{"id":"https://openalex.org/W2127737784","doi":"https://doi.org/10.1093/gerona/gls146","title":"Moderate Intensity, but Not High Intensity, Treadmill Exercise Training Alters Power Output Properties in Myocardium From Aged Rats","display_name":"Moderate Intensity, but Not High Intensity, Treadmill Exercise Training Alters Power Output Properties in Myocardium From Aged Rats","publication_year":2012,"publication_date":"2012-07-25","ids":{"openalex":"https://openalex.org/W2127737784","doi":"https://doi.org/10.1093/gerona/gls146","mag":"2127737784","pmid":"https://pubmed.ncbi.nlm.nih.gov/22843668","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3636676"},"language":"en","primary_location":{"id":"doi:10.1093/gerona/gls146","doi":"https://doi.org/10.1093/gerona/gls146","is_oa":true,"landing_page_url":"https://doi.org/10.1093/gerona/gls146","pdf_url":"https://academic.oup.com/biomedgerontology/article-pdf/67/11/1178/1657947/gls146.pdf","source":{"id":"https://openalex.org/S969433497","display_name":"The Journals of Gerontology Series A","issn_l":"1079-5006","issn":["1079-5006","1758-535X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/biomedgerontology/article-pdf/67/11/1178/1657947/gls146.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058808674","display_name":"Eunhee Chung","orcid":"https://orcid.org/0000-0002-4501-9333","observed_orcids":["https://orcid.org/0000-0002-4501-9333"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. Chung","raw_affiliation_strings":["Balke Biodynamics Laboratory, Department of Kinesiology,University of Wisconsin-Madison, Madison, Wisconsin 53706-1121, USA","Balke Biodynamics Laboratory, Department of Kinesiology, University of Wisconsin-Madison, Madison, Wisconsin","Present address: Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Balke Biodynamics Laboratory, Department of Kinesiology,University of Wisconsin-Madison, Madison, Wisconsin 53706-1121, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Balke Biodynamics Laboratory, Department of Kinesiology, University of Wisconsin-Madison, Madison, Wisconsin","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Present address: Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder","institution_ids":["https://openalex.org/I188538660"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010778688","display_name":"Gary M. Diffee","orcid":"https://orcid.org/0009-0002-2515-6434","observed_orcids":["https://orcid.org/0009-0002-2515-6434"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. M. Diffee","raw_affiliation_strings":["Balke Biodynamics Laboratory, Department of Kinesiology, University of Wisconsin-Madison, Madison, Wisconsin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Balke Biodynamics Laboratory, Department of Kinesiology, University of Wisconsin-Madison, Madison, Wisconsin","institution_ids":["https://openalex.org/I135310074"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4408,"currency":"USD","value_usd":4408},"apc_paid":null,"fwci":3.1148,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.91175799,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"67","issue":"11","first_page":"1178","last_page":"1187"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11922","display_name":"Cardiovascular Effects of Exercise","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/treadmill-training","display_name":"treadmill training","score":0.9470000267028809},{"id":"https://openalex.org/keywords/exercise-intensity","display_name":"exercise intensity","score":0.7110000252723694},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.578000009059906},{"id":"https://openalex.org/keywords/myocardial-contractility","display_name":"cardiac contractility","score":0.7870000004768372},{"id":"https://openalex.org/keywords/power-output","display_name":"output power","score":0.6629999876022339},{"id":"https://openalex.org/keywords/cardiac-aging","display_name":"cardiac aging","score":0.43299999833106995},{"id":"https://openalex.org/keywords/endurance-exercise","display_name":"endurance exercise","score":0.5669999718666077},{"id":"https://openalex.org/keywords/aged-rats","display_name":"aged rats","score":0.4000000059604645}],"concepts":[{"id":"https://openalex.org/C2778921608","wikidata":"https://www.wikidata.org/wiki/Q2002035","display_name":"Ventricle","level":2,"score":0.6958993673324585},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6447621583938599},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6343904733657837},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6141770482063293},{"id":"https://openalex.org/C93038891","wikidata":"https://www.wikidata.org/wiki/Q1061524","display_name":"Intensity (physics)","level":2,"score":0.6037584543228149},{"id":"https://openalex.org/C99830354","wikidata":"https://www.wikidata.org/wiki/Q362854","display_name":"Endurance training","level":2,"score":0.5796641707420349},{"id":"https://openalex.org/C2781464450","wikidata":"https://www.wikidata.org/wiki/Q839144","display_name":"Treadmill","level":2,"score":0.5379446744918823},{"id":"https://openalex.org/C2776811442","wikidata":"https://www.wikidata.org/wiki/Q5420058","display_name":"Exercise intensity","level":4,"score":0.43973538279533386},{"id":"https://openalex.org/C181588539","wikidata":"https://www.wikidata.org/wiki/Q219067","display_name":"Physical exercise","level":2,"score":0.41520172357559204},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3972531855106354},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.3295735716819763},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.24775275588035583},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.06853276491165161},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005080","descriptor_name":"Exercise Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009200","descriptor_name":"Myocardial Contraction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010805","descriptor_name":"Physical Conditioning, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011916","descriptor_name":"Rats, Inbred F344","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015180","descriptor_name":"Electrophoresis, Gel, Two-Dimensional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017079","descriptor_name":"Exercise Tolerance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018994","descriptor_name":"Myosin Light Chains","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D023421","descriptor_name":"Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D032342","descriptor_name":"Muscle Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D032342","descriptor_name":"Muscle Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/gerona/gls146","doi":"https://doi.org/10.1093/gerona/gls146","is_oa":true,"landing_page_url":"https://doi.org/10.1093/gerona/gls146","pdf_url":"https://academic.oup.com/biomedgerontology/article-pdf/67/11/1178/1657947/gls146.pdf","source":{"id":"https://openalex.org/S969433497","display_name":"The Journals of Gerontology Series A","issn_l":"1079-5006","issn":["1079-5006","1758-535X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2802521","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3636676","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3636676","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3636676","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Gerontol A Biol Sci Med Sci","raw_type":"Text"},{"id":"pmid:22843668","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22843668","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The journals of gerontology. Series A, Biological sciences and medical sciences","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.1093/gerona/gls146","doi":"https://doi.org/10.1093/gerona/gls146","is_oa":true,"landing_page_url":"https://doi.org/10.1093/gerona/gls146","pdf_url":"https://academic.oup.com/biomedgerontology/article-pdf/67/11/1178/1657947/gls146.pdf","source":{"id":"https://openalex.org/S969433497","display_name":"The Journals of Gerontology Series A","issn_l":"1079-5006","issn":["1079-5006","1758-535X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2440447594","display_name":"Impact of Exercise on Sarcopenia","funder_award_id":"R01AG030423","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G6794017997","display_name":null,"funder_award_id":"AG030423","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2127737784.pdf","grobid_xml":"https://content.openalex.org/works/W2127737784.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W10855421","https://openalex.org/W58485037","https://openalex.org/W117465397","https://openalex.org/W140343470","https://openalex.org/W196161356","https://openalex.org/W203112842","https://openalex.org/W932171548","https://openalex.org/W1255780710","https://openalex.org/W1969915992","https://openalex.org/W2001994888","https://openalex.org/W2005807537","https://openalex.org/W2007753231","https://openalex.org/W2010088771","https://openalex.org/W2014943518","https://openalex.org/W2020090580","https://openalex.org/W2055737724","https://openalex.org/W2057232483","https://openalex.org/W2060151654","https://openalex.org/W2080706304","https://openalex.org/W2086061329","https://openalex.org/W2089962035","https://openalex.org/W2095155578","https://openalex.org/W2099454136","https://openalex.org/W2106472569","https://openalex.org/W2108899429","https://openalex.org/W2114313623","https://openalex.org/W2130574722","https://openalex.org/W2131248866","https://openalex.org/W2138916112","https://openalex.org/W2139552357","https://openalex.org/W2140609968","https://openalex.org/W2141965959","https://openalex.org/W2142977250","https://openalex.org/W2145302582","https://openalex.org/W2151778033","https://openalex.org/W2154261214","https://openalex.org/W2154328830","https://openalex.org/W2161490141","https://openalex.org/W2167060696","https://openalex.org/W2174199828","https://openalex.org/W2179863336","https://openalex.org/W2186038875","https://openalex.org/W2187177752","https://openalex.org/W2188461633","https://openalex.org/W2261813870","https://openalex.org/W2272051904","https://openalex.org/W2280330048","https://openalex.org/W2401911936","https://openalex.org/W2410624751","https://openalex.org/W2412059802"],"related_works":["https://openalex.org/W1989225166","https://openalex.org/W7120413391","https://openalex.org/W117465397","https://openalex.org/W2099454136","https://openalex.org/W2396331935","https://openalex.org/W1948489235","https://openalex.org/W2288413406","https://openalex.org/W2373715574","https://openalex.org/W3176776130","https://openalex.org/W2080706304"],"abstract_inverted_index":{"Aging":[0],"is":[1,131],"characterized":[2],"by":[3,29],"a":[4,19,134],"progressive":[5],"decline":[6],"in":[7,36,61,104,108,116,122,139],"cardiac":[8],"function,":[9],"but":[10,106,148],"endurance":[11],"exercise":[12,31,55,83,129],"training":[13,32,56,84,130],"has":[14],"been":[15],"shown":[16],"to":[17,50,98,111,145],"retard":[18],"number":[20],"of":[21,24,46,54,65,81,142],"deleterious":[22],"effects":[23,53],"aging.":[25],"However,":[26],"underlying":[27],"mechanisms":[28],"which":[30],"improves":[33],"age-related":[34],"decrements":[35],"myocardial":[37],"contractile":[38],"function":[39],"are":[40],"not":[41,107,152],"well":[42],"understood.":[43],"The":[44],"purpose":[45],"this":[47,149],"study":[48],"was":[49,101,137,151],"determine":[51],"the":[52,140,143],"on":[57],"power":[58,95],"output":[59,96],"properties":[60],"permeablized":[62],"(skinned)":[63],"myocytes":[64],"old":[66],"rats.":[67],"Thirty-month-old":[68],"rats":[69],"were":[70],"divided":[71],"into":[72],"sedentary":[73],"control":[74],"(C)":[75],"and":[76,89],"groups":[77],"undergoing":[78],"11":[79],"weeks":[80],"treadmill":[82],"at":[85,90],"moderate":[86],"intensity":[87,92],"(MI)":[88],"high":[91],"(HI).":[93],"Peak":[94],"normalized":[97],"maximal":[99],"force":[100],"significantly":[102],"increased":[103],"MI":[105,128],"HI":[109,155],"compared":[110],"C":[112],"with":[113,154],"significant":[114,135],"increases":[115],"atrial":[117],"myosin":[118],"light":[119],"chain":[120],"1":[121],"ventricle.":[123],"These":[124],"results":[125],"suggest":[126],"that":[127],"beneficial":[132],"as":[133],"increase":[136],"seen":[138,153],"ability":[141],"myocardium":[144],"do":[146],"work,":[147],"effect":[150],"training.":[156]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}