https://orcid.org/0000-0002-0081-5264"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"N Hirokawa","raw_affiliation_strings":["Department of Anatomy and Cell Biology, Medical School, University of Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Cell Biology, Medical School, University of Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030768232","display_name":"Yoko Shiomura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Y Shiomura","raw_affiliation_strings":["Department of Anatomy and Cell Biology, Medical School, University of Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Cell Biology, Medical School, University of Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054212150","display_name":"Shigeo Okabe","orcid":"https://orcid.org/0000-0003-1216-8890","observed_orcids":["https://orcid.org/0000-0003-1216-8890"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"S Okabe","raw_affiliation_strings":["Department of Anatomy and Cell Biology, Medical School, University of Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Cell Biology, Medical School, University of Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I74801974"],"apc_list":null,"apc_paid":null,"fwci":5.9859,"has_fulltext":false,"cited_by_count":415,"citation_normalized_percentile":{"value":0.97707604,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"107","issue":"4","first_page":"1449","last_page":"1459"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.8022000193595886,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.8022000193595886,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.18299999833106995,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tau-protein","display_name":"tau protein","score":0.8870000243186951},{"id":"https://openalex.org/keywords/microtubules","display_name":"microtubules","score":0.9079999923706055},{"id":"https://openalex.org/keywords/microtubule-lattice","display_name":"microtubule lattice","score":0.6779999732971191},{"id":"https://openalex.org/keywords/map1a","display_name":"MAP1A","score":0.8730000257492065},{"id":"https://openalex.org/keywords/competitive-binding","display_name":"competitive binding","score":0.5350000262260437},{"id":"https://openalex.org/keywords/axons","display_name":"axons","score":0.5720000267028809},{"id":"https://openalex.org/keywords/neurons","display_name":"neurons","score":0.4580000042915344}],"concepts":[{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.9263837337493896},{"id":"https://openalex.org/C84425145","wikidata":"https://www.wikidata.org/wiki/Q422492","display_name":"Tubulin","level":3,"score":0.7606334686279297},{"id":"https://openalex.org/C2779546866","wikidata":"https://www.wikidata.org/wiki/Q531306","display_name":"Dimer","level":2,"score":0.7184865474700928},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.617711067199707},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5896773338317871},{"id":"https://openalex.org/C61081601","wikidata":"https://www.wikidata.org/wiki/Q1102066","display_name":"Microtubule-associated protein","level":3,"score":0.520694375038147},{"id":"https://openalex.org/C2778670691","wikidata":"https://www.wikidata.org/wiki/Q419507","display_name":"Tau protein","level":4,"score":0.4906977415084839},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.39675092697143555},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2582757771015167},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.17197659611701965},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.1294088363647461},{"id":"https://openalex.org/C46141821","wikidata":"https://www.wikidata.org/wiki/Q209402","display_name":"Nuclear magnetic resonance","level":1,"score":0.0945717990398407},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005613","descriptor_name":"Freeze Etching","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008869","descriptor_name":"Microtubule-Associated Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008869","descriptor_name":"Microtubule-Associated Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014404","descriptor_name":"Tubulin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1083/jcb.107.4.1449","doi":"https://doi.org/10.1083/jcb.107.4.1449","is_oa":false,"landing_page_url":"https://doi.org/10.1083/jcb.107.4.1449","pdf_url":null,"source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of cell biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2115262","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2115262","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cell Biol","raw_type":"Text"},{"id":"pmid:3139677","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3139677","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of cell biology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.277.6570","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.277.6570","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/62/21/J_Cell_Biol_1988_Oct_1_107(4)_1449-1459.tar.gz","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.334.7400","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.334.7400","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jcb.rupress.org/content/107/4/1449.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2115262","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2115262","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cell Biol","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W1534841581","https://openalex.org/W1562721449","https://openalex.org/W1611407165","https://openalex.org/W1929269608","https://openalex.org/W1967986618","https://openalex.org/W1969831036","https://openalex.org/W1971165215","https://openalex.org/W1975040221","https://openalex.org/W1982610985","https://openalex.org/W1994030229","https://openalex.org/W1995562130","https://openalex.org/W2012116143","https://openalex.org/W2014636427","https://openalex.org/W2018289835","https://openalex.org/W2023519337","https://openalex.org/W2027321010","https://openalex.org/W2032342779","https://openalex.org/W2034623311","https://openalex.org/W2037319070","https://openalex.org/W2044871094","https://openalex.org/W2047964353","https://openalex.org/W2053082340","https://openalex.org/W2060458492","https://openalex.org/W2062056783","https://openalex.org/W2065655530","https://openalex.org/W2068277146","https://openalex.org/W2073289396","https://openalex.org/W2078349619","https://openalex.org/W2091341876","https://openalex.org/W2097611008","https://openalex.org/W2100837269","https://openalex.org/W2105480231","https://openalex.org/W2106229148","https://openalex.org/W2115131844","https://openalex.org/W2120816696","https://openalex.org/W2128635872","https://openalex.org/W2159159780","https://openalex.org/W2166585705","https://openalex.org/W2167645201","https://openalex.org/W2397551719","https://openalex.org/W2405638106","https://openalex.org/W4256350582"],"related_works":["https://openalex.org/W7134686168","https://openalex.org/W4231020164","https://openalex.org/W2912869834","https://openalex.org/W2022417585","https://openalex.org/W2127229268","https://openalex.org/W7084305494","https://openalex.org/W7100759490","https://openalex.org/W2153104556","https://openalex.org/W4416525610","https://openalex.org/W2124306462"],"abstract_inverted_index":{"Tau":[0,170],"is":[1,38],"a":[2],"family":[3],"of":[4,26,50,64,71,121,134,155,161,201],"closely":[5,39],"related":[6],"proteins":[7],"(55,000-62,000":[8],"mol":[9],"wt)":[10],"which":[11],"are":[12,189,209],"contained":[13,190],"in":[14,28,159,191],"the":[15,24,42,54,61,65,76,98,117,122,131,138,145,150,198,206],"nerve":[16],"cells":[17],"and":[18,45,68,81,97,140,187,203],"copolymerize":[19],"with":[20,95],"tubulin":[21,89,158],"to":[22,41,125,143],"induce":[23],"formation":[25],"microtubules":[27,74,139,164],"vitro.":[29],"All":[30],"information":[31],"so":[32],"far":[33],"has":[34],"indicated":[35],"that":[36,197],"tau":[37,66,96,135,156,162,186,202],"apposed":[40],"microtubule":[43,55,118,207],"lattice,":[44],"there":[46],"was":[47,93,165],"no":[48],"indication":[49],"domains":[51],"projecting":[52,115],"from":[53,90,116],"polymer":[56],"lattice.":[57],"We":[58,105,129],"have":[59],"studied":[60],"molecular":[62],"structure":[63],"factor":[67],"its":[69],"mode":[70],"binding":[72,194,199],"on":[73,137,173,176,205],"using":[75],"quick-freeze,":[77],"deep-etch":[78],"method":[79],"(QF.DE)":[80],"low":[82],"angle":[83],"rotary":[84],"shadowing":[85],"technique.":[86],"Phosphocellulose":[87],"column-purified":[88],"porcine":[91],"brain":[92],"polymerized":[94],"centrifuged":[99],"pellets":[100],"were":[101],"processed":[102],"by":[103],"QF.DE.":[104],"observed":[106],"periodic":[107],"armlike":[108],"elements":[109],"(18.7":[110],"+/-":[111,180],"4.8":[112],"nm":[113,182],"long)":[114],"surface.":[119],"Most":[120],"projections":[123,136],"appeared":[124],"cross-link":[126],"adjacent":[127],"microtubules.":[128],"measured":[130],"longitudinal":[132],"periodicity":[133],"found":[141],"it":[142],"match":[144],"6-dimer":[146],"pattern":[147],"better":[148],"than":[149],"12-dimer":[151],"pattern.":[152],"The":[153],"stoichiometry":[154],"versus":[157],"preparations":[160],"saturated":[163],"1:approximately":[166],"5.0":[167],"(molar":[168],"ratio).":[169],"molecules":[171],"adsorbed":[172],"mica":[174],"took":[175],"rodlike":[177],"forms":[178],"(56.1":[179],"14.1":[181],"long).":[183],"Although":[184],"both":[185],"MAP1":[188],"axons,":[192],"competitive":[193],"studies":[195],"demonstrated":[196],"sites":[200],"MAP1A":[204],"surfaces":[208],"most":[210],"distinct,":[211],"although":[212],"they":[213],"may":[214],"partially":[215],"overlap.":[216]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":15},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":15},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":17}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
