{"id":"https://openalex.org/W2128359402","doi":"https://doi.org/10.1083/jcb.29.1.77","title":"STUDIES ON THE MICROTUBULES IN HELIOZOA","display_name":"STUDIES ON THE MICROTUBULES IN HELIOZOA","publication_year":1966,"publication_date":"1966-04-01","ids":{"openalex":"https://openalex.org/W2128359402","doi":"https://doi.org/10.1083/jcb.29.1.77","mag":"2128359402","pmid":"https://pubmed.ncbi.nlm.nih.gov/5920198","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2106954"},"language":"en","primary_location":{"id":"doi:10.1083/jcb.29.1.77","doi":"https://doi.org/10.1083/jcb.29.1.77","is_oa":false,"landing_page_url":"https://doi.org/10.1083/jcb.29.1.77","pdf_url":null,"source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Cell Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2106954/pdf/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111577187","display_name":"Lewis G. Tilney","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1338920048","display_name":"Marine Biological Laboratory","ror":"https://ror.org/046dg4z72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1338920048"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lewis G. Tilney","raw_affiliation_strings":["From the Marine Biological Laboratory, Woods Hole, Massachusetts, and the Biological Laboratories, Harvard University, Cambridge, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Marine Biological Laboratory, Woods Hole, Massachusetts, and the Biological Laboratories, Harvard University, Cambridge, Massachusetts","institution_ids":["https://openalex.org/I1338920048","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113499019","display_name":"Yukio Hiramoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1338920048","display_name":"Marine Biological Laboratory","ror":"https://ror.org/046dg4z72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1338920048"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yukio Hiramoto","raw_affiliation_strings":["From the Marine Biological Laboratory, Woods Hole, Massachusetts, and the Biological Laboratories, Harvard University, Cambridge, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Marine Biological Laboratory, Woods Hole, Massachusetts, and the Biological Laboratories, Harvard University, Cambridge, Massachusetts","institution_ids":["https://openalex.org/I1338920048","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012961152","display_name":"D Marsland","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1338920048","display_name":"Marine Biological Laboratory","ror":"https://ror.org/046dg4z72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1338920048"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas Marsland","raw_affiliation_strings":["From the Marine Biological Laboratory, Woods Hole, Massachusetts, and the Biological Laboratories, Harvard University, Cambridge, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Marine Biological Laboratory, Woods Hole, Massachusetts, and the Biological Laboratories, Harvard University, Cambridge, Massachusetts","institution_ids":["https://openalex.org/I1338920048","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":11.8832,"has_fulltext":true,"cited_by_count":203,"citation_normalized_percentile":{"value":0.99180328,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"29","issue":"1","first_page":"77","last_page":"95"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.7455999851226807,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.7455999851226807,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11879","display_name":"Protist diversity and phylogeny","score":0.09189999848604202,"subfield":{"id":"https://openalex.org/subfields/1105","display_name":"Ecology, Evolution, Behavior and Systematics"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.01899999938905239,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microtubules","display_name":"microtubules","score":0.9819999933242798},{"id":"https://openalex.org/keywords/heliozoa","display_name":"heliozoa","score":0.875},{"id":"https://openalex.org/keywords/axopodia","display_name":"axopodia","score":0.9559999704360962},{"id":"https://openalex.org/keywords/high-pressure","display_name":"high pressure","score":0.6230000257492065},{"id":"https://openalex.org/keywords/cytosomes","display_name":"cytosomes","score":0.7070000171661377},{"id":"https://openalex.org/keywords/pressure-adaptation","display_name":"pressure adaptation","score":0.49000000953674316},{"id":"https://openalex.org/keywords/ultrastructure","display_name":"ultrastructure","score":0.5070000290870667}],"concepts":[{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.9265907406806946},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6849258542060852},{"id":"https://openalex.org/C2777529624","wikidata":"https://www.wikidata.org/wiki/Q416475","display_name":"Glutaraldehyde","level":2,"score":0.6798874735832214},{"id":"https://openalex.org/C168240541","wikidata":"https://www.wikidata.org/wiki/Q45948","display_name":"Organelle","level":2,"score":0.6576077938079834},{"id":"https://openalex.org/C33947775","wikidata":"https://www.wikidata.org/wiki/Q271439","display_name":"Elongation","level":3,"score":0.649253785610199},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.578708827495575},{"id":"https://openalex.org/C93877712","wikidata":"https://www.wikidata.org/wiki/Q132560","display_name":"Electron microscope","level":2,"score":0.5600903034210205},{"id":"https://openalex.org/C84425145","wikidata":"https://www.wikidata.org/wiki/Q422492","display_name":"Tubulin","level":3,"score":0.45507633686065674},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3310365676879883},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.14679712057113647},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.13699275255203247},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.09316787123680115},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.06481000781059265},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.04960668087005615},{"id":"https://openalex.org/C112950240","wikidata":"https://www.wikidata.org/wiki/Q76005","display_name":"Ultimate tensile strength","level":2,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009940","descriptor_name":"Organoids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011312","descriptor_name":"Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056890","descriptor_name":"Eukaryota","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1083/jcb.29.1.77","doi":"https://doi.org/10.1083/jcb.29.1.77","is_oa":false,"landing_page_url":"https://doi.org/10.1083/jcb.29.1.77","pdf_url":null,"source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Cell Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2106954","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2106954/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2106954/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cell Biol","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:917099","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2106954","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:5920198","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/5920198","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of cell biology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.281.9084","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.281.9084","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/f8/3c/J_Cell_Biol_1966_Apr_1_29(1)_77-95.tar.gz","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2106954","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2106954/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2106954/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cell Biol","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2128359402.pdf","grobid_xml":"https://content.openalex.org/works/W2128359402.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W386484846","https://openalex.org/W1506024315","https://openalex.org/W1606860533","https://openalex.org/W1968130651","https://openalex.org/W1998427852","https://openalex.org/W2006127259","https://openalex.org/W2030502369","https://openalex.org/W2034912738","https://openalex.org/W2042110788","https://openalex.org/W2047668422","https://openalex.org/W2051381792","https://openalex.org/W2056526475","https://openalex.org/W2071835350","https://openalex.org/W2073250481","https://openalex.org/W2094848928","https://openalex.org/W2105254641","https://openalex.org/W2127911529","https://openalex.org/W2128941976","https://openalex.org/W2142596760","https://openalex.org/W2158949311","https://openalex.org/W2159671682","https://openalex.org/W2171560585","https://openalex.org/W2246310934","https://openalex.org/W2272173779","https://openalex.org/W2330596297","https://openalex.org/W2479594537","https://openalex.org/W2499774896"],"related_works":["https://openalex.org/W7098759648","https://openalex.org/W1944389997","https://openalex.org/W2308589165","https://openalex.org/W7097352582","https://openalex.org/W1986078346","https://openalex.org/W2091485569","https://openalex.org/W1607436774","https://openalex.org/W7096635954","https://openalex.org/W2907012755","https://openalex.org/W2790246064"],"abstract_inverted_index":{"Electron":[0],"microscope":[1],"preparations":[2],"were":[3,35,129],"made":[4],"of":[5,7,27,41,61,68,80,85,119,138,165,175,191,216],"specimens":[6,142],"Actinosphaerium":[8],"nucleofilum":[9],"fixed":[10],"in":[11,141,157,182,212,221],"glutaraldehyde":[12],"before,":[13],"during,":[14],"and":[15,44,59,107,122,177],"after":[16,65,101,231],"exposure":[17],"to":[18,22,153],"high":[19],"pressures":[20,128],"(4,000":[21],"8,000":[23,108,171],"psi).":[24],"A":[25],"study":[26],"this":[28],"material":[29,181],"showed":[30],"that,":[31],"although":[32],"other":[33],"organelles":[34],"relatively":[36,126],"stable,":[37],"the":[38,42,62,66,78,81,89,110,120,139,202,214,217,222,227],"microtubular":[39,192],"elements":[40],"axopodia":[43,123,140,168,228],"cytosome":[45],"became":[46],"unstable":[47],"under":[48,53],"pressure.":[49],"Their":[50],"rapid":[51],"disintegration":[52,86,111],"pressure":[54,90],"was":[55,91,112,132,151],"correlated":[56],"with":[57,201],"beading":[58],"retraction":[60],"axopodia.":[63,82],"Moreover,":[64],"release":[67],"pressure,":[69],"microtubules":[70,121,205],"reappeared":[71],"as":[72,88],"soon":[73],"as,":[74],"or":[75,167],"sooner":[76],"than":[77],"reextension":[79],"The":[83,173],"rate":[84],"increased":[87],"raised.":[92],"At":[93],"4,000":[94,148],"psi,":[95,149],"few":[96],"if":[97],"any":[98],"tubules":[99,166],"remained":[100],"10":[102],"min,":[103],"whereas":[104],"at":[105,147,160,170],"6,000":[106,161],"psi":[109],"much":[113],"more":[114],"rapid.":[115],"Some":[116],"adaptational":[117],"reorganization":[118],"occurred":[124,169],"while":[125],"low":[127],"maintained.":[130],"This":[131,194],"accompanied":[133],"by":[134,225],"an":[135,207],"actual":[136],"elongation":[137],"maintained":[143],"for":[144],"20":[145],"min":[146],"but":[150,219],"confined":[152],"knoblike":[154],"axopodial":[155],"remnants":[156],"animals":[158,184],"kept":[159],"psi.":[162,172],"No":[163],"regeneration":[164],"presence":[174],"fibers":[176],"a":[178],"finely":[179],"fibrillar":[180],"pressurized":[183],"suggests":[185],"that":[186,204],"these":[187],"may":[188],"be":[189],"derivatives":[190],"disintegration.":[193],"evidence,":[195],"though":[196],"purely":[197],"morphological,":[198],"is":[199],"consistent":[200],"hypothesis":[203],"play":[206],"important":[208],"role":[209],"not":[210],"only":[211],"maintaining":[213],"formstability":[215],"axopodia,":[218],"also":[220],"active":[223],"process":[224],"which":[226],"reextend":[229],"themselves":[230],"retraction.":[232]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}
