{"id":"https://openalex.org/W2128483353","doi":null,"title":"Functional magnetic resonance imaging (fMRI) and effects of L-dopa on visual function in normal and amblyopic subjects.","display_name":"Functional magnetic resonance imaging (fMRI) and effects of L-dopa on visual function in normal and amblyopic subjects.","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W2128483353","mag":"2128483353","pmid":"https://pubmed.ncbi.nlm.nih.gov/14971587","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1358998"},"language":"en","primary_location":{"id":"pmid:14971587","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14971587","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transactions of the American Ophthalmological Society","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1358998/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020343019","display_name":"Gary L. Rogers","orcid":"https://orcid.org/0000-0002-9224-3661","observed_orcids":["https://orcid.org/0000-0002-9224-3661"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gary L Rogers","raw_affiliation_strings":["Department of Ophthalmology, Ohio State University, Children's Hospital, Columbus, Ohio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Ohio State University, Children's Hospital, Columbus, Ohio, USA","institution_ids":["https://openalex.org/I52357470"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5020343019"],"corresponding_institution_ids":["https://openalex.org/I52357470"],"apc_list":null,"apc_paid":null,"fwci":0.7104,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.6302756,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"101","issue":null,"first_page":"401","last_page":"15"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10427","display_name":"Visual perception and processing mechanisms","score":0.7494999766349792,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10427","display_name":"Visual perception and processing mechanisms","score":0.7494999766349792,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10381","display_name":"Ophthalmology and Visual Impairment Studies","score":0.13120000064373016,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.018400000408291817,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amblyopia","display_name":"amblyopia","score":0.9639999866485596},{"id":"https://openalex.org/keywords/levodopa","display_name":"levodopa","score":0.9990000128746033},{"id":"https://openalex.org/keywords/visual-cortex-activation","display_name":"visual cortex activation","score":0.8610000014305115},{"id":"https://openalex.org/keywords/occipital-cortex","display_name":"occipital cortex","score":0.6909999847412109},{"id":"https://openalex.org/keywords/visual-acuity","display_name":"visual acuity","score":0.8259999752044678},{"id":"https://openalex.org/keywords/contrast-sensitivity","display_name":"contrast sensitivity","score":0.9810000061988831},{"id":"https://openalex.org/keywords/stereoacuity","display_name":"stereoacuity","score":0.9279999732971191},{"id":"https://openalex.org/keywords/binocular-fusion","display_name":"binocular fusion","score":0.968999981880188},{"id":"https://openalex.org/keywords/interocular-differences","display_name":"interocular differences","score":0.7419999837875366},{"id":"https://openalex.org/keywords/dopamine","display_name":"dopamine","score":0.367000013589859},{"id":"https://openalex.org/keywords/bold-fmri","display_name":"BOLD fMRI","score":0.597000002861023}],"concepts":[{"id":"https://openalex.org/C2779226451","wikidata":"https://www.wikidata.org/wiki/Q903809","display_name":"Functional magnetic resonance imaging","level":2,"score":0.7238279581069946},{"id":"https://openalex.org/C2779345533","wikidata":"https://www.wikidata.org/wiki/Q75785","display_name":"Visual cortex","level":2,"score":0.6381017565727234},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.5763806104660034},{"id":"https://openalex.org/C2778257484","wikidata":"https://www.wikidata.org/wiki/Q555066","display_name":"Visual acuity","level":2,"score":0.5580452084541321},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5571510195732117},{"id":"https://openalex.org/C2776502983","wikidata":"https://www.wikidata.org/wiki/Q690182","display_name":"Contrast (vision)","level":2,"score":0.5291645526885986},{"id":"https://openalex.org/C168260308","wikidata":"https://www.wikidata.org/wiki/Q7611259","display_name":"Stereoscopic acuity","level":3,"score":0.5286847949028015},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.4482637643814087},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.36518096923828125},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2468273639678955},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.08079653978347778},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.07997456192970276},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000550","descriptor_name":"Amblyopia","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D000550","descriptor_name":"Amblyopia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D003867","descriptor_name":"Depth Perception","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007980","descriptor_name":"Levodopa","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011601","descriptor_name":"Psychophysics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D014785","descriptor_name":"Vision, Ocular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D014792","descriptor_name":"Visual Acuity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015259","descriptor_name":"Dopamine Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015348","descriptor_name":"Vision, Binocular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015350","descriptor_name":"Contrast Sensitivity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmid:14971587","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14971587","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transactions of the American Ophthalmological Society","raw_type":"Clinical Trial"},{"id":"pmh:oai:pubmedcentral.nih.gov:1358998","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1358998/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trans Am Ophthalmol Soc","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.571.8303","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.571.8303","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.aosonline.org/xactions/2003/1545-6110_v101_p401.pdf","raw_type":"text"},{"id":"mag:2128483353","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14971587","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1358998","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1358998/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trans Am Ophthalmol Soc","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W32321936","https://openalex.org/W44967352","https://openalex.org/W50104942","https://openalex.org/W106986633","https://openalex.org/W150326656","https://openalex.org/W362398693","https://openalex.org/W1482811037","https://openalex.org/W1571144263","https://openalex.org/W1870538900","https://openalex.org/W1967009686","https://openalex.org/W1971111983","https://openalex.org/W1972220075","https://openalex.org/W1975449539","https://openalex.org/W1976329750","https://openalex.org/W1978415644","https://openalex.org/W1982280357","https://openalex.org/W1983315432","https://openalex.org/W1994469944","https://openalex.org/W1999908130","https://openalex.org/W2004960346","https://openalex.org/W2006051926","https://openalex.org/W2015169295","https://openalex.org/W2017120165","https://openalex.org/W2023912897","https://openalex.org/W2028235729","https://openalex.org/W2028596158","https://openalex.org/W2044148234","https://openalex.org/W2049625108","https://openalex.org/W2053120614","https://openalex.org/W2056930388","https://openalex.org/W2066063839","https://openalex.org/W2066742904","https://openalex.org/W2074433583","https://openalex.org/W2080104632","https://openalex.org/W2083553909","https://openalex.org/W2084146775","https://openalex.org/W2090687144","https://openalex.org/W2093366270","https://openalex.org/W2093947870","https://openalex.org/W2100224401","https://openalex.org/W2123381982","https://openalex.org/W2144920216","https://openalex.org/W2161550652","https://openalex.org/W2322988415","https://openalex.org/W2337245593","https://openalex.org/W2411494437","https://openalex.org/W2795972199","https://openalex.org/W3009649554","https://openalex.org/W3021510377","https://openalex.org/W4239393439","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2111308791","https://openalex.org/W2063944996","https://openalex.org/W2188118296","https://openalex.org/W7111466745","https://openalex.org/W2066063839","https://openalex.org/W7037387822","https://openalex.org/W2360661666","https://openalex.org/W2371459736","https://openalex.org/W1497355957","https://openalex.org/W2101916491"],"abstract_inverted_index":{"PURPOSE:":[0],"To":[1],"evaluate":[2],"the":[3,85,152,156,169,184,238,243,256],"effects":[4],"of":[5,9,37,41,72,97,113,137,181,213,245,258],"a":[6,38,79,116,200,250],"single":[7,39],"dose":[8,40],"levodopa":[10,42,69,173,233],"on":[11,15,20,24,248],"visual":[12,21,74,98,125,160,189,229,235],"cortex,":[13],"based":[14,23,247],"functional":[16],"MRI":[17,82],"(fMRI),":[18],"and":[19,29,56,65,111,115,130,142,162,203,264],"function,":[22],"psychophysical":[25],"tests,":[26],"in":[27,49,53,151,168,179,183,208,211,237],"amblyopic":[28,58,153,170,185,239],"normal":[30,55],"subjects.":[31],"METHOD:":[32],"A":[33],"prospective,":[34],"randomized":[35],"trial":[36],"(2":[43],"mg/kg":[44],"body":[45],"weight)":[46],"was":[47,76,176,221,225],"undertaken":[48,77],"an":[50],"institutional":[51],"setting":[52],"nine":[54],"six":[57],"subjects,":[59],"who":[60],"were":[61,91,148,165],"assessed":[62],"at":[63,102],"baseline":[64],"90":[66],"minutes":[67],"after":[68],"ingestion.":[70],"fMRI":[71,89,105,224,260],"occipital":[73],"cortex":[75],"with":[78],"1.5T":[80],"GE":[81],"scanner":[83],"utilizing":[84,259],"BOLD":[86],"contrast":[87,127,163],"technique.":[88],"stimuli":[90],"two":[92],"gratings":[93],"(0.5,":[94],"2.0":[95],"cycles/degree":[96],"angle)":[99],"that":[100],"counterphased":[101],"4":[103],"Hz.":[104],"parameters":[106],"for":[107,268],"analysis":[108],"included":[109,124],"AREA":[110,136],"LEVEL":[112,180,212,244],"activation":[114,138,182,214,246],"SUMMED":[117,143],"score":[118,144],"(AREA":[119],"x":[120],"LEVEL).":[121],"Psychophysical":[122],"tests":[123],"acuity,":[126],"sensitivity,":[128],"stereoacuity,":[129],"binocular":[131],"fusion.":[132],"RESULTS:":[133],"At":[134],"baseline,":[135],"(P":[139,145,194,215],"=":[140,146,195,216],".05)":[141,147],"significantly":[149,166],"less":[150],"compared":[154],"to":[155,227,261],"dominant":[157],"eyes.":[158],"Psychophysically,":[159],"acuity":[161,190,236],"sensitivity":[164],"worse":[167],"eye.":[171],"Following":[172],"ingestion,":[174],"there":[175],"significant":[177,192,201],"decrease":[178,207],"eye,":[186,240],"even":[187],"though":[188],"showed":[191,199,205],"improvement":[193],".03).":[196],"Also,":[197],"amblyopes":[198],"increase":[202],"normals":[204],"some":[206],"interocular":[209],"difference":[210],".04).":[217],"CONCLUSION:":[218],"Unique":[219],"information":[220],"obtained":[222],"when":[223],"utilized":[226],"assess":[228,262],"cortical":[230],"function.":[231],"While":[232],"improved":[234],"it":[241],"decreased":[242],"fMRI,":[249],"counterintuitive":[251],"finding.":[252],"The":[253],"results":[254],"highlight":[255],"value":[257],"amblyopia":[263],"provide":[265],"new":[266],"directions":[267],"research.":[269]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
