{"id":"https://openalex.org/W2127450786","doi":"https://doi.org/10.1021/bi060585v","title":"New Prospects for an Old Enzyme: Mammalian Cytochrome c Is Tyrosine-Phosphorylated in Vivo","display_name":"New Prospects for an Old Enzyme: Mammalian Cytochrome c Is Tyrosine-Phosphorylated in Vivo","publication_year":2006,"publication_date":"2006-07-06","ids":{"openalex":"https://openalex.org/W2127450786","doi":"https://doi.org/10.1021/bi060585v","mag":"2127450786","pmid":"https://pubmed.ncbi.nlm.nih.gov/16866357"},"language":"en","primary_location":{"id":"doi:10.1021/bi060585v","doi":"https://doi.org/10.1021/bi060585v","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi060585v","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002735757","display_name":"Icksoo Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]},{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Icksoo Lee","raw_affiliation_strings":["Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan 48201, and Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, Rhode Island 02912"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan 48201, and Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, Rhode Island 02912","institution_ids":["https://openalex.org/I185443292","https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052972032","display_name":"Arthur R. Salomon","orcid":"https://orcid.org/0000-0002-7223-8996","observed_orcids":["https://orcid.org/0000-0002-7223-8996"]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]},{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arthur R. Salomon","raw_affiliation_strings":["Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan 48201, and Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, Rhode Island 02912"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan 48201, and Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, Rhode Island 02912","institution_ids":["https://openalex.org/I185443292","https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000747236","display_name":"Kebing Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]},{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kebing Yu","raw_affiliation_strings":["Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan 48201, and Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, Rhode Island 02912"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan 48201, and Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, Rhode Island 02912","institution_ids":["https://openalex.org/I185443292","https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002413839","display_name":"Jeffrey W. Doan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]},{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey W. Doan","raw_affiliation_strings":["Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan 48201, and Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, Rhode Island 02912"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan 48201, and Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, Rhode Island 02912","institution_ids":["https://openalex.org/I185443292","https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026416444","display_name":"Lawrence I. Grossman","orcid":"https://orcid.org/0000-0002-1059-9358","observed_orcids":["https://orcid.org/0000-0002-1059-9358"]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]},{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lawrence I. Grossman","raw_affiliation_strings":["Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan 48201, and Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, Rhode Island 02912"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan 48201, and Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, Rhode Island 02912","institution_ids":["https://openalex.org/I185443292","https://openalex.org/I27804330"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048054959","display_name":"Maik H\u00fcttemann","orcid":"https://orcid.org/0000-0001-6310-7081","observed_orcids":["https://orcid.org/0000-0001-6310-7081"]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]},{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maik H\u00fcttemann","raw_affiliation_strings":["Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan 48201, and Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, Rhode Island 02912"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan 48201, and Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, Rhode Island 02912","institution_ids":["https://openalex.org/I185443292","https://openalex.org/I27804330"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.6884,"has_fulltext":false,"cited_by_count":102,"citation_normalized_percentile":{"value":0.82298753,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"45","issue":"30","first_page":"9121","last_page":"9128"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.8955000042915344,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.8955000042915344,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.019500000402331352,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.009600000455975533,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cytochrome-c","display_name":"cytochrome c","score":0.9890000224113464},{"id":"https://openalex.org/keywords/tyrosine-phosphorylation","display_name":"tyrosine phosphorylation","score":0.996999979019165},{"id":"https://openalex.org/keywords/cytochrome-c-oxidase","display_name":"cytochrome c oxidase","score":0.8349999785423279},{"id":"https://openalex.org/keywords/mitochondrial-electron-transport-chain","display_name":"mitochondrial electron transport chain","score":0.8740000128746033},{"id":"https://openalex.org/keywords/heme-iron-coordination","display_name":"heme iron coordination","score":0.5059999823570251},{"id":"https://openalex.org/keywords/apaf-1","display_name":"Apaf-1","score":0.6710000038146973},{"id":"https://openalex.org/keywords/cardiolipin-binding","display_name":"cardiolipin binding","score":0.8029999732971191},{"id":"https://openalex.org/keywords/phosphorylation-site-mapping","display_name":"phosphorylation site mapping","score":0.5799999833106995}],"concepts":[{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.7577110528945923},{"id":"https://openalex.org/C123249941","wikidata":"https://www.wikidata.org/wiki/Q306116","display_name":"Cytochrome c oxidase","level":3,"score":0.608330488204956},{"id":"https://openalex.org/C29311851","wikidata":"https://www.wikidata.org/wiki/Q408223","display_name":"Cytochrome c","level":3,"score":0.6044793725013733},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6024522185325623},{"id":"https://openalex.org/C2776165026","wikidata":"https://www.wikidata.org/wiki/Q188017","display_name":"Tyrosine","level":2,"score":0.573130190372467},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5386204123497009},{"id":"https://openalex.org/C2776217839","wikidata":"https://www.wikidata.org/wiki/Q189621","display_name":"Heme","level":3,"score":0.5311984419822693},{"id":"https://openalex.org/C85528070","wikidata":"https://www.wikidata.org/wiki/Q643602","display_name":"Protein tyrosine phosphatase","level":3,"score":0.4905666708946228},{"id":"https://openalex.org/C2777553839","wikidata":"https://www.wikidata.org/wiki/Q14330986","display_name":"Tyrosine phosphorylation","level":3,"score":0.4782101809978485},{"id":"https://openalex.org/C2780768313","wikidata":"https://www.wikidata.org/wiki/Q408068","display_name":"Cytochrome","level":3,"score":0.4544428586959839},{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.4476359486579895},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4407496750354767},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3327938914299011},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.26969194412231445},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23808038234710693}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002853","descriptor_name":"Chromatography, Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003576","descriptor_name":"Electron Transport Complex IV","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003576","descriptor_name":"Electron Transport Complex IV","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006736","descriptor_name":"Horses","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008929","descriptor_name":"Mitochondria, Heart","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013056","descriptor_name":"Spectrophotometry, Ultraviolet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D021241","descriptor_name":"Spectrometry, Mass, Electrospray Ionization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045304","descriptor_name":"Cytochromes c","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D045304","descriptor_name":"Cytochromes c","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045304","descriptor_name":"Cytochromes c","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1021/bi060585v","doi":"https://doi.org/10.1021/bi060585v","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi060585v","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:16866357","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16866357","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Comparative Study"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.549.6753","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.549.6753","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.cellpathway.com/papers/BiochemistryHuttemann.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W172276776","https://openalex.org/W1493332704","https://openalex.org/W1495424041","https://openalex.org/W1506059949","https://openalex.org/W1547052620","https://openalex.org/W1551289009","https://openalex.org/W1576575116","https://openalex.org/W1850214287","https://openalex.org/W1965490406","https://openalex.org/W1966687534","https://openalex.org/W1994270331","https://openalex.org/W1996935972","https://openalex.org/W1997252967","https://openalex.org/W2004704197","https://openalex.org/W2019690101","https://openalex.org/W2025713422","https://openalex.org/W2026242343","https://openalex.org/W2026465178","https://openalex.org/W2028135614","https://openalex.org/W2031901948","https://openalex.org/W2038248457","https://openalex.org/W2040360153","https://openalex.org/W2047039535","https://openalex.org/W2047486409","https://openalex.org/W2056892555","https://openalex.org/W2062897750","https://openalex.org/W2067568265","https://openalex.org/W2074564151","https://openalex.org/W2078188362","https://openalex.org/W2080007391","https://openalex.org/W2085415089","https://openalex.org/W2093421981","https://openalex.org/W2097970000","https://openalex.org/W2114964353","https://openalex.org/W2115344884","https://openalex.org/W2147357406","https://openalex.org/W2163003488","https://openalex.org/W2170181608","https://openalex.org/W2404089564"],"related_works":["https://openalex.org/W2028551440","https://openalex.org/W2073185054","https://openalex.org/W1602629252","https://openalex.org/W2592097772","https://openalex.org/W2528064348","https://openalex.org/W7074074516","https://openalex.org/W7010107854","https://openalex.org/W2115678203","https://openalex.org/W2085415089","https://openalex.org/W4404444667"],"abstract_inverted_index":{"Mammalian":[0],"cytochrome":[1,17],"c":[2,18,56,85,97,216,231],"(Cyt":[3],"c)":[4],"has":[5,88],"two":[6],"primary":[7],"functions:":[8],"transfer":[9],"of":[10,23,42,64,71,83,122,140,154,234,248,257,259],"electrons":[11],"from":[12,98,196],"the":[13,24,43,54,72,105,141,163,175,197,208],"bc1":[14],"complex":[15],"to":[16,76,137,162,183,238,253,264],"oxidase":[19],"(COX)":[20],"as":[21],"part":[22,153],"mitochondrial":[25],"electron":[26,57],"transport":[27],"chain":[28],"(ETC),":[29],"and":[30,48,186,201,223,256],"participation":[31],"in":[32,67,107,146,167,207,261],"type":[33],"II":[34],"apoptosis.":[35],"Several":[36],"studies":[37],"have":[38,50,94],"indicated":[39,117],"that":[40,53,103,157,174],"components":[41],"ETC":[44],"can":[45],"be":[46],"phosphorylated,":[47],"we":[49],"recently":[51],"shown":[52],"Cyt":[55,84,96,147,215,230,244],"acceptor":[58],"COX":[59,168],"is":[60,152,181,226],"phosphorylated":[61,150,214],"on":[62],"Tyr-304":[63],"subunit":[65,169],"I":[66],"liver":[68],"upon":[69],"activation":[70],"cAMP-dependent":[73],"pathway,":[74],"leading":[75],"strong":[77],"enzyme":[78],"inhibition.":[79],"However,":[80],"covalent":[81],"modification":[82],"through":[86],"phosphorylation":[87,109,123,165,250],"not":[89],"yet":[90],"been":[91],"reported.":[92],"We":[93],"isolated":[95],"cow":[99],"heart":[100],"under":[101],"conditions":[102],"preserve":[104],"physiological":[106],"vivo":[108,213],"status.":[110],"Western":[111],"analysis":[112,172],"with":[113,190,221,251,271],"an":[114],"anti-phosphotyrosine":[115],"antibody":[116],"tyrosine":[118,143,151,164],"phosphorylation.":[119],"The":[120,149],"site":[121,166],"was":[124],"definitively":[125],"assigned":[126],"by":[127],"immobilized":[128],"metal":[129],"affinity":[130],"chromatography/nano-liquid":[131],"chromatography/electrospray":[132],"ionization":[133],"mass":[134],"spectrometry":[135],"(IMAC/nano-LC/ESI-MS)":[136],"Tyr-97,":[138],"one":[139],"four":[142],"residues":[144,160],"present":[145],"c.":[148,245],"a":[155,229,266],"motif":[156],"contains":[158],"five":[159],"identical":[161],"I.":[170],"Spectral":[171],"revealed":[173],"characteristic":[176],"695":[177],"nm":[178,185],"absorption":[179],"band":[180,194],"shifted":[182],"687":[184],"reversed":[187],"after":[188],"treatment":[189],"alkaline":[191,242],"phosphatase.":[192],"This":[193],"results":[195],"Met-80-heme":[198],"iron":[199],"bond,":[200],"its":[202],"shift":[203],"might":[204],"indicate":[205],"changes":[206],"catalytic":[209],"heme":[210],"crevice.":[211],"In":[212],"shows":[217],"enhanced":[218],"sigmoidal":[219],"kinetics":[220],"COX,":[222],"half-maximal":[224],"turnover":[225],"observed":[227],"at":[228],"substrate":[232],"concentration":[233],"5.5":[235],"microM":[236,240],"compared":[237],"2.5":[239],"for":[241,269],"phosphatase-treated":[243],"Possible":[246],"consequences":[247],"Tyr-97":[249,260],"respect":[252],"cardiolipin":[254],"binding":[255],"location":[258],"close":[262],"proximity":[263],"Lys-7,":[265],"crucial":[267],"residue":[268],"interaction":[270],"Apaf-1":[272],"during":[273],"apoptosis,":[274],"are":[275],"discussed.":[276]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}