{"id":"https://openalex.org/W2127557331","doi":"https://doi.org/10.1073/pnas.1007953107","title":"A family of diiron monooxygenases catalyzing amino acid beta-hydroxylation in antibiotic biosynthesis","display_name":"A family of diiron monooxygenases catalyzing amino acid beta-hydroxylation in antibiotic biosynthesis","publication_year":2010,"publication_date":"2010-08-16","ids":{"openalex":"https://openalex.org/W2127557331","doi":"https://doi.org/10.1073/pnas.1007953107","mag":"2127557331","pmid":"https://pubmed.ncbi.nlm.nih.gov/20713732","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2932612"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.1007953107","doi":"https://doi.org/10.1073/pnas.1007953107","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1007953107","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2932612","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053309916","display_name":"Thomas M. Makris","orcid":"https://orcid.org/0000-0001-7927-620X","observed_orcids":["https://orcid.org/0000-0001-7927-620X"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas M. Makris","raw_affiliation_strings":["Department of Biochemistry, Molecular Biology, and Biophysics, and the Center for Metals in Biocatalysis, University of Minnesota, Minneapolis, MN 55455; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Molecular Biology, and Biophysics, and the Center for Metals in Biocatalysis, University of Minnesota, Minneapolis, MN 55455; and","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079989629","display_name":"Mrinmoy Chakrabarti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74973139","display_name":"Carnegie Mellon University","ror":"https://ror.org/05x2bcf33","country_code":"US","type":"education","lineage":["https://openalex.org/I74973139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mrinmoy Chakrabarti","raw_affiliation_strings":["Department of Chemistry, Carnegie Mellon University, Pittsburgh, PA 15213"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Carnegie Mellon University, Pittsburgh, PA 15213","institution_ids":["https://openalex.org/I74973139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058130714","display_name":"Eckard M\u00fcnck","orcid":"https://orcid.org/0000-0002-1867-0358","observed_orcids":["https://orcid.org/0000-0002-1867-0358"]},"institutions":[{"id":"https://openalex.org/I74973139","display_name":"Carnegie Mellon University","ror":"https://ror.org/05x2bcf33","country_code":"US","type":"education","lineage":["https://openalex.org/I74973139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eckard M\u00fcnck","raw_affiliation_strings":["Department of Chemistry, Carnegie Mellon University, Pittsburgh, PA 15213"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Carnegie Mellon University, Pittsburgh, PA 15213","institution_ids":["https://openalex.org/I74973139"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019917073","display_name":"John D. Lipscomb","orcid":"https://orcid.org/0000-0002-8158-5594","observed_orcids":["https://orcid.org/0000-0002-8158-5594"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John D. Lipscomb","raw_affiliation_strings":["Department of Biochemistry, Molecular Biology, and Biophysics, and the Center for Metals in Biocatalysis, University of Minnesota, Minneapolis, MN 55455; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Molecular Biology, and Biophysics, and the Center for Metals in Biocatalysis, University of Minnesota, Minneapolis, MN 55455; and","institution_ids":["https://openalex.org/I130238516"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.0111,"has_fulltext":false,"cited_by_count":92,"citation_normalized_percentile":{"value":0.93436986,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"107","issue":"35","first_page":"15391","last_page":"15396"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.7803000211715698,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.7803000211715698,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.21529999375343323,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11626","display_name":"Metalloenzymes and iron-sulfur proteins","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2105","display_name":"Renewable Energy, Sustainability and the Environment"},"field":{"id":"https://openalex.org/fields/21","display_name":"Energy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chloramphenicol-biosynthesis","display_name":"chloramphenicol biosynthesis","score":0.871999979019165},{"id":"https://openalex.org/keywords/cmla","display_name":"cmlA","score":0.8849999904632568},{"id":"https://openalex.org/keywords/nonribosomal-peptide-synthetase","display_name":"nonribosomal peptide synthetase","score":0.9909999966621399},{"id":"https://openalex.org/keywords/oxygenase-activity","display_name":"oxygenase activity","score":0.34200000762939453},{"id":"https://openalex.org/keywords/single-turnover-kinetics","display_name":"single-turnover kinetics","score":0.6930000185966492},{"id":"https://openalex.org/keywords/antibiotic-biosynthesis","display_name":"antibiotic biosynthesis","score":0.6930000185966492}],"concepts":[{"id":"https://openalex.org/C2777379556","wikidata":"https://www.wikidata.org/wiki/Q1443801","display_name":"Nonribosomal peptide","level":4,"score":0.8194390535354614},{"id":"https://openalex.org/C2781109383","wikidata":"https://www.wikidata.org/wiki/Q898497","display_name":"Hydroxylation","level":3,"score":0.7752708196640015},{"id":"https://openalex.org/C23296010","wikidata":"https://www.wikidata.org/wiki/Q417187","display_name":"Methane monooxygenase","level":3,"score":0.7277936935424805},{"id":"https://openalex.org/C36857842","wikidata":"https://www.wikidata.org/wiki/Q1501261","display_name":"Gene cluster","level":3,"score":0.5988527536392212},{"id":"https://openalex.org/C13002179","wikidata":"https://www.wikidata.org/wiki/Q6901821","display_name":"Monooxygenase","level":4,"score":0.5931182503700256},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5633350014686584},{"id":"https://openalex.org/C203075996","wikidata":"https://www.wikidata.org/wiki/Q139677","display_name":"Operon","level":4,"score":0.56011962890625},{"id":"https://openalex.org/C553450214","wikidata":"https://www.wikidata.org/wiki/Q851162","display_name":"Biosynthesis","level":3,"score":0.5524550676345825},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5085209608078003},{"id":"https://openalex.org/C2776834422","wikidata":"https://www.wikidata.org/wiki/Q5279660","display_name":"Dioxygenase","level":3,"score":0.4878966510295868},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4797995388507843},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.4194349944591522},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.4011607766151428},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3789009153842926},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22850030660629272},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.15387892723083496},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.08670061826705933}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002701","descriptor_name":"Chloramphenicol","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D004578","descriptor_name":"Electron Spin Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006899","descriptor_name":"Mixed Function Oxygenases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006899","descriptor_name":"Mixed Function Oxygenases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006899","descriptor_name":"Mixed Function Oxygenases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006900","descriptor_name":"Hydroxylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009876","descriptor_name":"Operon","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010453","descriptor_name":"Peptide Synthases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010453","descriptor_name":"Peptide Synthases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010453","descriptor_name":"Peptide Synthases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010649","descriptor_name":"Phenylalanine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D010649","descriptor_name":"Phenylalanine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010649","descriptor_name":"Phenylalanine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013302","descriptor_name":"Streptomyces","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D013302","descriptor_name":"Streptomyces","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013302","descriptor_name":"Streptomyces","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015204","descriptor_name":"Spectroscopy, Mossbauer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053898","descriptor_name":"Biosynthetic Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1073/pnas.1007953107","doi":"https://doi.org/10.1073/pnas.1007953107","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1007953107","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2932612","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2932612","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:20713732","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20713732","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2932612","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2932612","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1992781218","display_name":null,"funder_award_id":"EB001475","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G4321279440","display_name":null,"funder_award_id":"GM40466","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7674688661","display_name":"Study of O2 Activation by Mossbauer Spectroscopy","funder_award_id":"R01EB001475","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G8438479950","display_name":"Methane Monoxygenase Structure and Function","funder_award_id":"R01GM040466","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8723391352","display_name":null,"funder_award_id":"GM40466-S1","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W113471320","https://openalex.org/W1482589774","https://openalex.org/W1964174013","https://openalex.org/W1967314547","https://openalex.org/W1971733876","https://openalex.org/W1979198069","https://openalex.org/W1981704948","https://openalex.org/W1982793579","https://openalex.org/W1987358726","https://openalex.org/W1990619404","https://openalex.org/W1992510556","https://openalex.org/W1994393411","https://openalex.org/W1995750761","https://openalex.org/W1997254796","https://openalex.org/W1999229805","https://openalex.org/W2000968981","https://openalex.org/W2006842165","https://openalex.org/W2008650801","https://openalex.org/W2009223752","https://openalex.org/W2011607516","https://openalex.org/W2015055975","https://openalex.org/W2029442289","https://openalex.org/W2033035711","https://openalex.org/W2036080658","https://openalex.org/W2044428152","https://openalex.org/W2053364256","https://openalex.org/W2054642069","https://openalex.org/W2055134264","https://openalex.org/W2065459823","https://openalex.org/W2069189864","https://openalex.org/W2075979069","https://openalex.org/W2084919208","https://openalex.org/W2087793322","https://openalex.org/W2092493137","https://openalex.org/W2107656141","https://openalex.org/W2111404134","https://openalex.org/W2135255584","https://openalex.org/W2143514195","https://openalex.org/W2155543179","https://openalex.org/W2162624487","https://openalex.org/W2314593557","https://openalex.org/W2395171957","https://openalex.org/W2413315376"],"related_works":["https://openalex.org/W1926405170","https://openalex.org/W2792584246","https://openalex.org/W2313357478","https://openalex.org/W2990468104","https://openalex.org/W2504880853","https://openalex.org/W2526788875","https://openalex.org/W2000705309","https://openalex.org/W2044218686","https://openalex.org/W2729971436","https://openalex.org/W2748821064"],"abstract_inverted_index":{"The":[0,110],"biosynthesis":[1,34],"of":[2,9,35,113,153],"chloramphenicol":[3],"requires":[4],"a":[5,57,107,119,129,151],"beta-hydroxylation":[6],"tailoring":[7],"reaction":[8,20],"the":[10,24,31,38,77,94,103,124],"precursor":[11],"L-p-aminophenylalanine":[12],"(L-PAPA).":[13],"Here,":[14],"it":[15,117],"is":[16,21,74,84,96,102,127],"shown":[17],"that":[18,49,72,81,93,100,116,123],"this":[19],"catalyzed":[22],"by":[23],"enzyme":[25],"CmlA":[26,50,73,114,140],"from":[27],"an":[28,52],"operon":[29],"containing":[30],"genes":[32],"for":[33],"L-PAPA":[36,85,98],"and":[37,45,80,99,158],"nonribosomal":[39,64],"peptide":[40,65],"synthetase":[41,66],"CmlP.":[42,89],"EPR,":[43],"M\u00f6ssbauer,":[44],"optical":[46],"spectroscopies":[47],"reveal":[48],"contains":[51],"oxo-bridged":[53],"dinuclear":[54],"iron":[55],"cluster,":[56],"metal":[58],"center":[59],"not":[60,132],"previously":[61,133],"associated":[62],"with":[63],"chemistry.":[67],"Single-turnover":[68],"kinetic":[69],"studies":[70,91],"indicate":[71],"functional":[75],"in":[76,128,145],"diferrous":[78],"state":[79],"its":[82],"substrate":[83],"covalently":[86],"bound":[87],"to":[88,135],"Analytical":[90],"show":[92],"product":[95,147],"hydroxylated":[97],"O(2)":[101],"oxygen":[104],"source,":[105],"demonstrating":[106],"monooxygenase":[108,137],"reaction.":[109],"gene":[111],"sequence":[112],"shows":[115],"utilizes":[118],"lactamase":[120],"fold,":[121],"suggesting":[122],"diiron":[125],"cluster":[126],"protein":[130],"environment":[131],"known":[134],"effect":[136],"reactions.":[138],"Notably,":[139],"homologs":[141],"are":[142],"widely":[143],"distributed":[144],"natural":[146],"biosynthetic":[148],"pathways,":[149],"including":[150],"variety":[152],"pharmaceutically":[154],"important":[155],"beta-hydroxylated":[156],"antibiotics":[157],"cytostatics.":[159]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":8}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}