{"id":"https://openalex.org/W2127538704","doi":"https://doi.org/10.1016/j.cub.2010.01.055","title":"Lgl, aPKC, and Crumbs Regulate the Salvador/Warts/Hippo Pathway through Two Distinct Mechanisms","display_name":"Lgl, aPKC, and Crumbs Regulate the Salvador/Warts/Hippo Pathway through Two Distinct Mechanisms","publication_year":2010,"publication_date":"2010-04-01","ids":{"openalex":"https://openalex.org/W2127538704","doi":"https://doi.org/10.1016/j.cub.2010.01.055","mag":"2127538704","pmid":"https://pubmed.ncbi.nlm.nih.gov/20362447"},"language":"en","primary_location":{"id":"doi:10.1016/j.cub.2010.01.055","doi":"https://doi.org/10.1016/j.cub.2010.01.055","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cub.2010.01.055","pdf_url":"http://www.cell.com/article/S096098221000151X/pdf","source":{"id":"https://openalex.org/S128425624","display_name":"Current Biology","issn_l":"0960-9822","issn":["0960-9822","1879-0445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.cell.com/article/S096098221000151X/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073193911","display_name":"Nicola A. Grzeschik","orcid":"https://orcid.org/0000-0001-7106-4325","observed_orcids":["https://orcid.org/0000-0001-7106-4325"]},"institutions":[{"id":"https://openalex.org/I2800555584","display_name":"Peter MacCallum Cancer Centre","ror":"https://ror.org/02a8bt934","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800555584"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Nicola A. Grzeschik","raw_affiliation_strings":["Cell Cycle and Development, Peter MacCallum Cancer Centre, Victoria, Australia","Cell Cycle and Development, Peter MacCallum Cancer Centre, Melbourne, Victoria 3002, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Cycle and Development, Peter MacCallum Cancer Centre, Victoria, Australia","institution_ids":["https://openalex.org/I2800555584"]},{"raw_affiliation_string":"Cell Cycle and Development, Peter MacCallum Cancer Centre, Melbourne, Victoria 3002, Australia","institution_ids":["https://openalex.org/I2800555584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073043927","display_name":"Linda M. Parsons","orcid":"https://orcid.org/0000-0002-7738-8280","observed_orcids":["https://orcid.org/0000-0002-7738-8280"]},"institutions":[{"id":"https://openalex.org/I2800555584","display_name":"Peter MacCallum Cancer Centre","ror":"https://ror.org/02a8bt934","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800555584"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Linda M. Parsons","raw_affiliation_strings":["Cell Cycle and Development, Peter MacCallum Cancer Centre, Melbourne, Victoria 3002, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Cycle and Development, Peter MacCallum Cancer Centre, Melbourne, Victoria 3002, Australia","institution_ids":["https://openalex.org/I2800555584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071759576","display_name":"Melinda L. Allott","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800555584","display_name":"Peter MacCallum Cancer Centre","ror":"https://ror.org/02a8bt934","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800555584"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Melinda L. Allott","raw_affiliation_strings":["Cell Cycle and Development, Peter MacCallum Cancer Centre, Melbourne, Victoria 3002, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Cycle and Development, Peter MacCallum Cancer Centre, Melbourne, Victoria 3002, Australia","institution_ids":["https://openalex.org/I2800555584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022412897","display_name":"Kieran F. Harvey","orcid":"https://orcid.org/0000-0001-7845-369X","observed_orcids":["https://orcid.org/0000-0001-7845-369X"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I2800555584","display_name":"Peter MacCallum Cancer Centre","ror":"https://ror.org/02a8bt934","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800555584"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Kieran F. Harvey","raw_affiliation_strings":["Cell Growth and Proliferation, Peter MacCallum Cancer Centre, Melbourne, Victoria 3002, Australia","Department of Pathology, University of Melbourne, Melbourne, Victoria 3010, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Growth and Proliferation, Peter MacCallum Cancer Centre, Melbourne, Victoria 3002, Australia","institution_ids":["https://openalex.org/I2800555584"]},{"raw_affiliation_string":"Department of Pathology, University of Melbourne, Melbourne, Victoria 3010, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074934904","display_name":"Helena E. Richardson","orcid":"https://orcid.org/0000-0003-3852-4953","observed_orcids":["https://orcid.org/0000-0003-3852-4953"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I2800555584","display_name":"Peter MacCallum Cancer Centre","ror":"https://ror.org/02a8bt934","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800555584"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Helena E. Richardson","raw_affiliation_strings":["Cell Cycle and Development, Peter MacCallum Cancer Centre, Melbourne, Victoria 3002, Australia","Department of Anatomy and Cell Biology, University of Melbourne, Melbourne, Victoria 3010, Australia","Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria 3010, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Cycle and Development, Peter MacCallum Cancer Centre, Melbourne, Victoria 3002, Australia","institution_ids":["https://openalex.org/I2800555584"]},{"raw_affiliation_string":"Department of Anatomy and Cell Biology, University of Melbourne, Melbourne, Victoria 3010, Australia","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria 3010, Australia","institution_ids":["https://openalex.org/I165779595"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5074934904"],"corresponding_institution_ids":["https://openalex.org/I165779595","https://openalex.org/I2800555584"],"apc_list":{"value":7030,"currency":"USD","value_usd":7030},"apc_paid":null,"fwci":13.0989,"has_fulltext":true,"cited_by_count":341,"citation_normalized_percentile":{"value":0.99628722,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"20","issue":"7","first_page":"573","last_page":"581"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12065","display_name":"Hippo pathway signaling and YAP/TAZ","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12065","display_name":"Hippo pathway signaling and YAP/TAZ","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lethal-giant-larvae","display_name":"lethal giant larvae","score":0.8389999866485596},{"id":"https://openalex.org/keywords/atypical-protein-kinase-c","display_name":"atypical protein kinase C","score":0.9440000057220459},{"id":"https://openalex.org/keywords/crumbs","display_name":"Crumbs","score":0.9990000128746033},{"id":"https://openalex.org/keywords/yorkie","display_name":"Yorkie","score":0.8600000143051147},{"id":"https://openalex.org/keywords/expanded","display_name":"Expanded","score":0.9710000157356262},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.8389999866485596},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.5899999737739563},{"id":"https://openalex.org/keywords/tumor-suppressor-pathways","display_name":"tumor suppressor pathways","score":0.6740000247955322},{"id":"https://openalex.org/keywords/drosophila-eye","display_name":"Drosophila eye","score":0.8009999990463257},{"id":"https://openalex.org/keywords/tissue-growth-regulation","display_name":"tissue growth regulation","score":0.6970000267028809}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9519968032836914},{"id":"https://openalex.org/C172512520","wikidata":"https://www.wikidata.org/wiki/Q5768379","display_name":"Hippo signaling pathway","level":3,"score":0.506145179271698},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.48318639397621155},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.3439384400844574},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.22639894485473633}],"mesh":[{"descriptor_ui":"D000091102","descriptor_name":"YAP-Signaling Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000099317","descriptor_name":"Hippo Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005123","descriptor_name":"Eye","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D005123","descriptor_name":"Eye","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016764","descriptor_name":"Cell Polarity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017344","descriptor_name":"Genes, Insect","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D030801","descriptor_name":"Animals, Genetically Modified","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051034","descriptor_name":"Inhibitor of Apoptosis Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055785","descriptor_name":"Gene Knockdown Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.cub.2010.01.055","doi":"https://doi.org/10.1016/j.cub.2010.01.055","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cub.2010.01.055","pdf_url":"http://www.cell.com/article/S096098221000151X/pdf","source":{"id":"https://openalex.org/S128425624","display_name":"Current Biology","issn_l":"0960-9822","issn":["0960-9822","1879-0445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Biology","raw_type":"journal-article"},{"id":"pmid:20362447","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20362447","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current biology : CB","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.cub.2010.01.055","doi":"https://doi.org/10.1016/j.cub.2010.01.055","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cub.2010.01.055","pdf_url":"http://www.cell.com/article/S096098221000151X/pdf","source":{"id":"https://openalex.org/S128425624","display_name":"Current Biology","issn_l":"0960-9822","issn":["0960-9822","1879-0445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.504800021648407,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2646628065","display_name":"How does the body stop cells from growing and dividing excessively?","funder_award_id":"400335","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G2803810614","display_name":"Negative regulators of cell proliferation","funder_award_id":"350369","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2127538704.pdf","grobid_xml":"https://content.openalex.org/works/W2127538704.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W14681682","https://openalex.org/W1566467768","https://openalex.org/W1567765448","https://openalex.org/W1967532512","https://openalex.org/W1967582843","https://openalex.org/W1973493949","https://openalex.org/W1974673111","https://openalex.org/W1976356130","https://openalex.org/W1976577398","https://openalex.org/W1976990850","https://openalex.org/W1978746441","https://openalex.org/W1980398528","https://openalex.org/W1981265221","https://openalex.org/W1984282087","https://openalex.org/W1992418538","https://openalex.org/W1996812654","https://openalex.org/W2005233945","https://openalex.org/W2007455356","https://openalex.org/W2008127822","https://openalex.org/W2012569825","https://openalex.org/W2014669694","https://openalex.org/W2033500225","https://openalex.org/W2034696312","https://openalex.org/W2034820114","https://openalex.org/W2036206289","https://openalex.org/W2036525096","https://openalex.org/W2044851525","https://openalex.org/W2046985565","https://openalex.org/W2050850129","https://openalex.org/W2055484995","https://openalex.org/W2056182849","https://openalex.org/W2072692243","https://openalex.org/W2080042207","https://openalex.org/W2080200530","https://openalex.org/W2083106714","https://openalex.org/W2091621334","https://openalex.org/W2108938866","https://openalex.org/W2120546609","https://openalex.org/W2141595533","https://openalex.org/W2146321861","https://openalex.org/W2147760284","https://openalex.org/W2152642445","https://openalex.org/W2154122181","https://openalex.org/W2157193997"],"related_works":["https://openalex.org/W2103648307","https://openalex.org/W1976878917","https://openalex.org/W2115979125","https://openalex.org/W2018507089","https://openalex.org/W4391027113","https://openalex.org/W3140745524","https://openalex.org/W1972858031","https://openalex.org/W2073053682","https://openalex.org/W4323538613","https://openalex.org/W2034071612"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":20},{"year":2018,"cited_by_count":23},{"year":2017,"cited_by_count":19},{"year":2016,"cited_by_count":20},{"year":2015,"cited_by_count":28},{"year":2014,"cited_by_count":32},{"year":2013,"cited_by_count":43},{"year":2012,"cited_by_count":31}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}