{"id":"https://openalex.org/W2127945562","doi":"https://doi.org/10.1523/jneurosci.3579-13.2014","title":"Amyloid Deposition Is Linked to Aberrant Entorhinal Activity among Cognitively Normal Older Adults","display_name":"Amyloid Deposition Is Linked to Aberrant Entorhinal Activity among Cognitively Normal Older Adults","publication_year":2014,"publication_date":"2014-04-09","ids":{"openalex":"https://openalex.org/W2127945562","doi":"https://doi.org/10.1523/jneurosci.3579-13.2014","mag":"2127945562","pmid":"https://pubmed.ncbi.nlm.nih.gov/24719099","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3983800"},"language":"en","primary_location":{"id":"doi:10.1523/jneurosci.3579-13.2014","doi":"https://doi.org/10.1523/jneurosci.3579-13.2014","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.3579-13.2014","pdf_url":"https://www.jneurosci.org/content/jneuro/34/15/5200.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.jneurosci.org/content/jneuro/34/15/5200.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011879732","display_name":"Willem Huijbers","orcid":"https://orcid.org/0000-0003-3958-4069","observed_orcids":["https://orcid.org/0000-0003-3958-4069"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210127055","display_name":"Athinoula A. Martinos Center for Biomedical Imaging","ror":"https://ror.org/032q5ym94","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210127055","https://openalex.org/I48633490","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Willem Huijbers","raw_affiliation_strings":["Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, Harvard Aging Brain Study, Department of Neurology, and Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114","1Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115,","2Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts 02129,","3Harvard Aging Brain Study, Department of Neurology, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, Harvard Aging Brain Study, Department of Neurology, and Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210127055"]},{"raw_affiliation_string":"1Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115,","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"2Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts 02129,","institution_ids":["https://openalex.org/I4210087915","https://openalex.org/I4210127055"]},{"raw_affiliation_string":"3Harvard Aging Brain Study, Department of Neurology, and","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078734759","display_name":"Elizabeth C. Mormino","orcid":"https://orcid.org/0000-0002-4542-6537","observed_orcids":["https://orcid.org/0000-0002-4542-6537","https://orcid.org/0009-0003-3321-8081"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210127055","display_name":"Athinoula A. Martinos Center for Biomedical Imaging","ror":"https://ror.org/032q5ym94","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210127055","https://openalex.org/I48633490","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth C. Mormino","raw_affiliation_strings":["2Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts 02129,","3Harvard Aging Brain Study, Department of Neurology, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts 02129,","institution_ids":["https://openalex.org/I4210087915","https://openalex.org/I4210127055"]},{"raw_affiliation_string":"3Harvard Aging Brain Study, Department of Neurology, and","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030654032","display_name":"Sarah E. Wigman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210127055","display_name":"Athinoula A. Martinos Center for Biomedical Imaging","ror":"https://ror.org/032q5ym94","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210127055","https://openalex.org/I48633490","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah E. Wigman","raw_affiliation_strings":["1Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115,","2Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts 02129,","3Harvard Aging Brain Study, Department of Neurology, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115,","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"2Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts 02129,","institution_ids":["https://openalex.org/I4210087915","https://openalex.org/I4210127055"]},{"raw_affiliation_string":"3Harvard Aging Brain Study, Department of Neurology, and","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055051421","display_name":"Andrew M. Ward","orcid":"https://orcid.org/0000-0001-6948-4814","observed_orcids":["https://orcid.org/0000-0001-6948-4814"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210127055","display_name":"Athinoula A. Martinos Center for Biomedical Imaging","ror":"https://ror.org/032q5ym94","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210127055","https://openalex.org/I48633490","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew M. Ward","raw_affiliation_strings":["1Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115,","2Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts 02129,","3Harvard Aging Brain Study, Department of Neurology, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115,","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"2Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts 02129,","institution_ids":["https://openalex.org/I4210087915","https://openalex.org/I4210127055"]},{"raw_affiliation_string":"3Harvard Aging Brain Study, Department of Neurology, and","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057415951","display_name":"Patrizia Vannini","orcid":"https://orcid.org/0000-0002-9425-1059","observed_orcids":["https://orcid.org/0000-0002-9425-1059"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210127055","display_name":"Athinoula A. Martinos Center for Biomedical Imaging","ror":"https://ror.org/032q5ym94","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210127055","https://openalex.org/I48633490","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrizia Vannini","raw_affiliation_strings":["1Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115,","2Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts 02129,","3Harvard Aging Brain Study, Department of Neurology, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115,","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"2Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts 02129,","institution_ids":["https://openalex.org/I4210087915","https://openalex.org/I4210127055"]},{"raw_affiliation_string":"3Harvard Aging Brain Study, Department of Neurology, and","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048685065","display_name":"Donald G. McLaren","orcid":"https://orcid.org/0000-0002-0566-4610","observed_orcids":["https://orcid.org/0000-0002-0566-4610"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210127055","display_name":"Athinoula A. Martinos Center for Biomedical Imaging","ror":"https://ror.org/032q5ym94","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210127055","https://openalex.org/I48633490","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donald G. McLaren","raw_affiliation_strings":["2Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts 02129,","3Harvard Aging Brain Study, Department of Neurology, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts 02129,","institution_ids":["https://openalex.org/I4210087915","https://openalex.org/I4210127055"]},{"raw_affiliation_string":"3Harvard Aging Brain Study, Department of Neurology, and","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010168107","display_name":"John Alex Becker","orcid":"https://orcid.org/0000-0001-7435-1338","observed_orcids":["https://orcid.org/0000-0001-7435-1338"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210127055","display_name":"Athinoula A. Martinos Center for Biomedical Imaging","ror":"https://ror.org/032q5ym94","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210127055","https://openalex.org/I48633490","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Alex Becker","raw_affiliation_strings":["2Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts 02129,","3Harvard Aging Brain Study, Department of Neurology, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts 02129,","institution_ids":["https://openalex.org/I4210087915","https://openalex.org/I4210127055"]},{"raw_affiliation_string":"3Harvard Aging Brain Study, Department of Neurology, and","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005435770","display_name":"Aaron P. Schultz","orcid":"https://orcid.org/0000-0002-0418-0999","observed_orcids":["https://orcid.org/0000-0002-0418-0999"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210127055","display_name":"Athinoula A. Martinos Center for Biomedical Imaging","ror":"https://ror.org/032q5ym94","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210127055","https://openalex.org/I48633490","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron P. Schultz","raw_affiliation_strings":["2Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts 02129,","3Harvard Aging Brain Study, Department of Neurology, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts 02129,","institution_ids":["https://openalex.org/I4210087915","https://openalex.org/I4210127055"]},{"raw_affiliation_string":"3Harvard Aging Brain Study, Department of Neurology, and","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066159823","display_name":"Trey Hedden","orcid":"https://orcid.org/0009-0009-5677-2214","observed_orcids":["https://orcid.org/0009-0009-5677-2214"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210127055","display_name":"Athinoula A. Martinos Center for Biomedical Imaging","ror":"https://ror.org/032q5ym94","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210127055","https://openalex.org/I48633490","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Trey Hedden","raw_affiliation_strings":["2Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts 02129,","4Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts 02129,","institution_ids":["https://openalex.org/I4210087915","https://openalex.org/I4210127055"]},{"raw_affiliation_string":"4Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090842068","display_name":"Keith A. Johnson","orcid":"https://orcid.org/0000-0002-5916-6043","observed_orcids":["https://orcid.org/0000-0002-5916-6043","https://orcid.org/0000-0002-3577-8299"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keith A. Johnson","raw_affiliation_strings":["1Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115,","3Harvard Aging Brain Study, Department of Neurology, and","4Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115,","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"3Harvard Aging Brain Study, Department of Neurology, and","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"4Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001795846","display_name":"Reisa Anne Sperling","orcid":"https://orcid.org/0000-0003-1535-6133","observed_orcids":["https://orcid.org/0000-0003-1535-6133"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210127055","display_name":"Athinoula A. Martinos Center for Biomedical Imaging","ror":"https://ror.org/032q5ym94","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210127055","https://openalex.org/I48633490","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Reisa A. Sperling","raw_affiliation_strings":["1Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115,","2Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts 02129,","3Harvard Aging Brain Study, Department of Neurology, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115,","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"2Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts 02129,","institution_ids":["https://openalex.org/I4210087915","https://openalex.org/I4210127055"]},{"raw_affiliation_string":"3Harvard Aging Brain Study, Department of Neurology, and","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":9.1598,"has_fulltext":true,"cited_by_count":89,"citation_normalized_percentile":{"value":0.98581353,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"34","issue":"15","first_page":"5200","last_page":"5210"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.8213000297546387,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.8213000297546387,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.12129999697208405,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.033900000154972076,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amyloid-beta-deposition","display_name":"amyloid-beta deposition","score":0.9700000286102295},{"id":"https://openalex.org/keywords/entorhinal-cortex","display_name":"entorhinal cortex","score":0.9900000095367432},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.7369999885559082},{"id":"https://openalex.org/keywords/default-mode-network","display_name":"default mode network","score":0.8759999871253967},{"id":"https://openalex.org/keywords/medial-temporal-lobe","display_name":"medial temporal lobe","score":0.7149999737739563},{"id":"https://openalex.org/keywords/episodic-memory","display_name":"episodic memory","score":0.9309999942779541},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.5609999895095825},{"id":"https://openalex.org/keywords/cognitively-normal-older-adults","display_name":"cognitively normal older adults","score":0.8040000200271606},{"id":"https://openalex.org/keywords/functional-connectivity","display_name":"functional connectivity","score":0.578000009059906},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.5019999742507935},{"id":"https://openalex.org/keywords/memory-modulation","display_name":"memory modulation","score":0.30799999833106995}],"concepts":[{"id":"https://openalex.org/C2780715579","wikidata":"https://www.wikidata.org/wiki/Q2603645","display_name":"Entorhinal cortex","level":3,"score":0.9117889404296875},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7029509544372559},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.654460072517395},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.6066012978553772},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5664738416671753},{"id":"https://openalex.org/C2781099131","wikidata":"https://www.wikidata.org/wiki/Q744385","display_name":"Temporal lobe","level":3,"score":0.56021648645401},{"id":"https://openalex.org/C2777222312","wikidata":"https://www.wikidata.org/wiki/Q726562","display_name":"Neocortex","level":2,"score":0.49688103795051575},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.4836224615573883},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.47029802203178406},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.46906328201293945},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.4449717402458191},{"id":"https://openalex.org/C88576662","wikidata":"https://www.wikidata.org/wiki/Q18646","display_name":"Episodic memory","level":3,"score":0.44394034147262573},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3760523498058319},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27768027782440186},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.1808478832244873},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.14407119154930115},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.07173514366149902}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001931","descriptor_name":"Brain Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008568","descriptor_name":"Memory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018728","descriptor_name":"Entorhinal Cortex","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D018728","descriptor_name":"Entorhinal Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018728","descriptor_name":"Entorhinal Cortex","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1523/jneurosci.3579-13.2014","doi":"https://doi.org/10.1523/jneurosci.3579-13.2014","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.3579-13.2014","pdf_url":"https://www.jneurosci.org/content/jneuro/34/15/5200.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3159962","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3983800","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3983800","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3983800","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurosci","raw_type":"Text"},{"id":"pmid:24719099","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24719099","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of neuroscience : the official journal of the Society for Neuroscience","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1523/jneurosci.3579-13.2014","doi":"https://doi.org/10.1523/jneurosci.3579-13.2014","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.3579-13.2014","pdf_url":"https://www.jneurosci.org/content/jneuro/34/15/5200.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8999999761581421}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1032888771","display_name":null,"funder_award_id":"IIRG-06-27374","funder_id":"https://openalex.org/F4320306219","funder_display_name":"Alzheimer's Association"},{"id":"https://openalex.org/G1360098495","display_name":null,"funder_award_id":"P41-EB015896","funder_id":"https://openalex.org/F4320334293","funder_display_name":"Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital"},{"id":"https://openalex.org/G1838321799","display_name":"Influence of Age-related Neuropathology on Functional Brain Networks","funder_award_id":"K01AG040197","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G3171611343","display_name":null,"funder_award_id":"P41EB015896","funder_id":"https://openalex.org/F4320308349","funder_display_name":"Massachusetts General Hospital"},{"id":"https://openalex.org/G419202165","display_name":"Mentoring Imaging Research in Early AD","funder_award_id":"K24AG035007","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5021443450","display_name":null,"funder_award_id":"P01AG036694","funder_id":"https://openalex.org/F4320306219","funder_display_name":"Alzheimer's Association"},{"id":"https://openalex.org/G5737987324","display_name":"Associative Memory and Transitive Inference in Aging and Preclinical AD","funder_award_id":"F32AG042228","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G6209455021","display_name":"Evolution of memory related fMRI activation over the course of MCI and AD","funder_award_id":"R01AG027435","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G6473096149","display_name":"Characterizing the Evolution of Amyloid Deposition in Normal Elderly","funder_award_id":"R01AG037497","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G6618630211","display_name":"Neuroscience Training Program","funder_award_id":"T32GM007507","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6799078772","display_name":"Deficits in top-down processes during episodic memory in aging and preclinical AD","funder_award_id":"F32AG044054","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G7637191593","display_name":"Massachusetts Alzheimer's Disease Research Center","funder_award_id":"P50AG005134","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G7841877555","display_name":"Center for Functional Imaging Technologies","funder_award_id":"P41EB015896","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G9000885443","display_name":"Impact of Amyloid and Tau on the Aging Brain: The Harvard Aging Brain Study","funder_award_id":"P01AG036694","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320306219","display_name":"Alzheimer's Association","ror":"https://ror.org/0375f4d26"},{"id":"https://openalex.org/F4320308349","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78"},{"id":"https://openalex.org/F4320323832","display_name":"Centre d'Imagerie BioM\u00e9dicale","ror":"https://ror.org/03fw2bn12"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334293","display_name":"Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital","ror":"https://ror.org/032q5ym94"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"},{"id":"https://openalex.org/F4320338368","display_name":"FP7 People: Marie-Curie Actions","ror":"https://ror.org/00k4n6c32"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2127945562.pdf","grobid_xml":"https://content.openalex.org/works/W2127945562.grobid-xml"},"referenced_works_count":94,"referenced_works":["https://openalex.org/W1591304899","https://openalex.org/W1695738173","https://openalex.org/W1760829075","https://openalex.org/W1948376220","https://openalex.org/W1964350064","https://openalex.org/W1967642097","https://openalex.org/W1969039470","https://openalex.org/W1972095263","https://openalex.org/W1974594322","https://openalex.org/W1986900475","https://openalex.org/W1987064062","https://openalex.org/W1987110004","https://openalex.org/W1990313607","https://openalex.org/W1993571512","https://openalex.org/W1996496731","https://openalex.org/W1997301424","https://openalex.org/W1998633319","https://openalex.org/W2002610924","https://openalex.org/W2005359670","https://openalex.org/W2007996892","https://openalex.org/W2010216178","https://openalex.org/W2013803050","https://openalex.org/W2017022537","https://openalex.org/W2029497762","https://openalex.org/W2032847834","https://openalex.org/W2037403969","https://openalex.org/W2042974739","https://openalex.org/W2044614452","https://openalex.org/W2046104092","https://openalex.org/W2046638602","https://openalex.org/W2052742260","https://openalex.org/W2052816647","https://openalex.org/W2053082937","https://openalex.org/W2053257768","https://openalex.org/W2053569385","https://openalex.org/W2056081184","https://openalex.org/W2065331648","https://openalex.org/W2070069429","https://openalex.org/W2070119338","https://openalex.org/W2073271453","https://openalex.org/W2074274706","https://openalex.org/W2075348467","https://openalex.org/W2078524519","https://openalex.org/W2081126811","https://openalex.org/W2085409650","https://openalex.org/W2089613882","https://openalex.org/W2092932101","https://openalex.org/W2095963715","https://openalex.org/W2096963202","https://openalex.org/W2098485296","https://openalex.org/W2098580427","https://openalex.org/W2104163310","https://openalex.org/W2105103983","https://openalex.org/W2107018300","https://openalex.org/W2107523137","https://openalex.org/W2111464173","https://openalex.org/W2113518834","https://openalex.org/W2113538531","https://openalex.org/W2114222094","https://openalex.org/W2114555409","https://openalex.org/W2115296012","https://openalex.org/W2120546516","https://openalex.org/W2124443688","https://openalex.org/W2129497119","https://openalex.org/W2129771097","https://openalex.org/W2129788945","https://openalex.org/W2132766843","https://openalex.org/W2134711807","https://openalex.org/W2134858198","https://openalex.org/W2136435696","https://openalex.org/W2137284909","https://openalex.org/W2141271762","https://openalex.org/W2145526417","https://openalex.org/W2150073354","https://openalex.org/W2150872839","https://openalex.org/W2152160545","https://openalex.org/W2152223730","https://openalex.org/W2156981442","https://openalex.org/W2158592797","https://openalex.org/W2159838014","https://openalex.org/W2160150006","https://openalex.org/W2160719354","https://openalex.org/W2162010696","https://openalex.org/W2163248715","https://openalex.org/W2164922920","https://openalex.org/W2165576422","https://openalex.org/W2165942026","https://openalex.org/W2166207589","https://openalex.org/W2171249901","https://openalex.org/W2171776652","https://openalex.org/W2175405147","https://openalex.org/W2993343469","https://openalex.org/W4234482113","https://openalex.org/W4294214781"],"related_works":["https://openalex.org/W2108777783","https://openalex.org/W1997301424","https://openalex.org/W2405132195","https://openalex.org/W2154174038","https://openalex.org/W2589022663","https://openalex.org/W2085409650","https://openalex.org/W2163248715","https://openalex.org/W2113538531","https://openalex.org/W2158592797","https://openalex.org/W1987110004"],"abstract_inverted_index":{"Normal":[0],"aging":[1,151],"is":[2,46,68,152],"often":[3],"difficult":[4],"to":[5,41,49,86,107,128,143],"distinguish":[6],"from":[7],"the":[8,23,43,53,61,129,133,160],"earliest":[9],"stages":[10],"of":[11,35,55,132],"Alzheimer's":[12],"disease.":[13],"Years":[14],"before":[15],"clinical":[16],"memory":[17,66,96],"deficits":[18],"manifest,":[19],"amyloid-\u03b2":[20,50,56,101,141],"deposits":[21],"in":[22,25,110,147],"cortex":[24],"many":[26],"older":[27,77,99],"individuals.":[28],"Neuroimaging":[29],"studies":[30],"indicate":[31],"that":[32,74,119],"a":[33],"set":[34],"densely":[36],"connected":[37,127],"neocortical":[38,130,140],"regions,":[39],"referred":[40],"as":[42],"default":[44,134],"network,":[45],"especially":[47],"vulnerable":[48],"deposition.":[51],"Yet,":[52],"impact":[54],"on":[57],"age-related":[58],"changes":[59,158],"within":[60],"medial":[62],"temporal":[63],"lobe":[64],"(MTL)":[65],"system":[67],"less":[69],"clear.":[70],"Here":[71],"we":[72,117],"demonstrate":[73],"cognitively":[75],"normal":[76],"humans,":[78],"compared":[79],"with":[80,105,154],"young":[81],"adults,":[82,100],"show":[83,118],"reduced":[84],"ability":[85],"modulate":[87,108],"hippocampal":[88],"activations":[89],"and":[90],"entorhinal":[91,111,120,148],"deactivations":[92],"during":[93],"an":[94],"episodic":[95],"task.":[97],"Among":[98],"deposition":[102,142],"was":[103],"associated":[104,153],"failure":[106],"activity":[109],"cortex,":[112,149],"but":[113],"not":[114],"hippocampus.":[115],"Furthermore,":[116],"regions":[121,131],"demonstrating":[122],"amyloid-\u03b2-related":[123],"dysfunction":[124,145],"are":[125],"directly":[126],"network.":[135],"Together":[136],"these":[137],"findings":[138],"link":[139],"neuronal":[144],"specifically":[146],"while":[150],"more":[155],"widespread":[156],"functional":[157],"across":[159],"MTL.":[161]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}