{"id":"https://openalex.org/W2127906261","doi":"https://doi.org/10.1200/jco.2005.05.5319","title":"A \u201cBone\u201d Fide Predictor of Metastasis? Predicting Breast Cancer Metastasis to Bone","display_name":"A \u201cBone\u201d Fide Predictor of Metastasis? Predicting Breast Cancer Metastasis to Bone","publication_year":2006,"publication_date":"2006-04-25","ids":{"openalex":"https://openalex.org/W2127906261","doi":"https://doi.org/10.1200/jco.2005.05.5319","mag":"2127906261","pmid":"https://pubmed.ncbi.nlm.nih.gov/16636338"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2005.05.5319","doi":"https://doi.org/10.1200/jco.2005.05.5319","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2005.05.5319","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"editorial","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053081399","display_name":"Scott L. Kominsky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott L. Kominsky","raw_affiliation_strings":["Departments of Orthopedic Surgery and Oncology, Johns Hopkins University School of Medicine, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Orthopedic Surgery and Oncology, Johns Hopkins University School of Medicine, Baltimore, MD","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044143691","display_name":"Nancy E. Davidson","orcid":"https://orcid.org/0000-0003-1520-6442","observed_orcids":["https://orcid.org/0000-0003-1520-6442"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nancy E. Davidson","raw_affiliation_strings":["Departments of Orthopedic Surgery and Oncology, Johns Hopkins University School of Medicine, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Orthopedic Surgery and Oncology, Johns Hopkins University School of Medicine, Baltimore, MD","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"24","issue":"15","first_page":"2227","last_page":"2229"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12108","display_name":"Management of metastatic bone disease","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer-bone-metastasis","display_name":"breast cancer bone metastasis","score":0.9100000262260437},{"id":"https://openalex.org/keywords/metastasis-prediction","display_name":"metastasis prediction","score":0.8339999914169312},{"id":"https://openalex.org/keywords/bone-targeted-therapy","display_name":"bone-targeted therapy","score":0.6779999732971191},{"id":"https://openalex.org/keywords/bisphosphonates","display_name":"bisphosphonates","score":0.8830000162124634},{"id":"https://openalex.org/keywords/strontium-89-chloride","display_name":"strontium-89 chloride","score":0.8809999823570251},{"id":"https://openalex.org/keywords/radiopharmaceuticals","display_name":"radiopharmaceuticals","score":0.8339999914169312},{"id":"https://openalex.org/keywords/zoledronic-acid","display_name":"zoledronic acid","score":0.7599999904632568},{"id":"https://openalex.org/keywords/pamidronate","display_name":"pamidronate","score":0.9980000257492065},{"id":"https://openalex.org/keywords/skeletal-related-events","display_name":"skeletal-related events","score":0.503000020980835},{"id":"https://openalex.org/keywords/myelosuppression","display_name":"myelosuppression","score":0.7860000133514404}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8538549542427063},{"id":"https://openalex.org/C2777783956","wikidata":"https://www.wikidata.org/wiki/Q848085","display_name":"Bone metastasis","level":4,"score":0.7354229688644409},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6718543767929077},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5975730419158936},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5177878141403198},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47599637508392334},{"id":"https://openalex.org/C2993589390","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Breast cancer metastasis","level":5,"score":0.41907763481140137},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.39700108766555786}],"mesh":[{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004164","descriptor_name":"Diphosphonates","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019275","descriptor_name":"Radiopharmaceuticals","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1200/jco.2005.05.5319","doi":"https://doi.org/10.1200/jco.2005.05.5319","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2005.05.5319","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},{"id":"pmid:16636338","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16636338","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical oncology : official journal of the American Society of Clinical Oncology","raw_type":"Comment"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8700000047683716,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1531555307","https://openalex.org/W1890755091","https://openalex.org/W1986471913","https://openalex.org/W2020024347","https://openalex.org/W2026290443","https://openalex.org/W2026848195","https://openalex.org/W2051112719","https://openalex.org/W2063699543","https://openalex.org/W2082833890","https://openalex.org/W2082909442","https://openalex.org/W2085854693","https://openalex.org/W2087929119","https://openalex.org/W2093477167","https://openalex.org/W2100193180","https://openalex.org/W2112907191","https://openalex.org/W2128985829","https://openalex.org/W2137302084","https://openalex.org/W2153801209","https://openalex.org/W2159100092","https://openalex.org/W2163563958","https://openalex.org/W2165621847","https://openalex.org/W2165923646","https://openalex.org/W2314428698"],"related_works":["https://openalex.org/W2129303830","https://openalex.org/W2424409719","https://openalex.org/W2067721174","https://openalex.org/W2424403263","https://openalex.org/W2039582573","https://openalex.org/W3004808629","https://openalex.org/W2804534359","https://openalex.org/W4234266122","https://openalex.org/W1973142147","https://openalex.org/W2171402543"],"abstract_inverted_index":{"Bone":[0],"is":[1,44,102],"the":[2,15,39,49,59,65],"most":[3],"common":[4],"site":[5],"of":[6,17,61,67,88,108],"breast":[7],"cancer":[8],"metastasis,":[9],"with":[10,19,29,114],"bone":[11,68,90],"metastasis":[12,43,69],"occurring":[13],"in":[14,54],"majority":[16],"women":[18],"stage":[20],"IV":[21],"disease.":[22],"These":[23,81],"patients":[24],"may":[25],"experience":[26],"marked":[27],"morbidity":[28],"pain,":[30],"decreased":[31],"mobility,":[32],"neurologic":[33],"compromise,":[34],"and/or":[35],"pathologic":[36],"fractures.":[37],"Although":[38],"primary":[40],"treatment":[41,66],"for":[42],"systemic":[45,97],"therapy":[46,55],"directed":[47],"at":[48],"underlying":[50],"neoplasm,":[51],"recent":[52],"advances":[53],"have":[56],"led":[57],"to":[58,64,85],"development":[60],"agents":[62,82],"tailored":[63],"including":[70],"radiopharmaceuticals":[71,110],"(eg,":[72,77],"strontium-89":[73],"chloride)":[74],"and":[75,118],"bisphosphonates":[76],"zoledronate":[78],"or":[79],"pamidronate).":[80],"localize":[83],"predominantly":[84],"skeletal":[86],"areas":[87],"high":[89],"turnover":[91],"like":[92],"metastatic":[93],"sites,":[94],"thereby":[95],"limiting":[96],"exposure,":[98],"but":[99],"their":[100],"use":[101],"not":[103],"without":[104],"toxicity.":[105],"The":[106],"administration":[107],"bone-targeted":[109],"has":[111],"been":[112],"associated":[113],"painful":[115],"flare":[116],"responses":[117],"myelosuppres":[119]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
