{"id":"https://openalex.org/W2127998841","doi":"https://doi.org/10.2337/db09-1401","title":"Peroxisome-Generated Hydrogen Peroxide as Important Mediator of Lipotoxicity in Insulin-Producing Cells","display_name":"Peroxisome-Generated Hydrogen Peroxide as Important Mediator of Lipotoxicity in Insulin-Producing Cells","publication_year":2010,"publication_date":"2010-10-22","ids":{"openalex":"https://openalex.org/W2127998841","doi":"https://doi.org/10.2337/db09-1401","mag":"2127998841","pmid":"https://pubmed.ncbi.nlm.nih.gov/20971967","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3012172"},"language":"en","primary_location":{"id":"doi:10.2337/db09-1401","doi":"https://doi.org/10.2337/db09-1401","is_oa":true,"landing_page_url":"https://doi.org/10.2337/db09-1401","pdf_url":"https://diabetesjournals.org/diabetes/article-pdf/60/1/200/399076/zdb00111000200.pdf","source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://diabetesjournals.org/diabetes/article-pdf/60/1/200/399076/zdb00111000200.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051306105","display_name":"Matthias Elsner","orcid":"https://orcid.org/0000-0002-8865-1777","observed_orcids":["https://orcid.org/0000-0002-8865-1777"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Matthias Elsner","raw_affiliation_strings":["From the Institute of Clinical Biochemistry, Hannover Medical School, Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Institute of Clinical Biochemistry, Hannover Medical School, Hannover, Germany","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028884952","display_name":"Wiebke Gehrmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Wiebke Gehrmann","raw_affiliation_strings":["From the Institute of Clinical Biochemistry, Hannover Medical School, Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Institute of Clinical Biochemistry, Hannover Medical School, Hannover, Germany","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043148796","display_name":"Sigurd Lenzen","orcid":"https://orcid.org/0000-0003-2125-8193","observed_orcids":["https://orcid.org/0000-0003-2125-8193"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Sigurd Lenzen","raw_affiliation_strings":["From the Institute of Clinical Biochemistry, Hannover Medical School, Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Institute of Clinical Biochemistry, Hannover Medical School, Hannover, Germany","institution_ids":["https://openalex.org/I34809795"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5043148796"],"corresponding_institution_ids":["https://openalex.org/I34809795"],"apc_list":null,"apc_paid":null,"fwci":7.5724,"has_fulltext":true,"cited_by_count":226,"citation_normalized_percentile":{"value":0.97911387,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"60","issue":"1","first_page":"200","last_page":"208"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lipotoxicity","display_name":"lipotoxicity","score":0.949999988079071},{"id":"https://openalex.org/keywords/insulin-producing-cells","display_name":"insulin-producing cells","score":0.7590000033378601},{"id":"https://openalex.org/keywords/free-fatty-acids","display_name":"free fatty acids","score":0.8539999723434448},{"id":"https://openalex.org/keywords/palmitic-acid","display_name":"palmitic acid","score":0.9229999780654907},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.7570000290870667},{"id":"https://openalex.org/keywords/peroxisomal-beta-oxidation","display_name":"peroxisomal beta-oxidation","score":0.8320000171661377},{"id":"https://openalex.org/keywords/beta-cell-dysfunction","display_name":"beta-cell dysfunction","score":0.7889999747276306},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9179999828338623},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7160000205039978},{"id":"https://openalex.org/keywords/catalase","display_name":"catalase","score":0.7649999856948853},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":0.8730000257492065},{"id":"https://openalex.org/keywords/rinm5f-cells","display_name":"RINm5F cells","score":0.8489999771118164},{"id":"https://openalex.org/keywords/ins-1e-cells","display_name":"INS-1E cells","score":0.9710000157356262}],"concepts":[{"id":"https://openalex.org/C44353895","wikidata":"https://www.wikidata.org/wiki/Q6556772","display_name":"Lipotoxicity","level":4,"score":0.9632718563079834},{"id":"https://openalex.org/C127078168","wikidata":"https://www.wikidata.org/wiki/Q138639","display_name":"Peroxisome","level":3,"score":0.7887054681777954},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.6619806885719299},{"id":"https://openalex.org/C2778979269","wikidata":"https://www.wikidata.org/wiki/Q106951292","display_name":"Catalase","level":3,"score":0.6054204702377319},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5180773735046387},{"id":"https://openalex.org/C2775934118","wikidata":"https://www.wikidata.org/wiki/Q424169","display_name":"Propidium iodide","level":4,"score":0.45715707540512085},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.45291540026664734},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.435403048992157},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.434050589799881},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.4290541410446167},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.4283263385295868},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4213744103908539},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4161009192466736},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.41527673602104187},{"id":"https://openalex.org/C2779936771","wikidata":"https://www.wikidata.org/wiki/Q209727","display_name":"Palmitic acid","level":3,"score":0.41327109932899475},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3841966390609741},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.38395729660987854},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3753764033317566},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.24992120265960693},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.24187687039375305},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.15751299262046814},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.13676324486732483},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.06692704558372498},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000074435","descriptor_name":"Peroxisome-Targeting Signal 1 Receptor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005452","descriptor_name":"Fluoresceins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011917","descriptor_name":"Rats, Inbred Lew","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016086","descriptor_name":"Lentivirus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018160","descriptor_name":"Receptors, Cytoplasmic and Nuclear","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020675","descriptor_name":"Peroxisomes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056945","descriptor_name":"Hep G2 Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.2337/db09-1401","doi":"https://doi.org/10.2337/db09-1401","is_oa":true,"landing_page_url":"https://doi.org/10.2337/db09-1401","pdf_url":"https://diabetesjournals.org/diabetes/article-pdf/60/1/200/399076/zdb00111000200.pdf","source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2253852","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3012172","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3012172","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3012172","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"Text"},{"id":"pmid:20971967","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20971967","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.786.6039","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.786.6039","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/1c/1e/zdb200.PMC3012172.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.2337/db09-1401","doi":"https://doi.org/10.2337/db09-1401","is_oa":true,"landing_page_url":"https://doi.org/10.2337/db09-1401","pdf_url":"https://diabetesjournals.org/diabetes/article-pdf/60/1/200/399076/zdb00111000200.pdf","source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2956492175","display_name":null,"funder_award_id":"LSHM-CT-2006-518153","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2127998841.pdf","grobid_xml":"https://content.openalex.org/works/W2127998841.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W56426715","https://openalex.org/W1500111450","https://openalex.org/W1599557387","https://openalex.org/W1828550268","https://openalex.org/W1828613304","https://openalex.org/W1862194997","https://openalex.org/W1967782318","https://openalex.org/W1968048626","https://openalex.org/W1970303002","https://openalex.org/W1970420856","https://openalex.org/W1971701221","https://openalex.org/W1971713572","https://openalex.org/W1973568785","https://openalex.org/W1976315274","https://openalex.org/W1978998500","https://openalex.org/W1994567337","https://openalex.org/W2008081488","https://openalex.org/W2010094123","https://openalex.org/W2010290591","https://openalex.org/W2018301223","https://openalex.org/W2033125833","https://openalex.org/W2042362312","https://openalex.org/W2058677692","https://openalex.org/W2060734333","https://openalex.org/W2062406827","https://openalex.org/W2062412316","https://openalex.org/W2063720970","https://openalex.org/W2065615441","https://openalex.org/W2069971581","https://openalex.org/W2075741684","https://openalex.org/W2079230681","https://openalex.org/W2092055474","https://openalex.org/W2099256467","https://openalex.org/W2101641567","https://openalex.org/W2108709856","https://openalex.org/W2109168147","https://openalex.org/W2112645157","https://openalex.org/W2113544353","https://openalex.org/W2114918609","https://openalex.org/W2116313215","https://openalex.org/W2117403951","https://openalex.org/W2122886986","https://openalex.org/W2146845495","https://openalex.org/W2148911589","https://openalex.org/W2152201022","https://openalex.org/W2156044622","https://openalex.org/W2159896083","https://openalex.org/W2167523976","https://openalex.org/W2181817569","https://openalex.org/W2313812404","https://openalex.org/W2766278336","https://openalex.org/W4240699163","https://openalex.org/W6602375552","https://openalex.org/W6757578696"],"related_works":["https://openalex.org/W7099841417","https://openalex.org/W1846971709","https://openalex.org/W2018232315","https://openalex.org/W7096128915","https://openalex.org/W2009694328","https://openalex.org/W4205154040","https://openalex.org/W1990045305","https://openalex.org/W2274920478","https://openalex.org/W7170145247","https://openalex.org/W2062406827"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Type":[1],"2":[2],"diabetes":[3],"is":[4,9,37],"a":[5,220],"complex":[6],"disease":[7],"that":[8,34,201],"accompanied":[10],"by":[11,87,126],"elevated":[12],"levels":[13],"of":[14,49,75,111,145,183,223],"nonesterified":[15],"fatty":[16,224],"acids":[17],"(NEFAs),":[18],"which":[19],"contribute":[20],"to":[21,28,103,128,141],"\u03b2-cell":[22,25,226],"dysfunction":[23],"and":[24,58,89,107,150,163,185],"loss,":[26],"referred":[27],"as":[29,61,63,189,191],"lipotoxicity.":[30,40],"Experimental":[31],"evidence":[32],"suggests":[33],"oxidative":[35],"stress":[36],"involved":[38],"in":[39,54,64,147,151,156,180,192,204,209],"In":[41],"this":[42],"study,":[43],"we":[44,218],"analyzed":[45],"the":[46,105,108,117,148,152,157,165,172,181,205,210],"molecular":[47],"mechanisms":[48],"reactive":[50,112,230],"oxygen":[51,113,231],"species-mediated":[52],"lipotoxicity":[53,227],"insulin-producing":[55,83,142,187],"RINm5F":[56,184],"cells":[57,60,84,100,166,188],"INS-1E":[59,186],"well":[62,190],"primary":[65,193],"rat":[66,194],"islet":[67,195],"cells.":[68,143,196],"RESEARCH":[69],"DESIGN":[70],"AND":[71],"METHODS:":[72],"The":[73,198],"toxicity":[74],"saturated":[76,137],"NEFAs":[77,138],"with":[78],"different":[79],"chain":[80],"lengths":[81],"upon":[82],"was":[85,131,177],"determined":[86],"MTT":[88],"propidium":[90],"iodide":[91],"(PI)":[92],"viability":[93],"assays.":[94],"Catalase":[95],"or":[96],"superoxide":[97],"dismutase":[98],"overexpressing":[99],"were":[101,139],"used":[102],"analyze":[104],"nature":[106],"cellular":[109],"compartment":[110],"species":[114,232],"formation.":[115],"With":[116,171],"new":[118,221],"H\u2082O\u2082-sensitive":[119],"fluorescent":[120],"protein":[121],"HyPer":[122,173],"H\u2082O\u2082":[123,161,175,202],"formation":[124,162,203,233],"induced":[125],"exposure":[127],"palmitic":[129,168],"acid":[130],"determined.":[132],"RESULTS:":[133],"Only":[134],"long-chain":[135],"(>C14)":[136],"toxic":[140],"Overexpression":[144],"catalase":[146],"peroxisomes":[149,182,206],"cytosol,":[153],"but":[154],"not":[155],"mitochondria,":[158],"significantly":[159],"reduced":[160],"protected":[164],"against":[167],"acid-induced":[169,225],"toxicity.":[170,216],"protein,":[174],"generation":[176],"directly":[178],"detectable":[179],"CONCLUSIONS:":[197],"results":[199],"demonstrate":[200],"rather":[207],"than":[208],"mitochondria":[211],"are":[212],"responsible":[213],"for":[214],"NEFA-induced":[215],"Therefore,":[217],"propose":[219],"concept":[222],"mediated":[228],"via":[229],"through":[234],"peroxisomal":[235],"\u03b2-":[236],"oxidation.":[237]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":18},{"year":2021,"cited_by_count":26},{"year":2020,"cited_by_count":16},{"year":2019,"cited_by_count":18},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":16},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":17},{"year":2014,"cited_by_count":14},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":17}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}