{"id":"https://openalex.org/W2128388183","doi":"https://doi.org/10.1371/journal.pmed.0030513","title":"A Plant-Derived Morphinan as a Novel Lead Compound Active against Malaria Liver Stages","display_name":"A Plant-Derived Morphinan as a Novel Lead Compound Active against Malaria Liver Stages","publication_year":2006,"publication_date":"2006-12-20","ids":{"openalex":"https://openalex.org/W2128388183","doi":"https://doi.org/10.1371/journal.pmed.0030513","mag":"2128388183","pmid":"https://pubmed.ncbi.nlm.nih.gov/17194195","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1716192"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pmed.0030513","doi":"https://doi.org/10.1371/journal.pmed.0030513","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pmed.0030513","pdf_url":"https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.0030513&type=printable","source":{"id":"https://openalex.org/S197939330","display_name":"PLoS Medicine","issn_l":"1549-1277","issn":["1549-1277","1549-1676"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.0030513&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048100448","display_name":"M. Carraz","orcid":"https://orcid.org/0000-0001-8538-1567","observed_orcids":["https://orcid.org/0000-0001-8538-1567"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210121705","display_name":"Piti\u00e9-Salp\u00eatri\u00e8re Hospital","ror":"https://ror.org/02mh9a093","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210121705"]},{"id":"https://openalex.org/I4210123595","display_name":"Mus\u00e9um national d'Histoire naturelle","ror":"https://ror.org/03wkt5x30","country_code":"FR","type":"archive","lineage":["https://openalex.org/I4210123595"]},{"id":"https://openalex.org/I4405264447","display_name":"Universit\u00e9 Pierre-et-Marie-Curie","ror":"https://ror.org/01yvrd251","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081","https://openalex.org/I4405264447"]},{"id":"https://openalex.org/I4405277067","display_name":"Immuno-biologie cellulaire et mol\u00e9culaire des infections parasitaires","ror":"https://ror.org/01besfn56","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4405264447","https://openalex.org/I4405277067"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Ma\u00eblle Carraz","raw_affiliation_strings":["Laboratoire de Chimie et Biochimie des Substances Naturelles, Mus\u00e9um National d'Histoire Naturelle, Paris, France","Inserm U511, Universit\u00e9 Pierre et Marie Curie-Paris, Centre Hospitalier Universitaire Piti\u00e9-Salp\u00eatri\u00e8re, Paris, France","Universit\u00e9 Pierre et Marie Curie-Paris, Facult\u00e9 de M\u00e9decine Piti\u00e9-Salp\u00eatri\u00e8re, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Chimie et Biochimie des Substances Naturelles, Mus\u00e9um National d'Histoire Naturelle, Paris, France","institution_ids":["https://openalex.org/I4210123595"]},{"raw_affiliation_string":"Inserm U511, Universit\u00e9 Pierre et Marie Curie-Paris, Centre Hospitalier Universitaire Piti\u00e9-Salp\u00eatri\u00e8re, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210121705","https://openalex.org/I4405264447","https://openalex.org/I4405277067"]},{"raw_affiliation_string":"Universit\u00e9 Pierre et Marie Curie-Paris, Facult\u00e9 de M\u00e9decine Piti\u00e9-Salp\u00eatri\u00e8re, Paris, France","institution_ids":["https://openalex.org/I4405264447"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070047614","display_name":"Akino J\u00f6ssang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123595","display_name":"Mus\u00e9um national d'Histoire naturelle","ror":"https://ror.org/03wkt5x30","country_code":"FR","type":"archive","lineage":["https://openalex.org/I4210123595"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Akino Jossang","raw_affiliation_strings":["Laboratoire de Chimie et Biochimie des Substances Naturelles, Mus\u00e9um National d'Histoire Naturelle, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Chimie et Biochimie des Substances Naturelles, Mus\u00e9um National d'Histoire Naturelle, Paris, France","institution_ids":["https://openalex.org/I4210123595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020848386","display_name":"Jean\u2010Fran\u00e7ois Franetich","orcid":"https://orcid.org/0000-0002-3308-8550","observed_orcids":["https://orcid.org/0000-0002-3308-8550"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210121705","display_name":"Piti\u00e9-Salp\u00eatri\u00e8re Hospital","ror":"https://ror.org/02mh9a093","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210121705"]},{"id":"https://openalex.org/I4405264447","display_name":"Universit\u00e9 Pierre-et-Marie-Curie","ror":"https://ror.org/01yvrd251","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081","https://openalex.org/I4405264447"]},{"id":"https://openalex.org/I4405277067","display_name":"Immuno-biologie cellulaire et mol\u00e9culaire des infections parasitaires","ror":"https://ror.org/01besfn56","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4405264447","https://openalex.org/I4405277067"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean-Fran\u00e7ois Franetich","raw_affiliation_strings":["","Inserm U511, Universit\u00e9 Pierre et Marie Curie-Paris, Centre Hospitalier Universitaire Piti\u00e9-Salp\u00eatri\u00e8re, Paris, France","Universit\u00e9 Pierre et Marie Curie-Paris, Facult\u00e9 de M\u00e9decine Piti\u00e9-Salp\u00eatri\u00e8re, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Inserm U511, Universit\u00e9 Pierre et Marie Curie-Paris, Centre Hospitalier Universitaire Piti\u00e9-Salp\u00eatri\u00e8re, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210121705","https://openalex.org/I4405264447","https://openalex.org/I4405277067"]},{"raw_affiliation_string":"Universit\u00e9 Pierre et Marie Curie-Paris, Facult\u00e9 de M\u00e9decine Piti\u00e9-Salp\u00eatri\u00e8re, Paris, France","institution_ids":["https://openalex.org/I4405264447"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010198809","display_name":"Anthony Siau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210121705","display_name":"Piti\u00e9-Salp\u00eatri\u00e8re Hospital","ror":"https://ror.org/02mh9a093","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210121705"]},{"id":"https://openalex.org/I4405264447","display_name":"Universit\u00e9 Pierre-et-Marie-Curie","ror":"https://ror.org/01yvrd251","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081","https://openalex.org/I4405264447"]},{"id":"https://openalex.org/I4405277067","display_name":"Immuno-biologie cellulaire et mol\u00e9culaire des infections parasitaires","ror":"https://ror.org/01besfn56","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4405264447","https://openalex.org/I4405277067"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Anthony Siau","raw_affiliation_strings":["","Inserm U511, Universit\u00e9 Pierre et Marie Curie-Paris, Centre Hospitalier Universitaire Piti\u00e9-Salp\u00eatri\u00e8re, Paris, France","Universit\u00e9 Pierre et Marie Curie-Paris, Facult\u00e9 de M\u00e9decine Piti\u00e9-Salp\u00eatri\u00e8re, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Inserm U511, Universit\u00e9 Pierre et Marie Curie-Paris, Centre Hospitalier Universitaire Piti\u00e9-Salp\u00eatri\u00e8re, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210121705","https://openalex.org/I4405264447","https://openalex.org/I4405277067"]},{"raw_affiliation_string":"Universit\u00e9 Pierre et Marie Curie-Paris, Facult\u00e9 de M\u00e9decine Piti\u00e9-Salp\u00eatri\u00e8re, Paris, France","institution_ids":["https://openalex.org/I4405264447"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067867193","display_name":"Liliane Cic\u00e9ron","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210121705","display_name":"Piti\u00e9-Salp\u00eatri\u00e8re Hospital","ror":"https://ror.org/02mh9a093","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210121705"]},{"id":"https://openalex.org/I4405264447","display_name":"Universit\u00e9 Pierre-et-Marie-Curie","ror":"https://ror.org/01yvrd251","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081","https://openalex.org/I4405264447"]},{"id":"https://openalex.org/I4405277067","display_name":"Immuno-biologie cellulaire et mol\u00e9culaire des infections parasitaires","ror":"https://ror.org/01besfn56","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4405264447","https://openalex.org/I4405277067"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Liliane Ciceron","raw_affiliation_strings":["","Inserm U511, Universit\u00e9 Pierre et Marie Curie-Paris, Centre Hospitalier Universitaire Piti\u00e9-Salp\u00eatri\u00e8re, Paris, France","Universit\u00e9 Pierre et Marie Curie-Paris, Facult\u00e9 de M\u00e9decine Piti\u00e9-Salp\u00eatri\u00e8re, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Inserm U511, Universit\u00e9 Pierre et Marie Curie-Paris, Centre Hospitalier Universitaire Piti\u00e9-Salp\u00eatri\u00e8re, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210121705","https://openalex.org/I4405264447","https://openalex.org/I4405277067"]},{"raw_affiliation_string":"Universit\u00e9 Pierre et Marie Curie-Paris, Facult\u00e9 de M\u00e9decine Piti\u00e9-Salp\u00eatri\u00e8re, Paris, France","institution_ids":["https://openalex.org/I4405264447"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111753708","display_name":"Laurent Hannoun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121705","display_name":"Piti\u00e9-Salp\u00eatri\u00e8re Hospital","ror":"https://ror.org/02mh9a093","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210121705"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Laurent Hannoun","raw_affiliation_strings":["AP HP, Service de Chirurgie Digestive, H\u00e9pato-Bilio-Pancr\u00e9atique et Transplantation H\u00e9patique, Centre Hospitalo-Universitaire Piti\u00e9-Salp\u00eatri\u00e8re, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AP HP, Service de Chirurgie Digestive, H\u00e9pato-Bilio-Pancr\u00e9atique et Transplantation H\u00e9patique, Centre Hospitalo-Universitaire Piti\u00e9-Salp\u00eatri\u00e8re, Paris, France","institution_ids":["https://openalex.org/I4210121705"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073424910","display_name":"Robert W. Sauerwein","orcid":"https://orcid.org/0000-0002-3163-7202","observed_orcids":["https://orcid.org/0000-0002-3163-7202"]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Robert Sauerwein","raw_affiliation_strings":["University Medical Center St. Radboud, Department of Medical Microbiology, Nijmegen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Medical Center St. Radboud, Department of Medical Microbiology, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I2802934949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108251142","display_name":"Fran\u00e7ois Frappier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123595","display_name":"Mus\u00e9um national d'Histoire naturelle","ror":"https://ror.org/03wkt5x30","country_code":"FR","type":"archive","lineage":["https://openalex.org/I4210123595"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Fran\u00e7ois Frappier","raw_affiliation_strings":["Laboratoire de Chimie et Biochimie des Substances Naturelles, Mus\u00e9um National d'Histoire Naturelle, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Chimie et Biochimie des Substances Naturelles, Mus\u00e9um National d'Histoire Naturelle, Paris, France","institution_ids":["https://openalex.org/I4210123595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076890759","display_name":"Philippe Rasoanaivo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121490","display_name":"Institute Malgache De Recherches Appliqu\u00e9es","ror":"https://ror.org/02np7dp24","country_code":"MG","type":"nonprofit","lineage":["https://openalex.org/I4210121490"]}],"countries":["MG"],"is_corresponding":false,"raw_author_name":"Philippe Rasoanaivo","raw_affiliation_strings":["Laboratoire de Pharmacognosie Appliqu\u00e9e aux Maladies Infectieuses, Institut Malgache de Recherches Appliqu\u00e9es, Antananarivo, Madagascar"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Pharmacognosie Appliqu\u00e9e aux Maladies Infectieuses, Institut Malgache de Recherches Appliqu\u00e9es, Antananarivo, Madagascar","institution_ids":["https://openalex.org/I4210121490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052079454","display_name":"Georges Snounou","orcid":"https://orcid.org/0000-0002-6133-6398","observed_orcids":["https://orcid.org/0000-0002-6133-6398"]},"institutions":[{"id":"https://openalex.org/I4210123595","display_name":"Mus\u00e9um national d'Histoire naturelle","ror":"https://ror.org/03wkt5x30","country_code":"FR","type":"archive","lineage":["https://openalex.org/I4210123595"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Georges Snounou","raw_affiliation_strings":["Laboratoire de Parasitologie Compar\u00e9e et Mod\u00e8les Exp\u00e9rimentaux, Mus\u00e9um National d'Histoire Naturelle, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Parasitologie Compar\u00e9e et Mod\u00e8les Exp\u00e9rimentaux, Mus\u00e9um National d'Histoire Naturelle, Paris, France","institution_ids":["https://openalex.org/I4210123595"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077020153","display_name":"Dominique Mazier","orcid":"https://orcid.org/0000-0002-8059-1810","observed_orcids":["https://orcid.org/0000-0002-8059-1810"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210121705","display_name":"Piti\u00e9-Salp\u00eatri\u00e8re Hospital","ror":"https://ror.org/02mh9a093","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210121705"]},{"id":"https://openalex.org/I4405264447","display_name":"Universit\u00e9 Pierre-et-Marie-Curie","ror":"https://ror.org/01yvrd251","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081","https://openalex.org/I4405264447"]},{"id":"https://openalex.org/I4405277067","display_name":"Immuno-biologie cellulaire et mol\u00e9culaire des infections parasitaires","ror":"https://ror.org/01besfn56","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4405264447","https://openalex.org/I4405277067"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Dominique Mazier","raw_affiliation_strings":["","Assistance Publique-H\u00f4pitaux de Paris, Centre Hospitalo-Universitaire Piti\u00e9-Salp\u00eatri\u00e8re, Paris, France","Inserm U511, Universit\u00e9 Pierre et Marie Curie-Paris, Centre Hospitalier Universitaire Piti\u00e9-Salp\u00eatri\u00e8re, Paris, France","Universit\u00e9 Pierre et Marie Curie-Paris, Facult\u00e9 de M\u00e9decine Piti\u00e9-Salp\u00eatri\u00e8re, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Assistance Publique-H\u00f4pitaux de Paris, Centre Hospitalo-Universitaire Piti\u00e9-Salp\u00eatri\u00e8re, Paris, France","institution_ids":["https://openalex.org/I4210097159","https://openalex.org/I4210121705"]},{"raw_affiliation_string":"Inserm U511, Universit\u00e9 Pierre et Marie Curie-Paris, Centre Hospitalier Universitaire Piti\u00e9-Salp\u00eatri\u00e8re, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210121705","https://openalex.org/I4405264447","https://openalex.org/I4405277067"]},{"raw_affiliation_string":"Universit\u00e9 Pierre et Marie Curie-Paris, Facult\u00e9 de M\u00e9decine Piti\u00e9-Salp\u00eatri\u00e8re, Paris, France","institution_ids":["https://openalex.org/I4405264447"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5077020153"],"corresponding_institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210097159","https://openalex.org/I4210121705","https://openalex.org/I4405264447","https://openalex.org/I4405277067"],"apc_list":{"value":6460,"currency":"USD","value_usd":6460},"apc_paid":{"value":6460,"currency":"USD","value_usd":6460},"fwci":5.5727,"has_fulltext":true,"cited_by_count":77,"citation_normalized_percentile":{"value":0.95619119,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"3","issue":"12","first_page":"e513","last_page":"e513"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9101999998092651,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9101999998092651,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12685","display_name":"Phytochemical compounds biological activities","score":0.05909999832510948,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13188","display_name":"Synthesis and bioactivity of alkaloids","score":0.019500000402331352,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/morphinan-alkaloids","display_name":"morphinan alkaloids","score":0.9679999947547913},{"id":"https://openalex.org/keywords/antimalarial-drugs","display_name":"antimalarial drugs","score":0.7229999899864197},{"id":"https://openalex.org/keywords/plasmodium-yoelii","display_name":"Plasmodium yoelii","score":0.8389999866485596},{"id":"https://openalex.org/keywords/plasmodium-falciparum","display_name":"Plasmodium falciparum","score":0.9990000128746033},{"id":"https://openalex.org/keywords/liver-stage-parasites","display_name":"liver-stage parasites","score":0.515999972820282},{"id":"https://openalex.org/keywords/sporozoite-challenge","display_name":"sporozoite challenge","score":0.6539999842643738},{"id":"https://openalex.org/keywords/semisynthetic-derivatives","display_name":"semisynthetic derivatives","score":0.9300000071525574},{"id":"https://openalex.org/keywords/bioassay-guided-fractionation","display_name":"bioassay-guided fractionation","score":0.8569999933242798},{"id":"https://openalex.org/keywords/phytochemicals","display_name":"phytochemicals","score":0.593999981880188},{"id":"https://openalex.org/keywords/malaria-prophylaxis","display_name":"malaria prophylaxis","score":0.7839999794960022},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.5960000157356262},{"id":"https://openalex.org/keywords/hepatocytes","display_name":"hepatocytes","score":0.6129999756813049}],"concepts":[{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.7748513221740723},{"id":"https://openalex.org/C2777093003","wikidata":"https://www.wikidata.org/wiki/Q6508345","display_name":"Lead (geology)","level":2,"score":0.4947971701622009},{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.440392404794693},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39833056926727295},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3855185806751251},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3505583703517914},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29065337777137756},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2690685987472534},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000962","descriptor_name":"Antimalarials","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001681","descriptor_name":"Biological Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002458","descriptor_name":"Cell Fractionation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":true},{"descriptor_ui":"D008288","descriptor_name":"Malaria","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008288","descriptor_name":"Malaria","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D008517","descriptor_name":"Phytotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009019","descriptor_name":"Morphinans","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D010967","descriptor_name":"Plasmodium yoelii","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010967","descriptor_name":"Plasmodium yoelii","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D020128","descriptor_name":"Inhibitory Concentration 50","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D024301","descriptor_name":"Plant Bark","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1371/journal.pmed.0030513","doi":"https://doi.org/10.1371/journal.pmed.0030513","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pmed.0030513","pdf_url":"https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.0030513&type=printable","source":{"id":"https://openalex.org/S197939330","display_name":"PLoS Medicine","issn_l":"1549-1277","issn":["1549-1277","1549-1676"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1716192","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1716192","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Med","raw_type":"Text"},{"id":"pmid:17194195","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17194195","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS medicine","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-00148373v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/hal-00148373","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Medicine, 2006, 3 (12), pp.e513. &#x27E8;10.1371/journal.pmed.0030513&#x27E9;","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:HAL:hal-04741155v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-04741155","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Medicine, 2006, 3 (12), pp.e513. &#x27E8;10.1371/journal.pmed.0030513&#x27E9;","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:ed7760a79dcf439382c884cde7661ac5","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ed7760a79dcf439382c884cde7661ac5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Medicine, Vol 3, Iss 12, p e513 (2006)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/152620","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/A_Plant_Derived_Morphinan_as_a_Novel_Lead_Compound_Active_against_Malaria_Liver_Stages_/152620","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:repository.ubn.ru.nl:2066/49530","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2066/49530","pdf_url":null,"source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Plos Medicine, 3, 12, pp. e513-513","raw_type":"Article / Letter to editor"},{"id":"pmh:ru:oai:repository.ubn.ru.nl:2066/49530","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2066/49530","pdf_url":null,"source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Plos Medicine, 3, e513 - 513","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1371/journal.pmed.0030513","doi":"https://doi.org/10.1371/journal.pmed.0030513","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pmed.0030513","pdf_url":"https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.0030513&type=printable","source":{"id":"https://openalex.org/S197939330","display_name":"PLoS Medicine","issn_l":"1549-1277","issn":["1549-1277","1549-1676"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2128388183.pdf","grobid_xml":"https://content.openalex.org/works/W2128388183.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W146435173","https://openalex.org/W431104351","https://openalex.org/W1516448966","https://openalex.org/W1969503178","https://openalex.org/W1970213967","https://openalex.org/W1972415994","https://openalex.org/W1973441660","https://openalex.org/W1982205641","https://openalex.org/W1984539377","https://openalex.org/W1986216396","https://openalex.org/W1995745290","https://openalex.org/W1996534853","https://openalex.org/W2015089396","https://openalex.org/W2022174093","https://openalex.org/W2032050476","https://openalex.org/W2036838204","https://openalex.org/W2038910210","https://openalex.org/W2049066533","https://openalex.org/W2060461772","https://openalex.org/W2083876827","https://openalex.org/W2084721485","https://openalex.org/W2103205254","https://openalex.org/W2105668259","https://openalex.org/W2147862160","https://openalex.org/W2149347413","https://openalex.org/W2149349416","https://openalex.org/W2308387014","https://openalex.org/W2413643575","https://openalex.org/W2421194740","https://openalex.org/W2422812138","https://openalex.org/W2599644146","https://openalex.org/W2785534774","https://openalex.org/W3144037012","https://openalex.org/W4285719527","https://openalex.org/W4297904193"],"related_works":["https://openalex.org/W2009695623","https://openalex.org/W2051440560","https://openalex.org/W2034745024","https://openalex.org/W2153783740","https://openalex.org/W4210904999","https://openalex.org/W4328125324","https://openalex.org/W2061715178","https://openalex.org/W7097197172","https://openalex.org/W2050946288","https://openalex.org/W2011225451"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1],"global":[2],"spread":[3],"of":[4,119,194,222,244,262,282],"multidrug-resistant":[5],"malaria":[6,83,246,288],"parasites":[7,141],"has":[8,227],"led":[9],"to":[10,23,230,265,278],"an":[11,252],"urgent":[12],"need":[13],"for":[14,95,166,259],"new":[15],"chemotherapeutic":[16],"agents.":[17],"Drug":[18],"discovery":[19],"is":[20,45],"primarily":[21],"directed":[22],"the":[24,35,41,55,65,117,152,204,207,235,241,245,257,260,280],"asexual":[25],"blood":[26,43,242],"stages,":[27,38],"and":[28,88,106,109,132,175,184,273],"few":[29],"drugs":[30],"that":[31],"are":[32],"effective":[33],"against":[34,82,98,212,234,240],"obligatory":[36],"liver":[37,99,236],"from":[39,77,199],"which":[40],"pathogenic":[42],"infection":[44],"initiated,":[46],"have":[47,70],"become":[48],"available":[49],"since":[50],"primaquine":[51],"was":[52,164,209],"deployed":[53],"in":[54,84,102,110,142,189,251,271,287],"1950s.":[56],"METHODS":[57],"AND":[58],"FINDINGS:":[59],"Using":[60],"bioassay-guided":[61],"fractionation":[62],"based":[63],"on":[64,181],"parasite's":[66],"hepatic":[67,140,187,214],"stage,":[68,237],"we":[69],"isolated":[71],"a":[72,78,200,223,266,283],"novel":[73],"morphinan":[74],"alkaloid,":[75],"tazopsine,":[76,226],"plant":[79],"traditionally":[80],"used":[81],"Madagascar.":[85],"This":[86,248],"compound":[87],"readily":[89,218],"obtained":[90,219],"semisynthetic":[91,220],"derivatives":[92],"were":[93],"tested":[94],"inhibitory":[96,123,162],"activity":[97,163],"stage":[100,268],"development":[101,118],"vitro":[103],"(P.":[104,112],"falciparum":[105,134,186],"P.":[107,120,133,182,185],"yoelii)":[108],"vivo":[111],"yoelii).":[113],"Tazopsine":[114],"fully":[115],"inhibited":[116],"yoelii":[121,183],"(50%":[122],"concentration":[124],"[IC50]":[125],"3.1":[126],"muM,":[127,137,172,178],"therapeutic":[128],"index":[129],"[TI]":[130],"14)":[131],"(IC50":[135,170],"4.2":[136],"TI":[138,173,179],"7)":[139],"cultured":[143],"primary":[144],"hepatocytes,":[145],"with":[146,160],"inhibition":[147],"being":[148],"most":[149],"pronounced":[150],"during":[151],"early":[153],"developmental":[154],"stages.":[155,215],"One":[156],"derivative,":[157],"N-cyclopentyl-tazopsine":[158],"(NCP-tazopsine),":[159],"similar":[161],"selected":[165],"its":[167],"lower":[168],"toxicity":[169],"3.3":[171],"46,":[174],"IC50":[176],"42.4":[177],"60,":[180],"stages":[188],"vitro,":[190],"respectively).":[191],"Oral":[192],"administration":[193],"NCP-tazopsine":[195],"completely":[196],"protected":[197],"mice":[198],"sporozoite":[201],"challenge.":[202],"Unlike":[203],"parent":[205],"molecule,":[206],"derivative":[208,221],"uniquely":[210],"active":[211,233],"Plasmodium":[213],"CONCLUSIONS:":[216],"A":[217],"plant-derived":[224],"compound,":[225],"been":[228],"shown":[229],"be":[231],"specifically":[232],"but":[238],"inactive":[239],"forms":[243],"parasite.":[247],"unique":[249],"specificity":[250],"antimalarial":[253],"drug":[254,263],"severely":[255],"restricts":[256],"pressure":[258],"selection":[261],"resistance":[264],"parasite":[267],"limited":[269],"both":[270],"numbers":[272],"duration,":[274],"thus":[275],"allowing":[276],"researchers":[277],"envisage":[279],"incorporation":[281],"true":[284],"causal":[285],"prophylactic":[286],"control":[289],"programs.":[290]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":7},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
