{"id":"https://openalex.org/W2127469418","doi":"https://doi.org/10.1592/phco.29.9.1082","title":"Safety of Double\u2010Dose Transdermal Scopolamine","display_name":"Safety of Double\u2010Dose Transdermal Scopolamine","publication_year":2009,"publication_date":"2009-08-21","ids":{"openalex":"https://openalex.org/W2127469418","doi":"https://doi.org/10.1592/phco.29.9.1082","mag":"2127469418","pmid":"https://pubmed.ncbi.nlm.nih.gov/19698013"},"language":"en","primary_location":{"id":"doi:10.1592/phco.29.9.1082","doi":"https://doi.org/10.1592/phco.29.9.1082","is_oa":false,"landing_page_url":"https://doi.org/10.1592/phco.29.9.1082","pdf_url":null,"source":{"id":"https://openalex.org/S122731057","display_name":"Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy","issn_l":"0277-0008","issn":["0277-0008","1875-9114"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065467141","display_name":"Ronen Bar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150803","display_name":"Israel Defense Forces Medical Corps","ror":"https://ror.org/05w1yqq10","country_code":"IL","type":"government","lineage":["https://openalex.org/I4210150803"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Ronen Bar","raw_affiliation_strings":["Motion Sickness and Human Performance Laboratory, Israel Naval Medical Institute, Israel Defense Forces Medical Corps, Haifa, Israel. bar1906@netvision.net.il","Motion Sickness and Human Performance Laboratory, Israel Naval Medical Institute, Israel Defense Forces Medical Corps, Haifa, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Motion Sickness and Human Performance Laboratory, Israel Naval Medical Institute, Israel Defense Forces Medical Corps, Haifa, Israel. bar1906@netvision.net.il","institution_ids":["https://openalex.org/I4210150803"]},{"raw_affiliation_string":"Motion Sickness and Human Performance Laboratory, Israel Naval Medical Institute, Israel Defense Forces Medical Corps, Haifa, Israel","institution_ids":["https://openalex.org/I4210150803"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081489769","display_name":"Amnon Gil","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150803","display_name":"Israel Defense Forces Medical Corps","ror":"https://ror.org/05w1yqq10","country_code":"IL","type":"government","lineage":["https://openalex.org/I4210150803"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Amnon Gil","raw_affiliation_strings":["Motion Sickness and Human Performance Laboratory, Israel Naval Medical Institute, Israel Defense Forces Medical Corps, Haifa, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Motion Sickness and Human Performance Laboratory, Israel Naval Medical Institute, Israel Defense Forces Medical Corps, Haifa, Israel","institution_ids":["https://openalex.org/I4210150803"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006402398","display_name":"Tal Dror","orcid":"https://orcid.org/0000-0002-6454-6403","observed_orcids":["https://orcid.org/0000-0002-6454-6403"]},"institutions":[{"id":"https://openalex.org/I4210150803","display_name":"Israel Defense Forces Medical Corps","ror":"https://ror.org/05w1yqq10","country_code":"IL","type":"government","lineage":["https://openalex.org/I4210150803"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Dror Tal","raw_affiliation_strings":["Motion Sickness and Human Performance Laboratory, Israel Naval Medical Institute, Israel Defense Forces Medical Corps, Haifa, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Motion Sickness and Human Performance Laboratory, Israel Naval Medical Institute, Israel Defense Forces Medical Corps, Haifa, Israel","institution_ids":["https://openalex.org/I4210150803"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5065467141"],"corresponding_institution_ids":["https://openalex.org/I4210150803"],"apc_list":{"value":4030,"currency":"USD","value_usd":4030},"apc_paid":null,"fwci":2.0554,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.85064023,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"29","issue":"9","first_page":"1082","last_page":"1088"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11785","display_name":"Nausea and vomiting management","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11785","display_name":"Nausea and vomiting management","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10542","display_name":"Vestibular and auditory disorders","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11964","display_name":"Pregnancy and Medication Impact","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transdermal-scopolamine","display_name":"transdermal scopolamine","score":0.9570000171661377},{"id":"https://openalex.org/keywords/seasickness","display_name":"seasickness","score":0.9470000267028809},{"id":"https://openalex.org/keywords/motion-sickness","display_name":"motion sickness","score":0.9580000042915344},{"id":"https://openalex.org/keywords/adverse-effects","display_name":"adverse effects","score":0.8330000042915344},{"id":"https://openalex.org/keywords/blurred-vision","display_name":"blurred vision","score":0.906000018119812},{"id":"https://openalex.org/keywords/heart-rate","display_name":"heart rate","score":0.7710000276565552},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.9950000047683716},{"id":"https://openalex.org/keywords/cognitive-function","display_name":"cognitive function","score":0.9670000076293945},{"id":"https://openalex.org/keywords/visual-function","display_name":"visual function","score":0.8859999775886536},{"id":"https://openalex.org/keywords/sailors","display_name":"sailors","score":0.4009999930858612}],"concepts":[{"id":"https://openalex.org/C205679159","wikidata":"https://www.wikidata.org/wiki/Q3375179","display_name":"Transdermal","level":2,"score":0.8091220855712891},{"id":"https://openalex.org/C2779336972","wikidata":"https://www.wikidata.org/wiki/Q309067","display_name":"Motion sickness","level":2,"score":0.7514834403991699},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.7331222295761108},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.712348461151123},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.6573569178581238},{"id":"https://openalex.org/C2778576352","wikidata":"https://www.wikidata.org/wiki/Q337188","display_name":"Scopolamine","level":2,"score":0.641595184803009},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5881089568138123},{"id":"https://openalex.org/C2775842315","wikidata":"https://www.wikidata.org/wiki/Q1145270","display_name":"Transdermal patch","level":3,"score":0.5867568850517273},{"id":"https://openalex.org/C87813604","wikidata":"https://www.wikidata.org/wiki/Q1242899","display_name":"Crossover study","level":4,"score":0.5425530076026917},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.5072986483573914},{"id":"https://openalex.org/C2909050532","wikidata":"https://www.wikidata.org/wiki/Q337188","display_name":"Scopolamine Hydrobromide","level":4,"score":0.475629597902298},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.42882147431373596},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.22118410468101501},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16023841500282288},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C33789571","wikidata":"https://www.wikidata.org/wiki/Q410959","display_name":"Muscarinic acetylcholine receptor","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000279","descriptor_name":"Administration, Cutaneous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007557","descriptor_name":"Israel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008889","descriptor_name":"Military Personnel","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D009041","descriptor_name":"Motion Sickness","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011795","descriptor_name":"Surveys and Questionnaires","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012601","descriptor_name":"Scopolamine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D012601","descriptor_name":"Scopolamine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D012601","descriptor_name":"Scopolamine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D018592","descriptor_name":"Cross-Over Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1592/phco.29.9.1082","doi":"https://doi.org/10.1592/phco.29.9.1082","is_oa":false,"landing_page_url":"https://doi.org/10.1592/phco.29.9.1082","pdf_url":null,"source":{"id":"https://openalex.org/S122731057","display_name":"Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy","issn_l":"0277-0008","issn":["0277-0008","1875-9114"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy","raw_type":"journal-article"},{"id":"pmid:19698013","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19698013","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacotherapy","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W35710294","https://openalex.org/W47598414","https://openalex.org/W62996389","https://openalex.org/W126941526","https://openalex.org/W136634729","https://openalex.org/W140691243","https://openalex.org/W210533657","https://openalex.org/W1948496117","https://openalex.org/W1987611354","https://openalex.org/W2012468374","https://openalex.org/W2016452337","https://openalex.org/W2039828015","https://openalex.org/W2040921834","https://openalex.org/W2075078474","https://openalex.org/W2088332014","https://openalex.org/W2119941062","https://openalex.org/W2134749646","https://openalex.org/W2244042115","https://openalex.org/W2318961694","https://openalex.org/W2398017010","https://openalex.org/W2749083812","https://openalex.org/W3023932319","https://openalex.org/W4240415535"],"related_works":["https://openalex.org/W35710294","https://openalex.org/W126941526","https://openalex.org/W2123007540","https://openalex.org/W2000695024","https://openalex.org/W88260675","https://openalex.org/W2075078474","https://openalex.org/W2904794951","https://openalex.org/W139574992","https://openalex.org/W2081517316","https://openalex.org/W2053855264"],"abstract_inverted_index":{"STUDY":[0],"OBJECTIVE:":[1],"To":[2],"evaluate":[3],"the":[4,74,77,82,114,162,196,208,243],"safety":[5],"of":[6,76],"double-dose":[7,165,211],"transdermal":[8,44,52,226],"scopolamine":[9,45,53,57,95,159,227,245],"patch":[10,58,62,131,145,240],"therapy.":[11],"DESIGN:":[12],"Randomized,":[13],"crossover,":[14],"double-blind":[15],"study.":[16],"SETTING:":[17],"Motion":[18],"sickness":[19],"clinic":[20],"in":[21,156,181,231],"Haifa,":[22],"Israel.":[23],"PARTICIPANTS:":[24],"Twenty":[25],"male":[26],"sailors":[27],"aged":[28],"18-21":[29],"years":[30],"whose":[31],"seasickness":[32],"symptoms":[33],"improved":[34],"only":[35,197],"slightly":[36],"or":[37,55,188,251],"not":[38,221],"at":[39,69],"all":[40],"with":[41],"a":[42,60,204,238,259],"single":[43,239],"patch.":[46],"INTERVENTION:":[47],"Subjects":[48,133],"received":[49,81],"either":[50],"two":[51],"patches":[54],"one":[56],"plus":[59],"placebo":[61],"for":[63,85,147,200],"24":[64,86,128,142],"hours":[65,87,129,143],"(first":[66],"session).":[67,89],"After":[68],"least":[70],"1":[71],"week":[72],"from":[73],"end":[75],"first":[78,115],"session,":[79],"they":[80],"other":[83],"treatment":[84,149,230],"(second":[88],"MEASUREMENTS":[90],"AND":[91],"MAIN":[92],"RESULTS:":[93],"Plasma":[94],"concentrations,":[96],"physiologic":[97],"(heart":[98],"rate":[99],"and":[100,104,108,118,141,164,210],"blood":[101,184],"pressure),":[102],"visual,":[103,250],"cognitive":[105,186,252],"function":[106,124,190],"parameters,":[107],"adverse":[109,198,215,253],"effects":[110],"were":[111,179],"assessed":[112],"before":[113],"session":[116],"(baseline)":[117],"after":[119,130,140,144],"each":[120],"24-hour":[121],"session.":[122],"Visual":[123],"was":[125,154,195,203,217],"tested":[126],"again":[127],"removal.":[132],"also":[134],"completed":[135],"an":[136],"adverse-effects":[137],"questionnaire":[138],"immediately":[139],"removal":[146],"both":[148],"sessions.":[150],"A":[151],"significant":[152,177,205],"difference":[153,206],"found":[155,180],"mean":[157],"plasma":[158,244],"concentrations":[160],"between":[161,207],"single-dose":[163,209],"treatments":[166],"(81":[167],"vs":[168],"127":[169],"pg/ml":[170],"[therapeutic":[171],"level":[172],"100":[173],"pg/ml],":[174],"p<0.01).":[175],"No":[176],"differences":[178],"heart":[182],"rate,":[183],"pressure,":[185],"function,":[187],"visual":[189],"measurements.":[191],"Mild":[192],"blurred":[193],"vision":[194],"effect":[199,216],"which":[201],"there":[202],"treatments;":[212],"however,":[213],"this":[214],"judged":[218],"to":[219,235,237,266],"be":[220,263],"clinically":[222],"significant.":[223],"CONCLUSION:":[224],"Double-dose":[225],"may":[228],"improve":[229],"patients":[232],"who":[233],"fail":[234],"respond":[236],"by":[241],"increasing":[242],"concentration,":[246],"without":[247],"aggravating":[248],"systemic,":[249],"effects.":[254],"Thus":[255],"we":[256],"recommend":[257],"that":[258],"double":[260],"dose":[261],"can":[262],"administered":[264],"safely":[265],"these":[267],"patients.":[268]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
