{"id":"https://openalex.org/W2127793095","doi":"https://doi.org/10.1183/13993003/erj.44.suppl_58.p2818","title":"Late-breaking abstract: A phase 2a study of benralizumab in adults with COPD","display_name":"Late-breaking abstract: A phase 2a study of benralizumab in adults with COPD","publication_year":2014,"publication_date":"2014-09-01","ids":{"openalex":"https://openalex.org/W2127793095","doi":"https://doi.org/10.1183/13993003/erj.44.suppl_58.p2818","mag":"2127793095"},"language":"en","primary_location":{"id":"doi:10.1183/13993003/erj.44.suppl_58.p2818","doi":"https://doi.org/10.1183/13993003/erj.44.suppl_58.p2818","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003/erj.44.suppl_58.p2818","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Respiratory Journal","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048320859","display_name":"Christopher Edward Brightling","orcid":"https://orcid.org/0000-0002-9345-4903","observed_orcids":["https://orcid.org/0000-0002-9345-4903"]},"institutions":[{"id":"https://openalex.org/I153648349","display_name":"University of Leicester","ror":"https://ror.org/04h699437","country_code":"GB","type":"education","lineage":["https://openalex.org/I153648349"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Christopher Brightling","raw_affiliation_strings":["1Department of Respiratory Medicine, University of Leicester, Leicester, United Kingdom","Department of Respiratory Medicine, University of Leicester, Leicester, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Respiratory Medicine, University of Leicester, Leicester, United Kingdom","institution_ids":["https://openalex.org/I153648349"]},{"raw_affiliation_string":"Department of Respiratory Medicine, University of Leicester, Leicester, United Kingdom","institution_ids":["https://openalex.org/I153648349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021121714","display_name":"Mona Bafadhel","orcid":"https://orcid.org/0000-0002-9993-2478","observed_orcids":["https://orcid.org/0000-0002-9993-2478"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mona Bafadhel","raw_affiliation_strings":["2Department of Respiratory Medicine, University of Oxford, Oxford, United Kingdom","Department of Respiratory Medicine, University of Oxford, Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Respiratory Medicine, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"Department of Respiratory Medicine, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048656238","display_name":"Eugene R. Bleecker","orcid":"https://orcid.org/0000-0002-4767-3494","observed_orcids":["https://orcid.org/0000-0002-4767-3494"]},"institutions":[{"id":"https://openalex.org/I1282516798","display_name":"Atrium Health Wake Forest Baptist","ror":"https://ror.org/04v8djg66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282516798","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I4387930303","display_name":"Wake Forest Baptist Comprehensive Cancer Center","ror":"https://ror.org/0512csj88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282516798","https://openalex.org/I4387930303","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eugene Bleecker","raw_affiliation_strings":["3Section of Hematology/ Oncology, Wake Forest School of Medicine, Winston-Salem, NC,","Section of Hematology/ Oncology, Wake Forest School of Medicine, Winston-Salem, NC,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Section of Hematology/ Oncology, Wake Forest School of Medicine, Winston-Salem, NC,","institution_ids":["https://openalex.org/I1282516798","https://openalex.org/I4387930303","https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"raw_affiliation_string":"Section of Hematology/ Oncology, Wake Forest School of Medicine, Winston-Salem, NC,","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082888399","display_name":"Reynold A. Panettieri","orcid":"https://orcid.org/0000-0003-0834-4636","observed_orcids":["https://orcid.org/0000-0003-0834-4636"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Reynold Panettieri","raw_affiliation_strings":["4Pulmonary, Allergy, & Critical Care Division, University of Pennsylvania Medical Center, Philadelphia, PA,","Pulmonary, Allergy, & Critical Care Division, University of Pennsylvania Medical Center, Philadelphia, PA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Pulmonary, Allergy, & Critical Care Division, University of Pennsylvania Medical Center, Philadelphia, PA,","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Pulmonary, Allergy, & Critical Care Division, University of Pennsylvania Medical Center, Philadelphia, PA,","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111211413","display_name":"Dewei She","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dewei She","raw_affiliation_strings":["5Clinical Biostatistics, MedImmune, Gaithersburg, MD,","Clinical Biostatistics, MedImmune, Gaithersburg, MD,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Clinical Biostatistics, MedImmune, Gaithersburg, MD,","institution_ids":[]},{"raw_affiliation_string":"Clinical Biostatistics, MedImmune, Gaithersburg, MD,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103426355","display_name":"Christine K. Ward","orcid":"https://orcid.org/0000-0003-3332-5904","observed_orcids":["https://orcid.org/0000-0003-3332-5904"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christine K Ward","raw_affiliation_strings":["6Translational Sciences, MedImmune, Gaithersburg, MD,","Translational Sciences, MedImmune, Gaithersburg, Md"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Translational Sciences, MedImmune, Gaithersburg, MD,","institution_ids":[]},{"raw_affiliation_string":"Translational Sciences, MedImmune, Gaithersburg, Md","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101755661","display_name":"Xiao Ping Xu","orcid":"https://orcid.org/0000-0003-1083-3834","observed_orcids":["https://orcid.org/0000-0003-1083-3834"]},"institutions":[{"id":"https://openalex.org/I4210150756","display_name":"AstraZeneca (United States)","ror":"https://ror.org/043cec594","country_code":"US","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210150756"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiao Xu","raw_affiliation_strings":["7Global Medicines Development, AstraZeneca, Gaithersburg, MD,","Global Medicines Development, AstraZeneca, Gaithersburg, Md"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"7Global Medicines Development, AstraZeneca, Gaithersburg, MD,","institution_ids":["https://openalex.org/I4210150756"]},{"raw_affiliation_string":"Global Medicines Development, AstraZeneca, Gaithersburg, Md","institution_ids":["https://openalex.org/I4210150756"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044664487","display_name":"Ren\u00e9 van der Merwe","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rene van der Merwe","raw_affiliation_strings":["8Clinical Development, MedImmune, Cambridge, United Kingdom","Clinical Development, MedImmune, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"8Clinical Development, MedImmune, Cambridge, United Kingdom","institution_ids":[]},{"raw_affiliation_string":"Clinical Development, MedImmune, Cambridge, United Kingdom","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"44","issue":"Suppl 58","first_page":"P2818","last_page":"P2818"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.0066999997943639755,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/benralizumab","display_name":"benralizumab","score":0.9990000128746033},{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.996999979019165},{"id":"https://openalex.org/keywords/airway-eosinophils","display_name":"airway eosinophils","score":0.8820000290870667},{"id":"https://openalex.org/keywords/sputum-eosinophils","display_name":"sputum eosinophils","score":0.8870000243186951},{"id":"https://openalex.org/keywords/acute-exacerbation-of-copd","display_name":"COPD exacerbations","score":0.8230000138282776},{"id":"https://openalex.org/keywords/lung-function","display_name":"lung function","score":0.8050000071525574},{"id":"https://openalex.org/keywords/fev1","display_name":"FEV1","score":0.8679999709129333},{"id":"https://openalex.org/keywords/eosinophil-depletion","display_name":"eosinophil depletion","score":0.8009999990463257},{"id":"https://openalex.org/keywords/subgroup-analysis","display_name":"subgroup analysis","score":0.5879999995231628},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.5360000133514404},{"id":"https://openalex.org/keywords/biological-therapy","display_name":"biologic therapy","score":0.45399999618530273}],"concepts":[{"id":"https://openalex.org/C2779185760","wikidata":"https://www.wikidata.org/wiki/Q3638304","display_name":"Benralizumab","level":5,"score":0.9897982478141785},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9523009061813354},{"id":"https://openalex.org/C2776780178","wikidata":"https://www.wikidata.org/wiki/Q199804","display_name":"COPD","level":2,"score":0.7468233704566956},{"id":"https://openalex.org/C2776301714","wikidata":"https://www.wikidata.org/wiki/Q259346","display_name":"Sputum","level":3,"score":0.5648726224899292},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5340828895568848},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5307270288467407},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.4988706111907959},{"id":"https://openalex.org/C2777014857","wikidata":"https://www.wikidata.org/wiki/Q1383410","display_name":"Exacerbation","level":2,"score":0.4914335012435913},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.43823903799057007},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.43339940905570984},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.3733861446380615},{"id":"https://openalex.org/C2777037409","wikidata":"https://www.wikidata.org/wiki/Q107238","display_name":"Eosinophil","level":3,"score":0.21664172410964966},{"id":"https://openalex.org/C2777832160","wikidata":"https://www.wikidata.org/wiki/Q3306175","display_name":"Mepolizumab","level":4,"score":0.0776483416557312},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.057935625314712524},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1183/13993003/erj.44.suppl_58.p2818","doi":"https://doi.org/10.1183/13993003/erj.44.suppl_58.p2818","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003/erj.44.suppl_58.p2818","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Respiratory Journal","raw_type":"journal-article"},{"id":"mag:2127793095","doi":null,"is_oa":false,"landing_page_url":"http://erj.ersjournals.com/content/44/Suppl_58/P2818","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"European Respiratory Journal","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2171875475","https://openalex.org/W4410272835","https://openalex.org/W2320916122","https://openalex.org/W4242497267","https://openalex.org/W4404096874","https://openalex.org/W2975842537","https://openalex.org/W2946719800","https://openalex.org/W2948921314","https://openalex.org/W2505767862","https://openalex.org/W4404045789"],"abstract_inverted_index":{"RATIONALE:":[0],"Benralizumab":[1,131,223],"is":[2],"a":[3,60],"humanized,":[4],"afucosylated,":[5],"anti-interleukin-5":[6],"receptor":[7],"alpha":[8],"monoclonal":[9],"antibody":[10],"shown":[11],"to":[12,125,211,219],"deplete":[13],"blood":[14,135],"and":[15,36,48,83,109,136,166,200],"airway":[16,38],"eosinophils":[17,182],"in":[18,28,53,59,97,178,230],"subjects":[19,122,179,231],"with":[20,30,42,163,168,180,232,239],"asthma.":[21],"We":[22],"investigated":[23],"the":[24,54,117,227],"effects":[25],"of":[26,142],"benralizumab":[27,72,129,169,208],"adults":[29],"chronic":[31],"obstructive":[32],"pulmonary":[33],"disease":[34],"(COPD)":[35],"elevated":[37],"eosinophils.":[39,138],"METHODS:":[40],"Subjects":[41,66],"moderate-to-severe":[43,87],"COPD,":[44,233],">3%":[45],"sputum":[46,137],"eosinophils,":[47],">1":[49],"acute":[50],"exacerbation":[51,228],"(AECOPD)":[52],"previous":[55,220],"year":[56],"were":[57,114,123,188],"randomized":[58,124],"double-blind,":[61],"placebo":[62],"(PBO)-controlled,":[63],"multicenter":[64],"study.":[65],"received":[67],"PBO":[68,126,147,164,212],"or":[69,128],"100":[70],"mg":[71],"subcutaneously":[73],"on":[74,116],"weeks":[75],"1,":[76],"4,":[77],"8,":[78],"16,":[79],"24,":[80],"32,":[81],"40,":[82],"48.":[84],"Endpoints":[85],"included":[86],"AECOPD":[88,143,191],"rate":[89,144,192,229],"at":[90,148,185],"week":[91,149,186],"56":[92,150,187],"(primary),":[93],"forced":[94],"expiratory":[95],"volume":[96],"1":[98,101,157,197],"second":[99],"(FEV":[100],"),":[102],"COPD-specific":[103],"Saint":[104],"George's":[105],"Respiratory":[106],"Questionnaire":[107],"(SGRQ-C),":[108],"adverse":[110],"events.":[111],"Efficacy":[112],"analyses":[113],"conducted":[115],"per-protocol":[118],"population.":[119],"RESULTS:":[120],"101":[121],"(n=50)":[127],"(n=51).":[130],"depleted":[132],"both":[133],"peripheral":[134],"The":[139,214],"primary":[140],"endpoint":[141],"reduction":[145],"vs.":[146],"was":[151,161,217],"not":[152,225],"met,":[153],"however":[154],"pre-bronchodilator":[155],"FEV":[156,196],"change":[158],"from":[159],"baseline":[160,181],"-0.059L":[162],"(n=42),":[165],"0.128L":[167],"(n=37,":[170],"P=.01).":[171],"A":[172],"pre-specified":[173],"subgroup":[174],"analysis":[175],"demonstrated":[176],"that":[177],">300/uL,":[183],"improvements":[184],"greater":[189],"for":[190,207],"(58%":[193],"reduction,":[194],"P=0.28),":[195],"(0.318L,":[198],"P=0.22),":[199],"SGRQ-C":[201],"symptom":[202],"domain":[203],"(-13.1":[204],"points,":[205],"P=0.26)":[206],"(n=14)":[209],"compared":[210],"(n=7).":[213],"safety":[215,242],"profile":[216],"similar":[218],"studies.":[221],"CONCLUSIONS:":[222],"did":[224],"reduce":[226],"but":[234],"significantly":[235],"improved":[236],"lung":[237],"function":[238],"an":[240],"acceptable":[241],"profile.":[243]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
