{"id":"https://openalex.org/W2128536554","doi":"https://doi.org/10.2337/diab.37.9.1168","title":"Alteration of 1,2-Diacylglycerol Content in Myocardium From Diabetic Rats","display_name":"Alteration of 1,2-Diacylglycerol Content in Myocardium From Diabetic Rats","publication_year":1988,"publication_date":"1988-09-01","ids":{"openalex":"https://openalex.org/W2128536554","doi":"https://doi.org/10.2337/diab.37.9.1168","mag":"2128536554","pmid":"https://pubmed.ncbi.nlm.nih.gov/3044883"},"language":"en","primary_location":{"id":"doi:10.2337/diab.37.9.1168","doi":"https://doi.org/10.2337/diab.37.9.1168","is_oa":false,"landing_page_url":"https://doi.org/10.2337/diab.37.9.1168","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075895632","display_name":"Kenji Okumura","orcid":"https://orcid.org/0000-0002-7751-2624","observed_orcids":["https://orcid.org/0000-0002-7751-2624","https://orcid.org/0000-0003-1396-3001"]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenji Okumura","raw_affiliation_strings":["Department of Internal Medicine, Nagoya University School of Medicine\u2008Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Nagoya University School of Medicine\u2008Nagoya, Japan","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109352521","display_name":"Naohiko Akiyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naohiko Akiyama","raw_affiliation_strings":["Department of Internal Medicine, Nagoya University School of Medicine\u2008Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Nagoya University School of Medicine\u2008Nagoya, Japan","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113592693","display_name":"Hidekazu Hashimoto","orcid":"https://orcid.org/0000-0002-2548-3534","observed_orcids":["https://orcid.org/0000-0002-2548-3534"]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hidekazu Hashimoto","raw_affiliation_strings":["Department of Internal Medicine, Nagoya University School of Medicine\u2008Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Nagoya University School of Medicine\u2008Nagoya, Japan","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111793060","display_name":"Kouichi Ogawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kouichi Ogawa","raw_affiliation_strings":["Department of Internal Medicine, Nagoya University School of Medicine\u2008Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Nagoya University School of Medicine\u2008Nagoya, Japan","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109962309","display_name":"Tatsuo Satake","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tatsuo Satake","raw_affiliation_strings":["Department of Internal Medicine, Nagoya University School of Medicine\u2008Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Nagoya University School of Medicine\u2008Nagoya, Japan","institution_ids":["https://openalex.org/I60134161"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I60134161"],"apc_list":null,"apc_paid":null,"fwci":5.3044,"has_fulltext":false,"cited_by_count":65,"citation_normalized_percentile":{"value":0.96099837,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"37","issue":"9","first_page":"1168","last_page":"1172"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.7529000043869019,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.7529000043869019,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.07569999992847443,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.035599999129772186,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/1-2-diacylglycerol","display_name":"1,2-diacylglycerol","score":0.9990000128746033},{"id":"https://openalex.org/keywords/myocardium","display_name":"myocardium","score":0.8510000109672546},{"id":"https://openalex.org/keywords/streptozotocin-induced-diabetes","display_name":"streptozotocin-induced diabetes","score":0.9179999828338623},{"id":"https://openalex.org/keywords/insulin-therapy","display_name":"insulin therapy","score":0.7710000276565552},{"id":"https://openalex.org/keywords/diabetic-cardiomyopathy","display_name":"diabetic cardiomyopathy","score":0.9319999814033508},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.8050000071525574},{"id":"https://openalex.org/keywords/phospholipids","display_name":"phospholipids","score":0.8420000076293945},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.9490000009536743},{"id":"https://openalex.org/keywords/cholesterol","display_name":"cholesterol","score":0.9829999804496765},{"id":"https://openalex.org/keywords/second-messengers","display_name":"second messengers","score":0.5590000152587891},{"id":"https://openalex.org/keywords/diabetic-rats","display_name":"diabetic rats","score":0.5960000157356262}],"concepts":[{"id":"https://openalex.org/C36020004","wikidata":"https://www.wikidata.org/wiki/Q106951674","display_name":"Diacylglycerol kinase","level":4,"score":0.9467710256576538},{"id":"https://openalex.org/C2911120302","wikidata":"https://www.wikidata.org/wiki/Q257331","display_name":"Streptozocin","level":4,"score":0.8821540474891663},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8636152148246765},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8420811891555786},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.6689461469650269},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.612512469291687},{"id":"https://openalex.org/C2776553924","wikidata":"https://www.wikidata.org/wiki/Q5270132","display_name":"Diabetic cardiomyopathy","level":4,"score":0.5411388874053955},{"id":"https://openalex.org/C2776387844","wikidata":"https://www.wikidata.org/wiki/Q161466","display_name":"Diglyceride","level":3,"score":0.4877055585384369},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4437372088432312},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.42997249960899353},{"id":"https://openalex.org/C2779280383","wikidata":"https://www.wikidata.org/wiki/Q257331","display_name":"Streptozotocin","level":3,"score":0.29947221279144287},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.25991204380989075},{"id":"https://openalex.org/C2778797674","wikidata":"https://www.wikidata.org/wiki/Q847583","display_name":"Cardiomyopathy","level":3,"score":0.2524024248123169},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.1454870104789734},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.12096178531646729},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08822539448738098},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.06065714359283447}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004075","descriptor_name":"Diglycerides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005989","descriptor_name":"Glycerides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.2337/diab.37.9.1168","doi":"https://doi.org/10.2337/diab.37.9.1168","is_oa":false,"landing_page_url":"https://doi.org/10.2337/diab.37.9.1168","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},{"id":"doi:10.2337/diabetes.37.9.1168","doi":"https://doi.org/10.2337/diabetes.37.9.1168","is_oa":false,"landing_page_url":"https://doi.org/10.2337/diabetes.37.9.1168","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},{"id":"pmid:3044883","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3044883","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1991590385","https://openalex.org/W2043206882","https://openalex.org/W2587143396","https://openalex.org/W2310659789","https://openalex.org/W2041330839","https://openalex.org/W2090998943","https://openalex.org/W2075973812","https://openalex.org/W7145242770","https://openalex.org/W2082978591","https://openalex.org/W2077304944"],"abstract_inverted_index":{"1,2-Diacylglycerol":[0],"has":[1],"been":[2],"proposed":[3],"to":[4,49,110],"be":[5],"a":[6,185],"secondary":[7],"messenger;":[8],"therefore,":[9],"in":[10,19,80,92,115,122,137,145,154,164,192,208],"this":[11,170],"study":[12,171],"we":[13],"evaluated":[14],"the":[15,28,81,87,93,116,123,131,155,174,193,203,211,214,219],"amount":[16],"of":[17,30,47,53,62,69,74,142,150,169,176,195,202,221],"1,2-diacylglycerol":[18,34,113,132,165,187,207,216],"heart":[20],"tissue":[21],"from":[22],"streptozocin-induced":[23],"diabetic":[24,82,124,156],"rats":[25,37,125,138],"and":[26,41,44,89,100,106,218],"examined":[27],"effect":[29],"insulin":[31,70,104,224],"treatment":[32,153],"on":[33],"content.":[35,166],"Diabetic":[36],"had":[38],"lower":[39],"body":[40,50],"ventricular":[42,48],"weights":[43],"higher":[45,136],"ratios":[46],"weight,":[51],"all":[52],"which":[54,189],"shifted":[55],"toward":[56],"normal":[57],"values":[58],"after":[59],"4":[60,67,140],"wk":[61,68,141,149],"untreated":[63],"diabetes":[64,143,222],"followed":[65],"by":[66,97,103,179,223],"treatment.":[71],"The":[72,112,167],"contents":[73,91],"major":[75],"phospholipids":[76],"were":[77,95],"significantly":[78,120,135],"depressed":[79],"rat":[83],"hearts.":[84],"In":[85],"contrast,":[86],"triglyceride":[88],"cholesterol":[90],"myocardium":[94,117],"increased":[96],"streptozocin":[98,180],"injection":[99,181],"completely":[101],"normalized":[102],"treatment,":[105],"glucose":[107],"levels":[108],"returned":[109],"normal.":[111],"content":[114,133],"was":[118,134],"also":[119],"elevated":[121],"compared":[126],"with":[127,139,147,184],"age-matched":[128],"controls.":[129],"Moreover,":[130],"than":[144],"those":[146],"8":[148],"diabetes.":[151],"Insulin":[152,199],"rats,":[157],"however,":[158,210],"did":[159],"not":[160],"produce":[161],"any":[162],"decrease":[163],"results":[168],"suggest":[172],"that":[173,205],"development":[175],"cardiomyopathy":[177],"induced":[178],"is":[182,200,226],"associated":[183],"high":[186],"level,":[188],"may":[190],"result":[191],"activation":[194],"protein":[196],"kinase":[197],"C.":[198],"one":[201],"agonists":[204],"generates":[206],"myocytes;":[209],"relationship":[212],"between":[213],"sustained":[215],"level":[217],"normalization":[220],"administration":[225],"unclear.":[227]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
