{"id":"https://openalex.org/W2127429886","doi":"https://doi.org/10.1002/mabi.201300482","title":"Silk\u2010Pectin Hydrogel with Superior Mechanical Properties, Biodegradability, and Biocompatibility","display_name":"Silk\u2010Pectin Hydrogel with Superior Mechanical Properties, Biodegradability, and Biocompatibility","publication_year":2014,"publication_date":"2014-03-07","ids":{"openalex":"https://openalex.org/W2127429886","doi":"https://doi.org/10.1002/mabi.201300482","mag":"2127429886","pmid":"https://pubmed.ncbi.nlm.nih.gov/24610718"},"language":"en","primary_location":{"id":"doi:10.1002/mabi.201300482","doi":"https://doi.org/10.1002/mabi.201300482","is_oa":true,"landing_page_url":"https://doi.org/10.1002/mabi.201300482","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/mabi.201300482","source":{"id":"https://openalex.org/S182383103","display_name":"Macromolecular Bioscience","issn_l":"1616-5187","issn":["1616-5187","1616-5195"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Macromolecular Bioscience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/mabi.201300482","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037383580","display_name":"Keiji Numata","orcid":"https://orcid.org/0000-0003-2199-7420","observed_orcids":["https://orcid.org/0000-0003-2199-7420"]},"institutions":[{"id":"https://openalex.org/I4210110652","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Keiji Numata","raw_affiliation_strings":["Enzyme Research Team, RIKEN Biomass Engineering Program, RIKEN 2-1 Hirosawa, Wako-shi, Saitama, 351-0198 Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Enzyme Research Team, RIKEN Biomass Engineering Program, RIKEN 2-1 Hirosawa, Wako-shi, Saitama, 351-0198 Japan","institution_ids":["https://openalex.org/I4210110652"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040480540","display_name":"Shoya Yamazaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I171481255","display_name":"Shibaura Institute of Technology","ror":"https://ror.org/020wjcq07","country_code":"JP","type":"education","lineage":["https://openalex.org/I171481255"]},{"id":"https://openalex.org/I4210110652","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shoya Yamazaki","raw_affiliation_strings":["Department of Applied Chemistry, Materials Science Course, College of Engineering, Shibaura Institute of Technology, 3-7-5 Toyosu, Koto-ku, Tokyo, 135-8548 Japan","Enzyme Research Team, RIKEN Biomass Engineering Program, RIKEN 2-1 Hirosawa, Wako-shi, Saitama, 351-0198 Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Chemistry, Materials Science Course, College of Engineering, Shibaura Institute of Technology, 3-7-5 Toyosu, Koto-ku, Tokyo, 135-8548 Japan","institution_ids":["https://openalex.org/I171481255"]},{"raw_affiliation_string":"Enzyme Research Team, RIKEN Biomass Engineering Program, RIKEN 2-1 Hirosawa, Wako-shi, Saitama, 351-0198 Japan","institution_ids":["https://openalex.org/I4210110652"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009962436","display_name":"Takuya Katashima","orcid":"https://orcid.org/0000-0001-6184-3835","observed_orcids":["https://orcid.org/0000-0001-6184-3835"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takuya Katashima","raw_affiliation_strings":["Department of Bioengineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656 Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656 Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073413014","display_name":"Jo\u2010Ann Chuah","orcid":"https://orcid.org/0000-0002-0874-4667","observed_orcids":["https://orcid.org/0000-0002-0874-4667"]},"institutions":[{"id":"https://openalex.org/I4210110652","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Jo\u2010Ann Chuah","raw_affiliation_strings":["Enzyme Research Team, RIKEN Biomass Engineering Program, RIKEN 2-1 Hirosawa, Wako-shi, Saitama, 351-0198 Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Enzyme Research Team, RIKEN Biomass Engineering Program, RIKEN 2-1 Hirosawa, Wako-shi, Saitama, 351-0198 Japan","institution_ids":["https://openalex.org/I4210110652"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052426315","display_name":"Naofumi Naga","orcid":"https://orcid.org/0000-0003-0695-5011","observed_orcids":["https://orcid.org/0000-0003-0695-5011"]},"institutions":[{"id":"https://openalex.org/I171481255","display_name":"Shibaura Institute of Technology","ror":"https://ror.org/020wjcq07","country_code":"JP","type":"education","lineage":["https://openalex.org/I171481255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naofumi Naga","raw_affiliation_strings":["Department of Applied Chemistry, Materials Science Course, College of Engineering, Shibaura Institute of Technology, 3-7-5 Toyosu, Koto-ku, Tokyo, 135-8548 Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Chemistry, Materials Science Course, College of Engineering, Shibaura Institute of Technology, 3-7-5 Toyosu, Koto-ku, Tokyo, 135-8548 Japan","institution_ids":["https://openalex.org/I171481255"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011556710","display_name":"Takamasa Sakai","orcid":"https://orcid.org/0000-0001-5052-0512","observed_orcids":["https://orcid.org/0000-0001-5052-0512"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takamasa Sakai","raw_affiliation_strings":["Department of Bioengineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656 Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656 Japan","institution_ids":["https://openalex.org/I74801974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5037383580"],"corresponding_institution_ids":["https://openalex.org/I4210110652"],"apc_list":{"value":4880,"currency":"USD","value_usd":4880},"apc_paid":{"value":4880,"currency":"USD","value_usd":4880},"fwci":1.1221,"has_fulltext":true,"cited_by_count":67,"citation_normalized_percentile":{"value":0.71390321,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"14","issue":"6","first_page":"799","last_page":"806"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11966","display_name":"Silk-based biomaterials and applications","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11966","display_name":"Silk-based biomaterials and applications","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11419","display_name":"Supramolecular Self-Assembly in Materials","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/silk-fibroin","display_name":"silk fibroin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/pectin","display_name":"pectin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/dialysis","display_name":"dialysis","score":0.5799999833106995},{"id":"https://openalex.org/keywords/mechanical-properties-of-hydrogels","display_name":"hydrogel mechanical properties","score":0.7770000100135803},{"id":"https://openalex.org/keywords/biodegradability","display_name":"biodegradability","score":0.9319999814033508},{"id":"https://openalex.org/keywords/biocompatibility","display_name":"biocompatibility","score":1.0},{"id":"https://openalex.org/keywords/heterogeneous-networks","display_name":"heterogeneous networks","score":0.7419999837875366},{"id":"https://openalex.org/keywords/elastic-modulus","display_name":"elastic modulus","score":0.6119999885559082},{"id":"https://openalex.org/keywords/elastic-limit","display_name":"elastic limit","score":0.6859999895095825}],"concepts":[{"id":"https://openalex.org/C108586683","wikidata":"https://www.wikidata.org/wiki/Q17164826","display_name":"Self-healing hydrogels","level":2,"score":0.9451006650924683},{"id":"https://openalex.org/C2780431358","wikidata":"https://www.wikidata.org/wiki/Q653622","display_name":"SILK","level":2,"score":0.8980298042297363},{"id":"https://openalex.org/C122302759","wikidata":"https://www.wikidata.org/wiki/Q2345087","display_name":"Fibroin","level":3,"score":0.831944465637207},{"id":"https://openalex.org/C2780756937","wikidata":"https://www.wikidata.org/wiki/Q188154","display_name":"Pectin","level":2,"score":0.8230082392692566},{"id":"https://openalex.org/C2777230088","wikidata":"https://www.wikidata.org/wiki/Q864426","display_name":"Biocompatibility","level":2,"score":0.7935575246810913},{"id":"https://openalex.org/C2778540859","wikidata":"https://www.wikidata.org/wiki/Q152234","display_name":"Swelling","level":2,"score":0.48883432149887085},{"id":"https://openalex.org/C157021035","wikidata":"https://www.wikidata.org/wiki/Q696715","display_name":"Biodegradation","level":2,"score":0.4873843789100647},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.4652247130870819},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.46308499574661255},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4400133490562439},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.4024255871772766},{"id":"https://openalex.org/C126348684","wikidata":"https://www.wikidata.org/wiki/Q3456979","display_name":"Polymer science","level":1,"score":0.35144561529159546},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.3240099847316742},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.10045373439788818},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.041204243898391724},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008422","descriptor_name":"Materials Testing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010368","descriptor_name":"Pectins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D020100","descriptor_name":"Hydrogels","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D047011","descriptor_name":"Silk","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/mabi.201300482","doi":"https://doi.org/10.1002/mabi.201300482","is_oa":true,"landing_page_url":"https://doi.org/10.1002/mabi.201300482","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/mabi.201300482","source":{"id":"https://openalex.org/S182383103","display_name":"Macromolecular Bioscience","issn_l":"1616-5187","issn":["1616-5187","1616-5195"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Macromolecular Bioscience","raw_type":"journal-article"},{"id":"pmid:24610718","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24610718","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Macromolecular bioscience","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/mabi.201300482","doi":"https://doi.org/10.1002/mabi.201300482","is_oa":true,"landing_page_url":"https://doi.org/10.1002/mabi.201300482","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/mabi.201300482","source":{"id":"https://openalex.org/S182383103","display_name":"Macromolecular Bioscience","issn_l":"1616-5187","issn":["1616-5187","1616-5195"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Macromolecular Bioscience","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5475596417","display_name":"Plant cell wall-mimicking silk-pectin hydrogel for coral reef regeneration","funder_award_id":"25810110","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2127429886.pdf","grobid_xml":"https://content.openalex.org/works/W2127429886.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1505352099","https://openalex.org/W1965904253","https://openalex.org/W1971339046","https://openalex.org/W1972086723","https://openalex.org/W1981076043","https://openalex.org/W1983808544","https://openalex.org/W1993117229","https://openalex.org/W2005629845","https://openalex.org/W2014866452","https://openalex.org/W2015086435","https://openalex.org/W2018696463","https://openalex.org/W2031344083","https://openalex.org/W2036982932","https://openalex.org/W2040469730","https://openalex.org/W2040798388","https://openalex.org/W2044289073","https://openalex.org/W2054247573","https://openalex.org/W2054988877","https://openalex.org/W2058331622","https://openalex.org/W2058621622","https://openalex.org/W2059933286","https://openalex.org/W2064707228","https://openalex.org/W2077990286","https://openalex.org/W2080378523","https://openalex.org/W2080788812","https://openalex.org/W2082296643","https://openalex.org/W2109464227","https://openalex.org/W2132551021","https://openalex.org/W2140250096","https://openalex.org/W2144866800","https://openalex.org/W2157908104","https://openalex.org/W2159080918","https://openalex.org/W2165694975","https://openalex.org/W2318989303"],"related_works":["https://openalex.org/W2961458777","https://openalex.org/W4281397656","https://openalex.org/W2238941484","https://openalex.org/W4393040033","https://openalex.org/W2783154469","https://openalex.org/W1901466461","https://openalex.org/W4200531595","https://openalex.org/W4245228537","https://openalex.org/W2617712153","https://openalex.org/W7167601826"],"abstract_inverted_index":{"A":[0],"new":[1],"method":[2],"is":[3,40,69,81,88],"developed":[4],"to":[5,16,71,127],"prepare":[6],"silk":[7,23,51,55,63],"hydrogels":[8,11,18,39,101],"and":[9,30,33,94,117,129],"silk-pectin":[10,38,74,77],"via":[12],"dialysis":[13],"against":[14],"methanol":[15],"obtain":[17],"with":[19,50,125],"high":[20],"concentrations":[21],"of":[22,36,65,83,104,112,121],"fibroin.":[24],"The":[25,43,76],"relationship":[26],"between":[27],"the":[28,34,37,54],"mechanical":[29],"biological":[31],"properties":[32],"structure":[35],"subsequently":[41],"evaluated.":[42],"present":[44],"results":[45],"suggest":[46],"that":[47,61],"pectin":[48],"associates":[49],"molecules":[52],"when":[53],"concentration":[56,64],"exceeds":[57],"15":[58,67],"wt%,":[59],"suggesting":[60],"a":[62,84],"over":[66],"wt%":[68],"critical":[70],"construct":[72],"interacting":[73],"networks.":[75],"hydrogel":[78],"reported":[79],"here":[80],"composed":[82],"heterogeneous":[85],"network,":[86],"which":[87],"different":[89],"from":[90],"fiber-reinforced,":[91],"interpenetrated":[92],"networks":[93],"double-network":[95],"hydrogels,":[96],"as":[97,99],"well":[98],"high-stiffness":[100],"(elastic":[102],"modulus":[103],"4.7":[105],"\u00b1":[106,114,123],"0.9":[107],"MPa,":[108,116],"elastic":[109,118],"stress":[110],"limit":[111,120],"3.9":[113],"0.1":[115],"strain":[119],"48.4":[122],"0.5%)":[124],"regard":[126],"biocompatibility":[128],"biodegradability.":[130]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}