{"id":"https://openalex.org/W2128012017","doi":"https://doi.org/10.1684/ecn.2010.0215","title":"Identification of specific tumor necrosis factor-\u03b1-susceptible and -protective haplotypes associated with the risk of type 1 diabetes.","display_name":"Identification of specific tumor necrosis factor-\u03b1-susceptible and -protective haplotypes associated with the risk of type 1 diabetes.","publication_year":2010,"publication_date":"2010-12-01","ids":{"openalex":"https://openalex.org/W2128012017","doi":"https://doi.org/10.1684/ecn.2010.0215","mag":"2128012017","pmid":"https://pubmed.ncbi.nlm.nih.gov/21097392"},"language":"en","primary_location":{"id":"pmid:21097392","doi":"https://doi.org/10.1684/ecn.2010.0215","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21097392","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European cytokine network","raw_type":"Journal Article"},"parent_works":[],"lineage":["https://openalex.org/W2128012017"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005833249","display_name":"Mouna Stayoussef","orcid":"https://orcid.org/0000-0003-3485-8606","observed_orcids":["https://orcid.org/0000-0003-3485-8606"]},"institutions":[{"id":"https://openalex.org/I166928557","display_name":"University of Monastir","ror":"https://ror.org/00nhtcg76","country_code":"TN","type":"education","lineage":["https://openalex.org/I166928557"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Mouna Stayoussef","raw_affiliation_strings":["Research unit of Hematological and Autoimmune Diseases, Faculty of Pharmacy, University of Monastir, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research unit of Hematological and Autoimmune Diseases, Faculty of Pharmacy, University of Monastir, Tunisia","institution_ids":["https://openalex.org/I166928557"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025415984","display_name":"Jihen Benmansour","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jihen Benmansour","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037419482","display_name":"Fayza A. Al-Jenaidi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fayza A Al-Jenaidi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085275696","display_name":"Mansoor H. Rajab","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mansoor H Rajab","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078202877","display_name":"Hichem Ben Said","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hichem B Said","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076010551","display_name":"Mohamed Ourtani","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mohamed Ourtani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028389364","display_name":"Chiheb Ben Rayana","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chiheb B Rayana","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051791762","display_name":"Touhami Mahjoub","orcid":"https://orcid.org/0000-0002-0205-2731","observed_orcids":["https://orcid.org/0000-0002-0205-2731"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Touhami Mahjoub","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5045144382","display_name":"Wassim Youssef Almawi","orcid":"https://orcid.org/0000-0003-1633-9757","observed_orcids":["https://orcid.org/0000-0003-1633-9757"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wassim Y Almawi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8222,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.7048683,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"21","issue":"4","first_page":"285","last_page":"91"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9210000038146973},{"id":"https://openalex.org/keywords/tnf-gene-polymorphism","display_name":"TNF gene polymorphism","score":0.7990000247955322},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.9509999752044678},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.7620000243186951},{"id":"https://openalex.org/keywords/protective-haplotypes","display_name":"protective haplotypes","score":0.8510000109672546},{"id":"https://openalex.org/keywords/haplotypes","display_name":"haplotypes","score":0.6819999814033508},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.9319999814033508},{"id":"https://openalex.org/keywords/linkage-disequilibrium","display_name":"linkage disequilibrium","score":0.9610000252723694}],"concepts":[{"id":"https://openalex.org/C197754878","wikidata":"https://www.wikidata.org/wiki/Q80711","display_name":"Haplotype","level":4,"score":0.927376389503479},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.8087713122367859},{"id":"https://openalex.org/C35605836","wikidata":"https://www.wikidata.org/wiki/Q2064311","display_name":"Linkage disequilibrium","level":5,"score":0.728100061416626},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.5552522540092468},{"id":"https://openalex.org/C168007829","wikidata":"https://www.wikidata.org/wiki/Q857299","display_name":"Restriction fragment length polymorphism","level":4,"score":0.505579948425293},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.4534884989261627},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42435887455940247},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.42312347888946533},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3796234130859375},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35245728492736816},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.34787994623184204},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22653794288635254}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005820","descriptor_name":"Genetic Testing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006239","descriptor_name":"Haplotypes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016555","descriptor_name":"Matched-Pair Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":1,"locations":[{"id":"pmid:21097392","doi":"https://doi.org/10.1684/ecn.2010.0215","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21097392","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European cytokine network","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9907000064849854}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2134364334","https://openalex.org/W2808905462","https://openalex.org/W2031231101","https://openalex.org/W2031208558","https://openalex.org/W2028048291","https://openalex.org/W2033916082","https://openalex.org/W1970599818","https://openalex.org/W2020139678","https://openalex.org/W4289926991","https://openalex.org/W2047644721"],"abstract_inverted_index":{"AIM:":[0],"We":[1],"investigated":[2],"the":[3,79,87,109,119,129,135,153,161,170,193],"association":[4],"of":[5,53,89,131,142,152],"tumor":[6],"necrosis":[7],"factor":[8],"(TNF)\u03b1":[9],"gene":[10],"polymorphism":[11,48],"with":[12,232],"type":[13],"1":[14],"diabetes":[15],"(T1D).":[16],"METHODS:":[17],"TNF-\u03b1":[18,221],"-1031T/C,":[19],"-863C/A,":[20,225],"-857C/T,":[21,91,226],"-376G/A,":[22,92],"-308G/A,":[23,93],"-238G/A,":[24,228],"and":[25,37,66,94,99,111,134,145,148,181,192,211,227],"+488G/A":[26],"single":[27],"nucleotide":[28],"polymorphisms":[29],"(SNPs)":[30],"were":[31,72,84,125,167,190],"assessed":[32],"in":[33,74,78,86,158,223],"198":[34],"T1DM":[35],"patients":[36,76,98],"180":[38],"age-and":[39],"gender-matched,":[40],"normoglycemic":[41],"control":[42,80],"subjects":[43],"using":[44],"PCR-restriction":[45],"fragment":[46],"length":[47],"(RFLP).":[49],"RESULTS:":[50],"Higher":[51],"frequencies":[52],"-863A":[54],"(p":[55,61,68],"=":[56,62,69,173,179,184,197],"8.0":[57],"\u00d7":[58,64,175,186,199],"10-6),":[59],"-857T":[60],"1.4":[63,174],"10-4),":[65],"-238A":[67],"0.002)":[70],"alleles":[71],"seen":[73,157],"T1D":[75,205],"than":[77],"group.":[81],"Significant":[82],"differences":[83,166],"noted":[85],"distribution":[88],"-863T/C,":[90],"-238G/A":[95],"genotypes":[96],"between":[97,108,118,137],"controls.":[100],"Haploview":[101],"analysis":[102],"revealed":[103],"high":[104],"linkage":[105],"disequilibrium":[106],"(LD)":[107],"-376G/A":[110],"-308G/A":[112],"SNPs,":[113],"but":[114],"this":[115],"was":[116,156,164,202],"lower":[117],"other":[120,237],"polymorphisms.":[121],"Five-locus":[122],"TNF\u03b1":[123],"haplotypes":[124,188],"constructed":[126],"based":[127],"on":[128,236],"prevalence":[130],"individual":[132],"SNPs":[133],"LD":[136],"them.":[138],"An":[139],"increased":[140],"frequency":[141,151],"CTGGG,":[143],"CCGAG,":[144],"ACGGG":[146,182],"haplotypes,":[147],"a":[149],"reduced":[150],"CCGGG":[154,194],"haplotype":[155,195],"patients.":[159],"When":[160],"Bonferroni":[162],"correction":[163],"applied,":[165],"significant":[168],"for":[169],"CTGGG":[171],"(Pc":[172,178,183,196],"10-3),":[176],"CCGAG":[177],"0.023),":[180],"1.2":[185],"10-3)":[187],"which":[189,201],"greater,":[191],"3.8":[198],"10-5)":[200],"smaller,":[203],"among":[204],"patients,":[206],"thereby":[207],"conferring":[208],"susceptibility":[209],"to":[210,242],"protection":[212],"from":[213],"T1D,":[214],"respectively.":[215],"CONCLUSION:":[216],"These":[217],"results":[218],"demonstrate":[219],"that":[220],"polymorphisms,":[222],"particular":[224],"are":[229,240],"significantly":[230],"associated":[231],"T1D.":[233],"Additional":[234],"studies,":[235],"racial":[238],"groups,":[239],"needed":[241],"confirm":[243],"our":[244],"findings.":[245]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
