{"id":"https://openalex.org/W2128200717","doi":"https://doi.org/10.1210/jcem.74.6.1592868","title":"Pyruvate dehydrogenase activity is stimulated by growth hormone (GH) in human mononuclear cells: a new tool to measure GH responsiveness in man","display_name":"Pyruvate dehydrogenase activity is stimulated by growth hormone (GH) in human mononuclear cells: a new tool to measure GH responsiveness in man","publication_year":1992,"publication_date":"1992-06-01","ids":{"openalex":"https://openalex.org/W2128200717","doi":"https://doi.org/10.1210/jcem.74.6.1592868","mag":"2128200717","pmid":"https://pubmed.ncbi.nlm.nih.gov/1592868"},"language":"en","primary_location":{"id":"doi:10.1210/jcem.74.6.1592868","doi":"https://doi.org/10.1210/jcem.74.6.1592868","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jcem.74.6.1592868","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology &amp; Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091547802","display_name":"Jean\u2010Pierre Clot","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"J P Clot","raw_affiliation_strings":["INSERM U. 30, H\u00f4pital des Enfants-Malades, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U. 30, H\u00f4pital des Enfants-Malades, Paris, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071136848","display_name":"Chantal Benelli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"C Benelli","raw_affiliation_strings":["INSERM U. 30, H\u00f4pital des Enfants-Malades, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U. 30, H\u00f4pital des Enfants-Malades, Paris, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113531469","display_name":"Fran\u00e7oise Fouque","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"F Fouque","raw_affiliation_strings":["INSERM U. 30, H\u00f4pital des Enfants-Malades, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U. 30, H\u00f4pital des Enfants-Malades, Paris, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":null,"display_name":"R Bernard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"R Bernard","raw_affiliation_strings":["INSERM U. 30, H\u00f4pital des Enfants-Malades, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U. 30, H\u00f4pital des Enfants-Malades, Paris, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":null,"display_name":"D Durand","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"D Durand","raw_affiliation_strings":["INSERM U. 30, H\u00f4pital des Enfants-Malades, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U. 30, H\u00f4pital des Enfants-Malades, Paris, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110132059","display_name":"M C Postel-Vinay","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"M C Postel-Vinay","raw_affiliation_strings":["INSERM U. 30, H\u00f4pital des Enfants-Malades, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U. 30, H\u00f4pital des Enfants-Malades, Paris, France","institution_ids":["https://openalex.org/I154526488"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I154526488"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":1.5877,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.82237894,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"74","issue":"6","first_page":"1258","last_page":"1262"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12915","display_name":"Biochemical Acid Research Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pyruvate-dehydrogenase-complex","display_name":"pyruvate dehydrogenase complex","score":0.8989999890327454},{"id":"https://openalex.org/keywords/growth-hormone","display_name":"growth hormone","score":0.9750000238418579},{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.9670000076293945},{"id":"https://openalex.org/keywords/peripheral-blood-mononuclear-cells","display_name":"peripheral blood mononuclear cells","score":0.8069999814033508},{"id":"https://openalex.org/keywords/lymphocytes","display_name":"lymphocytes","score":0.7720000147819519},{"id":"https://openalex.org/keywords/monocytes","display_name":"monocytes","score":1.0},{"id":"https://openalex.org/keywords/enzyme-activity","display_name":"enzyme activity","score":0.621999979019165},{"id":"https://openalex.org/keywords/growth-hormone-deficiency-diagnosis","display_name":"growth hormone deficiency diagnosis","score":0.4059999883174896}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7877132892608643},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7795420289039612},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.7274911403656006},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.7188367247581482},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.716316282749176},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.6975291967391968},{"id":"https://openalex.org/C88099638","wikidata":"https://www.wikidata.org/wiki/Q412856","display_name":"Pyruvate dehydrogenase complex","level":3,"score":0.5966333150863647},{"id":"https://openalex.org/C25642318","wikidata":"https://www.wikidata.org/wiki/Q1992532","display_name":"Incubation","level":2,"score":0.5780050754547119},{"id":"https://openalex.org/C2776317432","wikidata":"https://www.wikidata.org/wiki/Q412547","display_name":"Dehydrogenase","level":3,"score":0.4868451952934265},{"id":"https://openalex.org/C28212737","wikidata":"https://www.wikidata.org/wiki/Q5381543","display_name":"Enzyme assay","level":3,"score":0.46992337703704834},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4156866669654846},{"id":"https://openalex.org/C2777318727","wikidata":"https://www.wikidata.org/wiki/Q409464","display_name":"Lactate dehydrogenase","level":3,"score":0.4122433662414551},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3818102777004242},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34693899750709534},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29739999771118164},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.24478766322135925},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13560566306114197}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004392","descriptor_name":"Dwarfism","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004392","descriptor_name":"Dwarfism","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011768","descriptor_name":"Pyruvate Dehydrogenase Complex","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D013006","descriptor_name":"Growth Hormone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1210/jcem.74.6.1592868","doi":"https://doi.org/10.1210/jcem.74.6.1592868","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jcem.74.6.1592868","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology &amp; Metabolism","raw_type":"journal-article"},{"id":"doi:10.1210/jc.74.6.1258","doi":"https://doi.org/10.1210/jc.74.6.1258","is_oa":false,"landing_page_url":"http://doi.org/10.1210/jc.74.6.1258","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Endocrinology &amp; Metabolism","raw_type":"journal-article"},{"id":"pmid:1592868","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1592868","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical endocrinology and metabolism","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1459854122","https://openalex.org/W1570859745","https://openalex.org/W1983323920","https://openalex.org/W2001620881","https://openalex.org/W2004293123","https://openalex.org/W2017094332","https://openalex.org/W2036134951","https://openalex.org/W2043469866","https://openalex.org/W2043805244","https://openalex.org/W2046971632","https://openalex.org/W2053910517","https://openalex.org/W2085013592","https://openalex.org/W2086557308","https://openalex.org/W2086865035","https://openalex.org/W2171118958","https://openalex.org/W2337718608","https://openalex.org/W2410339333","https://openalex.org/W2468119228"],"related_works":["https://openalex.org/W1991268537","https://openalex.org/W2005081985","https://openalex.org/W2083630779","https://openalex.org/W7218149781","https://openalex.org/W2046971632","https://openalex.org/W131523222","https://openalex.org/W1988721679","https://openalex.org/W1611863561","https://openalex.org/W2006610767","https://openalex.org/W1964658349"],"abstract_inverted_index":{"Human":[0],"peripheral":[1],"mononuclear":[2,175],"cells":[3],"(PMC)":[4],"were":[5,39,70,124],"used":[6],"to":[7,76,84,169],"examine":[8],"the":[9,16,19,78,85,184],"effects":[10,38],"of":[11,18,25,80,140,152,160,173,183,187],"hGH":[12,30,87,132,166,188],"and":[13,53,74,95,98,156],"insulin":[14,32,105,134],"on":[15],"activity":[17,63,92,109,142,172],"pyruvate":[20],"dehydrogenase":[21],"(PDH)":[22],"complex.":[23],"Incubation":[24],"PMC":[26,69,117],"with":[27,129,154,162],"10(-7)":[28,130],"mol/L":[29,131],"or":[31,133],"increased":[33,89,106],"basal":[34,90,107],"PDH":[35,62,91,108,136,171],"activity.":[36],"Hormonal":[37],"maximal":[40],"(50-60%":[41],"above":[42,100,114],"control":[43,101,115],"values)":[44],"at":[45,58],"15":[46,127,158],"min.":[47,60],"Later":[48],"on,":[49],"activation":[50],"progressively":[51],"decreased":[52],"was":[54,64,146],"no":[55],"longer":[56],"detectable":[57],"30":[59],"Total":[61],"unaffected":[65],"by":[66],"hormonal":[67,178],"treatment.":[68],"subfractionated":[71],"into":[72],"lymphocytes":[73,94],"monocytes":[75,96,112],"assess":[77],"sensitivity":[79],"each":[81],"cell":[82],"types":[83],"hormones.":[86],"significantly":[88],"in":[93,111,148,157,189],"(38%":[97],"70%":[99],"values,":[102],"respectively),":[103],"whereas":[104],"only":[110],"(151%":[113],"value).":[116],"from":[118],"healthy":[119],"subjects":[120],"aged":[121],"1-45":[122],"yr":[123],"incubated":[125],"for":[126],"min":[128],"before":[135],"measurement.":[137],"An":[138],"increase":[139],"enzyme":[141],"higher":[143],"than":[144],"20%":[145],"observed":[147],"26":[149],"patients":[150],"out":[151,159],"29":[153],"hGH,":[155],"18":[161],"insulin.":[163],"In":[164],"conclusion,":[165],"is":[167],"able":[168],"stimulate":[170],"human":[174],"cells.":[176],"This":[177],"effect":[179],"allows":[180],"rapid":[181],"evaluation":[182],"cellular":[185],"responsiveness":[186],"various":[190],"pathophysiologic":[191],"situations.":[192]},"counts_by_year":[{"year":2020,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
