{"id":"https://openalex.org/W2128519670","doi":"https://doi.org/10.1200/jco.2010.31.5911","title":"Intravenous Calcium and Magnesium for Oxaliplatin-Induced Sensory Neurotoxicity in Adjuvant Colon Cancer: NCCTG N04C7","display_name":"Intravenous Calcium and Magnesium for Oxaliplatin-Induced Sensory Neurotoxicity in Adjuvant Colon Cancer: NCCTG N04C7","publication_year":2010,"publication_date":"2010-12-29","ids":{"openalex":"https://openalex.org/W2128519670","doi":"https://doi.org/10.1200/jco.2010.31.5911","mag":"2128519670","pmid":"https://pubmed.ncbi.nlm.nih.gov/21189381"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2010.31.5911","doi":"https://doi.org/10.1200/jco.2010.31.5911","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2010.31.5911","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3058288","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057458005","display_name":"Axel F. Grothey","orcid":"https://orcid.org/0000-0002-9341-6499","observed_orcids":["https://orcid.org/0000-0002-9341-6499"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I2801420484","display_name":"Altru Health System","ror":"https://ror.org/01f8v1064","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801420484"]},{"id":"https://openalex.org/I4210090204","display_name":"Missouri Valley Cancer Consortium","ror":"https://ror.org/009dch554","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210090204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Axel Grothey","raw_affiliation_strings":["From the Mayo Clinic Rochester, Rochester; Duluth Community Clinical Oncology Program (CCOP), Duluth; CentraCare Clinic, St Cloud, MN; Illinois Oncology Research Association CCOP, Peoria, IL; Missouri Valley Cancer Consortium, Omaha, NE; Altru Health Systems, Grand Forks, ND; Siouxland Hematology-Oncology Associates, Sioux City, IA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Mayo Clinic Rochester, Rochester; Duluth Community Clinical Oncology Program (CCOP), Duluth; CentraCare Clinic, St Cloud, MN; Illinois Oncology Research Association CCOP, Peoria, IL; Missouri Valley Cancer Consortium, Omaha, NE; Altru Health Systems, Grand Forks, ND; Siouxland Hematology-Oncology Associates, Sioux City, IA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I2801420484","https://openalex.org/I4210090204"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081957836","display_name":"Daniel A. Nikcevich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I2801420484","display_name":"Altru Health System","ror":"https://ror.org/01f8v1064","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801420484"]},{"id":"https://openalex.org/I4210090204","display_name":"Missouri Valley Cancer Consortium","ror":"https://ror.org/009dch554","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210090204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel A. Nikcevich","raw_affiliation_strings":["From the Mayo Clinic Rochester, Rochester; Duluth Community Clinical Oncology Program (CCOP), Duluth; CentraCare Clinic, St Cloud, MN; Illinois Oncology Research Association CCOP, Peoria, IL; Missouri Valley Cancer Consortium, Omaha, NE; Altru Health Systems, Grand Forks, ND; Siouxland Hematology-Oncology Associates, Sioux City, IA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Mayo Clinic Rochester, Rochester; Duluth Community Clinical Oncology Program (CCOP), Duluth; CentraCare Clinic, St Cloud, MN; Illinois Oncology Research Association CCOP, Peoria, IL; Missouri Valley Cancer Consortium, Omaha, NE; Altru Health Systems, Grand Forks, ND; Siouxland Hematology-Oncology Associates, Sioux City, IA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I2801420484","https://openalex.org/I4210090204"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072257104","display_name":"Jeff A. Sloan","orcid":"https://orcid.org/0000-0002-3393-2387","observed_orcids":["https://orcid.org/0000-0002-3393-2387"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I2801420484","display_name":"Altru Health System","ror":"https://ror.org/01f8v1064","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801420484"]},{"id":"https://openalex.org/I4210090204","display_name":"Missouri Valley Cancer Consortium","ror":"https://ror.org/009dch554","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210090204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeff A. Sloan","raw_affiliation_strings":["From the Mayo Clinic Rochester, Rochester; Duluth Community Clinical Oncology Program (CCOP), Duluth; CentraCare Clinic, St Cloud, MN; Illinois Oncology Research Association CCOP, Peoria, IL; Missouri Valley Cancer Consortium, Omaha, NE; Altru Health Systems, Grand Forks, ND; Siouxland Hematology-Oncology Associates, Sioux City, IA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Mayo Clinic Rochester, Rochester; Duluth Community Clinical Oncology Program (CCOP), Duluth; CentraCare Clinic, St Cloud, MN; Illinois Oncology Research Association CCOP, Peoria, IL; Missouri Valley Cancer Consortium, Omaha, NE; Altru Health Systems, Grand Forks, ND; Siouxland Hematology-Oncology Associates, Sioux City, IA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I2801420484","https://openalex.org/I4210090204"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112218423","display_name":"John W. Kugler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I2801420484","display_name":"Altru Health System","ror":"https://ror.org/01f8v1064","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801420484"]},{"id":"https://openalex.org/I4210090204","display_name":"Missouri Valley Cancer Consortium","ror":"https://ror.org/009dch554","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210090204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John W. Kugler","raw_affiliation_strings":["From the Mayo Clinic Rochester, Rochester; Duluth Community Clinical Oncology Program (CCOP), Duluth; CentraCare Clinic, St Cloud, MN; Illinois Oncology Research Association CCOP, Peoria, IL; Missouri Valley Cancer Consortium, Omaha, NE; Altru Health Systems, Grand Forks, ND; Siouxland Hematology-Oncology Associates, Sioux City, IA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Mayo Clinic Rochester, Rochester; Duluth Community Clinical Oncology Program (CCOP), Duluth; CentraCare Clinic, St Cloud, MN; Illinois Oncology Research Association CCOP, Peoria, IL; Missouri Valley Cancer Consortium, Omaha, NE; Altru Health Systems, Grand Forks, ND; Siouxland Hematology-Oncology Associates, Sioux City, IA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I2801420484","https://openalex.org/I4210090204"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061188498","display_name":"Peter T. Silberstein","orcid":"https://orcid.org/0000-0003-1207-0287","observed_orcids":["https://orcid.org/0000-0003-1207-0287"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I2801420484","display_name":"Altru Health System","ror":"https://ror.org/01f8v1064","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801420484"]},{"id":"https://openalex.org/I4210090204","display_name":"Missouri Valley Cancer Consortium","ror":"https://ror.org/009dch554","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210090204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter T. Silberstein","raw_affiliation_strings":["From the Mayo Clinic Rochester, Rochester; Duluth Community Clinical Oncology Program (CCOP), Duluth; CentraCare Clinic, St Cloud, MN; Illinois Oncology Research Association CCOP, Peoria, IL; Missouri Valley Cancer Consortium, Omaha, NE; Altru Health Systems, Grand Forks, ND; Siouxland Hematology-Oncology Associates, Sioux City, IA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Mayo Clinic Rochester, Rochester; Duluth Community Clinical Oncology Program (CCOP), Duluth; CentraCare Clinic, St Cloud, MN; Illinois Oncology Research Association CCOP, Peoria, IL; Missouri Valley Cancer Consortium, Omaha, NE; Altru Health Systems, Grand Forks, ND; Siouxland Hematology-Oncology Associates, Sioux City, IA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I2801420484","https://openalex.org/I4210090204"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056482863","display_name":"Todor Dentchev","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I2801420484","display_name":"Altru Health System","ror":"https://ror.org/01f8v1064","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801420484"]},{"id":"https://openalex.org/I4210090204","display_name":"Missouri Valley Cancer Consortium","ror":"https://ror.org/009dch554","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210090204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Todor Dentchev","raw_affiliation_strings":["From the Mayo Clinic Rochester, Rochester; Duluth Community Clinical Oncology Program (CCOP), Duluth; CentraCare Clinic, St Cloud, MN; Illinois Oncology Research Association CCOP, Peoria, IL; Missouri Valley Cancer Consortium, Omaha, NE; Altru Health Systems, Grand Forks, ND; Siouxland Hematology-Oncology Associates, Sioux City, IA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Mayo Clinic Rochester, Rochester; Duluth Community Clinical Oncology Program (CCOP), Duluth; CentraCare Clinic, St Cloud, MN; Illinois Oncology Research Association CCOP, Peoria, IL; Missouri Valley Cancer Consortium, Omaha, NE; Altru Health Systems, Grand Forks, ND; Siouxland Hematology-Oncology Associates, Sioux City, IA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I2801420484","https://openalex.org/I4210090204"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078543517","display_name":"Donald B. Wender","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I2801420484","display_name":"Altru Health System","ror":"https://ror.org/01f8v1064","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801420484"]},{"id":"https://openalex.org/I4210090204","display_name":"Missouri Valley Cancer Consortium","ror":"https://ror.org/009dch554","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210090204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donald B. Wender","raw_affiliation_strings":["From the Mayo Clinic Rochester, Rochester; Duluth Community Clinical Oncology Program (CCOP), Duluth; CentraCare Clinic, St Cloud, MN; Illinois Oncology Research Association CCOP, Peoria, IL; Missouri Valley Cancer Consortium, Omaha, NE; Altru Health Systems, Grand Forks, ND; Siouxland Hematology-Oncology Associates, Sioux City, IA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Mayo Clinic Rochester, Rochester; Duluth Community Clinical Oncology Program (CCOP), Duluth; CentraCare Clinic, St Cloud, MN; Illinois Oncology Research Association CCOP, Peoria, IL; Missouri Valley Cancer Consortium, Omaha, NE; Altru Health Systems, Grand Forks, ND; Siouxland Hematology-Oncology Associates, Sioux City, IA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I2801420484","https://openalex.org/I4210090204"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013202100","display_name":"Paul J. Novotny","orcid":"https://orcid.org/0000-0002-1526-9817","observed_orcids":["https://orcid.org/0000-0002-1526-9817"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I2801420484","display_name":"Altru Health System","ror":"https://ror.org/01f8v1064","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801420484"]},{"id":"https://openalex.org/I4210090204","display_name":"Missouri Valley Cancer Consortium","ror":"https://ror.org/009dch554","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210090204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul J. Novotny","raw_affiliation_strings":["From the Mayo Clinic Rochester, Rochester; Duluth Community Clinical Oncology Program (CCOP), Duluth; CentraCare Clinic, St Cloud, MN; Illinois Oncology Research Association CCOP, Peoria, IL; Missouri Valley Cancer Consortium, Omaha, NE; Altru Health Systems, Grand Forks, ND; Siouxland Hematology-Oncology Associates, Sioux City, IA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Mayo Clinic Rochester, Rochester; Duluth Community Clinical Oncology Program (CCOP), Duluth; CentraCare Clinic, St Cloud, MN; Illinois Oncology Research Association CCOP, Peoria, IL; Missouri Valley Cancer Consortium, Omaha, NE; Altru Health Systems, Grand Forks, ND; Siouxland Hematology-Oncology Associates, Sioux City, IA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I2801420484","https://openalex.org/I4210090204"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062178341","display_name":"Umesh Chitaley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I2801420484","display_name":"Altru Health System","ror":"https://ror.org/01f8v1064","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801420484"]},{"id":"https://openalex.org/I4210090204","display_name":"Missouri Valley Cancer Consortium","ror":"https://ror.org/009dch554","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210090204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Umesh Chitaley","raw_affiliation_strings":["From the Mayo Clinic Rochester, Rochester; Duluth Community Clinical Oncology Program (CCOP), Duluth; CentraCare Clinic, St Cloud, MN; Illinois Oncology Research Association CCOP, Peoria, IL; Missouri Valley Cancer Consortium, Omaha, NE; Altru Health Systems, Grand Forks, ND; Siouxland Hematology-Oncology Associates, Sioux City, IA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Mayo Clinic Rochester, Rochester; Duluth Community Clinical Oncology Program (CCOP), Duluth; CentraCare Clinic, St Cloud, MN; Illinois Oncology Research Association CCOP, Peoria, IL; Missouri Valley Cancer Consortium, Omaha, NE; Altru Health Systems, Grand Forks, ND; Siouxland Hematology-Oncology Associates, Sioux City, IA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I2801420484","https://openalex.org/I4210090204"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019214686","display_name":"Steven R. Alberts","orcid":"https://orcid.org/0000-0002-5835-4122","observed_orcids":["https://orcid.org/0000-0002-5835-4122"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I2801420484","display_name":"Altru Health System","ror":"https://ror.org/01f8v1064","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801420484"]},{"id":"https://openalex.org/I4210090204","display_name":"Missouri Valley Cancer Consortium","ror":"https://ror.org/009dch554","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210090204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven R. Alberts","raw_affiliation_strings":["From the Mayo Clinic Rochester, Rochester; Duluth Community Clinical Oncology Program (CCOP), Duluth; CentraCare Clinic, St Cloud, MN; Illinois Oncology Research Association CCOP, Peoria, IL; Missouri Valley Cancer Consortium, Omaha, NE; Altru Health Systems, Grand Forks, ND; Siouxland Hematology-Oncology Associates, Sioux City, IA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Mayo Clinic Rochester, Rochester; Duluth Community Clinical Oncology Program (CCOP), Duluth; CentraCare Clinic, St Cloud, MN; Illinois Oncology Research Association CCOP, Peoria, IL; Missouri Valley Cancer Consortium, Omaha, NE; Altru Health Systems, Grand Forks, ND; Siouxland Hematology-Oncology Associates, Sioux City, IA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I2801420484","https://openalex.org/I4210090204"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008767553","display_name":"Charles L. Loprinzi","orcid":"https://orcid.org/0000-0001-8044-5752","observed_orcids":["https://orcid.org/0000-0001-8044-5752"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I2801420484","display_name":"Altru Health System","ror":"https://ror.org/01f8v1064","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801420484"]},{"id":"https://openalex.org/I4210090204","display_name":"Missouri Valley Cancer Consortium","ror":"https://ror.org/009dch554","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210090204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles L. Loprinzi","raw_affiliation_strings":["From the Mayo Clinic Rochester, Rochester; Duluth Community Clinical Oncology Program (CCOP), Duluth; CentraCare Clinic, St Cloud, MN; Illinois Oncology Research Association CCOP, Peoria, IL; Missouri Valley Cancer Consortium, Omaha, NE; Altru Health Systems, Grand Forks, ND; Siouxland Hematology-Oncology Associates, Sioux City, IA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Mayo Clinic Rochester, Rochester; Duluth Community Clinical Oncology Program (CCOP), Duluth; CentraCare Clinic, St Cloud, MN; Illinois Oncology Research Association CCOP, Peoria, IL; Missouri Valley Cancer Consortium, Omaha, NE; Altru Health Systems, Grand Forks, ND; Siouxland Hematology-Oncology Associates, Sioux City, IA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I2801420484","https://openalex.org/I4210090204"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":10.5272,"has_fulltext":false,"cited_by_count":198,"citation_normalized_percentile":{"value":0.99098571,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"29","issue":"4","first_page":"421","last_page":"427"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12937","display_name":"Chemotherapy-related skin toxicity","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oxaliplatin","display_name":"oxaliplatin","score":0.9700000286102295},{"id":"https://openalex.org/keywords/calcium-gluconate","display_name":"calcium gluconate","score":0.7300000190734863},{"id":"https://openalex.org/keywords/magnesium-sulfate","display_name":"magnesium sulfate","score":1.0},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.7979999780654907},{"id":"https://openalex.org/keywords/folfox","display_name":"FOLFOX","score":0.9810000061988831},{"id":"https://openalex.org/keywords/chemotherapy-induced-peripheral-neuropathy","display_name":"chemotherapy-induced peripheral neuropathy","score":0.6019999980926514},{"id":"https://openalex.org/keywords/muscle-spasm","display_name":"muscle spasm","score":0.7429999709129333},{"id":"https://openalex.org/keywords/treatment-discontinuation","display_name":"treatment discontinuation","score":0.5920000076293945}],"concepts":[{"id":"https://openalex.org/C2780962732","wikidata":"https://www.wikidata.org/wiki/Q422327","display_name":"Oxaliplatin","level":4,"score":0.9615097045898438},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8923990726470947},{"id":"https://openalex.org/C2777793932","wikidata":"https://www.wikidata.org/wiki/Q1116229","display_name":"Common Terminology Criteria for Adverse Events","level":3,"score":0.6192412376403809},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.4983255863189697},{"id":"https://openalex.org/C2778260052","wikidata":"https://www.wikidata.org/wiki/Q117636","display_name":"FOLFOX","level":5,"score":0.4937673509120941},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4855470359325409},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4648391902446747},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.43407681584358215},{"id":"https://openalex.org/C2777982462","wikidata":"https://www.wikidata.org/wiki/Q2481887","display_name":"Adjuvant therapy","level":3,"score":0.43225157260894775},{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.431879460811615},{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.41514843702316284},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3811831474304199},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3410460650920868},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.32968777418136597},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.2863450050354004},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077150","descriptor_name":"Oxaliplatin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077150","descriptor_name":"Oxaliplatin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077150","descriptor_name":"Oxaliplatin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077150","descriptor_name":"Oxaliplatin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D002125","descriptor_name":"Calcium Gluconate","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002125","descriptor_name":"Calcium Gluconate","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002125","descriptor_name":"Calcium Gluconate","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002125","descriptor_name":"Calcium Gluconate","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007262","descriptor_name":"Infusions, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007262","descriptor_name":"Infusions, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007262","descriptor_name":"Infusions, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007262","descriptor_name":"Infusions, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008278","descriptor_name":"Magnesium Sulfate","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008278","descriptor_name":"Magnesium Sulfate","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008278","descriptor_name":"Magnesium Sulfate","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008278","descriptor_name":"Magnesium Sulfate","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009944","descriptor_name":"Organoplatinum Compounds","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D009944","descriptor_name":"Organoplatinum Compounds","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D009944","descriptor_name":"Organoplatinum Compounds","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D009944","descriptor_name":"Organoplatinum Compounds","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011795","descriptor_name":"Surveys and Questionnaires","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011795","descriptor_name":"Surveys and Questionnaires","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011795","descriptor_name":"Surveys and Questionnaires","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011795","descriptor_name":"Surveys and Questionnaires","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012678","descriptor_name":"Sensation Disorders","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D012678","descriptor_name":"Sensation Disorders","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D012678","descriptor_name":"Sensation Disorders","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D012678","descriptor_name":"Sensation Disorders","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D012678","descriptor_name":"Sensation Disorders","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D012678","descriptor_name":"Sensation Disorders","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D012678","descriptor_name":"Sensation Disorders","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D012678","descriptor_name":"Sensation Disorders","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D012678","descriptor_name":"Sensation Disorders","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D012678","descriptor_name":"Sensation Disorders","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D012678","descriptor_name":"Sensation Disorders","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D012678","descriptor_name":"Sensation Disorders","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016009","descriptor_name":"Chi-Square Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016009","descriptor_name":"Chi-Square Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016009","descriptor_name":"Chi-Square Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016009","descriptor_name":"Chi-Square Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017024","descriptor_name":"Chemotherapy, Adjuvant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017024","descriptor_name":"Chemotherapy, Adjuvant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017024","descriptor_name":"Chemotherapy, Adjuvant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017024","descriptor_name":"Chemotherapy, Adjuvant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D020258","descriptor_name":"Neurotoxicity Syndromes","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D020258","descriptor_name":"Neurotoxicity Syndromes","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D020258","descriptor_name":"Neurotoxicity Syndromes","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D020258","descriptor_name":"Neurotoxicity Syndromes","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D020258","descriptor_name":"Neurotoxicity Syndromes","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D020258","descriptor_name":"Neurotoxicity Syndromes","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D020258","descriptor_name":"Neurotoxicity Syndromes","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D020258","descriptor_name":"Neurotoxicity Syndromes","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D020258","descriptor_name":"Neurotoxicity Syndromes","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D020258","descriptor_name":"Neurotoxicity Syndromes","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D020258","descriptor_name":"Neurotoxicity Syndromes","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D020258","descriptor_name":"Neurotoxicity Syndromes","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057239","descriptor_name":"Early Termination of Clinical Trials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057239","descriptor_name":"Early Termination of Clinical Trials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057239","descriptor_name":"Early Termination of Clinical Trials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057239","descriptor_name":"Early Termination of Clinical Trials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1200/jco.2010.31.5911","doi":"https://doi.org/10.1200/jco.2010.31.5911","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2010.31.5911","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},{"id":"pmid:21189381","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21189381","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical oncology : official journal of the American Society of Clinical Oncology","raw_type":"Clinical Trial, Phase III"},{"id":"pmh:oai:pubmedcentral.nih.gov:3058288","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3058288","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Clin Oncol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3058288","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3058288","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Clin Oncol","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.8399999737739563,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[{"id":"https://openalex.org/G1094409381","display_name":null,"funder_award_id":"CA 35101","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1109514914","display_name":null,"funder_award_id":"CA- 35113","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1423238671","display_name":null,"funder_award_id":"CA- 35269","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1539327064","display_name":null,"funder_award_id":"CA35103","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1672400004","display_name":null,"funder_award_id":"U10 CA035103","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1695119531","display_name":null,"funder_award_id":"U10CA037404","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G179864828","display_name":null,"funder_award_id":"CA35195","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1921431412","display_name":"Illinois Oncology Research Association Community Clinical Oncology Program","funder_award_id":"U10CA035113","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2268849960","display_name":null,"funder_award_id":"U10 CA035195","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2440672419","display_name":null,"funder_award_id":"CA-63849","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3295642875","display_name":null,"funder_award_id":"U10 CA035119","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G358241105","display_name":null,"funder_award_id":"(CA-25224","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3789417232","display_name":null,"funder_award_id":"CA-35415","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G42877212","display_name":null,"funder_award_id":"CA-37404","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G456380056","display_name":null,"funder_award_id":"U10 CA035415","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6127403653","display_name":"North Central Cancer Treatment Group","funder_award_id":"U10CA025224","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6640109214","display_name":"Missouri Valley Cancer Consortium CCOP","funder_award_id":"U10CA063849","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7636075064","display_name":"Duluth Community Clinical Oncology Program","funder_award_id":"U10CA035269","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7860541851","display_name":null,"funder_award_id":"U10 CA063848","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8643337564","display_name":"Iowa Oncology Research Association","funder_award_id":"U10CA035101","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8740717309","display_name":null,"funder_award_id":"N01 CA035119","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G937543590","display_name":null,"funder_award_id":"CA-63848","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1887588978","https://openalex.org/W1978123764","https://openalex.org/W1996167718","https://openalex.org/W1998182007","https://openalex.org/W2071258820","https://openalex.org/W2080382070","https://openalex.org/W2084268808","https://openalex.org/W2089603028","https://openalex.org/W2109054243","https://openalex.org/W2121368761","https://openalex.org/W2122169848","https://openalex.org/W2143028356","https://openalex.org/W2148622949","https://openalex.org/W2171232394","https://openalex.org/W2175773713","https://openalex.org/W2227478494","https://openalex.org/W4245465048"],"related_works":["https://openalex.org/W2809146871","https://openalex.org/W2235788479","https://openalex.org/W3110357236","https://openalex.org/W2037039278","https://openalex.org/W4386281525","https://openalex.org/W2138294834","https://openalex.org/W3140349894","https://openalex.org/W2324769698","https://openalex.org/W180781197","https://openalex.org/W2136984368"],"abstract_inverted_index":{"PURPOSE:":[0],"Cumulative":[1],"sensory":[2],"neurotoxicity":[3],"(sNT)":[4],"is":[5],"the":[6,21,82,136,174,195],"dose-limiting":[7],"toxicity":[8],"of":[9,17,84,130,176],"oxaliplatin,":[10],"which":[11],"commonly":[12],"leads":[13],"to":[14,59,125,143,161],"early":[15,238],"discontinuation":[16],"oxaliplatin-based":[18,98],"therapy":[19,48,99],"in":[20,73,227,257],"palliative":[22],"and":[23,53,69,119,192,234,240],"adjuvant":[24,47,258],"settings.":[25],"In":[26,202],"a":[27,74],"nonrandomized,":[28],"retrospective":[29],"study,":[30],"intravenous":[31],"(IV)":[32],"calcium/magnesium":[33],"(Ca/Mg)":[34],"was":[35,81,138,141,222],"associated":[36,207],"with":[37,43,49,86,208],"reduced":[38,212],"oxaliplatin-induced":[39,254],"sNT.":[40,127],"METHODS:":[41],"Patients":[42],"colon":[44,259],"cancer":[45],"undergoing":[46],"infusional":[50],"fluorouracil,":[51],"leucovorin,":[52],"oxaliplatin":[54,209],"(FOLFOX)":[55],"were":[56,122,134,158,168,210,230],"randomly":[57],"assigned":[58],"Ca/Mg":[60,152,172,233,248],"(1g":[61],"calcium":[62],"gluconate":[63],"plus":[64],"1g":[65],"magnesium":[66],"sulfate":[67],"pre-":[68],"post-oxaliplatin)":[70],"or":[71,89,96,181],"placebo,":[72],"double-blinded":[75],"manner.":[76],"The":[77],"primary":[78],"end":[79],"point":[80],"percentage":[83],"patients":[85,133,167],"grade":[87,179],"2":[88,180],"greater":[90,182],"sNT":[91,117,197,221,256],"at":[92],"any":[93],"time":[94],"during":[95],"after":[97],"by":[100,186,194],"National":[101],"Cancer":[102],"Institute":[103],"Common":[104],"Terminology":[105],"Criteria":[106],"for":[107,170],"Adverse":[108],"Events":[109],"(NCI":[110],"CTCAE;":[111],"version":[112],"3)":[113],"criteria.":[114],"An":[115],"oxaliplatin-specific":[116,196],"scale":[118,198],"patient":[120],"questionnaires":[121],"also":[123,193],"used":[124],"assess":[126],"After":[128],"104":[129],"300":[131],"planned":[132],"enrolled,":[135],"study":[137,245],"closed.":[139],"This":[140],"due":[142],"preliminary":[144],"reports":[145],"from":[146],"another":[147],"trial":[148],"that":[149,151],"suggested":[150],"decreased":[153,173,241],"treatment":[154],"efficacy;":[155],"these":[156],"data":[157],"subsequently":[159],"found":[160],"be":[162],"incorrect.":[163],"RESULTS:":[164],"Overall,":[165],"102":[166],"available":[169],"analysis.":[171],"incidence":[175],"chronic,":[177],"cumulative,":[178],"sNT,":[183],"as":[184,249],"measured":[185],"NCI":[187],"CTCAE":[188],"(P":[189,199,213],"=":[190,200,214],".038)":[191],".018).":[201],"addition,":[203],"acute":[204],"muscle":[205],"spasms":[206],"significantly":[211],".01)":[215],"No":[216,224],"effect":[217],"on":[218],"acute,":[219],"cold-induced":[220],"found.":[223],"substantial":[225],"differences":[226],"adverse":[228],"effects":[229],"noted":[231],"between":[232],"placebo.":[235],"CONCLUSION:":[236],"Despite":[237],"termination":[239],"statistical":[242],"power,":[243],"this":[244],"supports":[246],"IV":[247],"an":[250],"effective":[251],"neuroprotectant":[252],"against":[253],"cumulative":[255],"cancer.":[260]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":22},{"year":2014,"cited_by_count":20},{"year":2013,"cited_by_count":20},{"year":2012,"cited_by_count":31}],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2025-10-10T00:00:00"}