{"id":"https://openalex.org/W2128401351","doi":"https://doi.org/10.1111/j.1471-4159.2005.03118.x","title":"NT3 inhibits FGF2\u2010induced neural progenitor cell proliferation via the PI3K/GSK3 pathway","display_name":"NT3 inhibits FGF2\u2010induced neural progenitor cell proliferation via the PI3K/GSK3 pathway","publication_year":2005,"publication_date":"2005-04-26","ids":{"openalex":"https://openalex.org/W2128401351","doi":"https://doi.org/10.1111/j.1471-4159.2005.03118.x","mag":"2128401351","pmid":"https://pubmed.ncbi.nlm.nih.gov/15934945"},"language":"en","primary_location":{"id":"doi:10.1111/j.1471-4159.2005.03118.x","doi":"https://doi.org/10.1111/j.1471-4159.2005.03118.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1471-4159.2005.03118.x","pdf_url":null,"source":{"id":"https://openalex.org/S135837084","display_name":"Journal of Neurochemistry","issn_l":"0022-3042","issn":["0022-3042","1471-4159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurochemistry","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2128401351"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101765266","display_name":"Jin Lu","orcid":"https://orcid.org/0000-0001-7933-0309","observed_orcids":["https://orcid.org/0000-0001-7933-0309"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112820","display_name":"Shanghai Institute of Materia Medica","ror":"https://ror.org/022syn853","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112820"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lu Jin","raw_affiliation_strings":["Institute of Neuroscience, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Graduate School of Chinese Academy of Sciences, Shonghai, China","Lu Jin and Xinhua Hu contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Neuroscience, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Graduate School of Chinese Academy of Sciences, Shonghai, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210112820"]},{"raw_affiliation_string":"Lu Jin and Xinhua Hu contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101949607","display_name":"Xinhua Hu","orcid":"https://orcid.org/0000-0003-3559-4024","observed_orcids":["https://orcid.org/0000-0003-3559-4024"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112820","display_name":"Shanghai Institute of Materia Medica","ror":"https://ror.org/022syn853","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112820"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinhua Hu","raw_affiliation_strings":["Institute of Neuroscience, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Graduate School of Chinese Academy of Sciences, Shonghai, China","Lu Jin and Xinhua Hu contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Neuroscience, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Graduate School of Chinese Academy of Sciences, Shonghai, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210112820"]},{"raw_affiliation_string":"Lu Jin and Xinhua Hu contributed equally to this work","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113566217","display_name":"Linyin Feng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Linyin Feng","raw_affiliation_strings":["Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of Chinese Academy of Sciences, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of Chinese Academy of Sciences, Shanghai, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5113566217"],"corresponding_institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106477"],"apc_list":{"value":5330,"currency":"USD","value_usd":5330},"apc_paid":null,"fwci":1.0732,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.70744374,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"93","issue":"5","first_page":"1251","last_page":"1261"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neurotrophin-3","display_name":"neurotrophin-3","score":0.996999979019165},{"id":"https://openalex.org/keywords/fibroblast-growth-factor-2","display_name":"fibroblast growth factor 2","score":0.9819999933242798},{"id":"https://openalex.org/keywords/neural-progenitor-cell-proliferation","display_name":"neural progenitor proliferation","score":0.9399999976158142},{"id":"https://openalex.org/keywords/akt-phosphorylation","display_name":"Akt phosphorylation","score":0.8100000023841858},{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.8190000057220459},{"id":"https://openalex.org/keywords/neurotrophin-signaling","display_name":"neurotrophin signaling","score":0.6669999957084656}],"concepts":[{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.6318075060844421},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.6145203113555908},{"id":"https://openalex.org/C136834591","wikidata":"https://www.wikidata.org/wiki/Q2944097","display_name":"Neural stem cell","level":3,"score":0.6029285788536072},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5495426654815674},{"id":"https://openalex.org/C15729860","wikidata":"https://www.wikidata.org/wiki/Q2329919","display_name":"Progenitor","level":4,"score":0.523501455783844},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5214269161224365},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4236454665660858},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3996683955192566},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38017091155052185},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3496699929237366},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.19600117206573486},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1454494297504425}],"mesh":[{"descriptor_ui":"D000081082","descriptor_name":"Phosphoinositide-3 Kinase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002867","descriptor_name":"Chromones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009025","descriptor_name":"Morpholines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D016222","descriptor_name":"Fibroblast Growth Factor 2","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018874","descriptor_name":"Spheroids, Cellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020933","descriptor_name":"Neurotrophin 3","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D020933","descriptor_name":"Neurotrophin 3","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D038362","descriptor_name":"Glycogen Synthase Kinase 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1471-4159.2005.03118.x","doi":"https://doi.org/10.1111/j.1471-4159.2005.03118.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1471-4159.2005.03118.x","pdf_url":null,"source":{"id":"https://openalex.org/S135837084","display_name":"Journal of Neurochemistry","issn_l":"0022-3042","issn":["0022-3042","1471-4159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurochemistry","raw_type":"journal-article"},{"id":"pmid:15934945","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15934945","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8560000061988831,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321133","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":61,"referenced_works":["https://openalex.org/W177321913","https://openalex.org/W1569625891","https://openalex.org/W1655701149","https://openalex.org/W1748293968","https://openalex.org/W1806803216","https://openalex.org/W1834737933","https://openalex.org/W1859089489","https://openalex.org/W1963824410","https://openalex.org/W1966101784","https://openalex.org/W1969505025","https://openalex.org/W1972594843","https://openalex.org/W1978274895","https://openalex.org/W1983055247","https://openalex.org/W1990429207","https://openalex.org/W1992812889","https://openalex.org/W1998225973","https://openalex.org/W2001853125","https://openalex.org/W2014797861","https://openalex.org/W2014940168","https://openalex.org/W2015964634","https://openalex.org/W2019602411","https://openalex.org/W2023890277","https://openalex.org/W2025201512","https://openalex.org/W2026904817","https://openalex.org/W2029821046","https://openalex.org/W2033021415","https://openalex.org/W2033073864","https://openalex.org/W2035258932","https://openalex.org/W2046381759","https://openalex.org/W2047462832","https://openalex.org/W2054720881","https://openalex.org/W2056268965","https://openalex.org/W2056716973","https://openalex.org/W2057099486","https://openalex.org/W2057560198","https://openalex.org/W2058138221","https://openalex.org/W2058199689","https://openalex.org/W2063953284","https://openalex.org/W2065328727","https://openalex.org/W2068973826","https://openalex.org/W2069064984","https://openalex.org/W2070732456","https://openalex.org/W2079356804","https://openalex.org/W2082326701","https://openalex.org/W2085567491","https://openalex.org/W2088301689","https://openalex.org/W2103019360","https://openalex.org/W2110795584","https://openalex.org/W2122709827","https://openalex.org/W2138604866","https://openalex.org/W2141568187","https://openalex.org/W2150817988","https://openalex.org/W2155639900","https://openalex.org/W2156555850","https://openalex.org/W2157007804","https://openalex.org/W2162015825","https://openalex.org/W2164986141","https://openalex.org/W2166261688","https://openalex.org/W2327738989","https://openalex.org/W4240715610","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2142578494","https://openalex.org/W2025764240","https://openalex.org/W2055594404","https://openalex.org/W1967056471","https://openalex.org/W1981717362","https://openalex.org/W2795338278","https://openalex.org/W903662490","https://openalex.org/W2018970662","https://openalex.org/W2094423686"],"abstract_inverted_index":{"Neurotrophin":[0],"3":[1],"(NT3),":[2],"a":[3,59,63,73,113,142,168],"member":[4],"of":[5,13,105,116,120,127,188],"the":[6,10,23,85,147,186,203],"neurotrophin":[7],"family,":[8],"antagonizes":[9],"proliferative":[11],"effect":[12,126],"fibroblast":[14],"growth":[15,53,153],"factor":[16],"2":[17],"(FGF2)":[18],"on":[19,129],"cortical":[20],"precursors.":[21],"However,":[22],"mechanism":[24],"by":[25,136,200],"which":[26],"NT3":[27,48,100,128,148,165,201],"inhibits":[28,49],"FGF2-induced":[29,51,80,96,103,130,172,194],"neural":[30],"progenitor":[31],"(NP)":[32],"cell":[33,98,132,174,196],"proliferation":[34,133,197],"is":[35,198],"unclear.":[36],"Here,":[37],"using":[38],"an":[39],"FGF2-dependent":[40],"rat":[41],"neurosphere":[42,52,152],"culture":[43],"system,":[44],"we":[45],"found":[46],"that":[47,84,163,177,193],"both":[50,78,151],"and":[54,71,90,107,138,154,176,182],"bromodeoxyuridine":[55],"(BrdU)":[56],"incorporation":[57],"in":[58,170,185],"dose-dependent":[60],"manner.":[61],"U0126,":[62],"mitogen-activated":[64],"protein":[65],"kinase":[66,67,110,115],"1/2":[68],"(MEK1/2)":[69],"inhibitor,":[70,77,145],"LY294002,":[72,137],"phosphatidylinositol":[74],"3-kinase":[75],"(PI3K)":[76],"inhibited":[79,102,199],"BrdU":[81,155],"incorporation,":[82],"suggesting":[83],"extracellular":[86],"signal-regulated":[87],"kinase1/2":[88],"(ERK1/2)":[89],"PI3K":[91],"pathways":[92],"are":[93],"required":[94],"for":[95],"NP":[97,131,173,195],"proliferation.":[99],"significantly":[101],"phosphorylation":[104,119],"Akt":[106],"glycogen":[108],"synthase":[109],"3beta":[111],"(GSK3beta),":[112],"downstream":[114],"Akt,":[117],"whereas":[118],"ERK1/2":[121],"was":[122,134],"unaffected.":[123],"The":[124],"inhibitory":[125],"abolished":[135],"treatment":[139],"with":[140,159],"SB216763,":[141],"specific":[143],"GSK3":[144],"antagonized":[146],"effect,":[149],"rescuing":[150],"incorporation.":[156],"Moreover,":[157],"experiments":[158],"anti-NT3":[160,178],"antibody":[161,179],"revealed":[162],"endogenous":[164],"also":[166],"plays":[167],"role":[169],"inhibiting":[171],"proliferation,":[175],"enhanced":[180],"phospho-Akt":[181],"phospho-GSK3beta":[183],"levels":[184],"presence":[187],"FGF2.":[189],"These":[190],"findings":[191],"indicate":[192],"via":[202],"PI3K/GSK3":[204],"pathway.":[205]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}