{"id":"https://openalex.org/W2127444105","doi":"https://doi.org/10.1152/ajpgi.00418.2010","title":"Knockout of the neurokinin-1 receptor reduces cholangiocyte proliferation in bile duct-ligated mice","display_name":"Knockout of the neurokinin-1 receptor reduces cholangiocyte proliferation in bile duct-ligated mice","publication_year":2011,"publication_date":"2011-05-20","ids":{"openalex":"https://openalex.org/W2127444105","doi":"https://doi.org/10.1152/ajpgi.00418.2010","mag":"2127444105","pmid":"https://pubmed.ncbi.nlm.nih.gov/21596993","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3154601"},"language":"en","primary_location":{"id":"doi:10.1152/ajpgi.00418.2010","doi":"https://doi.org/10.1152/ajpgi.00418.2010","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpgi.00418.2010","pdf_url":null,"source":{"id":"https://openalex.org/S34136372","display_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","issn_l":"0193-1857","issn":["0193-1857","1522-1547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3154601","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045220703","display_name":"Shannon S. Glaser","orcid":"https://orcid.org/0000-0002-0749-773X","observed_orcids":["https://orcid.org/0000-0002-0749-773X"]},"institutions":[{"id":"https://openalex.org/I4210116927","display_name":"Central Texas Veterans Health Care System","ror":"https://ror.org/02dcp1550","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210116927","https://openalex.org/I4210144023"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shannon Glaser","raw_affiliation_strings":["Department of Medicine,","Division of Research, Central Texas Veterans Health Care System,","Scott &amp; White Digestive Disease Research Center, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine,","institution_ids":[]},{"raw_affiliation_string":"Division of Research, Central Texas Veterans Health Care System,","institution_ids":["https://openalex.org/I4210116927"]},{"raw_affiliation_string":"Scott &amp; White Digestive Disease Research Center, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059963876","display_name":"Eugenio Gaudio","orcid":"https://orcid.org/0000-0001-6180-3091","observed_orcids":["https://orcid.org/0000-0001-6180-3091"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Eugenio Gaudio","raw_affiliation_strings":["Department of Anatomical, Histological, Forensic Medicine and Orthopedics Sciences, University of Rome \u201cLa Sapienza,\u201d Rome, Italy;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomical, Histological, Forensic Medicine and Orthopedics Sciences, University of Rome \u201cLa Sapienza,\u201d Rome, Italy;","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103228791","display_name":"Anastasia Renzi","orcid":"https://orcid.org/0000-0002-9886-7088","observed_orcids":["https://orcid.org/0000-0002-9886-7088"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Anastasia Renzi","raw_affiliation_strings":["Department of Anatomical, Histological, Forensic Medicine and Orthopedics Sciences, University of Rome \"La Sapienza,\" Rome, Italy","Department of Medicine,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomical, Histological, Forensic Medicine and Orthopedics Sciences, University of Rome \"La Sapienza,\" Rome, Italy","institution_ids":["https://openalex.org/I861853513"]},{"raw_affiliation_string":"Department of Medicine,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016070188","display_name":"Romina Mancinelli","orcid":"https://orcid.org/0000-0003-2040-0581","observed_orcids":["https://orcid.org/0000-0003-2040-0581"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Romina Mancinelli","raw_affiliation_strings":["Department of Anatomical, Histological, Forensic Medicine and Orthopedics Sciences, University of Rome \u201cLa Sapienza,\u201d Rome, Italy;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomical, Histological, Forensic Medicine and Orthopedics Sciences, University of Rome \u201cLa Sapienza,\u201d Rome, Italy;","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066151943","display_name":"Yoshiyuki Ueno","orcid":"https://orcid.org/0000-0001-5623-4250","observed_orcids":["https://orcid.org/0000-0001-5623-4250"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshiyuki Ueno","raw_affiliation_strings":["Division of Gastroenterology, Tohoku University Graduate School of Medicine, Aobaku, Sendai, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Tohoku University Graduate School of Medicine, Aobaku, Sendai, Japan;","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091026103","display_name":"Julie K Venter","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Julie Venter","raw_affiliation_strings":["Department of Medicine,","Scott &amp; White Digestive Disease Research Center, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine,","institution_ids":[]},{"raw_affiliation_string":"Scott &amp; White Digestive Disease Research Center, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077994068","display_name":"Mellanie White","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mellanie White","raw_affiliation_strings":["Department of Medicine,","Scott &amp; White Digestive Disease Research Center, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine,","institution_ids":[]},{"raw_affiliation_string":"Scott &amp; White Digestive Disease Research Center, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019825516","display_name":"Shelley E. Kopriva","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shelley Kopriva","raw_affiliation_strings":["Department of Medicine,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087719982","display_name":"Valorie L. Chiasson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Valorie Chiasson","raw_affiliation_strings":["Department of Medicine,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056263186","display_name":"Sharon DeMorrow","orcid":"https://orcid.org/0000-0002-0511-9778","observed_orcids":["https://orcid.org/0000-0002-0511-9778"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sharon DeMorrow","raw_affiliation_strings":["Department of Medicine,","Scott &amp; White Digestive Disease Research Center, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine,","institution_ids":[]},{"raw_affiliation_string":"Scott &amp; White Digestive Disease Research Center, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030400303","display_name":"Heather Francis","orcid":"https://orcid.org/0000-0002-3466-3545","observed_orcids":["https://orcid.org/0000-0002-3466-3545","https://orcid.org/0000-0001-5428-641X"]},"institutions":[{"id":"https://openalex.org/I125029298","display_name":"Texas A&M Health Science Center","ror":"https://ror.org/01tx6pn92","country_code":"US","type":"education","lineage":["https://openalex.org/I125029298","https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heather Francis","raw_affiliation_strings":["Department of Medicine,","Division of Research and Education, Scott &amp; White and Texas A&amp;M Health Science Center College of Medicine, Temple, Texas;","Scott &amp; White Digestive Disease Research Center, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine,","institution_ids":[]},{"raw_affiliation_string":"Division of Research and Education, Scott &amp; White and Texas A&amp;M Health Science Center College of Medicine, Temple, Texas;","institution_ids":["https://openalex.org/I125029298"]},{"raw_affiliation_string":"Scott &amp; White Digestive Disease Research Center, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008932925","display_name":"Fanyin Meng","orcid":"https://orcid.org/0000-0002-7602-9091","observed_orcids":["https://orcid.org/0000-0002-7602-9091"]},"institutions":[{"id":"https://openalex.org/I125029298","display_name":"Texas A&M Health Science Center","ror":"https://ror.org/01tx6pn92","country_code":"US","type":"education","lineage":["https://openalex.org/I125029298","https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fanyin Meng","raw_affiliation_strings":["Department of Medicine,","Division of Research and Education, Scott &amp; White and Texas A&amp;M Health Science Center College of Medicine, Temple, Texas;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine,","institution_ids":[]},{"raw_affiliation_string":"Division of Research and Education, Scott &amp; White and Texas A&amp;M Health Science Center College of Medicine, Temple, Texas;","institution_ids":["https://openalex.org/I125029298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046759342","display_name":"Marco Marzioni","orcid":"https://orcid.org/0000-0001-6014-6165","observed_orcids":["https://orcid.org/0000-0001-6014-6165"]},"institutions":[{"id":"https://openalex.org/I122534668","display_name":"Marche Polytechnic University","ror":"https://ror.org/00x69rs40","country_code":"IT","type":"education","lineage":["https://openalex.org/I122534668"]},{"id":"https://openalex.org/I4210108813","display_name":"Azienda Ospedaliero-Universitaria delle Marche","ror":"https://ror.org/0213f0637","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210108813"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marco Marzioni","raw_affiliation_strings":["Department of Gastroenterology, Universit\u00e0 Politecnica delle Marche, Ospedali Riuniti General Hospital of Ancona, Italy;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Universit\u00e0 Politecnica delle Marche, Ospedali Riuniti General Hospital of Ancona, Italy;","institution_ids":["https://openalex.org/I122534668","https://openalex.org/I4210108813"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057239346","display_name":"Antonio Franchitto","orcid":"https://orcid.org/0000-0003-0822-3690","observed_orcids":["https://orcid.org/0000-0003-0822-3690"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Antonio Franchitto","raw_affiliation_strings":["Department of Anatomical, Histological, Forensic Medicine and Orthopedics Sciences, University of Rome \u201cLa Sapienza,\u201d Rome, Italy;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomical, Histological, Forensic Medicine and Orthopedics Sciences, University of Rome \u201cLa Sapienza,\u201d Rome, Italy;","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081350888","display_name":"Domenico Alvaro","orcid":"https://orcid.org/0000-0003-3771-9644","observed_orcids":["https://orcid.org/0000-0003-3771-9644"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Domenico Alvaro","raw_affiliation_strings":["Division of Gastroenterology, Department of Clinical Medicine, Polo Pontino, University of Rome, \u201cSapienza,\u201d Rome, Italy;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Department of Clinical Medicine, Polo Pontino, University of Rome, \u201cSapienza,\u201d Rome, Italy;","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011379118","display_name":"Scott C. Supowit","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott Supowit","raw_affiliation_strings":["Division of Cell Biology and Anatomy, Medicine, University of South Carolina Medical School, Columbia, South Carolina; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cell Biology and Anatomy, Medicine, University of South Carolina Medical School, Columbia, South Carolina; and","institution_ids":["https://openalex.org/I155781252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087239740","display_name":"Donald J. DiPette","orcid":"https://orcid.org/0000-0002-5762-9104","observed_orcids":["https://orcid.org/0000-0002-5762-9104","https://orcid.org/0009-0008-9446-7942"]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donald J. DiPette","raw_affiliation_strings":["Division of Cell Biology and Anatomy, Medicine, University of South Carolina Medical School, Columbia, South Carolina; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cell Biology and Anatomy, Medicine, University of South Carolina Medical School, Columbia, South Carolina; and","institution_ids":["https://openalex.org/I155781252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046002870","display_name":"Paolo Onori","orcid":"https://orcid.org/0000-0002-7195-3760","observed_orcids":["https://orcid.org/0000-0002-7195-3760"]},"institutions":[{"id":"https://openalex.org/I26415053","display_name":"University of L'Aquila","ror":"https://ror.org/01j9p1r26","country_code":"IT","type":"education","lineage":["https://openalex.org/I26415053"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paolo Onori","raw_affiliation_strings":["Experimental Medicine, University of L'Aquila, L'Aquila, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Experimental Medicine, University of L'Aquila, L'Aquila, Italy","institution_ids":["https://openalex.org/I26415053"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029205234","display_name":"Gianfranco D. Alpini","orcid":"https://orcid.org/0000-0002-6658-3021","observed_orcids":["https://orcid.org/0000-0002-6658-3021"]},"institutions":[{"id":"https://openalex.org/I4210116927","display_name":"Central Texas Veterans Health Care System","ror":"https://ror.org/02dcp1550","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210116927","https://openalex.org/I4210144023"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gianfranco Alpini","raw_affiliation_strings":["Department of Medicine,","Division of Research, Central Texas Veterans Health Care System,","Scott &amp; White Digestive Disease Research Center, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine,","institution_ids":[]},{"raw_affiliation_string":"Division of Research, Central Texas Veterans Health Care System,","institution_ids":["https://openalex.org/I4210116927"]},{"raw_affiliation_string":"Scott &amp; White Digestive Disease Research Center, and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5029205234"],"corresponding_institution_ids":["https://openalex.org/I4210116927"],"apc_list":null,"apc_paid":null,"fwci":1.2169,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.81302073,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"301","issue":"2","first_page":"G297","last_page":"G305"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.8169000148773193,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.8169000148773193,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.09030000120401382,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":0.02669999934732914,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neurokinin-1-receptor","display_name":"neurokinin-1 receptor","score":0.9789999723434448},{"id":"https://openalex.org/keywords/substance-p","display_name":"substance P","score":0.8069999814033508},{"id":"https://openalex.org/keywords/cholangiocyte-proliferation","display_name":"cholangiocyte proliferation","score":0.9800000190734863},{"id":"https://openalex.org/keywords/bile-duct-ligation","display_name":"bile duct ligation","score":0.9210000038146973},{"id":"https://openalex.org/keywords/biliary-hyperplasia","display_name":"biliary hyperplasia","score":0.9139999747276306},{"id":"https://openalex.org/keywords/cholangiopathy","display_name":"cholangiopathy","score":0.8159999847412109},{"id":"https://openalex.org/keywords/hepatocyte-apoptosis","display_name":"hepatocyte apoptosis","score":0.8080000281333923},{"id":"https://openalex.org/keywords/hepatocyte-steatosis","display_name":"hepatocyte steatosis","score":0.8650000095367432},{"id":"https://openalex.org/keywords/pka-phosphorylation","display_name":"PKA phosphorylation","score":0.7770000100135803},{"id":"https://openalex.org/keywords/camp-signaling","display_name":"cAMP signaling","score":0.9399999976158142},{"id":"https://openalex.org/keywords/alpha-calcitonin-gene-related-peptide","display_name":"alpha-calcitonin gene-related peptide","score":0.8759999871253967},{"id":"https://openalex.org/keywords/alpha-smooth-muscle-actin","display_name":"alpha-smooth muscle actin","score":0.9549999833106995},{"id":"https://openalex.org/keywords/ck19","display_name":"CK19","score":0.6859999895095825},{"id":"https://openalex.org/keywords/biliary-inflammation","display_name":"biliary tract inflammation","score":0.3019999861717224}],"concepts":[{"id":"https://openalex.org/C2780186670","wikidata":"https://www.wikidata.org/wiki/Q5104283","display_name":"Cholangiocyte","level":2,"score":0.8646144866943359},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7748932838439941},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7415802478790283},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5176156759262085},{"id":"https://openalex.org/C2778593092","wikidata":"https://www.wikidata.org/wiki/Q1075923","display_name":"Cholestasis","level":2,"score":0.4237421154975891},{"id":"https://openalex.org/C182704531","wikidata":"https://www.wikidata.org/wiki/Q1364740","display_name":"Knockout mouse","level":3,"score":0.41457292437553406},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32551300525665283},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2995434105396271},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12775149941444397}],"mesh":[{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000410","descriptor_name":"Alanine Transaminase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001219","descriptor_name":"Aspartate Aminotransferases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001652","descriptor_name":"Bile Ducts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001652","descriptor_name":"Bile Ducts","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001652","descriptor_name":"Bile Ducts","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D001663","descriptor_name":"Bilirubin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002452","descriptor_name":"Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002779","descriptor_name":"Cholestasis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008026","descriptor_name":"Ligation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009336","descriptor_name":"Necrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013373","descriptor_name":"Substance P","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015544","descriptor_name":"Inositol 1,4,5-Trisphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017868","descriptor_name":"Cyclic AMP-Dependent Protein Kinases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D018040","descriptor_name":"Receptors, Neurokinin-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018040","descriptor_name":"Receptors, Neurokinin-1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018809","descriptor_name":"Proliferating Cell Nuclear Antigen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D023421","descriptor_name":"Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024042","descriptor_name":"Collagen Type I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1152/ajpgi.00418.2010","doi":"https://doi.org/10.1152/ajpgi.00418.2010","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpgi.00418.2010","pdf_url":null,"source":{"id":"https://openalex.org/S34136372","display_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","issn_l":"0193-1857","issn":["0193-1857","1522-1547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3154601","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3154601","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Physiol Gastrointest Liver Physiol","raw_type":"Text"},{"id":"pmid:21596993","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21596993","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Gastrointestinal and liver physiology","raw_type":"Journal Article"},{"id":"pmh:oai:iris.uniroma1.it:11573/507774","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11573/507774","pdf_url":null,"source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3154601","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3154601","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Physiol Gastrointest Liver Physiol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.44999998807907104}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2399633780","display_name":null,"funder_award_id":"DK062975","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2450932047","display_name":"Regulation of Bile Duct Growth in Bile Duct Ligated Rats","funder_award_id":"R01DK062975","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G6152835084","display_name":"Dysregulation of hypothalamic neuropeptides is associated with biliary hyperplasia","funder_award_id":"R01DK082435","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G7184668884","display_name":"Role of the Renin-Angiotensin System in the Regulation of Biliary Proliferation","funder_award_id":"R01DK081442","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W68565609","https://openalex.org/W1489936284","https://openalex.org/W1510352950","https://openalex.org/W1752945314","https://openalex.org/W1801815609","https://openalex.org/W1844272684","https://openalex.org/W1966292953","https://openalex.org/W1968544303","https://openalex.org/W1971013426","https://openalex.org/W1972496381","https://openalex.org/W1973867916","https://openalex.org/W1975624789","https://openalex.org/W1979032136","https://openalex.org/W1982708256","https://openalex.org/W2004838290","https://openalex.org/W2009337005","https://openalex.org/W2016929653","https://openalex.org/W2028283539","https://openalex.org/W2035117251","https://openalex.org/W2038341639","https://openalex.org/W2038574243","https://openalex.org/W2046495835","https://openalex.org/W2049703232","https://openalex.org/W2051942658","https://openalex.org/W2052528853","https://openalex.org/W2054944860","https://openalex.org/W2059991847","https://openalex.org/W2064216898","https://openalex.org/W2071588419","https://openalex.org/W2075319350","https://openalex.org/W2077549265","https://openalex.org/W2077762233","https://openalex.org/W2086147744","https://openalex.org/W2086397529","https://openalex.org/W2091099965","https://openalex.org/W2116601505","https://openalex.org/W2122426005","https://openalex.org/W2124288445","https://openalex.org/W2130831747","https://openalex.org/W2143609597","https://openalex.org/W2145152689","https://openalex.org/W2153549414","https://openalex.org/W2162642444","https://openalex.org/W2395466827","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2132833468","https://openalex.org/W2122426005","https://openalex.org/W3044576199","https://openalex.org/W2124288445","https://openalex.org/W4293701556","https://openalex.org/W2059991847","https://openalex.org/W1752945314","https://openalex.org/W2586404251","https://openalex.org/W4225408420","https://openalex.org/W2580335599"],"abstract_inverted_index":{"In":[0,108,136,152,180,207,222],"bile":[1],"duct-ligated":[2],"(BDL)":[3],"rats,":[4],"cholangiocyte":[5,30,109],"proliferation":[6],"is":[7,19],"regulated":[8],"by":[9,72],"neuroendocrine":[10],"factors":[11],"such":[12],"as":[13],"\u03b1-calcitonin":[14],"gene-related":[15],"peptide":[16],"(\u03b1-CGRP).":[17],"There":[18],"no":[20],"evidence":[21],"that":[22],"the":[23,67,113,168,184,241],"sensory":[24],"neuropeptide":[25],"substance":[26],"P":[27],"(SP)":[28],"regulates":[29],"hyperplasia.":[31],"Wild-type":[32],"(WT,":[33],"(+/+))":[34],"and":[35,56,64,66,74,90,99,103,119,124,145,164,167,173,189,198,219,229],"NK-1":[36],"receptor":[37],"(NK-1R)":[38],"knockout":[39],"(NK-1R(-/-))":[40],"mice":[41,197,213],"underwent":[42],"sham":[43],"or":[44],"BDL":[45,155,193,201,205,210],"for":[46,87],"1":[47],"wk.":[48],"Then":[49],"we":[50,111],"evaluated":[51],"1)":[52],"NK-1R":[53,129,153,211,236],"expression,":[54],"transaminases,":[55],"bilirubin":[57,165],"serum":[58,162],"levels;":[59],"2)":[60],"necrosis,":[61],"hepatocyte":[62,143,147],"apoptosis":[63,144,176],"steatosis,":[65],"number":[68,169],"of":[69,115,170,186,232,235,243],"cholangiocytes":[70,172,208],"positive":[71],"CK-19":[73],"terminal":[75],"deoxynucleotidyl":[76],"transferase":[77],"biotin-dUTP":[78],"nick-end":[79],"labeling":[80],"in":[81,95,106,161,192,200,240,246],"liver":[82,97,182],"sections;":[83],"3)":[84],"mRNA":[85],"expression":[86,102,131,185,218],"collagen":[88,187],"1\u03b1":[89,188],"\u03b1-smooth":[91],"muscle":[92],"(\u03b1-SMA)":[93],"actin":[94],"total":[96,181],"samples;":[98],"4)":[100],"PCNA":[101,217],"PKA":[104,125,220,230],"phosphorylation":[105,231],"cholangiocytes.":[107,233],"lines,":[110],"determined":[112],"effects":[114],"SP":[116,224],"on":[117],"cAMP":[118,226],"D-myo-inositol":[120],"1,4,5-trisphosphate":[121],"levels,":[122,227],"proliferation,":[123,228],"phosphorylation.":[126,221],"Cholangiocytes":[127],"express":[128],"with":[130,150,178,195,204],"being":[132],"upregulated":[133],"following":[134],"BDL.":[135],"normal":[137,196],"NK-1R(-/-)":[138,202],"mice,":[139,156],"there":[140,157,214],"was":[141,158,215],"higher":[142],"scattered":[146],"steatosis":[148],"compared":[149,177,194,203],"controls.":[151,179],"(-)/(-)":[154,212],"a":[159],"decrease":[160],"transaminases":[163],"levels":[166],"CK-19-positive":[171],"enhanced":[174],"biliary":[175,244],"samples,":[183],"\u03b1-SMA":[190],"increased":[191,225],"decreased":[199,216],"mice.":[206],"from":[209],"vitro,":[223],"Targeting":[234],"may":[237],"be":[238],"important":[239],"inhibition":[242],"hyperplasia":[245],"cholangiopathies.":[247]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
