{"id":"https://openalex.org/W2128304597","doi":"https://doi.org/10.1161/hc4701.099585","title":"Adenovirus-Mediated Heme Oxygenase-1 Gene Delivery Inhibits Injury-Induced Vascular Neointima Formation","display_name":"Adenovirus-Mediated Heme Oxygenase-1 Gene Delivery Inhibits Injury-Induced Vascular Neointima Formation","publication_year":2001,"publication_date":"2001-11-27","ids":{"openalex":"https://openalex.org/W2128304597","doi":"https://doi.org/10.1161/hc4701.099585","mag":"2128304597","pmid":"https://pubmed.ncbi.nlm.nih.gov/11723024"},"language":"en","primary_location":{"id":"doi:10.1161/hc4701.099585","doi":"https://doi.org/10.1161/hc4701.099585","is_oa":false,"landing_page_url":"https://doi.org/10.1161/hc4701.099585","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005382945","display_name":"David A. Tulis","orcid":"https://orcid.org/0000-0003-3490-2283","observed_orcids":["https://orcid.org/0000-0003-3490-2283"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A. Tulis","raw_affiliation_strings":["From the Departments of Medicine (D.A.T., W.D., X.L., A.J.E., A.I.S.) and Pharmacology (W.D.), Baylor College of Medicine, and Veterans Affairs Medical Center (W.D., K.J.P., A.I.S.), Houston, Tex","David A. Tulis From the Departments of Medicine (D.A.T., W.D., X.L., A.J.E., A.I.S.) and Pharmacology (W.D.), Baylor College of Medicine, and Veterans Affairs Medical Center (W.D., K.J.P., A.I.S.), Houston, Tex"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Medicine (D.A.T., W.D., X.L., A.J.E., A.I.S.) and Pharmacology (W.D.), Baylor College of Medicine, and Veterans Affairs Medical Center (W.D., K.J.P., A.I.S.), Houston, Tex","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I2799886695"]},{"raw_affiliation_string":"David A. Tulis From the Departments of Medicine (D.A.T., W.D., X.L., A.J.E., A.I.S.) and Pharmacology (W.D.), Baylor College of Medicine, and Veterans Affairs Medical Center (W.D., K.J.P., A.I.S.), Houston, Tex","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I2799886695"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070064210","display_name":"William Durante","orcid":"https://orcid.org/0000-0001-6715-4352","observed_orcids":["https://orcid.org/0000-0001-6715-4352"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Durante","raw_affiliation_strings":["From the Departments of Medicine (D.A.T., W.D., X.L., A.J.E., A.I.S.) and Pharmacology (W.D.), Baylor College of Medicine, and Veterans Affairs Medical Center (W.D., K.J.P., A.I.S.), Houston, Tex","William Durante From the Departments of Medicine (D.A.T., W.D., X.L., A.J.E., A.I.S.) and Pharmacology (W.D.), Baylor College of Medicine, and Veterans Affairs Medical Center (W.D., K.J.P., A.I.S.), Houston, Tex"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Medicine (D.A.T., W.D., X.L., A.J.E., A.I.S.) and Pharmacology (W.D.), Baylor College of Medicine, and Veterans Affairs Medical Center (W.D., K.J.P., A.I.S.), Houston, Tex","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I2799886695"]},{"raw_affiliation_string":"William Durante From the Departments of Medicine (D.A.T., W.D., X.L., A.J.E., A.I.S.) and Pharmacology (W.D.), Baylor College of Medicine, and Veterans Affairs Medical Center (W.D., K.J.P., A.I.S.), Houston, Tex","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I2799886695"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011424433","display_name":"Xiaoming Liu","orcid":"https://orcid.org/0000-0002-3902-9105","observed_orcids":["https://orcid.org/0000-0002-3902-9105"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"XiaoMing Liu","raw_affiliation_strings":["From the Departments of Medicine (D.A.T., W.D., X.L., A.J.E., A.I.S.) and Pharmacology (W.D.), Baylor College of Medicine, and Veterans Affairs Medical Center (W.D., K.J.P., A.I.S.), Houston, Tex","XiaoMing Liu From the Departments of Medicine (D.A.T., W.D., X.L., A.J.E., A.I.S.) and Pharmacology (W.D.), Baylor College of Medicine, and Veterans Affairs Medical Center (W.D., K.J.P., A.I.S.), Houston, Tex"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Medicine (D.A.T., W.D., X.L., A.J.E., A.I.S.) and Pharmacology (W.D.), Baylor College of Medicine, and Veterans Affairs Medical Center (W.D., K.J.P., A.I.S.), Houston, Tex","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I2799886695"]},{"raw_affiliation_string":"XiaoMing Liu From the Departments of Medicine (D.A.T., W.D., X.L., A.J.E., A.I.S.) and Pharmacology (W.D.), Baylor College of Medicine, and Veterans Affairs Medical Center (W.D., K.J.P., A.I.S.), Houston, Tex","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I2799886695"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110077927","display_name":"Alida J. Evans","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alida J. Evans","raw_affiliation_strings":["From the Departments of Medicine (D.A.T., W.D., X.L., A.J.E., A.I.S.) and Pharmacology (W.D.), Baylor College of Medicine, and Veterans Affairs Medical Center (W.D., K.J.P., A.I.S.), Houston, Tex","Alida J. Evans From the Departments of Medicine (D.A.T., W.D., X.L., A.J.E., A.I.S.) and Pharmacology (W.D.), Baylor College of Medicine, and Veterans Affairs Medical Center (W.D., K.J.P., A.I.S.), Houston, Tex"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Medicine (D.A.T., W.D., X.L., A.J.E., A.I.S.) and Pharmacology (W.D.), Baylor College of Medicine, and Veterans Affairs Medical Center (W.D., K.J.P., A.I.S.), Houston, Tex","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I2799886695"]},{"raw_affiliation_string":"Alida J. Evans From the Departments of Medicine (D.A.T., W.D., X.L., A.J.E., A.I.S.) and Pharmacology (W.D.), Baylor College of Medicine, and Veterans Affairs Medical Center (W.D., K.J.P., A.I.S.), Houston, Tex","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I2799886695"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111898905","display_name":"Kelly J. Peyton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kelly J. Peyton","raw_affiliation_strings":["From the Departments of Medicine (D.A.T., W.D., X.L., A.J.E., A.I.S.) and Pharmacology (W.D.), Baylor College of Medicine, and Veterans Affairs Medical Center (W.D., K.J.P., A.I.S.), Houston, Tex","Kelly J. Peyton From the Departments of Medicine (D.A.T., W.D., X.L., A.J.E., A.I.S.) and Pharmacology (W.D.), Baylor College of Medicine, and Veterans Affairs Medical Center (W.D., K.J.P., A.I.S.), Houston, Tex"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Medicine (D.A.T., W.D., X.L., A.J.E., A.I.S.) and Pharmacology (W.D.), Baylor College of Medicine, and Veterans Affairs Medical Center (W.D., K.J.P., A.I.S.), Houston, Tex","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I2799886695"]},{"raw_affiliation_string":"Kelly J. Peyton From the Departments of Medicine (D.A.T., W.D., X.L., A.J.E., A.I.S.) and Pharmacology (W.D.), Baylor College of Medicine, and Veterans Affairs Medical Center (W.D., K.J.P., A.I.S.), Houston, Tex","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I2799886695"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112790524","display_name":"Andrew I. Schafer","orcid":"https://orcid.org/0009-0007-1206-6399","observed_orcids":["https://orcid.org/0009-0007-1206-6399"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew I. Schafer","raw_affiliation_strings":["From the Departments of Medicine (D.A.T., W.D., X.L., A.J.E., A.I.S.) and Pharmacology (W.D.), Baylor College of Medicine, and Veterans Affairs Medical Center (W.D., K.J.P., A.I.S.), Houston, Tex","Andrew I. Schafer From the Departments of Medicine (D.A.T., W.D., X.L., A.J.E., A.I.S.) and Pharmacology (W.D.), Baylor College of Medicine, and Veterans Affairs Medical Center (W.D., K.J.P., A.I.S.), Houston, Tex"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Medicine (D.A.T., W.D., X.L., A.J.E., A.I.S.) and Pharmacology (W.D.), Baylor College of Medicine, and Veterans Affairs Medical Center (W.D., K.J.P., A.I.S.), Houston, Tex","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I2799886695"]},{"raw_affiliation_string":"Andrew I. Schafer From the Departments of Medicine (D.A.T., W.D., X.L., A.J.E., A.I.S.) and Pharmacology (W.D.), Baylor College of Medicine, and Veterans Affairs Medical Center (W.D., K.J.P., A.I.S.), Houston, Tex","institution_ids":["https://openalex.org/I181547552"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.3057,"has_fulltext":false,"cited_by_count":162,"citation_normalized_percentile":{"value":0.95304088,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"104","issue":"22","first_page":"2710","last_page":"2715"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11848","display_name":"Heme Oxygenase-1 and Carbon Monoxide","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11848","display_name":"Heme Oxygenase-1 and Carbon Monoxide","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heme-oxygenase-1","display_name":"heme oxygenase-1","score":1.0},{"id":"https://openalex.org/keywords/adenoviral-gene-transfer","display_name":"adenoviral gene transfer","score":0.8629999756813049},{"id":"https://openalex.org/keywords/neointima-formation","display_name":"neointima formation","score":0.902999997138977},{"id":"https://openalex.org/keywords/balloon-angioplasty","display_name":"balloon angioplasty","score":0.8489999771118164},{"id":"https://openalex.org/keywords/vascular-injury","display_name":"vascular injury","score":0.6970000267028809},{"id":"https://openalex.org/keywords/arterial-remodeling","display_name":"arterial remodeling","score":0.8349999785423279},{"id":"https://openalex.org/keywords/carotid-artery","display_name":"carotid artery","score":0.9399999976158142},{"id":"https://openalex.org/keywords/tin-protoporphyrin","display_name":"tin protoporphyrin","score":0.9120000004768372},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9399999976158142},{"id":"https://openalex.org/keywords/dna-synthesis","display_name":"DNA synthesis","score":0.8809999823570251},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.578000009059906},{"id":"https://openalex.org/keywords/vascular-disease","display_name":"vascular disease","score":0.5550000071525574}],"concepts":[{"id":"https://openalex.org/C2777339539","wikidata":"https://www.wikidata.org/wiki/Q6993039","display_name":"Neointima","level":4,"score":0.8997995257377625},{"id":"https://openalex.org/C2779219270","wikidata":"https://www.wikidata.org/wiki/Q419972","display_name":"Heme oxygenase","level":4,"score":0.8060298562049866},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7779509425163269},{"id":"https://openalex.org/C2778283817","wikidata":"https://www.wikidata.org/wiki/Q6590597","display_name":"Restenosis","level":3,"score":0.6372730731964111},{"id":"https://openalex.org/C2776217839","wikidata":"https://www.wikidata.org/wiki/Q189621","display_name":"Heme","level":3,"score":0.5252313613891602},{"id":"https://openalex.org/C2780326628","wikidata":"https://www.wikidata.org/wiki/Q539795","display_name":"Angioplasty","level":2,"score":0.5111611485481262},{"id":"https://openalex.org/C2778095995","wikidata":"https://www.wikidata.org/wiki/Q17147174","display_name":"Neointimal hyperplasia","level":4,"score":0.49184751510620117},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.46104520559310913},{"id":"https://openalex.org/C2776820930","wikidata":"https://www.wikidata.org/wiki/Q9655","display_name":"Artery","level":2,"score":0.4381347894668579},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3650226593017578},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3052161931991577},{"id":"https://openalex.org/C2778583881","wikidata":"https://www.wikidata.org/wiki/Q1325542","display_name":"Stent","level":2,"score":0.27459824085235596},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14555567502975464},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1059943437576294},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08855181932449341},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000256","descriptor_name":"Adenoviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000800","descriptor_name":"Angioplasty, Balloon","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002339","descriptor_name":"Carotid Arteries","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D002339","descriptor_name":"Carotid Arteries","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006419","descriptor_name":"Heme Oxygenase (Decyclizing)","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D006419","descriptor_name":"Heme Oxygenase (Decyclizing)","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D006419","descriptor_name":"Heme Oxygenase (Decyclizing)","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006419","descriptor_name":"Heme Oxygenase (Decyclizing)","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008665","descriptor_name":"Metalloporphyrins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011524","descriptor_name":"Protoporphyrins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016893","descriptor_name":"Carotid Stenosis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D016893","descriptor_name":"Carotid Stenosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016893","descriptor_name":"Carotid Stenosis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017539","descriptor_name":"Tunica Intima","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D017539","descriptor_name":"Tunica Intima","qualifier_ui":"Q000293","qualifier_name":"injuries","is_major_topic":false},{"descriptor_ui":"D017539","descriptor_name":"Tunica Intima","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D017540","descriptor_name":"Tunica Media","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017540","descriptor_name":"Tunica Media","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018809","descriptor_name":"Proliferating Cell Nuclear Antigen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020287","descriptor_name":"In Situ Nick-End Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051547","descriptor_name":"Heme Oxygenase-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1161/hc4701.099585","doi":"https://doi.org/10.1161/hc4701.099585","is_oa":false,"landing_page_url":"https://doi.org/10.1161/hc4701.099585","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},{"id":"pmid:11723024","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11723024","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2585648094","display_name":null,"funder_award_id":"HL 36045","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G291726726","display_name":null,"funder_award_id":"HL59976","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3322089982","display_name":null,"funder_award_id":"HL-62467","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3634911948","display_name":"REGULATION OF PLATELET-ENDOTHELIAL INTERACTIONS","funder_award_id":"R01HL036045","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4458984540","display_name":"Carbon monoxide and vascular cell function","funder_award_id":"R01HL059976","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7538103224","display_name":"VASCULAR CELL CATIONIC AMINO ACID TRANSPORT &METABOLISM","funder_award_id":"5r01hl062467-04","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W56648938","https://openalex.org/W153662504","https://openalex.org/W1528925569","https://openalex.org/W1554317829","https://openalex.org/W1621595817","https://openalex.org/W1968692561","https://openalex.org/W1985597508","https://openalex.org/W2001019228","https://openalex.org/W2004214604","https://openalex.org/W2006689499","https://openalex.org/W2021669660","https://openalex.org/W2031923131","https://openalex.org/W2043836288","https://openalex.org/W2053700458","https://openalex.org/W2055655700","https://openalex.org/W2064063264","https://openalex.org/W2064642280","https://openalex.org/W2067739721","https://openalex.org/W2075984518","https://openalex.org/W2083472765","https://openalex.org/W2101093001","https://openalex.org/W2118479681","https://openalex.org/W2119012743","https://openalex.org/W2120505405","https://openalex.org/W2170662335","https://openalex.org/W2182534497","https://openalex.org/W2188389775"],"related_works":["https://openalex.org/W2064063264","https://openalex.org/W2368867218","https://openalex.org/W2181861265","https://openalex.org/W2004214604","https://openalex.org/W2023328084","https://openalex.org/W2060965268","https://openalex.org/W3083195411","https://openalex.org/W2037123879","https://openalex.org/W1528925569","https://openalex.org/W4239652851"],"abstract_inverted_index":{"BACKGROUND:":[0],"Recent":[1],"studies":[2],"have":[3,33],"demonstrated":[4,154],"that":[5,182,191,205],"systemic":[6],"pharmacological":[7],"induction":[8],"of":[9,16,38,130,134,159,167,194,215],"heme":[10,23],"oxygenase-1":[11],"(HO-1),":[12],"the":[13,17,36,61,71,137,171,196,213],"inducible":[14],"isoform":[15],"initial":[18],"and":[19,103,162,203],"rate-limiting":[20],"enzyme":[21],"for":[22,212],"catabolism,":[24],"attenuates":[25],"neointima":[26],"formation":[27],"after":[28,49,57,176],"experimental":[29],"vascular":[30,216],"injury.":[31,177],"We":[32],"now":[34],"investigated":[35],"ability":[37],"localized":[39],"adenovirus-mediated":[40],"HO-1":[41,66,138,183,206],"(Ad-HO-1)":[42],"gene":[43],"delivery":[44],"to":[45,78,83,88,110,147,152,200],"modify":[46],"arterial":[47],"remodeling":[48,198],"balloon":[50,58],"angioplasty.":[51],"METHODS":[52],"AND":[53],"RESULTS:":[54],"Two":[55],"weeks":[56],"angioplasty":[59],"in":[60,70,118,170,187],"rat":[62],"carotid":[63],"artery,":[64],"elevated":[65],"protein":[67],"was":[68],"observed":[69],"Ad-HO-1":[72,89,135,153],"arteries":[73,86,108],"compared":[74,106,122],"with":[75,107,123,136],"those":[76],"exposed":[77,87,109,151],"empty":[79],"adenovirus":[80],"(Ad-E)":[81],"or":[82],"PBS.":[84],"The":[85,112],"exhibited":[90],"significantly":[91,155,163],"reduced":[92],"neointimal":[93,98,104],"area,":[94,97],"medial":[95,172],"wall":[96,100,173],"area/medial":[99],"area":[101],"ratio,":[102],"thickness":[105],"Ad-E.":[111],"Ad-E":[113],"vessels":[114],"showed":[115],"subtle":[116],"reductions":[117],"each":[119,144],"morphometric":[120,145],"parameter":[121,146],"PBS":[124],"vessels.":[125],"In":[126],"a":[127,209],"separate":[128],"group":[129],"animals,":[131],"concomitant":[132],"treatment":[133,214],"inhibitor":[139],"tin":[140],"protoporphyrin":[141],"completely":[142],"restored":[143],"control":[148],"levels.":[149],"Arteries":[150],"increased":[156],"TUNEL":[157],"labeling":[158,166],"apoptotic":[160],"nuclei":[161],"decreased":[164],"PCNA":[165],"DNA":[168],"synthesis":[169],"48":[174],"hours":[175],"CONCLUSIONS:":[178],"These":[179],"results":[180],"indicate":[181],"represents":[184],"an":[185],"important":[186],"vivo":[188],"vasoprotective":[189],"mediator":[190],"is":[192],"capable":[193],"attenuating":[195],"pathophysiological":[197],"response":[199],"endovascular":[201],"injury":[202],"suggest":[204],"may":[207],"be":[208],"novel":[210],"target":[211],"disease.":[217]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}