{"id":"https://openalex.org/W2127621626","doi":"https://doi.org/10.1128/aac.01455-09","title":"Lersivirine, a Nonnucleoside Reverse Transcriptase Inhibitor with Activity against Drug-Resistant Human Immunodeficiency Virus Type 1","display_name":"Lersivirine, a Nonnucleoside Reverse Transcriptase Inhibitor with Activity against Drug-Resistant Human Immunodeficiency Virus Type 1","publication_year":2010,"publication_date":"2010-07-27","ids":{"openalex":"https://openalex.org/W2127621626","doi":"https://doi.org/10.1128/aac.01455-09","mag":"2127621626","pmid":"https://pubmed.ncbi.nlm.nih.gov/20660667","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2944613"},"language":"en","primary_location":{"id":"doi:10.1128/aac.01455-09","doi":"https://doi.org/10.1128/aac.01455-09","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aac.01455-09","pdf_url":null,"source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2944613/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111646887","display_name":"Romuald Corbau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189718659","display_name":"Pfizer (United Kingdom)","ror":"https://ror.org/04x4v8p40","country_code":"GB","type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I189718659"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Romuald Corbau","raw_affiliation_strings":["Departments of Discovery Biology","Department of Discovery Biology, Pfizer Global Research and Development, Sandwich, Kent CT13 9NJ, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Discovery Biology","institution_ids":[]},{"raw_affiliation_string":"Department of Discovery Biology, Pfizer Global Research and Development, Sandwich, Kent CT13 9NJ, United Kingdom","institution_ids":["https://openalex.org/I189718659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011087477","display_name":"Julie Mori","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Julie Mori","raw_affiliation_strings":["Development, Specialty Care"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Development, Specialty Care","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085891527","display_name":"Chris Phillips","orcid":"https://orcid.org/0000-0001-6569-9025","observed_orcids":["https://orcid.org/0000-0001-6569-9025"]},"institutions":[{"id":"https://openalex.org/I189718659","display_name":"Pfizer (United Kingdom)","ror":"https://ror.org/04x4v8p40","country_code":"GB","type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I189718659"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Chris Phillips","raw_affiliation_strings":["Discovery Chemistry, Antivirals Group, Pfizer Global Research and Development, Sandwich, Kent CT13 9NJ, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Chemistry, Antivirals Group, Pfizer Global Research and Development, Sandwich, Kent CT13 9NJ, United Kingdom","institution_ids":["https://openalex.org/I189718659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000201393","display_name":"Lesley Fishburn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lesley Fishburn","raw_affiliation_strings":["Departments of Discovery Biology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Discovery Biology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006185907","display_name":"Alex Mart\u00edn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alex Martin","raw_affiliation_strings":["Departments of Discovery Biology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Discovery Biology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091389261","display_name":"Charles E. Mowbray","orcid":"https://orcid.org/0000-0003-3538-8116","observed_orcids":["https://orcid.org/0000-0003-3538-8116"]},"institutions":[{"id":"https://openalex.org/I189718659","display_name":"Pfizer (United Kingdom)","ror":"https://ror.org/04x4v8p40","country_code":"GB","type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I189718659"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Charles Mowbray","raw_affiliation_strings":["Discovery Chemistry, Antivirals Group, Pfizer Global Research and Development, Sandwich, Kent CT13 9NJ, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Chemistry, Antivirals Group, Pfizer Global Research and Development, Sandwich, Kent CT13 9NJ, United Kingdom","institution_ids":["https://openalex.org/I189718659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059170665","display_name":"Wendy Panton","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wendy Panton","raw_affiliation_strings":["Departments of Discovery Biology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Discovery Biology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050721585","display_name":"Caroline Smith\u2010Burchnell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Caroline Smith-Burchnell","raw_affiliation_strings":["Departments of Discovery Biology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Discovery Biology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030052151","display_name":"Adele Thornberry","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Adele Thornberry","raw_affiliation_strings":["Departments of Discovery Biology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Discovery Biology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030631618","display_name":"Heather Ringrose","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189718659","display_name":"Pfizer (United Kingdom)","ror":"https://ror.org/04x4v8p40","country_code":"GB","type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I189718659"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Heather Ringrose","raw_affiliation_strings":["Discovery Chemistry, Antivirals Group, Pfizer Global Research and Development, Sandwich, Kent CT13 9NJ, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Chemistry, Antivirals Group, Pfizer Global Research and Development, Sandwich, Kent CT13 9NJ, United Kingdom","institution_ids":["https://openalex.org/I189718659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048660603","display_name":"Thorsten Kn\u00f6chel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189718659","display_name":"Pfizer (United Kingdom)","ror":"https://ror.org/04x4v8p40","country_code":"GB","type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I189718659"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Thorsten Kno\u0308chel","raw_affiliation_strings":["Discovery Chemistry, Antivirals Group, Pfizer Global Research and Development, Sandwich, Kent CT13 9NJ, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Chemistry, Antivirals Group, Pfizer Global Research and Development, Sandwich, Kent CT13 9NJ, United Kingdom","institution_ids":["https://openalex.org/I189718659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108975699","display_name":"Steve Irving","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189718659","display_name":"Pfizer (United Kingdom)","ror":"https://ror.org/04x4v8p40","country_code":"GB","type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I189718659"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Steve Irving","raw_affiliation_strings":["Discovery Chemistry, Antivirals Group, Pfizer Global Research and Development, Sandwich, Kent CT13 9NJ, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Chemistry, Antivirals Group, Pfizer Global Research and Development, Sandwich, Kent CT13 9NJ, United Kingdom","institution_ids":["https://openalex.org/I189718659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084731018","display_name":"Mike Westby","orcid":"https://orcid.org/0009-0000-2612-6689","observed_orcids":["https://orcid.org/0009-0000-2612-6689"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mike Westby","raw_affiliation_strings":["Departments of Discovery Biology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Discovery Biology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080574035","display_name":"Anthony Wood","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189718659","display_name":"Pfizer (United Kingdom)","ror":"https://ror.org/04x4v8p40","country_code":"GB","type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I189718659"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Anthony Wood","raw_affiliation_strings":["Discovery Chemistry, Antivirals Group, Pfizer Global Research and Development, Sandwich, Kent CT13 9NJ, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Chemistry, Antivirals Group, Pfizer Global Research and Development, Sandwich, Kent CT13 9NJ, United Kingdom","institution_ids":["https://openalex.org/I189718659"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069464538","display_name":"Manos Perros","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Manos Perros","raw_affiliation_strings":["Departments of Discovery Biology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Discovery Biology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111646887"],"corresponding_institution_ids":["https://openalex.org/I189718659"],"apc_list":null,"apc_paid":null,"fwci":6.578,"has_fulltext":false,"cited_by_count":62,"citation_normalized_percentile":{"value":0.9733017,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"54","issue":"10","first_page":"4451","last_page":"4463"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-nucleoside-reverse-transcriptase-inhibitors","display_name":"non-nucleoside reverse transcriptase inhibitors","score":0.9869999885559082},{"id":"https://openalex.org/keywords/hiv-1","display_name":"HIV-1","score":0.9160000085830688},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.7889999747276306},{"id":"https://openalex.org/keywords/reverse-transcriptase-mutations","display_name":"reverse transcriptase mutations","score":0.843999981880188},{"id":"https://openalex.org/keywords/k103n","display_name":"K103N","score":0.9179999828338623},{"id":"https://openalex.org/keywords/y181c","display_name":"Y181C","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pyrazoles","display_name":"pyrazole derivatives","score":0.8180000185966492},{"id":"https://openalex.org/keywords/antiretroviral-therapy","display_name":"antiretroviral therapy","score":0.7900000214576721},{"id":"https://openalex.org/keywords/small-molecule-inhibitors","display_name":"small molecule inhibitors","score":0.6019999980926514},{"id":"https://openalex.org/keywords/enzyme-binding-mode","display_name":"enzyme binding mode","score":0.41999998688697815}],"concepts":[{"id":"https://openalex.org/C156719811","wikidata":"https://www.wikidata.org/wiki/Q28774","display_name":"Reverse transcriptase","level":4,"score":0.916003942489624},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.7832554578781128},{"id":"https://openalex.org/C2777351918","wikidata":"https://www.wikidata.org/wiki/Q421559","display_name":"Reverse-transcriptase inhibitor","level":5,"score":0.685294508934021},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5410744547843933},{"id":"https://openalex.org/C153574943","wikidata":"https://www.wikidata.org/wiki/Q408939","display_name":"Nucleotidyltransferase","level":4,"score":0.5202399492263794},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5019400119781494},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.4799378514289856},{"id":"https://openalex.org/C182707283","wikidata":"https://www.wikidata.org/wiki/Q7315622","display_name":"Resistance mutation","level":5,"score":0.46649715304374695},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.4530943036079407},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.45308223366737366},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.41515493392944336},{"id":"https://openalex.org/C2776452011","wikidata":"https://www.wikidata.org/wiki/Q311463","display_name":"Sida","level":4,"score":0.20481973886489868},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.19606474041938782},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.1885102093219757},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.1463000774383545},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.11144521832466125},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09283265471458435},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.077004075050354},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07346421480178833}],"mesh":[{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009570","descriptor_name":"Nitriles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018894","descriptor_name":"Reverse Transcriptase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D024882","descriptor_name":"Drug Resistance, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054303","descriptor_name":"HIV Reverse Transcriptase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054303","descriptor_name":"HIV Reverse Transcriptase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/aac.01455-09","doi":"https://doi.org/10.1128/aac.01455-09","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aac.01455-09","pdf_url":null,"source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},{"id":"pmid:20660667","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20660667","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial agents and chemotherapy","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2944613","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2944613/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrob Agents Chemother","raw_type":"Text"},{"id":"pmh:oai:dora:psi_26886","doi":null,"is_oa":false,"landing_page_url":"https://www.dora.lib4ri.ch/psi/item/psi:26886","pdf_url":null,"source":{"id":"https://openalex.org/S4306402574","display_name":"DORA PSI (Paul Scherrer Institute)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2802229908","host_organization_name":"Paul Scherrer Institute","host_organization_lineage":["https://openalex.org/I2802229908"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2944613","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2944613/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrob Agents Chemother","raw_type":"Text"},"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W55384331","https://openalex.org/W72974347","https://openalex.org/W1659719610","https://openalex.org/W1922324557","https://openalex.org/W1963535341","https://openalex.org/W1985062379","https://openalex.org/W1989575903","https://openalex.org/W2001641653","https://openalex.org/W2007434340","https://openalex.org/W2015082477","https://openalex.org/W2015141219","https://openalex.org/W2020631657","https://openalex.org/W2022126281","https://openalex.org/W2029299482","https://openalex.org/W2031139322","https://openalex.org/W2034470753","https://openalex.org/W2035061658","https://openalex.org/W2037266897","https://openalex.org/W2040679107","https://openalex.org/W2040984741","https://openalex.org/W2053570554","https://openalex.org/W2054044810","https://openalex.org/W2059589103","https://openalex.org/W2084136477","https://openalex.org/W2084567960","https://openalex.org/W2103773011","https://openalex.org/W2112176542","https://openalex.org/W2116801949","https://openalex.org/W2120602370","https://openalex.org/W2130269601","https://openalex.org/W2138537958","https://openalex.org/W2140534639","https://openalex.org/W2144081223","https://openalex.org/W2156161019","https://openalex.org/W2161558889","https://openalex.org/W2165260654","https://openalex.org/W2172130850","https://openalex.org/W2181371485","https://openalex.org/W2401326293","https://openalex.org/W2414698896","https://openalex.org/W3191280760","https://openalex.org/W4229629134","https://openalex.org/W4236479494","https://openalex.org/W4247598445"],"related_works":["https://openalex.org/W334420719","https://openalex.org/W2129228641","https://openalex.org/W2143910776","https://openalex.org/W1921269275","https://openalex.org/W2142901991","https://openalex.org/W2085793273","https://openalex.org/W2145939627","https://openalex.org/W4234780417","https://openalex.org/W2316293659","https://openalex.org/W2054044810"],"abstract_inverted_index":{"The":[0,85],"nonnucleoside":[1],"reverse":[2,41],"transcriptase":[3,42],"inhibitors":[4,68],"(NNRTIs)":[5],"are":[6],"key":[7,110],"components":[8],"of":[9,18,36,73,107,120,132],"highly":[10,139],"active":[11],"antiretroviral":[12],"therapy":[13],"(HAART)":[14],"for":[15,122],"the":[16,29,34,39,54,80,91],"treatment":[17],"human":[19,133],"immunodeficiency":[20],"virus":[21],"type":[22],"1":[23],"(HIV-1).":[24],"A":[25],"major":[26],"problem":[27],"with":[28,113,144],"first":[30],"approved":[31],"NNRTIs":[32],"was":[33],"emergence":[35],"mutations":[37],"in":[38,44,94,99],"HIV-1":[40],"(RT),":[43],"particular":[45],"K103N":[46],"and":[47,64,79,125,141],"Y181C,":[48],"which":[49],"led":[50],"to":[51,53,62],"resistance":[52,102],"entire":[55],"class.":[56],"We":[57],"adopted":[58],"an":[59],"iterative":[60],"strategy":[61],"synthesize":[63],"test":[65],"small":[66],"molecule":[67],"from":[69],"a":[70,95,100,130,138],"chemical":[71],"series":[72],"pyrazoles":[74],"against":[75,129,147],"wild-type":[76],"(wt)":[77],"RT":[78,92,111],"most":[81],"prevalent":[82],"NNRTI-resistant":[83,148],"mutants.":[84],"emerging":[86],"candidate,":[87],"lersivirine":[88,136],"(UK-453,061),":[89],"binds":[90],"enzyme":[93],"novel":[96],"way":[97],"(resulting":[98],"unique":[101],"profile),":[103],"inhibits":[104],"over":[105],"60%":[106],"viruses":[108],"bearing":[109],"mutations,":[112],"50%":[114],"effective":[115],"concentrations":[116],"(EC(50)s)":[117],"within":[118],"10-fold":[119],"those":[121],"wt":[123],"viruses,":[124],"has":[126],"excellent":[127,145],"selectivity":[128],"range":[131],"targets.":[134],"Altogether":[135],"is":[137],"potent":[140],"selective":[142],"NNRTI,":[143],"efficacy":[146],"viruses.":[149]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":15}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}