{"id":"https://openalex.org/W2127688676","doi":"https://doi.org/10.1002/jnr.23048","title":"Neuronal responses to an asymmetrical alternating current field can mimic those produced by an imposed direct current field in vitro","display_name":"Neuronal responses to an asymmetrical alternating current field can mimic those produced by an imposed direct current field in vitro","publication_year":2012,"publication_date":"2012-04-14","ids":{"openalex":"https://openalex.org/W2127688676","doi":"https://doi.org/10.1002/jnr.23048","mag":"2127688676","pmid":"https://pubmed.ncbi.nlm.nih.gov/22504892"},"language":"en","primary_location":{"id":"doi:10.1002/jnr.23048","doi":"https://doi.org/10.1002/jnr.23048","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jnr.23048","pdf_url":null,"source":{"id":"https://openalex.org/S76417895","display_name":"Journal of Neuroscience Research","issn_l":"0360-4012","issn":["0360-4012","1097-4547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroscience Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081014714","display_name":"Linjie Pan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linjie Pan","raw_affiliation_strings":["Center for Paralysis Research, Department of Basic Medical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, Indiana 47907, USA","Center for Paralysis Research, Department of Basic Medical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, Indiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Paralysis Research, Department of Basic Medical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, Indiana 47907, USA","institution_ids":["https://openalex.org/I219193219"]},{"raw_affiliation_string":"Center for Paralysis Research, Department of Basic Medical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, Indiana","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080609262","display_name":"John Cirillo","orcid":"https://orcid.org/0000-0002-3404-6408","observed_orcids":["https://orcid.org/0000-0002-3404-6408"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Cirillo","raw_affiliation_strings":["Center for Paralysis Research, Department of Basic Medical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, Indiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Paralysis Research, Department of Basic Medical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, Indiana","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045100984","display_name":"Richard B. Borgens","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Richard Ben Borgens","raw_affiliation_strings":["Center for Paralysis Research, Department of Basic Medical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, Indiana","Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Paralysis Research, Department of Basic Medical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, Indiana","institution_ids":["https://openalex.org/I219193219"]},{"raw_affiliation_string":"Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana","institution_ids":["https://openalex.org/I219193219"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5045100984"],"corresponding_institution_ids":["https://openalex.org/I219193219"],"apc_list":{"value":4840,"currency":"USD","value_usd":4840},"apc_paid":null,"fwci":0.5518,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.58621706,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"90","issue":"8","first_page":"1522","last_page":"1532"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12061","display_name":"Axon Guidance and Neuronal Signaling","score":0.4668000042438507,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12061","display_name":"Axon Guidance and Neuronal Signaling","score":0.4668000042438507,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10874","display_name":"Electromagnetic Fields and Biological Effects","score":0.27000001072883606,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.08229999989271164,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuronal-polarity","display_name":"neuronal polarity","score":0.6269999742507935},{"id":"https://openalex.org/keywords/sympathetic-neurons","display_name":"sympathetic neurons","score":0.8360000252723694},{"id":"https://openalex.org/keywords/neurite-orientation","display_name":"neurite orientation","score":0.796999990940094},{"id":"https://openalex.org/keywords/chick-embryo","display_name":"chick embryo","score":0.7110000252723694}],"concepts":[{"id":"https://openalex.org/C2776620479","wikidata":"https://www.wikidata.org/wiki/Q159241","display_name":"Direct current","level":3,"score":0.6123929619789124},{"id":"https://openalex.org/C2777361361","wikidata":"https://www.wikidata.org/wiki/Q1112585","display_name":"Polarity (international relations)","level":3,"score":0.6058156490325928},{"id":"https://openalex.org/C2779876028","wikidata":"https://www.wikidata.org/wiki/Q124164","display_name":"Alternating current","level":3,"score":0.5957539081573486},{"id":"https://openalex.org/C2779843651","wikidata":"https://www.wikidata.org/wiki/Q7390335","display_name":"SIGNAL (programming language)","level":2,"score":0.5884212851524353},{"id":"https://openalex.org/C113246987","wikidata":"https://www.wikidata.org/wiki/Q1534415","display_name":"Neurite","level":3,"score":0.5453143119812012},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5370520353317261},{"id":"https://openalex.org/C131584629","wikidata":"https://www.wikidata.org/wiki/Q4308705","display_name":"Coupling (piping)","level":2,"score":0.5066638588905334},{"id":"https://openalex.org/C165801399","wikidata":"https://www.wikidata.org/wiki/Q25428","display_name":"Voltage","level":2,"score":0.48815637826919556},{"id":"https://openalex.org/C197424946","wikidata":"https://www.wikidata.org/wiki/Q1165717","display_name":"Waveform","level":3,"score":0.46752050518989563},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.4629133343696594},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4318939745426178},{"id":"https://openalex.org/C148043351","wikidata":"https://www.wikidata.org/wiki/Q4456944","display_name":"Current (fluid)","level":2,"score":0.41222304105758667},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.35933977365493774},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.34621548652648926},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.32701125741004944},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3087863326072693},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.29801511764526367},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2928121089935303},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000320","descriptor_name":"Adrenergic Fibers","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002645","descriptor_name":"Chickens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":true},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/jnr.23048","doi":"https://doi.org/10.1002/jnr.23048","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jnr.23048","pdf_url":null,"source":{"id":"https://openalex.org/S76417895","display_name":"Journal of Neuroscience Research","issn_l":"0360-4012","issn":["0360-4012","1097-4547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroscience Research","raw_type":"journal-article"},{"id":"pmid:22504892","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22504892","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neuroscience research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1661921944","https://openalex.org/W1923545801","https://openalex.org/W1945237426","https://openalex.org/W1947528063","https://openalex.org/W1954098543","https://openalex.org/W1963520280","https://openalex.org/W1995655400","https://openalex.org/W2002991449","https://openalex.org/W2012127058","https://openalex.org/W2017071950","https://openalex.org/W2031556847","https://openalex.org/W2059565069","https://openalex.org/W2062464503","https://openalex.org/W2067036589","https://openalex.org/W2085833721","https://openalex.org/W2088067134","https://openalex.org/W2092422188","https://openalex.org/W2118661742","https://openalex.org/W2120216837","https://openalex.org/W2120894727","https://openalex.org/W2131627152","https://openalex.org/W2171345480"],"related_works":["https://openalex.org/W2087736370","https://openalex.org/W2062464503","https://openalex.org/W1661921944","https://openalex.org/W2060298783","https://openalex.org/W2085833721","https://openalex.org/W3202638968","https://openalex.org/W1969617159","https://openalex.org/W6990724679","https://openalex.org/W1991625704","https://openalex.org/W1923545801"],"abstract_inverted_index":{"The":[0],"remarkable":[1],"polarity-dependent":[2],"growth":[3,156],"and":[4,93,112,120,128,157],"anatomical":[5],"organization":[6,158],"of":[7,28,50,59,125,131,142,171,178],"neurons":[8,111],"in":[9,55,84,108,118],"vitro":[10],"produced":[11],"by":[12,25,159],"imposed":[13],"direct":[14],"current":[15,38],"(DC)":[16],"voltage":[17,74],"gradients":[18,75],"(electrical":[19],"fields;":[20],"Ef)":[21],"can":[22,63,102,189],"be":[23,64,190],"mimicked":[24],"another":[26],"type":[27],"electrical":[29,40],"cue.":[30],"This":[31,116],"is":[32],"a":[33,135,150,172],"properly":[34],"structured":[35],"asymmetrical":[36],"alternating":[37],"(AC)":[39],"field":[41],"(A-ACEf).":[42],"Here":[43],"we":[44],"provide":[45,89],"details":[46],"on":[47],"the":[48,90,105,129,140,169],"construction":[49],"an":[51,60,98],"AC":[52,61,73,100],"signal":[53],"generator":[54],"which":[56],"all":[57],"components":[58],"waveform":[62],"individually":[65],"controlled.":[66],"We":[67,87],"show":[68],"that":[69,97,188],"1)":[70],"conventional":[71],"symmetrical":[72],"will":[76],"not":[77],"induce":[78],"growth,":[79],"guidance,":[80],"or":[81,180],"architectural":[82],"changes":[83],"sympathetic":[85,110],"neurons.":[86],"also":[88,167],"first":[91],"qualitative":[92],"quantitative":[94],"data":[95,166],"showing":[96],"asymmetric":[99],"application":[101],"indeed":[103],"mimic":[104,175],"DC":[106],"response":[107],"chick":[109],"their":[113],"growing":[114],"neurites.":[115],"shift":[117],"orientation":[119,137],"neuronal":[121],"anatomy":[122],"requires":[123],"dieback":[124],"some":[126],"neurites":[127],"extension":[130],"others":[132],"to":[133,139,149,153,174],"produce":[134],"preferred":[136],"perpendicular":[138],"gradient":[141],"voltage.":[143],"Our":[144],"new":[145],"results":[146],"may":[147],"lead":[148],"noninvasive":[151],"means":[152,173],"modify":[154],"nerve":[155],"magnetic":[160],"inductive":[161],"coupling":[162],"at":[163],"distance.":[164],"These":[165],"indicate":[168],"possibility":[170],"DC-dependent":[176],"release":[177],"drugs":[179],"other":[181],"biologically":[182],"active":[183],"molecules":[184],"from":[185],"electrically":[186],"sensitive":[187],"loaded":[191],"with":[192],"these":[193],"chemical":[194],"cargos.":[195]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}