{"id":"https://openalex.org/W2128510941","doi":null,"title":"p15 (INK4B) and E-cadherin CpG island methylation is frequent in Egyptian acute myeloid leukemia.","display_name":"p15 (INK4B) and E-cadherin CpG island methylation is frequent in Egyptian acute myeloid leukemia.","publication_year":2006,"publication_date":"2006-09-01","ids":{"openalex":"https://openalex.org/W2128510941","mag":"2128510941","pmid":"https://pubmed.ncbi.nlm.nih.gov/17671532"},"language":"en","primary_location":{"id":"pmid:17671532","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17671532","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Egyptian National Cancer Institute","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087251090","display_name":"Nayera H. Elshakankiry","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Nayera H El-Shakankiry","raw_affiliation_strings":["The Department of Clinical Pathology, National Cancer Institute, Cairo University, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Clinical Pathology, National Cancer Institute, Cairo University, Egypt","institution_ids":["https://openalex.org/I145487455"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019863392","display_name":"Ghada I. Mossallam","orcid":"https://orcid.org/0000-0001-7112-8624","observed_orcids":["https://orcid.org/0000-0001-7112-8624"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ghada I Mossallam","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4057,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.64768336,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"18","issue":"3","first_page":"227","last_page":"32"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.8070999979972839,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.8070999979972839,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.18700000643730164,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.953000009059906},{"id":"https://openalex.org/keywords/cdkn2b","display_name":"CDKN2B","score":0.9150000214576721},{"id":"https://openalex.org/keywords/e-cadherin","display_name":"E-cadherin","score":0.984000027179718},{"id":"https://openalex.org/keywords/promoter-hypermethylation","display_name":"promoter hypermethylation","score":0.8550000190734863},{"id":"https://openalex.org/keywords/cpg-island-methylation","display_name":"CpG island methylation","score":0.9300000071525574},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.9070000052452087},{"id":"https://openalex.org/keywords/hypomethylating-agents","display_name":"hypomethylating agents","score":0.9160000085830688},{"id":"https://openalex.org/keywords/epigenetic-silencing","display_name":"epigenetic silencing","score":0.7839999794960022},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.8859999775886536},{"id":"https://openalex.org/keywords/egyptian-patients","display_name":"Egyptian patients","score":0.8330000042915344}],"concepts":[{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.8453494310379028},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.8080751895904541},{"id":"https://openalex.org/C2779277951","wikidata":"https://www.wikidata.org/wiki/Q5255196","display_name":"Demethylating agent","level":5,"score":0.6742227077484131},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.6595505475997925},{"id":"https://openalex.org/C140173407","wikidata":"https://www.wikidata.org/wiki/Q1138358","display_name":"CpG site","level":5,"score":0.6505535244941711},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.640325129032135},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.545661211013794},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.4916013181209564},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47176721692085266},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.44246500730514526},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.4239659309387207},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4160955846309662},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.41469258069992065},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31748971343040466},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24668288230895996},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1776846945285797},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.13192227482795715}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004534","descriptor_name":"Egypt","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015820","descriptor_name":"Cadherins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050762","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p15","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:17671532","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17671532","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Egyptian National Cancer Institute","raw_type":"Journal Article"},{"id":"mag:2128510941","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17671532","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W191043282","https://openalex.org/W287045091","https://openalex.org/W1486183464","https://openalex.org/W1492452294","https://openalex.org/W1516326873","https://openalex.org/W1533247917","https://openalex.org/W1912879943","https://openalex.org/W1964769402","https://openalex.org/W1966170687","https://openalex.org/W1971991365","https://openalex.org/W1975924585","https://openalex.org/W2003653617","https://openalex.org/W2006354293","https://openalex.org/W2027847241","https://openalex.org/W2043475782","https://openalex.org/W2054244468","https://openalex.org/W2059223797","https://openalex.org/W2062145659","https://openalex.org/W2066367871","https://openalex.org/W2077317303","https://openalex.org/W2091897357","https://openalex.org/W2112442017","https://openalex.org/W2128146359","https://openalex.org/W2140236449","https://openalex.org/W2140317067","https://openalex.org/W2141566331","https://openalex.org/W2148838874","https://openalex.org/W2177231732","https://openalex.org/W2210620858","https://openalex.org/W2249312162","https://openalex.org/W2399681931","https://openalex.org/W2412410165","https://openalex.org/W2412719483","https://openalex.org/W2470517880"],"related_works":["https://openalex.org/W3012291247","https://openalex.org/W2154837612","https://openalex.org/W7100768082","https://openalex.org/W1974840866","https://openalex.org/W2006354293","https://openalex.org/W2092087093","https://openalex.org/W2760279491","https://openalex.org/W1964627786","https://openalex.org/W2560688416","https://openalex.org/W3177164758"],"abstract_inverted_index":{"BACKGROUND:":[0],"Hypermethylation":[1],"within":[2],"the":[3,32,50,106,143,156,168,172,194,202,205,214,230,238,270,277,292,303],"promoters":[4],"of":[5,21,31,44,52,72,84,142,147,164,186,193,198,213,219,228,237,274,280,294,313],"selected":[6],"genes":[7,241],"is":[8,26,47],"an":[9,66,93,263],"epigenetic":[10],"pathway":[11],"that":[12,249],"appears":[13],"to":[14,48,68,95,268,290],"be":[15,37,76,153,182],"especially":[16],"common":[17],"in":[18,58,65,119,139,167,190,225,234,258,276],"all":[19,197,229],"types":[20],"human":[22],"haematopoeitic":[23],"neoplasms.":[24],"It":[25],"usually":[27],"associated":[28],"with":[29],"inactivation":[30],"involved":[33],"genes,":[34],"and":[35,54,99,115,178,204,221,251,261,272,310],"can":[36],"reversed":[38],"using":[39,128],"demethylating":[40,79,300],"agents.":[41],"The":[42],"aim":[43],"this":[45],"study":[46],"evaluate":[49],"frequency":[51],"p15":[53,114,134,157,220,250],"E-cadherin":[55,116,187,222,252],"promoter":[56,135,253],"methylation":[57,118,129,136,163,185,212,218,254,275],"Egyptian":[59,259],"acute":[60,123],"myeloid":[61,124],"leukemia":[62,125],"(AML)":[63,126],"patients":[64,73,127,295],"attempt":[67],"identify":[69],"a":[70,82,89,161,286],"subset":[71,293],"who":[74,296],"might":[75,297],"candidates":[77],"for":[78,265,306],"agents":[80],"as":[81,88,92],"form":[83],"targeted":[85,307],"therapy":[86],"either":[87],"primary":[90],"or":[91],"adjunct":[94],"current":[96],"standard":[97],"induction":[98],"post-remission":[100],"regimens.":[101],"MATERIAL":[102],"AND":[103],"METHODS:":[104],"In":[105,145,171,196],"present":[107],"work":[108],"we":[109],"have":[110],"studied":[111],"tumor-associated":[112],"aberrant":[113],"promotor":[117],"59":[120],"newly":[121],"diagnosed":[122],"specific":[130],"PCR.":[131],"RESULTS:":[132],"Aberrant":[133,184],"was":[137,188,223],"detected":[138,189,224],"49%":[140],"(29/59)":[141],"patients.":[144],"4":[146],"these":[148,199],"patients,":[149],"no":[150],"DNA":[151,180],"could":[152,181],"amplified":[154,209],"by":[155],"unmethylated":[158,179,206],"reaction":[159],"showing":[160],"complete":[162],"both":[165,176,201,240],"alleles":[166,207],"examined":[169,215],"region.":[170,216],"remaining":[173],"25":[174],"cases":[175,200,231,239],"methylated":[177,203],"amplified.":[183],"63%":[191],"(37/59)":[192],"cases.":[195],"were":[208,242],"denoting":[210],"partial":[211],"Concomitant":[217],"40%":[226],"(23/59)":[227],"tested,":[232],"while":[233],"27%":[235],"(16/59)":[236],"not":[243],"methylated.":[244],"CONCLUSION:":[245],"These":[246],"results":[247],"demonstrate":[248],"are":[255],"frequent":[256],"events":[257],"AML":[260],"provide":[262],"impetus":[264],"larger":[266],"studies":[267],"define":[269,291],"extent":[271],"pattern":[273],"various":[278],"subgroups":[279],"AML.":[281],"Methylation":[282],"studies,":[283],"therefore,":[284],"represent":[285],"novel":[287],"additional":[288],"tool":[289],"benefit":[298],"from":[299],"agents,thus":[301],"providing":[302],"molecular":[304],"basis":[305],"therapeutic":[308],"approaches":[309],"better":[311],"designing":[312],"risk-adapted":[314],"therapy.":[315]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
