{"id":"https://openalex.org/W2127748980","doi":"https://doi.org/10.1210/jcem-61-5-842","title":"Evidence for a Role of Endogenous Estrogen in the Hypothalamic Control of Gonadotropin Secretion in Men*","display_name":"Evidence for a Role of Endogenous Estrogen in the Hypothalamic Control of Gonadotropin Secretion in Men*","publication_year":1985,"publication_date":"1985-11-01","ids":{"openalex":"https://openalex.org/W2127748980","doi":"https://doi.org/10.1210/jcem-61-5-842","mag":"2127748980","pmid":"https://pubmed.ncbi.nlm.nih.gov/2413063"},"language":"en","primary_location":{"id":"doi:10.1210/jcem-61-5-842","doi":"https://doi.org/10.1210/jcem-61-5-842","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jcem-61-5-842","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology &amp; Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087822746","display_name":"Stephen J. Winters","orcid":"https://orcid.org/0000-0003-3721-7388","observed_orcids":["https://orcid.org/0000-0003-3721-7388"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210138181","display_name":"UPMC Montefiore","ror":"https://ror.org/03bzbh797","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769","https://openalex.org/I4210138181"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"STEPHEN J. WINTERS","raw_affiliation_strings":["Department of Medicine, Montefiore Hospital, and the University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Montefiore Hospital, and the University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210138181"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071645670","display_name":"Philip Troen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210138181","display_name":"UPMC Montefiore","ror":"https://ror.org/03bzbh797","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769","https://openalex.org/I4210138181"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"PHILIP TROEN","raw_affiliation_strings":["Department of Medicine, Montefiore Hospital, and the University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Montefiore Hospital, and the University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210138181"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":6.6872,"has_fulltext":false,"cited_by_count":89,"citation_normalized_percentile":{"value":0.97158177,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"61","issue":"5","first_page":"842","last_page":"845"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endogenous-estrogen","display_name":"endogenous estrogen","score":0.871999979019165},{"id":"https://openalex.org/keywords/luteinizing-hormone","display_name":"luteinizing hormone","score":0.8769999742507935},{"id":"https://openalex.org/keywords/lh-pulse-frequency","display_name":"LH pulse frequency","score":0.5989999771118164},{"id":"https://openalex.org/keywords/lh-pulse-amplitude","display_name":"LH pulse amplitude","score":0.921999990940094},{"id":"https://openalex.org/keywords/lh-alpha-subunit","display_name":"LH alpha subunit","score":0.8190000057220459},{"id":"https://openalex.org/keywords/clomiphene","display_name":"clomiphene citrate","score":0.9440000057220459},{"id":"https://openalex.org/keywords/gonadotropin-releasing-hormone","display_name":"gonadotropin-releasing hormone","score":0.8100000023841858},{"id":"https://openalex.org/keywords/testosterone","display_name":"testosterone","score":0.5649999976158142},{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.9819999933242798},{"id":"https://openalex.org/keywords/follicle-stimulating-hormone","display_name":"follicle-stimulating hormone","score":0.7760000228881836}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.9142135381698608},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.9056616425514221},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.7411239743232727},{"id":"https://openalex.org/C2778782382","wikidata":"https://www.wikidata.org/wiki/Q409770","display_name":"Gonadotropin","level":3,"score":0.6768141388893127},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.6489264369010925},{"id":"https://openalex.org/C79191276","wikidata":"https://www.wikidata.org/wiki/Q7259620","display_name":"Pulsatile flow","level":2,"score":0.6100683212280273},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.5356103777885437},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.5272758603096008},{"id":"https://openalex.org/C2778641792","wikidata":"https://www.wikidata.org/wiki/Q418730","display_name":"Clomifene","level":5,"score":0.488972544670105},{"id":"https://openalex.org/C2777003273","wikidata":"https://www.wikidata.org/wiki/Q164386","display_name":"Hypothalamus","level":2,"score":0.46889036893844604},{"id":"https://openalex.org/C2778894405","wikidata":"https://www.wikidata.org/wiki/Q318896","display_name":"Gonadotropin-releasing hormone","level":4,"score":0.45809632539749146},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4488454759120941},{"id":"https://openalex.org/C2778575703","wikidata":"https://www.wikidata.org/wiki/Q50265477","display_name":"Luteinizing hormone","level":3,"score":0.4257362484931946},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.4232110381126404},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2760434150695801},{"id":"https://openalex.org/C2777702977","wikidata":"https://www.wikidata.org/wiki/Q187082","display_name":"Ovulation","level":3,"score":0.18432188034057617},{"id":"https://openalex.org/C2781230225","wikidata":"https://www.wikidata.org/wiki/Q3150564","display_name":"Ovulation induction","level":4,"score":0.08203563094139099}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002996","descriptor_name":"Clomiphene","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005640","descriptor_name":"Follicle Stimulating Hormone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006062","descriptor_name":"Gonadotropins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007031","descriptor_name":"Hypothalamus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007986","descriptor_name":"Luteinizing Hormone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D010908","descriptor_name":"Pituitary Hormones, Anterior","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011863","descriptor_name":"Radioimmunoassay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013739","descriptor_name":"Testosterone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015292","descriptor_name":"Glycoprotein Hormones, alpha Subunit","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1210/jcem-61-5-842","doi":"https://doi.org/10.1210/jcem-61-5-842","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jcem-61-5-842","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology &amp; Metabolism","raw_type":"journal-article"},{"id":"pmid:2413063","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2413063","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical endocrinology and metabolism","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8199999928474426}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3396019356","display_name":"General Clinical Research Center","funder_award_id":"M01RR000056","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2386727613","https://openalex.org/W2095691066","https://openalex.org/W1979928831","https://openalex.org/W1997943532","https://openalex.org/W2148807607","https://openalex.org/W4242477359","https://openalex.org/W1969445220","https://openalex.org/W2589075404","https://openalex.org/W2136688633","https://openalex.org/W2090597093"],"abstract_inverted_index":{"To":[0],"examine":[1],"the":[2,29,37,147,171,176],"mechanism":[3],"by":[4,53],"which":[5,64],"endogenous":[6,143],"estrogens":[7,144,163],"inhibit":[8],"gonadotropin":[9,182],"secretion":[10,83],"in":[11,23,60,71,78,101,108,170],"men,":[12],"blood":[13],"samples":[14],"were":[15,47],"drawn":[16],"every":[17],"10":[18],"min":[19],"for":[20,49],"12":[21],"h":[22],"five":[24],"men":[25],"before":[26,87],"and":[27,51,74,88,104,113,118,130,155],"at":[28],"completion":[30],"of":[31,34,150,157,175],"3":[32],"weeks":[33],"treatment":[35],"with":[36,67,97],"estrogen":[38],"antagonist":[39],"clomiphene":[40,90,124],"citrate":[41],"(50":[42],"mg":[43],"twice":[44],"daily).":[45],"Samples":[46],"analyzed":[48],"LH":[50,62,129],"alpha-subunit":[52,82,132],"RIA.":[54],"Clomiphene":[55],"produced":[56],"a":[57,68,75,98,105,135],"3-fold":[58,122],"rise":[59],"circulating":[61],"levels,":[63],"was":[65,84],"associated":[66],"80%":[69],"increase":[70,77,100,107],"pulse":[72,79,102,109,133],"frequency":[73,103],"70%":[76],"amplitude.":[80,110],"Immunoreactive":[81],"also":[85],"pulsatile":[86,181],"after":[89,123],"treatment.":[91,125],"Mean":[92],"alpha-levels":[93],"rose":[94],"70%,":[95],"together":[96],"39%":[99],"41%":[106],"Circulating":[111],"testosterone":[112],"estradiol":[114],"levels":[115,120],"increased":[116,121],"2-fold":[117],"FSH":[119],"Insofar":[126],"as":[127,164,166],"each":[128],"uncombined":[131],"reflects":[134],"LHRH":[136],"secretory":[137],"episode,":[138],"our":[139],"data":[140],"indicate":[141],"that":[142,162,179],"tonically":[145],"restrain":[146],"hypothalamic":[148,177],"release":[149],"LHRH.":[151],"From":[152],"these":[153],"results":[154],"those":[156],"previous":[158],"studies,":[159],"we":[160],"conclude":[161],"well":[165],"androgens":[167],"are":[168],"important":[169],"testicular":[172],"feedback":[173],"inhibition":[174],"oscillator":[178],"governs":[180],"secretion.":[183]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}
