{"id":"https://openalex.org/W2128243791","doi":null,"title":"Keratinocytes in tissue engineering of human skin: invitro and in vivo studies","display_name":"Keratinocytes in tissue engineering of human skin: invitro and in vivo studies","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W2128243791","mag":"2128243791"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:liu-21283","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-21283","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/masterThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-21283","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108574325","display_name":"Camilla Fredriksson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"C. Fredriksson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5108574325"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11422","display_name":"Burn Injury Management and Outcomes","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/keratinocytes","display_name":"keratinocytes","score":0.9860000014305115},{"id":"https://openalex.org/keywords/skin-tissue-engineering","display_name":"skin tissue engineering","score":0.7360000014305115},{"id":"https://openalex.org/keywords/full-thickness-wounds","display_name":"full-thickness wounds","score":0.8119999766349792},{"id":"https://openalex.org/keywords/re-epithelialization","display_name":"re-epithelialization","score":0.8399999737739563},{"id":"https://openalex.org/keywords/cultured-epithelial-autografts","display_name":"cultured epithelial autografts","score":0.8050000071525574},{"id":"https://openalex.org/keywords/split-thickness-skin-graft","display_name":"split-thickness skin graft","score":0.8519999980926514},{"id":"https://openalex.org/keywords/silver-containing-dressings","display_name":"silver-containing dressings","score":0.781000018119812},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.7419999837875366},{"id":"https://openalex.org/keywords/apligraf","display_name":"Apligraf","score":0.8199999928474426},{"id":"https://openalex.org/keywords/chronic-wounds","display_name":"chronic wounds","score":0.5550000071525574},{"id":"https://openalex.org/keywords/burns","display_name":"burns","score":0.5889999866485596},{"id":"https://openalex.org/keywords/pressure-ulcers","display_name":"pressure ulcers","score":0.7329999804496765},{"id":"https://openalex.org/keywords/venous-ulcers","display_name":"venous ulcers","score":0.843999981880188}],"concepts":[{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.7107280492782593},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6550686359405518},{"id":"https://openalex.org/C2777459323","wikidata":"https://www.wikidata.org/wiki/Q5259911","display_name":"Human skin","level":2,"score":0.6516227126121521},{"id":"https://openalex.org/C175933922","wikidata":"https://www.wikidata.org/wiki/Q3344895","display_name":"Artificial skin","level":2,"score":0.6329749822616577},{"id":"https://openalex.org/C2777074287","wikidata":"https://www.wikidata.org/wiki/Q1473931","display_name":"Keratinocyte","level":3,"score":0.5457096695899963},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.5384104251861572},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.529705286026001},{"id":"https://openalex.org/C2776458125","wikidata":"https://www.wikidata.org/wiki/Q1827343","display_name":"Epidermis (zoology)","level":2,"score":0.5075985193252563},{"id":"https://openalex.org/C2776391296","wikidata":"https://www.wikidata.org/wiki/Q7535389","display_name":"Skin equivalent","level":4,"score":0.46990177035331726},{"id":"https://openalex.org/C190567982","wikidata":"https://www.wikidata.org/wiki/Q7535422","display_name":"Skin repair","level":3,"score":0.4358367919921875},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.39904525876045227},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39673447608947754},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.37323933839797974},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.36646929383277893},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3534330129623413},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34501779079437256},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2578889727592468},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.07443735003471375},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:DiVA.org:liu-21283","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-21283","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/masterThesis"},{"id":"mag:2128243791","doi":null,"is_oa":false,"landing_page_url":"http://liu.diva-portal.org/smash/get/diva2:240943/FULLTEXT02.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:liu-21283","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-21283","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/masterThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W119640732","https://openalex.org/W133464363","https://openalex.org/W1522702756","https://openalex.org/W1569577235","https://openalex.org/W1967194093","https://openalex.org/W1970113458","https://openalex.org/W1978474838","https://openalex.org/W1983683981","https://openalex.org/W2007409518","https://openalex.org/W2008460138","https://openalex.org/W2011653132","https://openalex.org/W2031768006","https://openalex.org/W2033122418","https://openalex.org/W2033194136","https://openalex.org/W2040107579","https://openalex.org/W2044487005","https://openalex.org/W2049043712","https://openalex.org/W2061992885","https://openalex.org/W2076950376","https://openalex.org/W2083815915","https://openalex.org/W2086943348","https://openalex.org/W2091271152","https://openalex.org/W2129042454","https://openalex.org/W2139162721","https://openalex.org/W2143619605","https://openalex.org/W2144314842","https://openalex.org/W2144814682","https://openalex.org/W2158048826","https://openalex.org/W2168363250","https://openalex.org/W2169874880","https://openalex.org/W2170792191","https://openalex.org/W2399148692","https://openalex.org/W2403010988","https://openalex.org/W2408246684","https://openalex.org/W2491699159","https://openalex.org/W3187945838"],"related_works":["https://openalex.org/W2043723813","https://openalex.org/W2363869350","https://openalex.org/W1992512727","https://openalex.org/W2372978603","https://openalex.org/W1992780910","https://openalex.org/W2011679449","https://openalex.org/W4317545728","https://openalex.org/W2004264224","https://openalex.org/W2409888047","https://openalex.org/W2478023071"],"abstract_inverted_index":{"Full":[0],"thickness":[1,137,437],"wounds,":[2],"such":[3],"as":[4,206,208,273,275,393,446,448],"deep":[5],"burns,":[6],"need":[7],"restoration":[8,382],"of":[9,16,29,38,46,51,68,75,99,253,281,292,309,358,371,383,387,400,411,418,421,435],"both":[10,162],"the":[11,17,32,73,97,127,133,186,195,202,250,254,259,269,282,290,310,330,335,341,348,372,378,381,384,388,401,405,415,419],"dermal":[12,70,128,163,356,385],"and":[13,27,35,58,63,66,80,88,107,110,118,164,184,246,303,432,452],"epidermal":[14,134,165,251],"layers":[15],"skin.":[18,255,325],"In":[19,72,218,284,326],"normal":[20],"wound":[21,33,203,270,342],"healing,":[22],"re-epithelialization":[23,331],"occurs":[24,48],"by":[25,36,49,55,60,194],"migration":[26],"proliferation":[28,62],"keratinocytes":[30,146,231],"from":[31,41],"edges":[34],"differentiation":[37],"stem":[39],"cells":[40,300],"remaining":[42],"hair":[43],"follicles.":[44],"Restoration":[45],"dermis":[47],"influx":[50],"growth":[52],"factors":[53,200],"secreted":[54],"macrophages,":[56],"platelets,":[57],"fibroblasts;":[59],"fibroblast":[61],"subsequent":[64],"synthesis":[65],"remodeling":[67],"collagenous":[69],"matrix.":[71],"case":[74,410],"full-thickness":[76],"acute":[77],"burn":[78],"injuries":[79],"chronic":[81],"wounds":[82],"(e.g.":[83],"pressure":[84,260,427],"ulcers,":[85],"venous":[86,182],"ulcers":[87,183],"diabetic":[89],"foot":[90],"ulcers),":[91],"these":[92],"processes":[93],"are":[94,159,167],"defective.":[95],"With":[96],"principles":[98],"tissue":[100,398],"engineering":[101],"in":[102,147,171,210,232,242,323,340],"mind":[103],"(to":[104],"correct,":[105],"improve":[106],"maintain":[108],"tissues":[109],"their":[111],"functions),":[112],"researchers":[113],"have":[114],"developed":[115],"promising":[116],"materials":[117],"methods":[119],"to":[120,124,244,264,332,407,443],"make":[121],"it":[122],"possible":[123],"restore":[125],"either":[126],"(Integra\u00ae":[129],"DRT,":[130],"Alloderm\u00ae)":[131],"or":[132],"layer":[135,252,386],"(split":[136],"skin":[138,174,190,438],"grafts":[139],"(STSG),":[140],"cultured":[141,229],"epithelial":[142],"autografts":[143],"(CEA),":[144],"autologous":[145],"single":[148,233],"cell":[149,234,266,311],"suspension).":[150],"It":[151],"is":[152,177,185],"now":[153],"well":[154,207,447],"established":[155],"that":[156,258,347,369],"superior":[157],"results":[158],"obtained":[160],"if":[161],"components":[166],"combined,":[168],"for":[169,179,215,227,248,396],"example":[170],"a":[172,236,293,394,409],"bilayered":[173,188],"equivalent.":[175],"Apligraf\u00ae":[176],"recommended":[178],"use":[180,211,420],"on":[181,198,377],"only":[187],"living":[189],"equivalent":[191],"currently":[192],"approved":[193],"FDA.":[196],"Studies":[197],"different":[199,224,316],"affecting":[201],"healing":[204,343],"capacity":[205],"techniques":[209,226],"provide":[212],"valuable":[213],"information":[214],"further":[216],"development.":[217],"this":[219],"licentiate":[220],"thesis,":[221],"we":[222,328],"evaluated":[223],"transplantation":[225,302,434],"delivering":[228],"human":[230,324],"suspension,":[235],"measure":[237,441],"becoming":[238],"more":[239],"frequently":[240],"used":[241,263],"addition":[243],"STSG":[245],"CEA":[247],"restoring":[249],"We":[256,313,345,365,403],"found":[257,346],"device,":[261],"commonly":[262],"spray":[265,294],"suspension":[267],"onto":[268],"with":[271,289,352,425],"pressures":[272],"high":[274],"200":[276],"kPa,":[277],"killed":[278],"around":[279,362],"0%":[280],"cells.":[283],"comparison,":[285],"an":[286,305],"ordinary":[287],"syringe":[288],"attachment":[291],"nozzle":[295],"showed":[296],"almost":[297],"90%":[298],"viable":[299],"post":[301],"provided":[304],"equally":[306],"good":[307],"distribution":[308],"suspension.":[312],"also":[314,367],"studied":[315],"silver":[317,321,349],"containing":[318],"dressings":[319,336,350,373],"regarding":[320],"accumulation":[322,357],"addition,":[327],"graded":[329],"evaluate":[333],"whether":[334],"caused":[337,355],"any":[338],"delay":[339],"process.":[344],"tested,":[351],"few":[353],"exceptions,":[354],"silver,":[359],"primarily":[360],"aggregated":[361],"blood":[363],"vessels.":[364],"could":[366],"show":[368],"most":[370],"had":[374,404],"negative":[375],"effect":[376],"re-epithelialization.":[379],"For":[380],"skin,":[389],"Integra\u00ae":[390,422],"DRT":[391],"functions":[392],"scaffold":[395],"guided":[397],"regeneration":[399],"dermis.":[402],"possibility":[406],"study":[408],"necrotizing":[412],"fasciitis":[413],"were":[414],"treatment":[416],"consisted":[417],"DTR":[423],"together":[424],"sub-atmospheric":[426],"(after":[428],"initial":[429],"surgical":[430],"debridement)":[431],"later":[433],"split":[436],"grafts.":[439],"This":[440],"proved":[442],"be":[444],"safe":[445],"giving":[449],"satisfactory":[450],"pliable":[451],"aesthetically":[453],"acceptable":[454],"result.":[455]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}