{"id":"https://openalex.org/W2127658779","doi":"https://doi.org/10.2337/diacare.15.10.1413","title":"Stress and Diabetes Mellitus","display_name":"Stress and Diabetes Mellitus","publication_year":1992,"publication_date":"1992-10-01","ids":{"openalex":"https://openalex.org/W2127658779","doi":"https://doi.org/10.2337/diacare.15.10.1413","mag":"2127658779","pmid":"https://pubmed.ncbi.nlm.nih.gov/1425110"},"language":"en","primary_location":{"id":"doi:10.2337/diacare.15.10.1413","doi":"https://doi.org/10.2337/diacare.15.10.1413","is_oa":true,"landing_page_url":"https://doi.org/10.2337/diacare.15.10.1413","pdf_url":"https://diabetesjournals.org/care/article-pdf/15/10/1413/441270/15-10-1413.pdf","source":{"id":"https://openalex.org/S49878492","display_name":"Diabetes Care","issn_l":"0149-5992","issn":["0149-5992","1935-5548"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes Care","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://diabetesjournals.org/care/article-pdf/15/10/1413/441270/15-10-1413.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010891660","display_name":"Richard S. Surwit","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard S Surwit","raw_affiliation_strings":["Departments of Psychiatry and Medicine, Duke University Medical Center\u2008Durham, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Psychiatry and Medicine, Duke University Medical Center\u2008Durham, North Carolina","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005404464","display_name":"Mark S. Schneider","orcid":"https://orcid.org/0009-0008-1552-951X","observed_orcids":["https://orcid.org/0009-0008-1552-951X"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark S Schneider","raw_affiliation_strings":["Departments of Psychiatry and Medicine, Duke University Medical Center\u2008Durham, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Psychiatry and Medicine, Duke University Medical Center\u2008Durham, North Carolina","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112804316","display_name":"Mark N. Feinglos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark N Feinglos","raw_affiliation_strings":["Departments of Psychiatry and Medicine, Duke University Medical Center\u2008Durham, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Psychiatry and Medicine, Duke University Medical Center\u2008Durham, North Carolina","institution_ids":["https://openalex.org/I4210126298"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210126298"],"apc_list":null,"apc_paid":null,"fwci":1.1139,"has_fulltext":true,"cited_by_count":412,"citation_normalized_percentile":{"value":0.71818182,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"15","issue":"10","first_page":"1413","last_page":"1422"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.8960000276565552,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.8960000276565552,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.02879999950528145,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.014000000432133675,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stress","display_name":"stress","score":0.7319999933242798},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.9750000238418579},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.8299999833106995},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":1.0},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.9620000123977661},{"id":"https://openalex.org/keywords/fight-or-flight-response","display_name":"fight-or-flight response","score":0.7960000038146973},{"id":"https://openalex.org/keywords/stress-hormones","display_name":"stress hormones","score":0.9739999771118164},{"id":"https://openalex.org/keywords/insulin-deficiency","display_name":"insulin deficiency","score":0.8939999938011169},{"id":"https://openalex.org/keywords/autonomic-neuropathy","display_name":"autonomic neuropathy","score":0.9829999804496765}],"concepts":[{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.8621151447296143},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8214572668075562},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.6133496761322021},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6027902364730835},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6021214127540588},{"id":"https://openalex.org/C2780668416","wikidata":"https://www.wikidata.org/wiki/Q202758","display_name":"Hypoglycemia","level":3,"score":0.5657758116722107},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.5539339780807495},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5313252806663513},{"id":"https://openalex.org/C2780473172","wikidata":"https://www.wikidata.org/wiki/Q5572518","display_name":"Glycemic","level":3,"score":0.505343496799469},{"id":"https://openalex.org/C125370674","wikidata":"https://www.wikidata.org/wiki/Q1527480","display_name":"Stressor","level":2,"score":0.5040730237960815},{"id":"https://openalex.org/C172268261","wikidata":"https://www.wikidata.org/wiki/Q4764988","display_name":"Animal studies","level":2,"score":0.4349607229232788},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.41600242257118225},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.41440489888191223},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008820","descriptor_name":"Mice, Obese","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013312","descriptor_name":"Stress, Physiological","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D013315","descriptor_name":"Stress, Psychological","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.2337/diacare.15.10.1413","doi":"https://doi.org/10.2337/diacare.15.10.1413","is_oa":true,"landing_page_url":"https://doi.org/10.2337/diacare.15.10.1413","pdf_url":"https://diabetesjournals.org/care/article-pdf/15/10/1413/441270/15-10-1413.pdf","source":{"id":"https://openalex.org/S49878492","display_name":"Diabetes Care","issn_l":"0149-5992","issn":["0149-5992","1935-5548"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes Care","raw_type":"journal-article"},{"id":"pmid:1425110","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1425110","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes care","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.2337/diacare.15.10.1413","doi":"https://doi.org/10.2337/diacare.15.10.1413","is_oa":true,"landing_page_url":"https://doi.org/10.2337/diacare.15.10.1413","pdf_url":"https://diabetesjournals.org/care/article-pdf/15/10/1413/441270/15-10-1413.pdf","source":{"id":"https://openalex.org/S49878492","display_name":"Diabetes Care","issn_l":"0149-5992","issn":["0149-5992","1935-5548"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes Care","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1031938712","display_name":"STRESS, GLYCEMIC REACTIVITY AND RISK FOR TYPE 2 DIABETES","funder_award_id":"R01DK043106","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2161541818","display_name":"NEUROBIOLOGY OF BIABETES MELLITUS","funder_award_id":"K02MH000303","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G4649464765","display_name":"GENETICS OF A MURINE MODEL OF TYPE 2 DIABETES","funder_award_id":"R01DK042923","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2127658779.pdf","grobid_xml":"https://content.openalex.org/works/W2127658779.grobid-xml"},"referenced_works_count":60,"referenced_works":["https://openalex.org/W952344","https://openalex.org/W207784940","https://openalex.org/W324279386","https://openalex.org/W1576665792","https://openalex.org/W1608351814","https://openalex.org/W1845113677","https://openalex.org/W1963826335","https://openalex.org/W1967793539","https://openalex.org/W1969308939","https://openalex.org/W1974625803","https://openalex.org/W1978085704","https://openalex.org/W1981109210","https://openalex.org/W1981404311","https://openalex.org/W1982918280","https://openalex.org/W1985939147","https://openalex.org/W1988637286","https://openalex.org/W1993976562","https://openalex.org/W1994232119","https://openalex.org/W1996028034","https://openalex.org/W1996408601","https://openalex.org/W2000013466","https://openalex.org/W2008339640","https://openalex.org/W2008394801","https://openalex.org/W2010131014","https://openalex.org/W2026731271","https://openalex.org/W2035146403","https://openalex.org/W2039118206","https://openalex.org/W2041547806","https://openalex.org/W2050448997","https://openalex.org/W2061182616","https://openalex.org/W2064537880","https://openalex.org/W2065838027","https://openalex.org/W2075789214","https://openalex.org/W2080094839","https://openalex.org/W2086019396","https://openalex.org/W2089375806","https://openalex.org/W2099365033","https://openalex.org/W2108889980","https://openalex.org/W2111827011","https://openalex.org/W2117106591","https://openalex.org/W2118386917","https://openalex.org/W2121801623","https://openalex.org/W2127217270","https://openalex.org/W2132665064","https://openalex.org/W2133884882","https://openalex.org/W2145490597","https://openalex.org/W2154671613","https://openalex.org/W2162772306","https://openalex.org/W2168523134","https://openalex.org/W2316587817","https://openalex.org/W2317345647","https://openalex.org/W2319554769","https://openalex.org/W2319900464","https://openalex.org/W2323651968","https://openalex.org/W2324818654","https://openalex.org/W2326474576","https://openalex.org/W2328599023","https://openalex.org/W2330082577","https://openalex.org/W2339779641","https://openalex.org/W2944495621"],"related_works":["https://openalex.org/W81440177","https://openalex.org/W2324235231","https://openalex.org/W4295809583","https://openalex.org/W3163264132","https://openalex.org/W2316549914","https://openalex.org/W6930377325","https://openalex.org/W4214552559","https://openalex.org/W2117198062","https://openalex.org/W2237313520","https://openalex.org/W2047668571"],"abstract_inverted_index":{"Stress":[0,10,34],"is":[1,24,51,102,230],"a":[2,25,56,62,208],"potential":[3],"contributor":[4],"to":[5,15,164,236],"chronic":[6],"hyperglycemia":[7,221],"in":[8,44,55,59,74,89,98,154,171,185,197,222,242],"diabetes.":[9,90,156,174,188],"has":[11],"long":[12],"been":[13],"shown":[14,121,138],"have":[16,109,120,137,146],"major":[17],"effects":[18,95],"on":[19,151,192],"metabolic":[20],"activity.":[21],"Energy":[22],"mobilization":[23],"primary":[26],"result":[27,43,63],"of":[28,38,52,64,70,82,96,124,132,158,167,183,195,202,211,225,233,239],"the":[29,36,65,94,133,165,181,193,198,215,226,237],"fight":[30],"or":[31,67,145],"flight":[32],"response.":[33],"stimulates":[35],"release":[37],"various":[39,125],"hormones,":[40],"which":[41],"can":[42,113,127,141],"elevated":[45],"blood":[46],"glucose":[47,75],"levels.":[48],"Although":[49,104,189],"this":[50,159,223,240],"adaptive":[53],"importance":[54],"healthy":[57],"organism,":[58],"diabetes,":[60,117],"as":[61],"relative":[66],"absolute":[68],"lack":[69],"insulin,":[71],"stress-induced":[72],"increases":[73],"cannot":[76],"be":[77,87,162],"metabolized":[78],"properly.":[79],"Furthermore,":[80,228],"regulation":[81],"these":[83],"stress":[84,97,112,140,184,196,218],"hormones":[85],"may":[86,161],"abnormal":[88],"However,":[91],"evidence":[92,179,232],"characterizing":[93],"type":[99,115,172,186,203],"I":[100,116,173],"diabetes":[101,205],"contradictory.":[103],"some":[105],"retrospective":[106],"human":[107,190],"studies":[108,119,136,191],"suggested":[110],"that":[111,122,139,217],"precipitate":[114],"animal":[118,212],"stressors":[123],"kinds":[126],"precipitate--or":[128],"prevent--various":[129],"experimental":[130],"models":[131],"disease.":[134,227],"Human":[135],"stimulate":[142],"hyperglycemia,":[143],"hypoglycemia,":[144],"no":[147],"affect":[148],"at":[149],"all":[150],"glycemic":[152],"status":[153],"established":[155],"Much":[157],"confusion":[160],"attributable":[163],"presence":[166],"autonomic":[168,234],"neuropathy,":[169],"common":[170],"In":[175],"contrast,":[176],"more":[177],"consistent":[178],"supports":[180,214],"role":[182,194],"II":[187,204],"onset":[199],"and":[200,245],"course":[201],"are":[206],"few,":[207],"large":[209],"body":[210],"study":[213],"notion":[216],"reliably":[219],"produces":[220],"form":[224],"there":[229],"mounting":[231],"contributions":[235],"pathophysiology":[238],"condition":[241],"both":[243],"animals":[244],"humans.":[246]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":59},{"year":2024,"cited_by_count":30},{"year":2023,"cited_by_count":24},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":25},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":21},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":15},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}