{"id":"https://openalex.org/W2127773607","doi":"https://doi.org/10.4155/fmc.15.110","title":"How can Novel Microscopic Approaches Shed Light on the Function of Nucleic Acid-Based Drugs?","display_name":"How can Novel Microscopic Approaches Shed Light on the Function of Nucleic Acid-Based Drugs?","publication_year":2015,"publication_date":"2015-09-01","ids":{"openalex":"https://openalex.org/W2127773607","doi":"https://doi.org/10.4155/fmc.15.110","mag":"2127773607","pmid":"https://pubmed.ncbi.nlm.nih.gov/26381477"},"language":"en","primary_location":{"id":"doi:10.4155/fmc.15.110","doi":"https://doi.org/10.4155/fmc.15.110","is_oa":true,"landing_page_url":"https://doi.org/10.4155/fmc.15.110","pdf_url":"https://www.future-science.com/doi/pdf/10.4155/fmc.15.110","source":{"id":"https://openalex.org/S122867665","display_name":"Future Medicinal Chemistry","issn_l":"1756-8919","issn":["1756-8919","1756-8927"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320316","host_organization_name":"Future Science Ltd","host_organization_lineage":["https://openalex.org/P4310320316"],"host_organization_lineage_names":["Future Science Ltd"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Future Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"editorial","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.future-science.com/doi/pdf/10.4155/fmc.15.110","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023889495","display_name":"Daniel B. Vocelle","orcid":"https://orcid.org/0000-0003-0252-2673","observed_orcids":["https://orcid.org/0000-0003-0252-2673"]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Vocelle","raw_affiliation_strings":["Department of Chemical Engineering &amp; Materials Science, Michigan State University, 428 S. Shaw Lane, Room2527, East Lansing, MI48824, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering &amp; Materials Science, Michigan State University, 428 S. Shaw Lane, Room2527, East Lansing, MI48824, USA","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102757744","display_name":"Christina Chan","orcid":"https://orcid.org/0000-0003-3054-2727","observed_orcids":["https://orcid.org/0000-0003-3054-2727","https://orcid.org/0009-0003-7693-8206"]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christina Chan","raw_affiliation_strings":["Department of Chemical Engineering &amp; Materials Science, Michigan State University, 428 S. Shaw Lane, Room2527, East Lansing, MI48824, USA","Departments of Biochemistry &amp; Molecular Biology, Michigan State University, East Lansing, MI48824, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering &amp; Materials Science, Michigan State University, 428 S. Shaw Lane, Room2527, East Lansing, MI48824, USA","institution_ids":["https://openalex.org/I87216513"]},{"raw_affiliation_string":"Departments of Biochemistry &amp; Molecular Biology, Michigan State University, East Lansing, MI48824, USA","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062535976","display_name":"S. Patrick Walton","orcid":"https://orcid.org/0000-0003-1708-8603","observed_orcids":["https://orcid.org/0000-0003-1708-8603"]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Patrick Walton","raw_affiliation_strings":["Department of Chemical Engineering &amp; Materials Science, Michigan State University, 428 S. Shaw Lane, Room2527, East Lansing, MI48824, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering &amp; Materials Science, Michigan State University, 428 S. Shaw Lane, Room2527, East Lansing, MI48824, USA","institution_ids":["https://openalex.org/I87216513"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I87216513"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":"13","first_page":"1623","last_page":"1625"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.4821999967098236,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.4821999967098236,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.28780001401901245,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.03959999978542328,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nucleic-acid-therapeutics","display_name":"nucleic acid therapeutics","score":0.9950000047683716},{"id":"https://openalex.org/keywords/fluorescent-proteins","display_name":"fluorescent proteins","score":0.6520000100135803},{"id":"https://openalex.org/keywords/electron-microscopy","display_name":"electron microscopy","score":0.6050000190734863},{"id":"https://openalex.org/keywords/sub-angstrom-resolution","display_name":"sub-angstrom resolution","score":0.828000009059906},{"id":"https://openalex.org/keywords/fluorescence-imaging","display_name":"fluorescence imaging","score":0.3330000042915344}],"concepts":[{"id":"https://openalex.org/C24107716","wikidata":"https://www.wikidata.org/wiki/Q123619","display_name":"Nucleic acid","level":2,"score":0.7711070775985718},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5924266576766968},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.5810263752937317},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42331159114837646},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.421403706073761},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39885592460632324},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.30657529830932617},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2753840982913971}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D009696","descriptor_name":"Nucleic Acids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D009696","descriptor_name":"Nucleic Acids","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D009696","descriptor_name":"Nucleic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D031541","descriptor_name":"Fluorescence Resonance Energy Transfer","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D046529","descriptor_name":"Microscopy, Electron, Transmission","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.4155/fmc.15.110","doi":"https://doi.org/10.4155/fmc.15.110","is_oa":true,"landing_page_url":"https://doi.org/10.4155/fmc.15.110","pdf_url":"https://www.future-science.com/doi/pdf/10.4155/fmc.15.110","source":{"id":"https://openalex.org/S122867665","display_name":"Future Medicinal Chemistry","issn_l":"1756-8919","issn":["1756-8919","1756-8927"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320316","host_organization_name":"Future Science Ltd","host_organization_lineage":["https://openalex.org/P4310320316"],"host_organization_lineage_names":["Future Science Ltd"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Future Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:26381477","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26381477","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Future medicinal chemistry","raw_type":"Editorial"}],"best_oa_location":{"id":"doi:10.4155/fmc.15.110","doi":"https://doi.org/10.4155/fmc.15.110","is_oa":true,"landing_page_url":"https://doi.org/10.4155/fmc.15.110","pdf_url":"https://www.future-science.com/doi/pdf/10.4155/fmc.15.110","source":{"id":"https://openalex.org/S122867665","display_name":"Future Medicinal Chemistry","issn_l":"1756-8919","issn":["1756-8919","1756-8927"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320316","host_organization_name":"Future Science Ltd","host_organization_lineage":["https://openalex.org/P4310320316"],"host_organization_lineage_names":["Future Science Ltd"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Future Medicinal Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.428600013256073,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G172311494","display_name":null,"funder_award_id":"GM089866","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2110954206","display_name":"Deep Sequencing to Screen Functional Antibody Epitopes","funder_award_id":"R21CA176854","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2744987802","display_name":null,"funder_award_id":"CA176854","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8275328381","display_name":"Maximizing siRNA Function through Mechanism-based Sequence and Vehicle Design","funder_award_id":"R01GM089866","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2127773607.pdf","grobid_xml":"https://content.openalex.org/works/W2127773607.grobid-xml"},"referenced_works_count":17,"referenced_works":["https://openalex.org/W35846350","https://openalex.org/W1483024467","https://openalex.org/W1647075334","https://openalex.org/W1909655902","https://openalex.org/W1965175092","https://openalex.org/W1981556349","https://openalex.org/W1995143570","https://openalex.org/W1998305436","https://openalex.org/W2018011172","https://openalex.org/W2026198085","https://openalex.org/W2046194311","https://openalex.org/W2049517718","https://openalex.org/W2063485157","https://openalex.org/W2087793806","https://openalex.org/W2099172783","https://openalex.org/W2155239981","https://openalex.org/W2282586133"],"related_works":["https://openalex.org/W2330121845","https://openalex.org/W7052686046","https://openalex.org/W2748445877","https://openalex.org/W4406411954","https://openalex.org/W2410704943","https://openalex.org/W2022250939","https://openalex.org/W4412337033","https://openalex.org/W2110590389","https://openalex.org/W2402041472","https://openalex.org/W2547874250"],"abstract_inverted_index":{"How":[0],"can":[1],"novel":[2],"microscopic":[3],"approaches":[4,14],"shed":[5],"light":[6,28],"on":[7],"the":[8,19,23],"function":[9],"of":[10,26],"nucleic":[11],"acid-based":[12],"drugs?\"State-of-the-art":[13],"leverage":[15],"fluorescent":[16],"proteins":[17],"across":[18],"visible":[20,27],"spectrum,":[21],"surpass":[22],"resolution":[24,32],"limits":[25],"and":[29],"achieve":[30],"sub-\u00c5ngstr\u00f6m":[31],"with":[33],"electron":[34],"microscopy.":[35]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
