{"id":"https://openalex.org/W2128215326","doi":"https://doi.org/10.1200/jco.2006.10.4125","title":"p53 Gene and Protein Status: The Role of p53 Alterations in Predicting Outcome in Patients With Bladder Cancer","display_name":"p53 Gene and Protein Status: The Role of p53 Alterations in Predicting Outcome in Patients With Bladder Cancer","publication_year":2007,"publication_date":"2007-11-29","ids":{"openalex":"https://openalex.org/W2128215326","doi":"https://doi.org/10.1200/jco.2006.10.4125","mag":"2128215326","pmid":"https://pubmed.ncbi.nlm.nih.gov/18048815"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2006.10.4125","doi":"https://doi.org/10.1200/jco.2006.10.4125","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2006.10.4125","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035554273","display_name":"Ben George","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ben George","raw_affiliation_strings":["From the Departments of Pathology, Urology, Preventive Medicine, and Biochemistry, University of Southern California, Keck School of Medicine, Los Angeles; and Roche Molecular Systems, Pleasanton, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Pathology, Urology, Preventive Medicine, and Biochemistry, University of Southern California, Keck School of Medicine, Los Angeles; and Roche Molecular Systems, Pleasanton, CA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108554877","display_name":"Ram H. Datar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ram H. Datar","raw_affiliation_strings":["From the Departments of Pathology, Urology, Preventive Medicine, and Biochemistry, University of Southern California, Keck School of Medicine, Los Angeles; and Roche Molecular Systems, Pleasanton, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Pathology, Urology, Preventive Medicine, and Biochemistry, University of Southern California, Keck School of Medicine, Los Angeles; and Roche Molecular Systems, Pleasanton, CA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086270619","display_name":"Lin Wu","orcid":"https://orcid.org/0000-0001-7078-7767","observed_orcids":["https://orcid.org/0000-0001-7078-7767"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lin Wu","raw_affiliation_strings":["From the Departments of Pathology, Urology, Preventive Medicine, and Biochemistry, University of Southern California, Keck School of Medicine, Los Angeles; and Roche Molecular Systems, Pleasanton, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Pathology, Urology, Preventive Medicine, and Biochemistry, University of Southern California, Keck School of Medicine, Los Angeles; and Roche Molecular Systems, Pleasanton, CA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063174892","display_name":"Jie Cai","orcid":"https://orcid.org/0000-0003-3864-3338","observed_orcids":["https://orcid.org/0000-0003-3864-3338"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jie Cai","raw_affiliation_strings":["From the Departments of Pathology, Urology, Preventive Medicine, and Biochemistry, University of Southern California, Keck School of Medicine, Los Angeles; and Roche Molecular Systems, Pleasanton, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Pathology, Urology, Preventive Medicine, and Biochemistry, University of Southern California, Keck School of Medicine, Los Angeles; and Roche Molecular Systems, Pleasanton, CA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029414665","display_name":"Nancy Patten","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nancy Patten","raw_affiliation_strings":["From the Departments of Pathology, Urology, Preventive Medicine, and Biochemistry, University of Southern California, Keck School of Medicine, Los Angeles; and Roche Molecular Systems, Pleasanton, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Pathology, Urology, Preventive Medicine, and Biochemistry, University of Southern California, Keck School of Medicine, Los Angeles; and Roche Molecular Systems, Pleasanton, CA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110362452","display_name":"Stephen Beil","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen J. Beil","raw_affiliation_strings":["From the Departments of Pathology, Urology, Preventive Medicine, and Biochemistry, University of Southern California, Keck School of Medicine, Los Angeles; and Roche Molecular Systems, Pleasanton, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Pathology, Urology, Preventive Medicine, and Biochemistry, University of Southern California, Keck School of Medicine, Los Angeles; and Roche Molecular Systems, Pleasanton, CA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067387322","display_name":"Susan G. Groshen","orcid":"https://orcid.org/0000-0001-9705-1012","observed_orcids":["https://orcid.org/0000-0001-9705-1012"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan Groshen","raw_affiliation_strings":["From the Departments of Pathology, Urology, Preventive Medicine, and Biochemistry, University of Southern California, Keck School of Medicine, Los Angeles; and Roche Molecular Systems, Pleasanton, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Pathology, Urology, Preventive Medicine, and Biochemistry, University of Southern California, Keck School of Medicine, Los Angeles; and Roche Molecular Systems, Pleasanton, CA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110196369","display_name":"John P. Stein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Stein","raw_affiliation_strings":["From the Departments of Pathology, Urology, Preventive Medicine, and Biochemistry, University of Southern California, Keck School of Medicine, Los Angeles; and Roche Molecular Systems, Pleasanton, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Pathology, Urology, Preventive Medicine, and Biochemistry, University of Southern California, Keck School of Medicine, Los Angeles; and Roche Molecular Systems, Pleasanton, CA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083604118","display_name":"Donald G. Skinner","orcid":"https://orcid.org/0000-0002-4567-0601","observed_orcids":["https://orcid.org/0000-0002-4567-0601"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donald Skinner","raw_affiliation_strings":["From the Departments of Pathology, Urology, Preventive Medicine, and Biochemistry, University of Southern California, Keck School of Medicine, Los Angeles; and Roche Molecular Systems, Pleasanton, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Pathology, Urology, Preventive Medicine, and Biochemistry, University of Southern California, Keck School of Medicine, Los Angeles; and Roche Molecular Systems, Pleasanton, CA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088347458","display_name":"Peter A. Jones","orcid":"https://orcid.org/0000-0001-8309-4767","observed_orcids":["https://orcid.org/0000-0001-8309-4767"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter A. Jones","raw_affiliation_strings":["From the Departments of Pathology, Urology, Preventive Medicine, and Biochemistry, University of Southern California, Keck School of Medicine, Los Angeles; and Roche Molecular Systems, Pleasanton, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Pathology, Urology, Preventive Medicine, and Biochemistry, University of Southern California, Keck School of Medicine, Los Angeles; and Roche Molecular Systems, Pleasanton, CA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110824843","display_name":"Richard J. C\u00f4t\u00e9","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard J. Cote","raw_affiliation_strings":["From the Departments of Pathology, Urology, Preventive Medicine, and Biochemistry, University of Southern California, Keck School of Medicine, Los Angeles; and Roche Molecular Systems, Pleasanton, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Pathology, Urology, Preventive Medicine, and Biochemistry, University of Southern California, Keck School of Medicine, Los Angeles; and Roche Molecular Systems, Pleasanton, CA","institution_ids":["https://openalex.org/I1174212"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1174212"],"apc_list":null,"apc_paid":null,"fwci":15.068,"has_fulltext":false,"cited_by_count":126,"citation_normalized_percentile":{"value":0.99390892,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"25","issue":"34","first_page":"5352","last_page":"5358"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.014000000432133675,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p53-gene","display_name":"p53 gene","score":0.8019999861717224},{"id":"https://openalex.org/keywords/bladder-cancer","display_name":"bladder cancer","score":0.9950000047683716},{"id":"https://openalex.org/keywords/tp53-mutation","display_name":"TP53 mutation","score":0.7310000061988831},{"id":"https://openalex.org/keywords/nuclear-accumulation","display_name":"nuclear accumulation","score":0.47099998593330383},{"id":"https://openalex.org/keywords/exon-5-mutations","display_name":"exon 5 mutations","score":0.7820000052452087},{"id":"https://openalex.org/keywords/time-to-recurrence","display_name":"time to recurrence","score":0.7179999947547913},{"id":"https://openalex.org/keywords/risk-of-recurrence","display_name":"recurrence risk","score":0.6079999804496765},{"id":"https://openalex.org/keywords/clinical-outcomes","display_name":"clinical outcomes","score":0.5429999828338623},{"id":"https://openalex.org/keywords/prognostic-stratification","display_name":"prognostic stratification","score":0.6639999747276306},{"id":"https://openalex.org/keywords/mutation-sites","display_name":"mutation sites","score":0.6669999957084656}],"concepts":[{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.6833008527755737},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6629079580307007},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5432504415512085},{"id":"https://openalex.org/C2994225774","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Gene mutation","level":4,"score":0.5254337191581726},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4733051359653473},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.44781211018562317},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4444175958633423},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.344075083732605},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.33025115728378296},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2888699173927307}],"mesh":[{"descriptor_ui":"D001749","descriptor_name":"Urinary Bladder Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001749","descriptor_name":"Urinary Bladder Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001749","descriptor_name":"Urinary Bladder Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001749","descriptor_name":"Urinary Bladder Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D002295","descriptor_name":"Carcinoma, Transitional Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002295","descriptor_name":"Carcinoma, Transitional Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002295","descriptor_name":"Carcinoma, Transitional Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002295","descriptor_name":"Carcinoma, Transitional Cell","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D005091","descriptor_name":"Exons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016158","descriptor_name":"Genes, p53","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1200/jco.2006.10.4125","doi":"https://doi.org/10.1200/jco.2006.10.4125","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2006.10.4125","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},{"id":"pmid:18048815","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18048815","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical oncology : official journal of the American Society of Clinical Oncology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.997.2390","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.997.2390","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://hwmaint.jco.ascopubs.org/cgi/reprint/25/34/5352.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G7697201532","display_name":"MOLECULAR MECHANISMS OF HUMAN BLADDER CARCINOGENESIS","funder_award_id":"P01CA086871","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7799802062","display_name":"MOLECULAR/CELLULAR PATHWAYS OF BLADDER CA++ PROGRESSION","funder_award_id":"U01CA070903","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000910363","display_name":"University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)","funder_award_id":"P30CA014089","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W159634854","https://openalex.org/W192633127","https://openalex.org/W345560851","https://openalex.org/W1536690700","https://openalex.org/W1571175410","https://openalex.org/W1859397449","https://openalex.org/W1967163162","https://openalex.org/W1988145726","https://openalex.org/W1991494214","https://openalex.org/W1995211857","https://openalex.org/W1999386832","https://openalex.org/W2010119958","https://openalex.org/W2016575939","https://openalex.org/W2018070800","https://openalex.org/W2024613014","https://openalex.org/W2042316019","https://openalex.org/W2045022920","https://openalex.org/W2048047750","https://openalex.org/W2061805562","https://openalex.org/W2075245660","https://openalex.org/W2084147994","https://openalex.org/W2099450299","https://openalex.org/W2101657563","https://openalex.org/W2109609879","https://openalex.org/W2113363756","https://openalex.org/W2119682635","https://openalex.org/W2128846890","https://openalex.org/W2140178932","https://openalex.org/W2140208171","https://openalex.org/W2148142571","https://openalex.org/W2169990287","https://openalex.org/W2206183265","https://openalex.org/W2235927535","https://openalex.org/W2294550615","https://openalex.org/W2316359380","https://openalex.org/W2318856916","https://openalex.org/W2336140582","https://openalex.org/W2430014149","https://openalex.org/W3041047318"],"related_works":["https://openalex.org/W2274999241","https://openalex.org/W2140321800","https://openalex.org/W1974690013","https://openalex.org/W2367078636","https://openalex.org/W2045022920","https://openalex.org/W1966548021","https://openalex.org/W2419396980","https://openalex.org/W2081095111","https://openalex.org/W1975631558","https://openalex.org/W2318856916"],"abstract_inverted_index":{"PURPOSE:":[0],"The":[1,64,100],"p53":[2,14,29,56,70,82,87,101,130,168,223,260],"gene":[3,32,57,71,88,102,131,169,189,199,210,224],"status":[4,44,94,122],"(mutation)":[5],"and":[6,31,45,58,79,92,103,132,140,170,190,204,211,225,239,262],"protein":[7,15,30,59,93,104,121,133,171,226],"alterations":[8,261],"(nuclear":[9],"accumulation":[10],"detectable":[11],"by":[12],"immunohistochemistry;":[13],"status)":[16],"are":[17],"associated":[18,137,147],"with":[19,95,138,148,152,162],"bladder":[20,237,266],"cancer":[21,238],"progression.":[22],"Substantial":[23],"discordance":[24],"is":[25],"documented":[26],"between":[27,41],"the":[28,39,42,51,55,69,129,157,163,167,185,205,222,232,241,257,263],"status,":[33,89],"yet":[34,109],"no":[35],"studies":[36],"have":[37],"examined":[38],"relationship":[40,53],"gene-protein":[43],"clinical":[46,52,141,149,233],"outcome.":[47,142],"This":[48],"study":[49],"evaluated":[50],"of":[54,68,111,125,220,259,265],"statuses.":[60],"MATERIALS":[61],"AND":[62],"METHODS:":[63],"complete":[65],"coding":[66],"region":[67],"was":[72],"queried":[73],"using":[74],"DNA":[75],"from":[76],"paraffin-embedded":[77],"tissues":[78],"employing":[80],"a":[81,119,197],"gene-sequencing":[83],"chip.":[84],"We":[85,216],"compared":[86],"mutation":[90,144,243],"site,":[91],"time":[96],"to":[97],"recurrence.":[98],"RESULTS:":[99],"statuses":[105,134,172,227],"show":[106,217],"significant":[107],"concordance,":[108],"35%":[110],"cases":[112],"showed":[113,156],"discordance.":[114],"Exon":[115],"5":[116,154],"mutations":[117,155],"demonstrated":[118],"wild-type":[120,164],"in":[123,230,236,248],"18":[124],"22":[126],"samples.":[127],"Both":[128],"were":[135,146],"significantly":[136],"stage":[139],"Specific":[143],"sites":[145],"outcome;":[150],"tumors":[151],"exon":[153],"same":[158],"outcome":[159,187,195,207],"as":[160],"those":[161],"gene.":[165],"Combining":[166],"stratifies":[173],"patients":[174,183],"into":[175],"three":[176],"distinct":[177],"groups,":[178],"based":[179],"on":[180],"recurrence-free":[181],"intervals:":[182],"showing":[184],"best":[186],"(wild-type":[188],"unaltered":[191],"protein),":[192],"an":[193,201,212],"intermediate":[194],"(either":[196],"mutated":[198,209],"or":[200],"altered":[202,213],"protein)":[203],"worst":[206],"(a":[208],"protein).":[214],"CONCLUSION:":[215],"that":[218,240],"evaluation":[219],"both":[221],"provides":[228],"information":[229],"assessing":[231,249],"recurrence":[234,250],"risk":[235],"specific":[242],"site":[244],"may":[245,254],"be":[246],"important":[247],"risk.":[251],"These":[252],"findings":[253],"substantially":[255],"impact":[256],"assessment":[258],"management":[264],"cancer.":[267]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":16}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}