{"id":"https://openalex.org/W2127699503","doi":"https://doi.org/10.1146/annurev.biochem.72.121801.161459","title":"Protein Disulfide Bond Formation in Prokaryotes","display_name":"Protein Disulfide Bond Formation in Prokaryotes","publication_year":2003,"publication_date":"2003-06-01","ids":{"openalex":"https://openalex.org/W2127699503","doi":"https://doi.org/10.1146/annurev.biochem.72.121801.161459","mag":"2127699503","pmid":"https://pubmed.ncbi.nlm.nih.gov/12524212"},"language":"en","primary_location":{"id":"doi:10.1146/annurev.biochem.72.121801.161459","doi":"https://doi.org/10.1146/annurev.biochem.72.121801.161459","is_oa":false,"landing_page_url":"https://doi.org/10.1146/annurev.biochem.72.121801.161459","pdf_url":null,"source":{"id":"https://openalex.org/S53860259","display_name":"Annual Review of Biochemistry","issn_l":"0066-4154","issn":["0066-4154","1545-4509"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Biochemistry","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091272822","display_name":"Hiroshi Kadokura","orcid":"https://orcid.org/0000-0001-7308-7141","observed_orcids":["https://orcid.org/0000-0001-7308-7141"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hiroshi Kadokura","raw_affiliation_strings":["Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115,","Department of Microbiology & Molecular Genetics Harvard Medical School Boston, Massachusetts 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115,","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Microbiology & Molecular Genetics Harvard Medical School Boston, Massachusetts 02115, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002350338","display_name":"Federico Katzen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Federico Katzen","raw_affiliation_strings":["Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115,","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111493013","display_name":"Jon Beckwith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jon Beckwith","raw_affiliation_strings":["Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115,","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I136199984"],"apc_list":null,"apc_paid":null,"fwci":3.0171,"has_fulltext":false,"cited_by_count":554,"citation_normalized_percentile":{"value":0.94426049,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"72","issue":"1","first_page":"111","last_page":"135"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.008299999870359898,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-disulfide-bond-formation","display_name":"protein disulfide bond formation","score":0.9190000295639038},{"id":"https://openalex.org/keywords/disulfide-reduction","display_name":"disulfide bond reduction","score":0.8019999861717224},{"id":"https://openalex.org/keywords/cysteine-pairing","display_name":"cysteine pairing","score":0.718999981880188},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.7960000038146973},{"id":"https://openalex.org/keywords/dsba","display_name":"DsbA","score":0.890999972820282},{"id":"https://openalex.org/keywords/dsbb","display_name":"DsbB","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dsbc","display_name":"DsbC","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dsbd","display_name":"DsbD","score":1.0},{"id":"https://openalex.org/keywords/disulfide-bond-isomerase","display_name":"disulfide bond isomerase","score":0.7519999742507935},{"id":"https://openalex.org/keywords/protein-folding","display_name":"protein folding","score":0.6420000195503235},{"id":"https://openalex.org/keywords/electron-transfer-pathway","display_name":"electron transfer pathway","score":0.6269999742507935},{"id":"https://openalex.org/keywords/prokaryotic-proteins","display_name":"prokaryotic proteins","score":0.7210000157356262}],"concepts":[{"id":"https://openalex.org/C27256138","wikidata":"https://www.wikidata.org/wiki/Q1230226","display_name":"Disulfide bond","level":2,"score":0.6819338798522949},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5668115615844727},{"id":"https://openalex.org/C204328495","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein folding","level":2,"score":0.4395403563976288},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3996100425720215},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.34954530000686646},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.33149856328964233},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2742076814174652}],"mesh":[{"descriptor_ui":"D003545","descriptor_name":"Cysteine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004220","descriptor_name":"Disulfides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004220","descriptor_name":"Disulfides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004579","descriptor_name":"Electron Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010088","descriptor_name":"Oxidoreductases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011387","descriptor_name":"Prokaryotic Cells","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D011387","descriptor_name":"Prokaryotic Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013879","descriptor_name":"Thioredoxins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013879","descriptor_name":"Thioredoxins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019704","descriptor_name":"Protein Disulfide-Isomerases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019704","descriptor_name":"Protein Disulfide-Isomerases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019897","descriptor_name":"Periplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1146/annurev.biochem.72.121801.161459","doi":"https://doi.org/10.1146/annurev.biochem.72.121801.161459","is_oa":false,"landing_page_url":"https://doi.org/10.1146/annurev.biochem.72.121801.161459","pdf_url":null,"source":{"id":"https://openalex.org/S53860259","display_name":"Annual Review of Biochemistry","issn_l":"0066-4154","issn":["0066-4154","1545-4509"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Biochemistry","raw_type":"journal-article"},{"id":"pmid:12524212","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12524212","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual review of biochemistry","raw_type":"Journal Article"},{"id":"pmh:oai:irdb.nii.ac.jp:00897:0005889456","doi":null,"is_oa":false,"landing_page_url":"http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100901230","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Annual Review of Biochemistry","raw_type":"book"},{"id":"pmh:oai:t2r2.star.titech.ac.jp:50670471","doi":null,"is_oa":false,"landing_page_url":"http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100901230","pdf_url":null,"source":{"id":"https://openalex.org/S4377196385","display_name":"Tokyo Tech Research Repository (Tokyo Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114531698","host_organization_name":"Tokyo Institute of Technology","host_organization_lineage":["https://openalex.org/I114531698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Book"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2708609285","display_name":"Microbial Diversity in Mechanisms of Disulfide Bond Formation and Reduction","funder_award_id":"R01GM041883","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5931219053","display_name":"Disulfide Bond Formation: Mechanisms for Isomerization and Novel Pathways","funder_award_id":"R01GM055090","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306095","display_name":"American Cancer Society","ror":"https://ror.org/02e463172"},{"id":"https://openalex.org/F4320310652","display_name":"Charles A. King Trust","ror":"https://ror.org/01ctnwa22"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":103,"referenced_works":["https://openalex.org/W107262396","https://openalex.org/W175782524","https://openalex.org/W193732993","https://openalex.org/W1504241430","https://openalex.org/W1522290718","https://openalex.org/W1525086545","https://openalex.org/W1563504653","https://openalex.org/W1830036395","https://openalex.org/W1904630744","https://openalex.org/W1925087414","https://openalex.org/W1953089537","https://openalex.org/W1973554224","https://openalex.org/W1976365154","https://openalex.org/W1977273560","https://openalex.org/W1977294234","https://openalex.org/W1977885347","https://openalex.org/W1979511138","https://openalex.org/W1979913231","https://openalex.org/W1979955102","https://openalex.org/W1984563861","https://openalex.org/W1984815460","https://openalex.org/W1989534424","https://openalex.org/W1989663904","https://openalex.org/W1991498388","https://openalex.org/W1991719301","https://openalex.org/W1992314116","https://openalex.org/W1994645861","https://openalex.org/W1998510617","https://openalex.org/W2000460384","https://openalex.org/W2000918396","https://openalex.org/W2002920425","https://openalex.org/W2007245883","https://openalex.org/W2007399721","https://openalex.org/W2009535317","https://openalex.org/W2009664225","https://openalex.org/W2009869391","https://openalex.org/W2010329747","https://openalex.org/W2014761342","https://openalex.org/W2017426758","https://openalex.org/W2021024369","https://openalex.org/W2023338795","https://openalex.org/W2026209245","https://openalex.org/W2028465235","https://openalex.org/W2029112137","https://openalex.org/W2030156792","https://openalex.org/W2030626819","https://openalex.org/W2031320132","https://openalex.org/W2032336739","https://openalex.org/W2032599079","https://openalex.org/W2036357948","https://openalex.org/W2036508367","https://openalex.org/W2036990405","https://openalex.org/W2040473562","https://openalex.org/W2043378343","https://openalex.org/W2043580912","https://openalex.org/W2044511004","https://openalex.org/W2049799358","https://openalex.org/W2050206654","https://openalex.org/W2050455566","https://openalex.org/W2051452587","https://openalex.org/W2054702523","https://openalex.org/W2056756821","https://openalex.org/W2061563016","https://openalex.org/W2061745332","https://openalex.org/W2062115941","https://openalex.org/W2062418567","https://openalex.org/W2066878866","https://openalex.org/W2072597086","https://openalex.org/W2074994853","https://openalex.org/W2077017946","https://openalex.org/W2077745185","https://openalex.org/W2077952827","https://openalex.org/W2080933624","https://openalex.org/W2082735691","https://openalex.org/W2085124671","https://openalex.org/W2085742094","https://openalex.org/W2086166301","https://openalex.org/W2088630421","https://openalex.org/W2090273203","https://openalex.org/W2092999001","https://openalex.org/W2097126166","https://openalex.org/W2102837599","https://openalex.org/W2105746183","https://openalex.org/W2107227535","https://openalex.org/W2117379106","https://openalex.org/W2120142951","https://openalex.org/W2122529728","https://openalex.org/W2126079531","https://openalex.org/W2132830499","https://openalex.org/W2133128654","https://openalex.org/W2140514518","https://openalex.org/W2143933896","https://openalex.org/W2148090290","https://openalex.org/W2150657386","https://openalex.org/W2154085118","https://openalex.org/W2156366212","https://openalex.org/W2160338675","https://openalex.org/W2160753240","https://openalex.org/W2163624487","https://openalex.org/W2163754069","https://openalex.org/W2168058720","https://openalex.org/W2169060424","https://openalex.org/W2280036301"],"related_works":["https://openalex.org/W1975542266","https://openalex.org/W7098437566","https://openalex.org/W2950836937","https://openalex.org/W1927059920","https://openalex.org/W1974012770","https://openalex.org/W4285211914","https://openalex.org/W1988372753","https://openalex.org/W2135604463","https://openalex.org/W2095383910","https://openalex.org/W2132098097"],"abstract_inverted_index":{"Disulfide":[0],"bonds":[1,31],"formed":[2],"between":[3,65],"pairs":[4,38],"of":[5,10,13,28,39,50,56,58,68,78],"cysteines":[6,40],"are":[7,41,83],"important":[8],"features":[9],"the":[11,26,36,44,54],"structure":[12],"many":[14],"proteins.":[15],"Elaborate":[16],"electron":[17],"transfer":[18],"pathways":[19],"have":[20],"evolved":[21],"Escherichia":[22],"coli":[23],"to":[24,33],"promote":[25],"formation":[27,61],"these":[29,88],"covalent":[30],"and":[32,73,80],"ensure":[34],"that":[35],"correct":[37],"joined":[42],"in":[43,53,85],"final":[45],"folded":[46],"protein.":[47],"These":[48],"transfers":[49],"electrons":[51],"consist,":[52],"main,":[55],"cascades":[57],"disulfide":[59],"bond":[60],"or":[62],"reduction":[63],"steps":[64],"a":[66],"series":[67],"proteins":[69],"(DsbA,":[70],"DsbB,":[71],"DsbC,":[72],"DsbD).":[74],"A":[75],"surprising":[76],"variety":[77],"mechanisms":[79],"protein":[81],"structures":[82],"involved":[84],"carrying":[86],"out":[87],"steps.":[89]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":22},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":20},{"year":2014,"cited_by_count":19},{"year":2013,"cited_by_count":31},{"year":2012,"cited_by_count":28}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}